Abstract: A process is provided for the free radical polymerization of monomers derived from substituted or unsubstituted acrylic acid/methacrylic acid and esters thereof for the production of a polymer having a narrow molecular weight distribution and an average molecular weight of less than 4000. These polymers are produced by the solution polymerizing of said monomers wherein 20-40% by weight of the monomer composition is hydroxyalkyl acrylate or methacrylate in the presence of a solvent system suitable for high solids coating applications and in the presence of an initiating amount of a tertiary alkyl hydroperoxide and/or its derivatives having at least 5 carbons wherein the initiator and monomers, alone or in combination, are added continuously at a programmed rate wherein the rate of addition corresponds approximately to the rate of decomposition of said monomer and initiator. These polymers are used for high solids coating applications.
Abstract: Compounds possessing antiallergy activity have the formula: ##STR1## wherein R and R.sup.1 are independently hydrogen or alkyl, or R and R.sup.1 together with the attached nitrogen form a heterocyclic ring system selected from the group consisting of piperidinyl, pyrrolidinyl, morpholinyl and 1, 2, 3, 4-tetrohydroquinolinyl, and R.sup.2 is phenyl or phenyl monosubstituted with a lower alkyl, a nitro, a halogenated methyl, a halogen or a lower alkoxy group.
Abstract: The trans isomeric form of 1,3,4,6,7,11b-hexahydro-7-aryl-2H-pyrazino[2,1-a]isoquinolines are prepared using novel 3-phenyl-4-arylacyl-2-piperazinones and 3-phenyl-4-(2-hydroxy-2-arylethyl) piperazines as intermediates. The process involves reacting a nove piperazinone with a reducing agent such as aluminum hydrides, borane or lithium borohydrides, and then reacting the resulting piperazine with a strong acid, such as polyphosphoric or sulfuric acid.
Abstract: A photoelectric-piezoelectric velocity and impact sensor has a plurality of photoelectric light sources and associated photodetectors disposed on axes defining an array of light beams. A first electronic circuit is operatively coupled to the photodetectors for generating a signal representative of the moment in time when at least one light beam of the array is broken by a projectile passing through the array. A substantially planar transducer is disposed coplanar with and spaced apart from the array for generating a signal when the projectile strikes the transducer after passing through the array. A second electronic circuit responsive to the signal from the transducer is provided for generating a signal representative of the moment in time when the projectile strikes the transducer. A calculating circuit responsive to the signal from the first circuit and the signal from the second circuit is provided for calculating the velocity of the projectile as a function of the time difference between the signals.
Abstract: Substituted 3,5-diphenyl-3-[(1H-1,2,4-triazol-1-yl) methyl]-2-methylisoxazolidines in which hydrogens of their phenyl rings may be replaced by halogen, lower alkoxy, lower alkyl or nitro groups are useful as antifungal agents.
Abstract: 5-(phenyl or phenoxymethyl)-3-(2-furanyl)-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolid ine and related derivatives in which one or more hydrogens on the phenyl ring are replaced by halogen, lower alkyl, lower alkoxy, nitro and combinations thereof are useful as antifungal agents.
Abstract: Novel 1 2(H)-phthalazones are disclosed along with a method of treating either allergic rihinitis or bronchial asthma by the administration to a mammal an effective amount of a compound of the formula: ##STR1## wherein R.sub.1 is hydrogen, hydroxyl, C.sub.1 -C.sub.4 alkoxy, or C.sub.1 -C.sub.4 alkylthio,R.sub.2 is ##STR2## or 1-pyrrolidinyl, R.sub.3 and R.sub.4 are independently hydrogen or C.sub.1 -C.sub.4 alkyl,X is CH.sub.2, O or NR.sub.5,Y is ethylene or ethenylene,R.sub.5 is hydrogen or C.sub.1 -C.sub.4 alkyl,n is 2, 3 or 4,and all stereoisomeric forms and pharmaceutical acceptable addition salts thereof.
Abstract: 5-(Phenyl or phenoxymethyl)-3-(2-thienyl)-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolid ines and related derivatives in which one or more hydrogens on the 5-phenyl or phenoxy rings are replaced by halogen, lower alkyl, lower alkoxy, nitro and combinations thereof are useful as antifungal agents.
Abstract: Compounds are provided of the following general structure: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are independently selected from hydrogen or methyl; A is amino, C.sub.1 -C.sub.4 monoalkylamino, C.sub.2 -C.sub.8 dialkylamino, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl or cyclopropylamino; and where W and Q are independently selected from 2-pyridinyl, 3-pyridinyl or 4-pyridinly or phenyl, provided W and Q are not both phenyl.
Abstract: Peptides and Peptide amides such as cholecystokinin (CCK-8) are synthesized in improved yields and purity by a solid phase process. The requisite protected peptide is elaborated and sulfated on a solid support, deprotected, and cleaved from the solid support to give the total synthesis of CCK-8 on a solid support. Thereafter, the peptide is purified in a single step by ion exchange chromatography to provide analytically pure CCK-8.
Abstract: 5-(Hydroxy or alkoxyalkyl)-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines and related derivatives in which hydrogens of the phenyl ring are replaced by halogen, lower alkyl or lower alkoxy groups are useful as antifungal agents.
Abstract: 3-Phenyl-3-(1H-imidazol-1-ylmethyl)-2-methyl-5-[(phenylamino)methyl]isoxazo lidine and related derivatives in which hydrogens of their phenyl rings may be replaced by one or more halogen, lower alkoxy, lower alkyl and nitro groups are useful as antifungal agents.
Abstract: 3-Phenyl-3-(1H-1,2,4-triazol-1-methyl)-2-methyl-5-alkylisoxazolidines and related derivatives in which hydrogens in the phenyl ring are replaced by halogen, lower alkyl or lower alkoxy groups are useful as antifungal agents.
Abstract: Analgesic 1,2,3,4-tetrahydroisoquinolines of the formula (1) ##STR1## wherein R.sub.1 and R.sub.2 respectively are hydrogen, hydroxy or alkoxy of 1 to 4 carbon atoms, R.sub.3 and R.sub.4 respectively are hydrogen or alkyl of 1 to 4 carbon atoms, and R.sub.5 is hydroxy, nitro or ##STR2## wherein R.sub.6 and R.sub.7 respectively are hydrogen, alkyl of 1 to 4 carbon atoms or RCO-- wherein R is hydrogen or alkyl of 1 to 4 carbon atoms; pharmaceutically acceptable addition salts thereof with non-toxic acids; analgesic compositions thereof in an inert, pharmaceutical carrier; and methods of preparation from corresponding R.sub.1, R.sub.2, R.sub.3 and R.sub.4 -substituted tetrahydroisoquinolines.
Abstract: Decanter pond level or radius is adjusted incrementally by means of an annular retainer plate having an eccentric recess formed in the surface thereof which faces hub openings. The recess receives a plate dam slidably therewithin. Each retainer plate or retainer, typically 6 in number, is mounted over a hub opening. The dam is mounted over the hub opening such that its weir surface substantially coincides with the rotating pond level. By rotating the retainer around the prepositioned dam in increments preset in the retainer, the dam moves radially inwardly or outwardly depending upon the position of the recess eccentricity with respect to the hub opening. The dam is provided with two different weir surfaces, each usable with a different side of the dam, thus permitting the number of adjustments to the pond level to be doubled. A modification discloses infinite or stepless pond level adjustments.
Abstract: A formulation of a drug wherein the drug is present as a coated, drug-resin complex suspended in a liquid carrier which carrier also contains a second ionic component bearing the same charge as the coated complexed drug, the second ionic component being present as an uncoated, insoluble drug-resin complex.
Abstract: Empty boxes for packing articles thereinto, typically fruit, are packed by handpackers, for example, stationed along a plurality of fruit packing lines, each line provided with an empty box accumulation station. As soon as a box is packed and conveyed to a palletizer, an empty box is conveyed to the accumulation station on conveyor belt means from a box buffer station in closest proximity thereto and immediately upstream thereof to stack up against the last, or most upstream of the accumulated boxes, causing each box in each upstream buffer station to be conveyed downstream to thereby maintain each buffer station satisfied, the last box of the most upstream buffer station being supplied from a main box holding station. Box movement is controlled by photocell switches inputting signals to a microprocessor indicating the absence or presence of a box at a predetermined location.
August 21, 1985
Date of Patent:
August 9, 1988
Richard D. Walters, Jon De Young, Clarence M. Rasmussen, Louie S. Almares
Abstract: 1,2,4-Triazolo[4,3-d]-4-azatricyclo[126.96.36.199.sup.3,8 ]-undecane and 3-derivatives and intermediates thereof are described. The compounds are useful and antiinflammatory and antihypoxia agents.