Patents Assigned to Prognosys Biosciences, Inc.
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Patent number: 11542543Abstract: The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.Type: GrantFiled: March 11, 2022Date of Patent: January 3, 2023Assignee: Prognosys Biosciences, Inc.Inventor: Mark S. Chee
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Publication number: 20220389491Abstract: The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.Type: ApplicationFiled: August 1, 2022Publication date: December 8, 2022Applicant: Prognosys Biosciences, Inc.Inventor: Mark S. Chee
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Patent number: 11519022Abstract: The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.Type: GrantFiled: June 27, 2022Date of Patent: December 6, 2022Assignee: Prognosys Biosciences, Inc.Inventor: Mark S. Chee
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Patent number: 11499188Abstract: The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired ROIs. Such validated ROIs and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like.Type: GrantFiled: October 21, 2019Date of Patent: November 15, 2022Assignee: Prognosys Biosciences, Inc.Inventor: Mark S. Chee
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Patent number: 11499187Abstract: The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired ROIs. Such validated ROIs and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like.Type: GrantFiled: October 21, 2019Date of Patent: November 15, 2022Assignee: Prognosys Biosciences, Inc.Inventor: Mark S. Chee
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Patent number: 11479810Abstract: The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.Type: GrantFiled: June 17, 2022Date of Patent: October 25, 2022Assignee: Prognosys Biosciences, Inc.Inventor: Mark S. Chee
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Publication number: 20220333171Abstract: The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.Type: ApplicationFiled: June 27, 2022Publication date: October 20, 2022Applicant: Prognosys Biosciences, Inc.Inventor: Mark S. Chee
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Publication number: 20220325325Abstract: The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the biological targets comprise proteins, and the methods and assay systems do not depend on imaging techniques for the spatial information of the targets. The present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents; and a decoding scheme providing a readout that is digital in nature.Type: ApplicationFiled: June 2, 2022Publication date: October 13, 2022Applicant: Prognosys Biosciences, Inc.Inventors: Mark S. CHEE, David A. ROUTENBERG
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Publication number: 20220315998Abstract: The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.Type: ApplicationFiled: June 17, 2022Publication date: October 6, 2022Applicant: Prognosys Biosciences, Inc.Inventor: Mark S. Chee
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Patent number: 11447822Abstract: The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired ROIs. Such validated ROIs and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like.Type: GrantFiled: October 21, 2019Date of Patent: September 20, 2022Assignee: Prognosys Biosciences, Inc.Inventor: Mark S. Chee
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Publication number: 20220290219Abstract: The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.Type: ApplicationFiled: May 26, 2022Publication date: September 15, 2022Applicant: Prognosys Biosciences, Inc.Inventor: Mark S. CHEE
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Publication number: 20220260581Abstract: The present invention provides methods for constructing peptide construct sets and methods of use of these peptide construct sets in assay systems for peptide analysis, and in particular for use in high throughput peptide analysis. The methods allow for analysis of large sets of peptide constructs in a cost-effective manner, employing molecular biological techniques that are both robust and easily parallelized. Thus, the methods allow for the construction of peptide construct sets encompassing, e.g., the human proteome.Type: ApplicationFiled: April 22, 2022Publication date: August 18, 2022Applicant: Prognosys Biosciences, Inc.Inventors: Igor A. KOZLOV, Mark S. CHEE, Petr CAPEK, David A. ROUTENBERG
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Patent number: 11401545Abstract: The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.Type: GrantFiled: December 20, 2021Date of Patent: August 2, 2022Assignee: Prognosys Biosciences, Inc.Inventor: Mark S. Chee
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Patent number: 11384386Abstract: The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.Type: GrantFiled: September 23, 2020Date of Patent: July 12, 2022Assignee: Prognosys Biosciences, Inc.Inventor: Mark S. Chee
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Patent number: 11371086Abstract: The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.Type: GrantFiled: September 21, 2021Date of Patent: June 28, 2022Assignee: Prognosys Biosciences, Inc.Inventor: Mark S. Chee
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Patent number: 11365442Abstract: The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.Type: GrantFiled: September 25, 2020Date of Patent: June 21, 2022Assignee: Prognosys Biosciences, Inc.Inventor: Mark S. Chee
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Patent number: 11359228Abstract: The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the biological targets comprise proteins, and the methods and assay systems do not depend on imaging techniques for the spatial information of the targets. The present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents; and a decoding scheme providing a readout that is digital in nature.Type: GrantFiled: February 8, 2022Date of Patent: June 14, 2022Assignee: Prognosys Biosciences, Inc.Inventors: Mark S. Chee, David A. Routenberg
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Patent number: 11352665Abstract: The present invention provides oligonucleotide constructs, sets of such oligonucleotide constructs, and methods of using such oligonucleotide constructs to provide validated sequences or sets of validated sequences corresponding to desired ROIs. Such validated ROIs and constructs containing these have a wide variety of uses, including in synthetic biology, quantitative nucleic acid analysis, polymorphism and/or mutation screening, and the like.Type: GrantFiled: April 22, 2021Date of Patent: June 7, 2022Assignee: Prognosys Biosciences, Inc.Inventor: Mark S. Chee
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Patent number: 11340232Abstract: The present invention provides methods for constructing peptide construct sets and methods of use of these peptide construct sets in assay systems for peptide analysis, and in particular for use in high throughput peptide analysis. The methods allow for analysis of large sets of peptide constructs in a cost-effective manner, employing molecular biological techniques that are both robust and easily parallelized. Thus, the methods allow for the construction of peptide construct sets encompassing, e.g., the human proteome.Type: GrantFiled: April 30, 2018Date of Patent: May 24, 2022Assignee: Prognosys Biosciences, Inc.Inventors: Igor A. Kozlov, Mark S. Chee, Petr Capek, David A. Routenberg
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Publication number: 20220154255Abstract: The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the biological targets comprise proteins, and the methods and assay systems do not depend on imaging techniques for the spatial information of the targets. The present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents; and a decoding scheme providing a readout that is digital in nature.Type: ApplicationFiled: February 8, 2022Publication date: May 19, 2022Applicant: Prognosys Biosciences, Inc.Inventors: Mark S. CHEE, David A. ROUTENBERG