Abstract: The present disclosure relates to a group of peptide compounds and their use in identifying molecules that stimulate proteasome or immunoproteasome are disclosed herein. Composition matters and methods of uses are within the scope of this disclosure.
Type:
Grant
Filed:
August 13, 2021
Date of Patent:
November 7, 2023
Assignee:
Purdue Research Foundation
Inventors:
Darci Jones Trader, Rachel Anne Coleman
Abstract: The present application relates to a method of weed control for a crop field using a synergistic effect of two herbicides cellulosin and isoxaben. A composition matter together with said method comprising cellulosin and isoxaben is within the scope of the present invention.
Abstract: A method of casting an article includes forming a melt comprising copper, introducing manganese into the melt to produce a copper-manganese alloy, and casting the copper-manganese alloy in a mold to form the article. The carbon and oxygen contents of the copper-manganese alloy are controlled in order to control the formation of graphite, manganese carbide, and/or manganese oxide particles within the article. Copper-manganese alloys containing carbon are also provided, as well as articles made therefrom in cast or wrought form.
Type:
Grant
Filed:
April 28, 2021
Date of Patent:
November 7, 2023
Assignee:
Purdue Research Foundation
Inventors:
Kevin Paul Trumble, Kevin Joseph Chaput
Abstract: A thermoplasmonic device includes a titanium film and a plurality of titanium nitride tube elements disposed on the titanium film. Each of the titanium nitride tube elements includes an open top and a titanium nitride bottom. Each of the titanium nitride tube elements has titanium nitride tubular middle portion that extends from the open top to the titanium nitride bottom.
Type:
Grant
Filed:
May 2, 2022
Date of Patent:
November 7, 2023
Assignee:
Purdue Research Foundation
Inventors:
Vladimir M. Shalaev, Zhaxylyk Kudyshev, Alexandra Boltasseva, Alberto Naldoni, Alexander Kildishev, Luca Mascaretti, {hacek over (S)}t{hacek over (e)}phán Kment, Radek Zbo{hacek over (r)}il, Jeong Eun Yoo, Patrik Schmuki
Abstract: The present application relates to an automated segmentation method for use with echocardiograms (echo). The method uses an iterative Dijkstra's algorithm, a strategic node selection, and a novel cost matrix formulation based on intensity peak prominence and is this termed the “Prominence Iterative Dijkstra's” algorithm, or ProID.
Type:
Grant
Filed:
March 11, 2021
Date of Patent:
November 7, 2023
Assignee:
Purdue Research Foundation
Inventors:
Brett Albert Meyers, Pavlos P. Vlachos, Melissa Brindise
Abstract: A nanostructured material system for efficient collection of photo-excited carriers is provided. They system comprises a plurality of plasmonic metal nitride core material elements coupled to a plurality of semiconductor material elements. The plasmonic nanostructured elements form ohmic junctions at the surface of the semiconductor material or at close proximity with the semiconductor material elements. A nanostructured material system for efficient collection of photo-excited carriers is also provided, comprising a plurality of plasmonic transparent conducting oxide core material elements coupled to a plurality of semiconductor material elements. The field enhancement, local temperature increase and energized hot carriers produced by nanostructures of these plasmonic material systems play enabling roles in various chemical processes. They induce, enhance, or mediate catalytic activities in the neighborhood when excited near the resonance frequencies.
Type:
Grant
Filed:
July 7, 2022
Date of Patent:
November 7, 2023
Assignee:
Purdue Research Foundation
Inventors:
Urcan Guler, Alberto Naldoni, Alexander V. Kildishev, Alexandra Boltasseva, Vladimir M. Shalaev
Abstract: A method of depositing a multiphase material. The method includes providing a Continuous Multifunctional Composite (CMC) phase containing at least one continuous element in a polymeric matrix, passing the CMC phase through a feeding system containing a cutting system, producing a predetermined length of the CMC phase, providing a flow a molten polymer such that the molten polymer and the CMC phase are merged into a continuous co-extrusion nozzle so as to produce a co-extruded multiphase material, and depositing the co-extruded multiphase material onto a surface. An apparatus for depositing a multiphase material. The apparatus contains a co-extrusion nozzle, a means to introduce a CMC phase and a molten polymer into the co-extrusion nozzle, such that the molten polymer and the CMC phase are co-extruded and deposited on a surface. An article containing a CMC phase containing continuous elements embedded in a polymer resin forming a multiphase structure.
Type:
Grant
Filed:
January 2, 2022
Date of Patent:
November 7, 2023
Assignee:
Purdue Research Foundation
Inventors:
Eduardo Barocio, Jorge A. Ramirez, Miguel Angel Ramirez, Bastian Brenken, Robert Byron Pipes
Abstract: Described herein are compounds of the formulae (I)-(III) and (Ia)-(IIIa) and pharmaceutically acceptable salts, isomers, mixture of isomers, crystalline forms, non-crystalline forms, hydrates, or solvates thereof, as well as methods using compounds of the formulae (I)-(III) and (Ia)-(IIIa) to, among other things, treat cancer.
Type:
Grant
Filed:
July 26, 2018
Date of Patent:
November 7, 2023
Assignees:
Purdue Research Foundation, The Regents of the University of California
Abstract: A method of producing gallium-doped zinc oxide films with enhanced conductivity. The method includes depositing a gallium-doped zinc oxide film on a substrate using a pulsed laser and subjecting the deposited gallium-dope zinc oxide film to a post-treatment effecting recrystallization in the deposited film, wherein the recrystallization enhances the conductivity of the film. Another method of producing gallium-doped zinc oxide films with enhanced conductivity. The method includes the steps of depositing a gallium-doped zinc oxide film on a substrate using a pulsed laser and subjecting the deposited gallium-dope zinc oxide film to an ultraviolet laser beam resulting in recrystallization in the film, wherein the recrystallization enhances the conductivity of the film. A film comprising gallium-doped zinc oxide wherein the film contains a recrystallized grain structure on its surface.
Abstract: A method to treat a patient with a Clostridium difficile infection comprising administering a therapeutically effective amount of diiodohydroxyquinoline, with or without one or more anti-infective agents.
Abstract: A sensing system includes a base material, a plurality of electrodes, a capacitive sensing channel and a controller. The stretchable base material has a resistance distribution that changes in response to being mechanically deformed as a result of a human body contact. The base material has a rebound elasticity. The electrodes are attached to a perimeter of the base material, the capacitive sensing channel is attached to the base material. The controller is operatively connected to the plurality of electrodes and the capacitive sensing channel. The controller is configured to measure instantaneous voltage measurements from the plurality of electrodes, and determine whether the base material is mechanically deformed based on the instantaneous voltage measurements using a support vector machine classifier.
Abstract: The present disclosure provides pro-angiogenic proteoglycan mimetics that can provide a provisional, pro-angiogenic scaffold to support tissue regeneration while limiting systemic exposure to VEGF activity. These mimetics can protect a collagen matrix from rapid degradation, and in conjunction with EPCs promote angiogenesis in order to accelerate ischemic wound healing. For example, the provided compounds can be delivered from the end of a catheter following balloon angioplasty to coat the collagen exposed areas, prevent platelet binding and thrombosis, support capture of EPCs from blood to facilitate reendothelialization, and reduce late-lumen loss (neointimal hyperplasia).
Type:
Application
Filed:
February 14, 2023
Publication date:
November 2, 2023
Applicants:
The Regents of the University of California, Purdue Research Foundation
Inventors:
Alyssa Panitch, Emily Michelle Misnick, Jenny B. Lin, Kit S. Lam, Ruiwu Liu, Dake Hao, Aijun Wang
Abstract: A graphics processing unit and methods for comping and executing instructions with opportunistic inter-path reconvergence are provided. An single instruction multiple thread (SIMT) stack of graphics processing unit may store data entries, each data entry comprising an operand mask. The operand mask may include bits corresponding to threads of a warp. The graphics processing unit core may access an instruction for an entry on the SIMT stack. Each of the threads may execute the instruction using either a first set of operands or a second set of operands depending on the corresponding bits of the operand mask.
Abstract: The invention generally relates to two-dimensional mass spectrometry using ion micropacket detection. In certain aspects, the invention provides systems including a mass spectrometer having an ion trap and one or more detectors. The system includes a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to: apply one or more scan functions to the ion trap that excite a precursor ion and eject a product ion from the ion trap; and determine a secular frequency of the product ion by detecting micropackets of the product ion as the micropackets are ejected from the ion trap.
Type:
Grant
Filed:
May 23, 2019
Date of Patent:
October 31, 2023
Assignee:
Purdue Research Foundation
Inventors:
Robert Graham Cooks, Dalton Snyder, Lucas Szalwinski
Abstract: Nanoassembly methods for producing quasi-3D plasmonic films with periodic nanoarrays of nano-sized surface features. A sacrificial layer is deposited on a surface of a donor substrate having periodic nanoarrays of nanopattern features formed thereon. A plasmon film is deposited onto the sacrificial layer and a dielectric spacer is deposited on the plasmon film. The donor substrate having the sacrificial layer, plasmon film, and dielectric spacer thereon is immersed in a bath of etchant to selectively remove the sacrificial layer such that the plasmon film and the dielectric spacer thereon adhere to the surface of the donor substrate. The dielectric spacer and the plasmon film are mechanically separated from the donor substrate to define a quasi-three dimensional (3D) plasmonic film having periodic nanoarrays of nano-sized surface features defined by the nanopattern features of the donor substrate surface. The quasi-3D plasmonic film is then applied to a receiver substrate.
Type:
Grant
Filed:
December 2, 2022
Date of Patent:
October 31, 2023
Assignee:
Purdue Research Foundation
Inventors:
Chi Hwan Lee, Zahyun Ku, Augustine Michael Urbas, Bongjoong Kim
Abstract: A nanodevice provides for electric-field control of magnon-QSD interactions. The nanodevice includes a ferroelectric substrate, a ferromagnetic material disposed over the ferroelectric substrate, and a nanodiamond including an ensemble of nitrogen-vacancy (NV) spins, each NV magnetically interfacing with the ferromagnetic material. An electric field is measured by applying a voltage across the ferroelectric substrate and the ferromagnetic material, changing a magnon excitation spectrum of the ferromagnetic material with respect to an electron spin resonance frequency of the ensemble of NV spins, and measuring a relaxation rate of the ensemble of NV spins.
Type:
Grant
Filed:
November 30, 2021
Date of Patent:
October 31, 2023
Assignee:
Purdue Research Foundation
Inventors:
Vladimir M. Shalaev, Pramey Upadhyaya, Abhishek Bharatbhai Solanki, Simeon I. Bogdanov, Yong P. Chen, Mohammad Mushfiqur Rahman, Avinash Rustagi
Abstract: A method of generating object surface texture in thermal infrared images is disclosed which includes receiving heat radiation from a scene by a spectropolarimetric imaging system, generating a plurality of spectral frames associated with the scene, each frame having a plurality of pixels, for each pixel from the generated plurality of spectral frames, extracting spectral information associated with the scene, including pixel-specific temperature representing an objects temperature, and thermal texture factor representing the objects texture, for each of a plurality of materials having a specific emissivity in a library, generating reference spectral information as a function of temperature and thermal texture, matching the extracted spectral information for each pixel from the generated plurality of spectral frames to the generated reference spectral information using a statistical method to minimize the associated variation, and extracting spectral metadata from the matched reference spectral information for
Abstract: A system may include a non-intrusive sensor circuitry configured to provide electrical measurement data, including, for example, current data, voltage data, power factor data, active power consumption data, reactive power consumption data, or a combination thereof. A transient event detector may sweep the electrical measurement data with a first window and a second window, the first window adjacent to the second window. The transient event detector may identify a start and end of transient activity based on electrical measurement data referenced by separate adjacent windows. The transient event detector may capture a transient activity data segment comprising a portion of the electrical measurement data between first index and the second index.
Abstract: Drug delivery devices that have a flexible film, an array of nanoscopic, porous needles attached to a surface of the flexible film, and a therapeutic drug cargo loaded onto the needles. The drug delivery device may be applied to living tissue such that the surface of the flexible film contacts the living tissue and some or all of the needles are inserted into the tissue. The flexible film may then be dissolved while leaving the needles inserted in the tissue. The needles degrade in the living tissue over time causing release of the therapeutic drug cargo loaded onto the needles.
Type:
Grant
Filed:
June 10, 2021
Date of Patent:
October 24, 2023
Assignees:
Purdue Research Foundation, Industry-University Cooperation Foundation Hanyang University
Abstract: The present disclosure relates to novel two-dimensional halide perovskite materials, and the method of making and using the two-dimensional halide perovskite materials.