Abstract: A process for the isolation and purification of substantially pure chemicals, including silica gel, sodium silicate, aluminum silicate, iron oxide, and rare earth elements (or rare earth metals, REEs), from massive industrial waste coal ash including a plurality of caustic extractions of coal ash at an elevated temperature, followed by an acidic treatment to dissolve aluminum silicate and REEs. Dissolved aluminum silicate is precipitated out by pH adjustment as a solid product while REEs remain in the solution. REEs are captured and enriched using an ion exchange column. Alternatively, the solution containing aluminum silicate and REEs is heated to produce silica gel, which is separated from the enriched REEs solution. REEs are then isolated and purified from the enriched solution to afford substantially pure individual REE by a ligand-assisted chromatography.

Abstract: A microfabricated valve with no moving parts. In one embodiment, the valve includes a reservoir of a liquid that is in fluid communication with an outlet channel having a throat that is less than 100 microns wide. Preferably, the channel is an elongated slit. The configuration of channel is adapted and configured such that surface tension of the liquid prevents flow out of the channel. A heater increases the temperature of the meniscus of the fluid, until a portion of the fluid is ejected from the channel. The ejection of the fluid creates both a thrusting effect and a cooling effect.

Abstract: The present invention generally relates to a process of nanoparticle formulations and its composition matter for systemic treatment of sepsis. In particular, this invention discloses a method for preparing tannic acid-ferric nanoparticles, optionally incorporating a component of vitamin D3, coated with zwitterionic chitosan (ZWC) and polymyxin B (PMB). The invention described herein also pertains to pharmaceutical compositions and methods for the treatment of sepsis.

Abstract: The invention generally relates to a sample dispenser including an internal standard and methods of use thereof.

Abstract: A system and method which allows the basic checkpoint-reverse-mode AD strategy (of recursively decomposing the computation to reduce storage requirements of reverse-mode AD) to be applied to arbitrary programs: not just programs consisting of loops, but programs with arbitrarily complex control flow. The method comprises (a) transforming the program into a formalism that allows convenient manipulation by formal tools, and (b) introducing a set of operators to allow computations to be decomposed by running them for a given period of time then pausing them, while treating the paused program as a value subject to manipulation.

Abstract: In some examples, an electronic device comprises an interface to receive a video of a human face, a memory storing executable code, and a processor coupled to the interface and to the memory. As a result of executing the executable code, the processor is to receive the video from the interface, use a facial detection technique to produce a sequence of images of the human face based on the video, use a neural network to predict a photoplethysmographic (PPG) signal based on the sequence of images, convert the PPG signal to a frequency domain signal, and determine a heart rate by performing a frequency analysis on the frequency domain signal.

Abstract: A device for measuring and monitoring heart rate, respiration rate, and oxygen saturation of a subject is disclosed, which includes a biometric sensor board having a photosensor adapted to measure reflectance of red and infrared lights off skin tissue, wherein the biometric sensor board adapted to control one or more light emitting diodes (LEDs), wherein brightness of the LEDs are automatically adjusted to account for skin tone, thereby generating photoplethysmographic data, a processor unit adapted to analyze data measured by the biometric sensor board, and a display adapted to display results of the processed data remotely.

Abstract: A system to reduce probability of a crash in an intersection is disclosed which includes one or more way-sensor systems, the one or more sensor systems adapted to provide position and velocity vector of an object approaching the intersection on an associated path, a processing unit including configured to: determine timing of the object with respect to a predefined zone of the intersection on the associated path, determine the current and future status of the associated traffic lights on the associated path of the object, predict timing of the object with respect to the predefined zone and future status of the associated traffic light, if timing prediction is within a predetermined threshold, modify the current status, wherein tgreen is extended, if timing prediction is outside of the predetermined threshold, modify the current status, wherein tgreen is reduced, and repeating above steps until the object has cleared the intersection.

Abstract: The present disclosure relates to a novel compound suitable for a metal-free primary explosive, and the method of making and using the novel compound. The novel compound can undergo a deflagration to detonation transition (DDT) to initiate detonation of a larger body of secondary explosive.

Abstract: A load balancing method is disclosed, the method includes establishing a processing network including a plurality of task-processing processors interconnected therewith, each processor of the plurality having a queue of tasks to be processed, establishing a k-regular graph including nodes and branches connecting the nodes, where k is the degree of the graph, assigning d walkers to the k-regular graph, where each walker is randomly assigned to a node, receiving a new task to be processed, walking from the assigned nodes to new nodes by randomly choosing a new node from one or more available nodes, without backtracking from each of the assigned nodes to a node from which each of the d walkers immediately walked, comparing the queues of the new nodes, determining which queue of the new nodes has the least number of tasks; and assigning the new task to the node with the least number of tasks.

Abstract: An implantable drug delivery device and method for delivering a drug to a living body. The device includes a housing having at least one opening, a reservoir within the housing adapted to contain the drug, a temporary seal closing the at least one opening of the housing, and a heating element in thermal contact with the temporary seal. The heating element is adapted to generate heat in response to a magnetic field to melt the temporary seal and release the drug within the reservoir through the at least one opening of the housing.

Abstract: A combination of active agents for the treatment of Lowe Syndrome (LS) comprising a RhoA inhibitor and a mTOR inhibitor; a pharmaceutical composition comprising the combination and a pharmaceutically acceptable carrier; a combination of pharmaceutical compositions in which one composition comprises a RhoA inhibitor and the other composition comprises a mTOR inhibitor; and a method of treating a patient for LS.

Abstract: The invention generally relates to mass spectral analysis. In certain embodiments, methods of the invention involve analyzing a lipid containing sample using a mass spectrometry technique, in which the technique utilizes a liquid phase that does not destroy native tissue morphology during analysis. Due to the use of a liquid phase that does not destroy native tissue morphology during analysis, a subsequent staining technique can be performed on the tissue sample and an overlaid image can be produced of a mass spectral image and a staining image.

Abstract: A turbine row for an axial or mixed-flow fluid machine may include an airfoil, having a leading edge, a trailing edge, a pressure surface and a suction surface. The turbine row may further include two endwalls, extending from upstream of the airfoil leading edge to downstream of the airfoil trailing edge. The endwalls may define an inlet upstream of the leading edge of the airfoil and an outlet downstream of the airfoil. The endwalls have a contoured geometry which provides an increase in channel height from the inlet to the outlet and guarantees a throat area larger than the area of the inlet.

Abstract: A virtual thermocouple system for non-invasively predicting product characteristics is disclosed, which includes one or more temperature sensing systems including a resistive network which includes a temperature sensing device comprising a plurality of negative temperature coefficient (NTC) thermistors, and a load resistor, a corresponding system-on-chip coupled to a corresponding resistive network and configured to i) power the corresponding resistive network, ii) receive corresponding signals from each NTC thermistor of the corresponding temperature sensing device, iii) process the signal associated with each NTC thermistor of the corresponding temperature sensing device and thus generate data associated with each NTC thermistor, and iv) transmitting the processed data, a power generating device configured to provide power to the corresponding system-on-chip, and a base stations adapted to i) receive the processed data from a corresponding system-on-chip, and ii) using a predefined model, and non-invasively

Abstract: An autonomous construction robotic system is disclosed which includes a processing unit, a robotic arm, the robotic arm is adapted to be coupled to a central attachment arm and thereby position the central attachment arm according to a plurality of degrees of freedom, a panel handling and fastening system, including a panel handling assembly coupled to the central attachment arm and adapted to pick and place a construction panel onto a framed structure within a construction zone, and a vision system adapted to provide visual information to the processing unit associated with the framed structure, wherein the processing unit processes the visual information to automatically determine placement position of the construction panel on the framed structure.

Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

Abstract: Embodiments provide, among other compounds, a family of compounds that can be used as therapeutic anti-cancer agents, methods for using such compounds to treat cancer, and methods of making such compounds.

Abstract: The invention generally relates to electrophoretic mass spectrometry probes and systems and methods of uses thereof. In certain aspects, the invention provides a mass spectrometry probe having a hollow body with a distal tip, an electrically conductive hollow conduit, and an electrode. The electrically conductive hollow conduit may be operably coupled to a reservoir and a power source, and the electrically conductive hollow conduit may be configured to transport a liquid sample into the hollow body and polarize the liquid sample as it flows through the electrically conductive hollow conduit and into in the hollow body. The electrode and the electrically conductive hollow conduit are disposed within the hollow body (e.g., at different heights within the hollow body).

Abstract: An environmental sensor system for monitoring nucleation in a lyophilization chamber is disclosed which includes a sensor unit, including a temperature sensor, a pressure sensor, and a reader circuit in electronic communication with the sensor unit; wherein the sensor unit is adapted to sealingly fit around a vial placed in a lyophilization chamber and further adapted to be energized by the reader circuit and provide signals associated with temperature and pressure within the vial in a non-invasive manner in which the sensors are configured to be positioned in a headspace within the vial but not in contact with product within the vial.