Abstract: Bis-amide inhibitors of SARS-CoV-2 (COVID); pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.

Abstract: A method is disclosed which includes receiving an incoming time-varying signal as ambient signal, applying a signal cancellation filter to the incoming time-varying signal to thereby generate an attenuated version of the incoming time-varying signal, selectively choosing one or more selected classes of signals to be broadcasted while other signals are to be attenuated, continually applying the incoming time-varying signal to a classifier to identify presence of the one or more selected classes in the incoming time-varying signal, adding a snippet of a pre-recorded signal associated with each of the identified classes to thereby generate a string of signal snippets associated with the identified classes, and repeating in a loop, combining the attenuated version of the received time-varying signal with the repeated string of signal snippets and broadcasting the combination.

Abstract: An image generator engine for generating distorted images from an input image is disclosed which includes a random seed generator adapted to generate random seeds, a model adapted to receive the random seeds and generate a first plurality of sets of Zernike coefficients (FPSZC), a pixel shifter adapted to shift pixels of the input image, a phase to space (P2S) transformer adapted to in parallel receive the FPSZC and generate a predetermined number of P2S coefficients, a learned basis function generator adapted to generate learned basis function matrices, a convolver adapted to convolve each pixel of the tilted image by the learned basis functions thereby generating a plurality of convolved pixels, and a blurrer adapted to receive the plurality of the convolved pixels and multiply by the corresponding P2S coefficients and apply a summation to generate the distorted image.

Abstract: A gluten-free, clean label, plant protein composition; a spreadable, gluten-free, clean label, plant protein composition; food products for human consumption comprising same; and methods of making.

Abstract: The invention generally relates to methods of coupling a carbon containing moiety to an amine containing moiety.

Abstract: Methods for rapidly concentrating a food sample for efficient detection of bacteria are disclosed. A microfiltration approach followed by centrifugation was used to concentrate the cells with an enzyme (e.g., a protease) added at the beginning of the process to facilitate more efficient micro-filtering. The enzyme was found to have no significant effect on cell viability.

Abstract: The present disclosure relates to novel ?-opioid receptor agonists, and the method of making and using the novel ?-opioid receptor agonists. The novel ?-opioid receptor agonists are selective ?-opioid receptor agonists that have substantially no beta-arrestin 2 recruitment or low beta-arrestin 2 recruitment. The novel ?-opioid receptor agonists may be used for the treatment for alcohol use disorders and other co-occurring psychiatric disorders.

Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells wherein the CAR T cells comprise a CAR and the CAR comprises an E2 anti-fluorescein antibody fragment, and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

Abstract: A crowd management system (CMS), is disclosed which includes a command and control (C2) subsystem, a sensor network in communication with the C2 subsystem and adapted to provide signals corresponding to geographical number of individuals in a venue, and one or more crowd management devices (CMDs) further in communication with the C2 subsystem, each of the CMDs including a base adapted to release air at a high pressure, the base further including a positional device adapted to position the base according to a selective position, and an inflatable body terminating into a predefined shape adapted to convey a predefined message to individuals near the CMDs.

Abstract: The present disclosure relates to a novel composite film configured for CO2 sensing, and the method of making and using the novel composite film. The novel composite film comprises a carbon nanotube film and a CO2 absorbing layer deposited on the carbon nanotube film, wherein the CO2 absorbing layer comprises a mixture of a branched polyethylenimine, a polyethylene glycol, and poly[1-(4-vinylbenzyl)-3-methylimidazolium tetrafluoroborate] of formula I: wherein n ranges from 10-300.

Abstract: The invention generally relates to systems and methods for conducting reactions and screening for reaction products.

Abstract: A high enthalpy and low-cost Hypersonic Test Facility (HTF), which employs nitrous oxide to generate clean air-like gas; and a method of decomposing nitrous oxide in the presence of a catalyst in a catalytic decomposition chamber in a HTF.

Abstract: Certain pressure sensor devices are much smaller than prior art devices, yet are at least as sensitive as the prior art devices. A capacitive pressure sensor can include a flexible substrate that permits bending of a pressure sensing region without significantly affecting operation thereof. The pressure sensor can include a flexible membrane in which an electrode is sandwiched between two layers of polymeric material. The sandwiched electrode can be extremely close to a reference electrode so as to provide for highly sensitive capacitance readings, yet the membrane can be restricted from contacting the reference electrode under high pressure condition.

Abstract: The present invention generally relates to tetrahydro-3H-pyrazolo-[4,3-f]-quinolone and tetrahydro-3H-pyrrolo-[3,2-f]quinoline-containing compounds as a tubulin polymerization inhibitor for the treatment of various cancers, and methods of uses thereof. Pharmaceutical compositions and the methods for treating those kinase related diseases are within the scope of this invention.

Abstract: An accelerator for processing of a convolutional neural network (CNN) includes a compute core having a plurality of compute units. Each compute unit includes a first memory cache configured to store at least one vector in a map trace, a second memory cache configured to store at least one vector in a kernel trace, and a plurality of vector multiply-accumulate units (vMACs) connected to the first and second memory caches. Each vMAC includes a plurality of multiply-accumulate units (MACs). Each MAC includes a multiplier unit configured to multiply a first word that of the at least one vector in the map trace by a second word of the at least one vector in the kernel trace to produce an intermediate product, and an adder unit that adds the intermediate product to a third word to generate a sum of the intermediate product and the third word.

Abstract: This invention relates to a method for increasing wetting capability of a biomimetic polymer adhesive comprising the step of introducing plurality of phosphate moieties into said biomimetic polymer adhesive. In particular, the present disclosure relates a method to manufacture a biomimetic polymer adhesive with an increased wetting capability by inducing plurality of phosphate moieties by copolymerization of phosphate-containing monomer, such as monoacryloxyethyl phosphate (MAEP), together with other monomers, or by way of post-polymerization chemical derivertizations. The process and the product thereof are within the scope of this disclosure.

Abstract: An in-memory vector addition method for a dynamic random access memory (DRAM) is disclosed which includes consecutively transposing two numbers across a plurality of rows of the DRAM, each number transposed across a fixed number of rows associated with a corresponding number of bits, assigning a scratch-pad including two consecutive bits for each bit of each number being added, two consecutive bits for carry-in (Cin), and two consecutive bits for carry-out-bar (Cout), assigning a plurality of bits in a transposed orientation to hold results as a sum of the two numbers, for each bit position of the two numbers: computing the associated sum of the bit position; and placing the computed sum in the associated bit of the sum.

Abstract: A method of determining a device behavior, wherein the method includes using a first procedure. The first procedure includes discretizing a user specified nano-device structure for at least one quantum method. Additionally, the first procedure includes solving the at least one quantum method, thereby having a solution of the at least one quantum method. Moreover, the first procedure includes extracting a parameter out of the solution of the at least one quantum method. Next, the first procedure includes applying at least one approximate method to the user-specified nano-device structure using the parameter. The first procedure additionally includes solving the at least one approximate method to the user-specified nano-device structure using the parameter. The first procedure also includes extracting the device behavior of the user-specified nano-device structure. Next, the method of determining the device behavior includes iterating the first procedure until a condition is satisfied.

Abstract: A rotating detonation engine (RDE) is disclosed which includes a housing, an injector assembly disposed within the housing, the injector assembly includes a fuel manifold, an oxidizer manifold, and a combustion chamber, fuel from the fuel manifold and an oxidizer from the oxidizer manifold are combined and combusted in the combustion chamber, each of the fuel and oxidizer manifolds communicates with the combustion chamber via a plurality of Tesla valves each via a corresponding port, wherein the plurality of Tesla valves substantially eliminate reverse flow of exhaust gases from the combustion chamber back to the fuel manifold or the oxidizer manifold.

Abstract: A photochemical reactor is disclosed which includes a reaction chamber, the reaction chamber includes a frame, one or more circuit boards each coupled to the frame and each carrying a plurality of light sources, a power source coupling, adapted to power the one or more circuit boards, and a vial receiver centrally disposed about the one or more circuit boards. The photochemical reactor further includes an agitator configured to rotate the vial receiver.