Patents Assigned to Purdue Research
  • Bi-phasic quasi-static brain communication device and method
    Patent number: 12144997
    Abstract: A system and method for brain-machine interface communication utilizing Bi-Phasic Quasi-Static Brain Communication (BP-QBC). The system includes a first device and a second device that are in wireless communication together. The system and method include signal transmission between the first device and the second device through dipole coupling. The system is configured to utilize compressive sensing and collision avoidance for enhanced net energy efficiency. The system and method utilize fully electrical quasi-static signaling to militate against energy transduction losses.
    Type: Grant
    Filed: December 23, 2021
    Date of Patent: November 19, 2024
    Assignee: Purdue Research Foundation
    Inventors: Shreyas Sen, Baibhab Chatterjee, Mayukh Nath
  • Dynamically adjustable width wheelchair
    Patent number: 12144767
    Abstract: An adjustable wheelchair and components thereof are provided. The wheelchair may include a first chassis connected to a first wheel on a first side of the wheelchair. The first chasses may include a first strut configured to laterally translate while supporting a seat. The wheelchair may further include a second chassis connected to a second wheel on a second side of the wheelchair. The second chasses may include a second strut configured to laterally translate while supporting the seat. A jack may be connected to the first chasses and second chasses. The jack may operatively cause the first and second chassis expand away from each other and contract toward each other to vary a width between the first side and second side of the wheelchair.
    Type: Grant
    Filed: March 31, 2021
    Date of Patent: November 19, 2024
    Assignee: Purdue Research Foundation
    Inventors: Quinn Alexander Joyce, Eric Eagon
  • Twinned two-dimensional tellurium crystals with co-existing opposite chirality
    Patent number: 12145843
    Abstract: Processes for synthesizing substrate-free twinned 2D tellurium crystals with co-existing opposite chirality, and twinned 2D tellurium crystals produced thereby. The substrate-free twinned 2D tellurium crystals include a first wing and a second wing, the first wing and second wing have opposite chirality, and the first wing and the second wing are joined together at an angle to form a V-shaped crystal.
    Type: Grant
    Filed: September 30, 2021
    Date of Patent: November 19, 2024
    Assignee: Purdue Research Foundation
    Inventors: Wenzhuo Wu, Yixiu Wang
  • Methods and compositions for car T cell therapy
    Patent number: 12144850
    Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: November 19, 2024
    Assignees: Purdue Research Foundation, Endocyte, Inc
    Inventors: Philip Stewart Low, Haiyan Chu, Yong Gu Lee
  • Technique for therapeutic contact lens systems
    Patent number: 12145336
    Abstract: The invention relates to electronic contact lens systems, methods for fabrication thereof, and uses thereof for treatment of ophthalmic diseases and conditions, for example, meibomian gland dysfunction.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: November 19, 2024
    Assignee: Purdue Research Foundation
    Inventor: Chi Hwan Lee
  • MICROFLUIDIC SYSTEM AND METHOD OF USE AND MEASUREMENT
    Publication number: 20240375100
    Abstract: A microfluidic device is disclosed which includes two or more solution inlets each adapted to be selectively opened and closed and each adapted to receive a respective solution, two or more loading channels each coupled to a respective solution inlet and each adapted to hold the respective solution, a fluidic force inlet coupled to the two or more solution inlets and adapted to provide a fluidic force to each respective loading channel, and a mixing channel coupled to the two or more loading channels and adapted to mix each solution held in each of the two or more loading channels when a fluidic force is applied, the mixing channel terminating at a trap zone adapted to receive the mixed solution from the mixing channel, the trap zone including a fluidic force outlet adapted to release the received fluidic force.
    Type: Application
    Filed: May 7, 2024
    Publication date: November 14, 2024
    Applicant: Purdue Research Foundation
    Inventors: Hui Ma, Tamara L. Kinzer-Ursem, Jacqueline C. Linnes
  • Method of enhancing corrosion resistance of oxidizable materials and components made therefrom
    Patent number: 12139794
    Abstract: Methods of enhancing the corrosion resistance of an oxidizable material exposed to a supercritical fluid is disclosed One method includes placing a surface layer on an oxidizable material, and choosing a buffered supercritical fluid containing a reducing agent with the composition of the buffered supercritical fluid containing the reducing agent chosen to avoid the corrosion of the surface layer or reduce the rate of corrosion of the surface layer and avoid the corrosion of the oxidizable material or reduce the rate of corrosion of the oxidizable material at a temperature above the supercritical temperature and supercritical pressure of the supercritical fluid.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: November 12, 2024
    Assignee: Purdue Research Foundation
    Inventor: Kenneth H. Sandhage
  • Systems and methods for light collection and distribution
    Patent number: 12143152
    Abstract: A modulating circuit adapted to modulate between an energy harvesting mode and a wireless transmitter mode is disclosed which includes a solar cell, an energy-harvesting circuit, a first switch coupling the solar cell to the energy harvesting circuit and controlled by a first control line, a second switch coupling the solar cell to a programmable current source and controlled by a second control line, a transmitter/energy harvesting mode circuit adapted to select between a transmitter mode and an energy harvesting mode, and a symbol-to-current mapping circuit adapted to encode data to be communicated by the solar cell, the symbol-to-current mapping circuit adapted to adjust the programmable current source to thereby provide a metered current to the solar cell.
    Type: Grant
    Filed: October 7, 2022
    Date of Patent: November 12, 2024
    Assignee: Purdue Research Foundation
    Inventor: Walter Daniel Leon-Salas
  • Collagen compositions and methods of use
    Patent number: 12138368
    Abstract: The present disclosure provides an engineered collagen composition comprising collagen, wherein the collagen composition is compressed to form a gradient of at least one physical property. Methods of using and of manufacturing the engineered collagen compositions of the present disclosure are also provided.
    Type: Grant
    Filed: October 3, 2022
    Date of Patent: November 12, 2024
    Assignee: Purdue Research Foundation
    Inventors: Sherry L. Voytik-Harbin, Tylor Anthony Novak, Kevin Blum, Corey Philip Neu
  • Electrophoretic mass spectrometry probes and systems and uses thereof
    Patent number: 12142472
    Abstract: The invention generally relates to electrophoretic mass spectrometry probes and systems and methods of uses thereof. In certain aspects, the invention provides a mass spectrometry probe having a hollow body with a distal tip, an electrically conductive hollow conduit, and an electrode. The electrically conductive hollow conduit may be operably coupled to a reservoir and a power source, and the electrically conductive hollow conduit may be configured to transport a liquid sample into the hollow body and polarize the liquid sample as it flows through the electrically conductive hollow conduit and into in the hollow body. The electrode and the electrically conductive hollow conduit are disposed within the hollow body (e.g., at different heights within the hollow body).
    Type: Grant
    Filed: November 16, 2023
    Date of Patent: November 12, 2024
    Assignees: Purdue Research Foundation, AMGEN INC.
    Inventors: Robert Graham Cooks, Tawnya Flick
  • Spin orbit torque based electronic neuron
    Patent number: 12141686
    Abstract: An electronic neuron device that includes a thresholding unit which utilizes current-induced spin-orbit torque (SOT). A two-step switching scheme is implemented with the device. In the first step, a charge current through heavy metal (HM) places the magnetization of a nano-magnet along the hard-axis (i.e. an unstable point for the magnet). In the second step, the device receives a current (from an electronic synapse) which moves the magnetization from the unstable point to one of the two stable states. The polarity of the net synaptic current determines the final orientation of the magnetization. A resistive crossbar array may also be provided which functions as the synapse generating a bipolar current that is a weighted sum of the inputs of the device.
    Type: Grant
    Filed: August 20, 2020
    Date of Patent: November 12, 2024
    Assignee: Purdue Research Foundation
    Inventors: Abhronil Sengupta, Sri Harsha Choday, Yusung Kim, Kaushik Roy
  • Processes and systems for biological hydrogen production from organic waste using yeast
    Patent number: 12139738
    Abstract: Processes and systems for biologically producing hydrogen gas from organic waste, including food waste. Such a process includes biologically producing hydrogen gas from organic waste by anaerobic fermentation of the organic waste with at least one strain of yeast.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: November 12, 2024
    Assignee: Purdue Research Foundation
    Inventors: Robert A. Kramer, Libbie S. W. Pelter, John A. Patterson
  • NOVEL VACCINE FORMULATIONS FOR MYCOBACTERIUM TUBERCULOSIS AND USE OF THEREOF
    Publication number: 20240366741
    Abstract: The present invention discloses a recombinant adenovirus vector of a replication-defective human adenovirus (HAdv85C5) or a bovine adenovirus (BAdv85C5) comprising a recombinant adenovirus vector having a heterologous DNA segment encoding mycobacterial Ag85B-p25 epitope (SEQ ID NO: 1), mycobacterial Ag85B-p25 epitope fusion of autophagy-inducing peptide-C5 (SEQ ID NO: 2), or a substantially homologous functional fragment thereof. The vector, having a heterologous DNA segment of SEQ ID NO: 3, SEQ ID NO: 4, or a substantially homologous functional fragment thereof, is an effective vaccine for therapeutically or prophylactically immunizing a subject for protection of infections by various microorganisms, especially Mycobacterium tuberculosis (Mtb), which causes the widespread tuberculosis. Methods of uses and pharmaceutical composition matters are within the scope of this disclosure.
    Type: Application
    Filed: March 8, 2022
    Publication date: November 7, 2024
    Applicants: Purdue Research Foundation, HOUSTON METHODIST RESEARCH INSTITUTE
    Inventors: Suresh Kumar Mittal, Chinnaswamy Jagannath
  • PREBIOTIC COMPOSITION AND METHOD OF USE TO IMPROVE GASTROINTESTINAL HEALTH IN PATIENTS WITH DYSBIOSIS AND LEAKY GUT
    Publication number: 20240366654
    Abstract: A composition comprising (i) a resistant starch, (ii) a resistant non-starch ?-linked glucan, (iii) a cereal bran, which is optionally stabilized, and (iv) inulin, a fructo-oligosaccharide, or both; an ingestible formulation comprising the composition; and a method of improving gastrointestinal health in a human with a condition, disease, or disorder, which method comprises administering to the human the composition or the ingestible formulation.
    Type: Application
    Filed: July 15, 2022
    Publication date: November 7, 2024
    Applicants: Purdue Research Foundation, Rush University Medical Center
    Inventors: Bruce R. Hamaker, Thaisa Moro Cantu Jungles, Ali Keshavarzian
  • All-Optical Epsilon-Near-Zero Enabled Streak Camera
    Publication number: 20240369404
    Abstract: A streak camera is disclosed which includes an entrance slit forming a first end of the streak camera, the entrance slit having a width and height, an image capture device forming a second send of the streak camera, and an epsilon-near-zero (ENZ) slab defined by a bandgap energy and plasma frequency disposed within the streak camera, the ENZ slab configured to receive two beams with a predetermined delay therebetween, the two beams include i) a witness beam through the entrance slit at an incident angle ?, and ii) a trigger beam at substantially a normal incident angle, wherein the trigger beam applies energy at a level below the bandgap energy of the ENZ slab to thereby modify refractive index of the ENZ slab, and thus generate a modified witness beam at a time-varying exit angle ?(t) onto the image capture device.
    Type: Application
    Filed: April 30, 2024
    Publication date: November 7, 2024
    Applicant: Purdue Research Foundation
    Inventors: Vladimir M. SHALAEV, Alexandra BOLTASSEVA, Colton B. FRUHLING, Mustafa Goksu OZLU
  • Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
    Patent number: 12133900
    Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds. The disclosure also relates to compositions for incorporating the compounds as used for the targeted imaging of tumors. Conjugation of the amino acid linking groups increase specificity and detection of the compound. Methods and compositions for use thereof in diagnostic imaging are contemplated.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: November 5, 2024
    Assignee: Purdue Research Foundation
    Inventors: Philip Stewart Low, Sumith A. Kularatne, Sakkarapalayam M. Mahalingam
  • Inlets for hypersonic air-breathing vehicles and design methods and systems therefor
    Patent number: 12134997
    Abstract: Systems and methods capable for use in the development of high-speed, shape-transitioning, inward-turning inlets for air-breathing hypersonic vehicles, and inlets formed thereby. The systems and methods preferably provide for designing high-speed inlets for air-breathing hypersonic vehicles, wherein unique solutions are defined in each osculating plane of the inlet. Such systems and methods optionally provide an optimization process for tuning the post throat-shock Mach number of the inlet, and/or designs a shock-capture surface using a parallel-streamlines methodology, and/or a double cowl-lip geometry to allow flow to spill overboard.
    Type: Grant
    Filed: August 31, 2023
    Date of Patent: November 5, 2024
    Assignees: Purdue Research Foundation, University of Notre Dame Du Lac
    Inventors: Mark Edward Noftz, Joseph Stephen Jewell, Andrew James Shuck, Jonathan Poggie, Andrew Nixon Bustard, Thomas James Juliano
  • Heat assisted detection and ranging based on spectropolarimetric imaging
    Patent number: 12135240
    Abstract: Summary: The invention relates to a temperature sensor, full-A magnetic element (3) that has at least one magnetic Layer (1), its magnetic properties depend on the temperature characterized in that—The magnetic layer (1) has a vortex-shaped magnetization distribution with a magnetic vortex core (2) has, wherein the vortex-shaped magnetization distribution is formed in a layer plane and the vortex core (2) is formed perpendicular to the layer plane,—An excitation unit (15) which is used to excite the vortex-shaped Magnetization distribution to a gyrotropic magnetization motion is provided,—A detection unit (16) for detecting a resonance frequency the gyrotropic magnetization movement is provided and—An evaluation unit (19) for determining a temperature from the resonance frequency of the gyrotropic magnetization movement is provided.
    Type: Grant
    Filed: December 6, 2020
    Date of Patent: November 5, 2024
    Assignee: Purdue Research Foundation
    Inventors: Zubin Jacob, Fanglin Bao, Xueji Wang
  • Arrangement for lithium-ion battery thermal events prediction, prevention, and control
    Patent number: 12136712
    Abstract: A method of measuring temperature of a battery having an internally disposed thermal protection arrangement is disclosed which includes providing at least one sensor holder having an electrode side and a housing side disposed within a housing, with at least one cavity provided on the electrode side, providing at least one temperature sensor placed in the at least one cavity of the at least one sensor holder, the outer surface of the at least one temperature sensor being flush with the remaining surface of the at least one sensor holder, attaching the at least one sensor holder to one of a first electrode or a second electrode of the battery, coupling the at least one temperature sensor to a header, and measuring the temperature of the battery.
    Type: Grant
    Filed: August 16, 2022
    Date of Patent: November 5, 2024
    Assignee: Purdue Research Foundation
    Inventors: Vikas Tomar, Bing Li, Vilas G. Pol, Ryan Andrew Adams, Mihit Hitendra Parekh
  • Systems and methods for confocal microscopy
    Patent number: 12135411
    Abstract: A confocal microscope system includes a light source configured to form a light beam, a scanning unit, and an objective lens. The scanning unit is in the form of a mechanically driven scanning unit with a controllable scanning trajectory, and is configured to direct the light beam through the scanning trajectory. The objective lens defines a pupil plane and a focal plane. The light beam is directed from the scanning unit to the objective lens. The confocal microscope system is configured for multi-color line-scanning confocal microscopy, and implements multi-color fluorescence imaging without laser excitation crosstalk.
    Type: Grant
    Filed: August 11, 2022
    Date of Patent: November 5, 2024
    Assignee: Purdue Research Foundation
    Inventors: Meng Cui, Hehai Jiang