Abstract: The present invention relates to a pharmaceutical composition comprising N-(4-(6,7-dimethoxy quinolin-4-yloxy)phenyl)-N?-(4-fluoro phenyl) cyclopropane-1,1-dicarboxamide, (2S)-hydroxy butanedioate of formula-1 and a pharmaceutically acceptable carrier wherein the said pharmaceutical composition has a dimer impurity of formula-2 less than about 2.0% as measured by HPLC.

Abstract: The present invention proposes a rescue system and method for man overboard with remote monitoring, which is implemented by a rescue system consisted of an onboard processing unit, a distress signal module, an unmanned rescue vehicle, an autonomous ship, a communication module, and a shore control center (SCC). The technical effect of the present invention is that when a person falls into the water, the unmanned rescue vehicle can automatically locate and monitor the falling target immediately, and the shore control center (SCC) can accurately locate the relative position between the unmanned rescue vehicle and the ship where the person falls. Thereby, the shore control center (SCC) can control the rescue process throughout the entire process and release rescue device for rescue.

Abstract: A management server enables a user to make a dish on a selected date and time and a selected space designated by a company. A user information management unit manages user information including confirmation information and profile information; a company information management unit manages company information including information regarding a space; a recipe determination unit determines a recipe of the dish on the basis of the user information and the company information; an ordering unit orders at least one of an ingredient and a seasoning for making the dish on the basis of the recipe; and a content management unit manages content related to the recipe to be provided to the user. The confirmation information of the user indicates the selected space and the selected date and time, and the information regarding the designated space includes constraint information regarding use of the space.

Abstract: The present invention discloses a vessel collision avoiding system and method based on Artificial Potential Field algorithm, the method comprises the following steps: (S1) obtaining a vessel information, at least one obstacle information and a target information; (S2) establishing an Artificial Potential Field (APF) by the vessel information, the at least one obstacle information and the target information, wherein the Artificial Potential Field comprises an attractive field of the target and a repulsive field of the obstacle; (S3) combining the attractive field and the repulsive field to obtain a first resultant force; (S4) Adding an external force to the Artificial Potential Field based on the vessel information or the obstacle information; (S5) combining the first resultant force and the external force to obtain a second resultant force; and (S6) the vessel sails in the direction of the second resultant force to avoid the obstacle.

Abstract: A method of removing fixed pattern noise, comprising: S01: performing a single-frame segmented exposure on a pixel array; S02: reading a of the pixel array, comprising: S021: performing a soft reset, so as to set the reset signal of the pixel unit to an intermediate voltage, and reading a differential reset signal; S022: performing a hard reset so as to set the reset signal of the pixel unit to a high voltage; S023: turning on a transmission MOS transistor to enable an exposure signal of to photodiode to transmitted to the floating diffusion area, and reading a differential pixel transmission signal; S03: subtracting the differential reset signal from the differential pixel transmission signal to obtain an exposure signal with fixed pattern noise removed. Another method is removing fixed pattern noise and an image sensor are further provided.

Abstract: The present invention relates to an improved process for the preparation of 4-({(1R)-2-[5-(2-fluoro-3-methoxy phenyl)-3-{[2-fluoro-6-(trifluoro methyl) phenyl] methyl}-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl]-1-phenylethyl}amino) butanoic acid of formula (I) or its pharmaceutically acceptable salts.

Abstract: The present invention provides pure (1?R,6R,6aR,7R,13S,14S,16R)-5-(acetyloxy)-3?,4?,6,6a,7,13,14,16-octahydro-6?,8,14-trihydroxy-7?,9-dimethoxy-4,10,23-trimethyl spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7, 8]isoquino[3,2-b][3] benzazocine-20,1?(211)-isoquinolin]-19-one of formula (1) substantially free from one or more impurities selected from intermediate compound of formula (50), cyclic impurity of formula (A), deshydroxy impurity of formula (B) and hydroxy impurity of formula (C).

Abstract: A razor head includes a frame including two opposing long side walls and two opposing short side walls, connectors each connecting two points of the frame in an interior of the frame, and elongated blades arranged on an inner side of the frame. The blades are coupled to only two of the connectors, the two connectors to which the blades are coupled connecting the two long side walls to each other. In a case where a position in the frame in a longitudinal direction is represented by a percentage, when a middle of the frame in the longitudinal direction is 0% and two ends of the frame in the longitudinal direction that correspond to inner surfaces of the two short side walls are 100%, the two connectors to which the blades are coupled are each arranged in a range from 30% to 90% between the middle and the two ends.

Abstract: A full load test system of an electrical power converter and the test method thereof is disclosed. The full load test method of the electrical power converter comprises the following steps: (a) providing a power converter under test (PCUT); (b) configuring the PCUT in/on a test circuit; (c) serially connecting the PCUT with at least one bidirectional power converter in the test circuit; (d) connecting the test circuit to an alternating current low voltage three-phase power source; and (e) performing a test of the PCUT under full-load condition.

Abstract: The present invention relates to an improved process for the preparation of 3?,7?-dihydroxy6?-ethyl-5?-cholan-24-oic acid compound of formula-1, represented by the following structural formula: Formula-1 The present invention also relates to process for the preparation of ethylene diamine and tertiary butyl amine salts of 3?,7?-dihydroxy6?-ethyl-5?-cholan-24-oic acid which are useful in the preparation of pure 3?,7?-dihydroxy6?-ethyl-5?-cholan-24-oic acid.

Abstract: A razor head includes a frame, elongated blades arranged on an inner side of the frame, and two bridge walls each extending between two points of the frame in an interior of the frame, the bridge walls each including projections arranged in an arrangement direction of the blades. Each of the blades is held between adjacent ones of the projections of the bridge walls. Each of the projections includes a first flat surface and a second flat surface. In each of the bridge walls, the first flat surface and the second flat surface are shifted from each other in a longitudinal direction of the blades so as not to overlap each other, and the first flat surfaces and the second flat surfaces are located on the same position as viewed in the arrangement direction. Each of the projections has a horizontal cross-sectional shape of a parallelogram.

Abstract: The present invention discloses an image sensor for real-time calibration of dark current, including a pixel array comprises at least a pixel unit, the pixel unit includes a pixel photosensitive portion, a pixel dark shielding portion and a subtraction circuit, photodiodes in the pixel photosensitive portion and the pixel dark shielding portion are isolated by deep trench isolations, the pixel dark shielding portion are covered by a dark shielding layer; both of the pixel photosensitive portion and the pixel dark shielding portion adopt a same voltage and sequential control, a light ambient voltage signal and a non-light ambient voltage signal are generated and connected to both ends of a subtraction circuit to realize subtraction and dark current calibration.

Abstract: The present invention relates to process for the preparation of 2-(3,5-dichlorophenyl)-1,3- benzoxazole-6-carboxylic acid of formula (I), its pharmaceutically acceptable salts and polymorphs thereof which are used in the treatment of cardiomyopathy of wild type or hereditary transthyretin-mediated amyloidosis.

Abstract: An entity recognition method, apparatus, electronic device, and computer-readable storage medium are provided. The method includes: determining at least one entity boundary word corresponding to a text sequence; determining at least one entity candidate region in the text sequence based on the at least one entity boundary word; and performing entity recognition on the text sequence and identifying at least one entity in the text sequence based on the at least one entity candidate region.

Abstract: The present disclosure provides an image sensor and a method for manufacturing deep trench and through-silicon via of the image sensor, wherein: providing a pixel silicon wafer, performing a silicon wafer thinning on a second side of the pixel silicon wafer; forming a deep trench on the the second side of the pixel silicon wafer; filling the deep trench with organic material; coating photoresist on the second side of the pixel silicon wafer; etching the second side of the pixel silicon wafer to form a through-silicon via according to the through-silicon via pattern; depositing a dielectric protective layer on the surface of the deep trench and the surface of the through-silicon via; filling the deep trench with organic material; coating the photoresist on the second side of the pixel silicon wafer; etching the second side of the pixel silicon wafer to form a contact hole according to the contact hole pattern, depositing a barrier layer on the surface of the deep trench and the surface of the through-silicon v

Abstract: The present disclosure discloses an infrared sensor structure, comprises a cantilever switch array, the cantilever switch array comprises cantilever switches, and each cantilever switch comprises a cantilever beam and a switch corresponding to the cantilever beam, vertical heights from the cantilever beams to the switches in different cantilever switches are different from each other, when the cantilever beams are deformed towards the switches and connect to the switches, the switches turn on; wherein, deformations of different cantilever beams produced by absorbing infrared signal are different from each other, the intensity of the infrared signal can be quantified by number of the switches on, so as to realize detection of the infrared signal. The manufacturing of the infrared sensor structure in the present disclosure can be compatible with the existing semiconductor CMOS process.

Abstract: The present invention relates to novel crystalline forms of butanedioic acid 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl) pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide of formula-la and process for preparation thereof. The present invention also relates to a process for the preparation of 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d] pyrimidine-6-carboxamide. Further, the present application also relates to acid addition salts of 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d] pyrimidine-6-carboxamide and process for the preparation thereof.

Abstract: Disclosed is an apparatus for tracking an object based on radar image reconstruction, the apparatus including a two-dimensional image producing unit configured to produce a two-dimensional image by collecting multiple one-dimensional radar signals from which clutter is removed, an object detecting unit configured to determine the presence or absence of an object from the two-dimensional image and estimate a two-dimensional position of the present object, and an object tracking unit configured to track a movement path of the object based on the two-dimensional position estimated by the object detecting unit.

Abstract: The present invention relates to a vessel navigation system and navigation method thereof, the method includes: (a) driving a vessel to sail along a sailing path including at least two nodes, the at least two nodes include a first node and a second node connected by a first line segment; (b) generating a first tracking point on the first line segment when a distance between the vessel and the first node being less than a first length, and driving the vessel to sail according to the first tracking point; (c) generating a second tracking point on the first line segment when a distance between the vessel and the first tracking point being less than the first length, and driving the vessel to sail according to the second tracking point; and then completing the navigation of the sailing path by repeating the step (b) and step (c) until the vessel passes through each node.

Abstract: The present invention relates to novel crystalline polymorphs of sodium (4R,12aS)-9-{[(2,4-difluorophenyl) methyl] carbamoyl}-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1?,2?:4,5] pyrazino[2,1-b] [1,3] oxazin-7-olate represented by the following structural formula-1a and process for their preparation. The present invention further relates to novel solvated forms of sodium (4R,12aS)-9-{[(2,4-difluoro phenyl) methyl] carbamoyl}-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1?,2?:4,5] pyrazino[2,1-b][1,3] oxazin-7-olate compound of formula-1a and process for their preparation.