Abstract: A safety needle having a rigid outer structure within which there is a cannula holding element of being movably coupled to an injector pen for a drug is provided. The cannula holding element supports a cannula having a first extremity and a second extremity for administration of the drug. A moving protective element associated with the rigid structure, covers the second extremity of the cannula after administration, with provision being made for a deforming member capable of deforming the cannula after administration of the drug so that the second extremity of the cannula remains within the protective element. The deforming member is associated with the protective element and is capable of rotating autonomously with respect thereto after administration of the drug to deform the cannula.

Abstract: The present invention, relates to solid state forms of N-[2-[(1 S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide represented by the following structural formula-1 and process for their preparation. The present invention also relates to an improved process for the preparation of N-[2-[(1 S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide compound of formula-1 and intermediates thereof.

Abstract: The present invention relates to a process for the preparation of D-glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl)oxy)phenyl] methyl]phenyl]-, (IS) formula-1.

Abstract: The present disclosure provides a FINFET device integrated with a TFET and its manufacturing method. Two end portions of the fin structure respectively form an N-type doped drain and a source which is consisted by a top P-type doped region and a bottom N-type doped region. As a result, the bottom N-type doped region of the source, the drain, the channel, the high-k dielectric layer and the gate structure on the surface of the sidewall of the fin structure form a MOS FINFET device, and the top P-type doped region of the source, the drain, the channel, the high-k dielectric layer and the gate structure on the top surface of the fin structure form the TFET device. The integration of the TFET and the FINFET is achieved, which decreases the cost.

Abstract: The present invention discloses a test structure and a method for judging the de-embedding accuracy of RF devices, which comprises testing the S parameters of a target device test structure, an introduced device test structure and an auxiliary test structure, respectively. Then calculating de-embedding S parameters of the target device test structure and the introduced device test structure according to the above-tested results, respectively. Finally, calculating performance parameters of the target device test structure according to the above-calculated de-embedding S parameters. So, the accuracy of the de-embedding method is determined by comparing the consistency of the performance parameters. The present invention can directly judge the de-embedding accuracy and the applicable frequency range of a given de-embedding method by analyzing the testing data. Further, the using of the parallel test structure and the cascade test structure together can increase the reliability of the judgment results.

Abstract: A pile guide frame is coupled with at least one rotatable arm and includes a plurality of leveling modules for compensating for differences in height of the seabed. The rotatable arm can be rotated along a supporting frame and thereby move a pile guide module to facilitate pile-driving operations.

Abstract: A pile guide frame is coupled with at least one rotatable arm and includes a plurality of leveling modules for compensating for differences in height of the seabed. The rotatable arm can be rotated along a supporting frame and thereby move a pile guide module to facilitate pile-driving operations. A method for operating a pile guide frame coupled with at least one rotatable arm is also provided.

Abstract: One aspect of the invention relates to a mutant polypeptide comprising the amino acid sequence of Escherichia coli tetracycline efflux pump A (TetA). Another aspect of the invention relates to a polynucleotide encoding a polypeptide of TetA, a fragment thereof, or a mutant thereof. Another aspect of the invention relates to a first expression plasmid vector comprising one or more first polynucleotides encoding a first polypeptide comprising a tetracycline efflux pump polypeptide, a fragment thereof or a mutant thereof, one or more second polynucleotides independently selected from the group consisting of a third polynucleotide encoding a third polypeptide comprising a lysine decarboxylase polypeptide, a fragment thereof or a mutant thereof, and a fourth polynucleotide encoding a fourth polypeptide comprising a lysine biosynthesis polypeptide, a fragment thereof or a mutant thereof.

Abstract: The invention provides CadA polypeptides with mutations that increase activity in alkaline pH compared to the wild-type lysine decarboxylase. The invention also provides methods of generating such mutant polypeptides, microorganisms genetically modified to overexpress the mutant polypeptides, and methods of generating such microorganisms.

Abstract: A method and an apparatus for forwarding a heterogeneous protocol message, and a network switching device are provided, the method includes: receiving a network message; parsing the network message to obtain a destination address of the network message; looking up in a preset forwarding table a port corresponding to the destination address and a first protocol corresponding to the port; judging whether the first protocol matches a second protocol of the network message; performing, if not, protocol conversion on the network message in accordance with a preset conversion rule, so that the protocol type of the network message matches the port; forwarding the protocol-converted network message through the port. In the present disclosure, protocol conversion can be performed on messages from different protocol networks, so that the network switching device implements communication between different networks, and has a flexible protocol processing mode and powerful scalability.

Abstract: Embodiments of the present invention provide a method and device for processing Dynamic Vision Sensor (DVS) events. The method comprises the operations of: acquiring a DVS event map sequence; for any DVS event map in the DVS event map sequence, extracting a DVS event feature descriptor, where the DVS event feature descriptor has a scale-invariant feature and/or a rotation-invariant feature; determining, according to the extracted DVS event feature descriptor, a three-dimensional space pose of the DVS event map at the current moment; and, generating, according to the three-dimensional space pose of each DVS event map, a DVS event map sequence with temporal consistency. The embodiments of the present invention are used for generating, from a DVS event map sequence, a DVS event map sequence with temporal consistency.

Abstract: The invention relates to the directed evolution of CYP52A12 gene and the use thereof for the production of a dicarboxylic acid. In particular, it relates to a method of preparing a long chain dicarboxylic acid producing strain by using directed evolution and homologous recombination, a strain obtained by the method that is capable of producing a long chain dicarboxylic acid under an acidic condition and the use thereof. In particular, the invention relates to a method of preparing a long chain dicarboxylic acid producing strain by directed evolution of CYP52A12 gene and homologous recombination, a strain obtained by the method that is capable of producing a long chain dicarboxylic acid under an acidic condition and the use thereof. By directed evolution of CYP52A12 gene, one strain which has a base mutation at the promoter region of said gene and is capable of producing a long chain dicarboxylic acid under an acidic condition in a shortened fermentation time is screened out in the invention.

Abstract: The present invention discloses a method for producing a long chain dicarboxylic acid by fermentation as well as a fermentation broth, a treated fermentation broth and a wastewater. The salt content in the fermentation broth is controlled to be below 20% by the fermentation method of the present invention. The method for producing a long chain dicarboxylic acid by fermentation provided by the present invention can effectively reduce the amount of alkali used in the fermentation process and the amount of acid used in the subsequent extraction of the long chain dicarboxylic acid, thereby reducing the amount of salt in the whole production process of the long chain dicarboxylic acid. At the same time, the method of the present invention also has many advantages such as shortening the fermentation time, increasing the acid production, reducing the amount of medium, and suitable for the production of various types of long-chain dicarboxylic acids, etc.

Abstract: One aspect of the invention relates to a mutant polypeptide comprising the amino acid sequence of Escherichia coli tetracycline efflux pump A (TetA). Another aspect of the invention relates to a polynucleotide encoding a polypeptide of TetA, a fragment thereof, or a mutant thereof. Another aspect of the invention relates to a first expression plasmid vector comprising one or more first polynucleotides encoding a first polypeptide comprising a tetracycline efflux pump polypeptide, a fragment thereof or a mutant thereof, one or more second polynucleotides independently selected from the group consisting of a third polynucleotide encoding a third polypeptide comprising a lysine decarboxylase polypeptide, a fragment thereof or a mutant thereof, and a fourth polynucleotide encoding a fourth polypeptide comprising a lysine biosynthesis polypeptide, a fragment thereof or a mutant thereof.

Abstract: Embodiments of the present invention provide a method and an apparatus for predicting a residual, which method is applied to three-dimensional video encoding or multi-visual angle video encoding and comprises searching, when performing inter frame image prediction encoding on a prediction unit, a corresponding unit of the prediction unit in an adjacent visual angle encoded at the same time; and predicting a time domain predicted residual of the prediction unit by utilizing a time domain predicted residual of the corresponding unit in the encoded adjacent visual angle.

Abstract: A manufacturing method for gate-all-around structures in semiconductor IC manufacturing field includes forming a buried gate layer on the semiconductor substrate, forming an epitaxial layer in non-buried-gate-layer regions and planarizing the epitaxial layer so that the top surface of the epitaxial layer is at the same level with the top surface of the buried gate layer; forming a fin structure on the buried gate layer; forming a gate structure traversing and surrounding the fin structure. Since the gate structure wraps around four sides of the fin to effectively control the channel, the channel width is increased compared with the double-gate or triple gate structure, thereby increasing the effective area of the channel. The present invention solves the conventional problems like complex process and high cost without degrading the device performance. It has the advantages of simplicity, compatibility with the traditional IC planar process, low cost, and easy implementation.

Abstract: The present disclosure provides a method for isolating a long chain dicarboxylic acid from fermentation broth containing microbial cells. Also provided is a substantially pure long chain dicarboxylic acid isolated by the method.

Abstract: An example topology construction method for satisfying partition tolerance, comprising: combining the consortium blockchain consensus mechanism with the network topology structure to make the consortium blockchain consensus satisfy the partition tolerance in probability; abstracting the partition tolerance of a system into a class of convergent Markov process and computing a steady-state probability of the system; estimating the probability and the average minimum repair time of failing to meet consistency or availability in the event of a partition failure with a given number of failure channels, and a partition tolerance probability and an average minimum repair time of the system are obtained; and analyzing the resource overhead and the partition tolerance under different network topologies according to the obtained partition tolerance probability and the average minimum repair time, and constructing the network topology structure with suitable scale and high partition tolerance for the consortium blockcha

Abstract: A razor blade cartridge is detachably attached to a holder. A socket portion is provided to the holder. A coupler projection, which detachably attaches to the socket portion through the insertion/ejection opening of the socket portion, is provided to the blade cartridge. A guide portion, which extends towards the opposite side from the skin contacting surface of the blade cartridge and is supported by the socket portion of the holder, is provided to the coupler projection of the blade cartridge. The end of the guide portion is provided with a manipulation portion, which is manipulated at the manipulation opening of the socket portion to release the guide portion from the socket portion and the manipulation of which removes the blade cartridge from the insertion/ejection opening of the socket portion. Thus, the blade cartridge can be easily removed by a gentle application of pressure on the manipulation portion.

Abstract: Provided herein is a genetically modified host cell comprising a heterologous nucleic acid encoding a biofilm dispersal polypeptide that decreases intracellular c-di-GMP levels and enhances the production of lysine and lysine derivatives. Further provided are methods of generating such cell and producing lysine and lysine derivatives using the genetically modified host cell.