Patents Assigned to Ramot - Tel-Aviv University
  • Apparatus and methods for enzymatic debridement of skin lesions
    Patent number: 9155828
    Abstract: An apparatus for debridement of devitalized tissue in skin lesions, that includes a plurality of height- and angle-adjustable inlet tubes and at least one outlet tube and a member that forms an occlusive seal around a skin lesion. The plurality of inlet tubes is adapted for directing a continuous stream of enzymatic solution to the surface and into the entire volume of the wound bed of the lesion and the at least one outlet is adapted for removing the enzymatic solution, fluids draining from the lesion and tissue debris from the occluded skin lesion.
    Type: Grant
    Filed: July 18, 2011
    Date of Patent: October 13, 2015
    Assignees: Ramot at Tel-Aviv University Ltd., EnzySurge Ltd.
    Inventors: Amihay Freeman, Eran Hirszowicz, Michal Beeri-Lipperman
  • Method and system for analyzing craniofacial complex images
    Patent number: 9153022
    Abstract: In a method of analysis, a target image is registered to define a plurality of keypoints arranged in sets corresponding to polygons or linear segments in the target image. A database of registered and annotated images is accessed and a polygon-wise comparison between the target image and each database image is employed. The comparison is used for projecting annotated locations from the database images into the target image.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: October 6, 2015
    Assignees: Mor Research Applications Ltd., Ramot at Tel-Aviv University Ltd.
    Inventors: Yehuda Finkelstein, Lior Wolf
  • Thio-salalen catalyst
    Patent number: 9150676
    Abstract: Catalysts comprising thio-salalen ligands. Also, catalyst systems comprising the catalyst and an activator; methods to prepare the ligands, catalysts and catalyst systems; processes to polymerize olefins using the catalysts and/or catalyst systems; and the olefin polymers prepared according to the processes.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: October 6, 2015
    Assignees: ExxonMobil Chemical Patents Inc., Ramot at Tel-Aviv University Ltd.
    Inventors: Moshe Kol, Konstantin Press, Ayellet Lynn Stopper, Matthew W. Holtcamp, Meagan E. Evans, David A. Cano
  • METHODS AND KITS FOR PREDICTING PROGNOSIS OF CANCER USING SOLUBLE MORTALIN IN BLOOD
    Publication number: 20150268242
    Abstract: Provided are methods of determining a presence or level of soluble mortalin in a body fluid of a subject, and predicting prognosis of a subject diagnosed with cancer (e.g., solid tumor) by determining the presence or level of soluble mortalin in a body fluid of the subject. Also provided are kits for determining presence and/or level of soluble mortalin in a body fluid of the subject and/or predicting prognosis of a subject diagnosed with cancer, comprising at least two distinct antibodies to mortalin directed against different epitopes of said mortalin.
    Type: Application
    Filed: October 9, 2013
    Publication date: September 24, 2015
    Applicants: RAMOT AT TEL-AVIV UNIVERSITY LTD., SEMMELWEIS UNIVERSITY
    Inventors: Zvi Fishelson, Zoltan Prohaszka
  • Method and system for correcting gaze offset
    Patent number: 9141875
    Abstract: A method of correcting gaze offset in an image of at least one individual having eyes is disclosed. The method comprises: processing the image to extract location of at least one eye over the image, processing the image to replace imagery data associated with each location of each eye with replacement data thereby providing a corrected image, and transmitting the corrected image to a display device. The replacement data are preferably previously-recorded imagery data which respectively correspond to the same eye but a different gaze.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: September 22, 2015
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Lior Wolf, Ziv Freund
  • Systems and methods for detection of cellular stress
    Patent number: 9140650
    Abstract: There are provided methods for detection and measurement of stress in a cell, the method including introducing a labeled tRNA into the cell and detecting a change in subcellular localization of the labeled tRNA in the cell, based on the signal emitted from the labeled tRNA. There are further provided methods and systems for the generation of a stress index of a living cell. There are further provided methods and systems for detection of stress in a living cell, comprising detection of changes in subcellular localization of labeled tRNA in a cell, wherein the detection is performed in real time.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: September 22, 2015
    Assignees: Ramot at Tel Aviv University Ltd., Anima Cell Metrology, Inc.
    Inventors: Orna Elroy-Stein, Marcelo Ehrlich, Sima Barhoom, Zeev Smilansky
  • METHOD AND SYSTEM FOR PROCESSING AN IMAGE FEATURING MULTIPLE SCALES
    Publication number: 20150256735
    Abstract: A method of processing an image is disclosed. The method comprises obtaining an image decomposed into a set of scaled images, each being characterized by a different image-scale; and calculating, for each of at least some scaled images, a relative luminance between the scaled image and another scaled image of the set, using intensities in the scaled image and intensities in the another scaled image. The method further comprises processing each scaled image using an adaptation procedure featuring an image-specific effective saturation function of the relative luminance, thereby providing a processed scaled image; combining at least some of the processed scaled images to provide a combined image; and outputting the combined image to a computer readable medium.
    Type: Application
    Filed: May 21, 2015
    Publication date: September 10, 2015
    Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: Yuval BARKAN, Hedva SPITZER, Yael FALTIN GEFEN
  • Method and system of classifying medical images
    Patent number: 9122955
    Abstract: A method of generating a category model for classifying medical images. The method comprises providing a plurality of medical images each categorized as one of a plurality of categorized groups, generating an index of a plurality of visual words according to a distribution of a plurality of local descriptors in each the image, modeling a category model mapping a relation between each visual word and at least one of the categorized groups according to the index, and outputting the category model for facilitating the categorization of an image based on local descriptors thereof.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: September 1, 2015
    Assignees: Ramot at Tel-Aviv University Ltd., Tel HaShomer Medical Research Infrastructure and Services Ltd., Bar-Ilan University
    Inventors: Hayit Greenspan, Jacob Goldberger, Uri Avni, Eli Konen, Michal Sharon
  • Three-dimensional microbattery having a porous silicon anode
    Patent number: 9123954
    Abstract: An electrical energy storage device (20) includes a silicon substrate (22), which is formed so as to define a multiplicity of micro-containers (24, 26) having porous silicon walls (28), which are configured to serve as an anode layer. A cathode layer (34) overlies the micro-containers, with a separator layer (32) intermediate the anode layer and the cathode layer.
    Type: Grant
    Filed: May 23, 2011
    Date of Patent: September 1, 2015
    Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventor: Menachem Nathan
  • Transmission system with ISI channel and method of operating thereof
    Patent number: 9118518
    Abstract: There is provided a transmission system and method of operating thereof. The method comprises: dividing a data sequence to be transmitted into a plurality of data blocks; encoding one or more data blocks with one or more linear systematic cyclic codes thus giving rise to encoded data blocks; transmitting said encoded data blocks over an ISI transmission channel; upon receiving, applying a linear integer-forcing (IF) equalization to the received data blocks; processing the output of the IF equalization thereby detecting for each encoded data block a valid codeword with maximal likelihood of decoding; and reconstructing the data blocks using the respective detected valid codewords.
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: August 25, 2015
    Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: Uri Erez, Or Ordentlich
  • RECTIFYING ANTENNA DEVICE WITH NANOSTRUCTURE DIODE
    Publication number: 20150229165
    Abstract: A rectifying antenna device is disclosed. The device comprises a pair of electrode structures, and at least one nanostructure diode contacting at least a first electrode structure of the pair and being at least in proximity to a second electrode structure of the pair. At least one electrode structure of the pair receives AC radiation, and the nanostructure diode(s) at least partially rectifies a current generated by the AC radiation.
    Type: Application
    Filed: April 26, 2015
    Publication date: August 13, 2015
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Yael HANEIN, Amir BOAG, Jacob SCHEUER, Inbal FRIEDLER
  • Compounds suited as nanocarriers for active agents and their use
    Patent number: 9102595
    Abstract: The invention relates to a compound suited as entity carrier, having the general formula (I) wherein X is an amine-containing residue further defined herein. The invention further relates to the use of such compounds, a nanocarrier system, a kit comprising such compounds and methods for gene silencing and anti-cancer treatment.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: August 11, 2015
    Assignees: Ramot at Tel-Aviv University Ltd., Freie Universitaet Berlin
    Inventors: Rainer Haag, Wiebke Fischer, Mohiuddin Abdul Quadir, Ronit Satchi-Fainaro, Paula Ofek
  • System and a method for nano imprinting
    Patent number: 9104948
    Abstract: A method for creating a highly accurate nanostructure is provided, the method includes: (i) creating a highly accurate nanostructure prototype, wherein the highly accurate nanostructure prototype, when illuminated with a predefined illumination, provides a unique optical pattern; (ii) creating at least one highly accurate nanostructure mold from the highly accurate nanostructure prototype, wherein each highly accurate nanostructure mold enables a creation of a highly accurate nanostructure that is substantially similar to the highly accurate nano structure prototype and which, when illuminated with the predefined illumination, provides the unique optical pattern; and (iii) molding the highly accurate nano structure using the highly accurate nano structure mold, wherein the highly accurate nanostructure, when illuminated with the predefined illumination, provides the unique optical pattern.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: August 11, 2015
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventor: Jacob Scheuer
  • ENDO180-TARGETED PARTICLES FOR SELECTIVE DELIVERY OF THERAPEUTIC AND DIAGNOSTIC AGENTS
    Publication number: 20150216998
    Abstract: Disclosed herein are compositions comprising lipid based particles and anti-ENDO180 antibodies and to methods of using the same for targeted delivery of therapeutic agents to cancer and fibrotic cells useful for treating cell proliferative diseases or disorders including fibrosis, cancer and to attenuate tumor progression.
    Type: Application
    Filed: December 31, 2012
    Publication date: August 6, 2015
    Applicants: RAMOT AT TEL-AVIV UNIVERSITY LTD., QBI ENTERPRISES LTD.
    Inventors: Elena Feinstein, Dan Peer
  • Dipeptide analogs for treating conditions associated with amyloid fibril formation
    Patent number: 9096645
    Abstract: Dipeptide analogs comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety derived from alpha-aminoisobutyric acid (Aib) are disclosed. The dipeptide analogs exhibit an improved performance in inhibiting amyloid fibril formation, as compared to previously described dipeptides. Compositions containing the dipeptide analogs and uses thereof in treating amyloid-associated diseases and disorders are also disclosed.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: August 4, 2015
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Ehud Gazit, Yaniv Amir, Ludmila Buzhansky, Ulrich Abel, Anat Frydman-Marom
  • Conjugates of a polymer, a bisphosphonate and an anti-angiogenesis agent and uses thereof in the treatment and monitoring of bone related diseases
    Patent number: 9095618
    Abstract: Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and a bisphosphonate bone targeting agent, and processes of preparing same, are disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment of bone related disorders are also disclosed.
    Type: Grant
    Filed: January 20, 2014
    Date of Patent: August 4, 2015
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Ronit Satchi-Fainaro, Keren Miller, Doron Shabat, Rotem Erez
  • Method and system for processing an image featuring multiple scales
    Patent number: 9092838
    Abstract: A method of processing an image is disclosed. The method comprises obtaining an image decomposed into a set of scaled images, each being characterized by a different image-scale; and calculating, for each of at least some scaled images, a relative luminance between the scaled image and another scaled image of the set, using intensities in the scaled image and intensities in the another scaled image. The method further comprises processing each scaled image using an adaptation procedure featuring an image-specific effective saturation function of the relative luminance, thereby providing a processed scaled image; combining at least some of the processed scaled images to provide a combined image; and outputting the combined image to a computer readable medium.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: July 28, 2015
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Yuval Barkan, Hedva Spitzer, Yael Faltin Gefen
  • Method and system for processing an image
    Patent number: 9092878
    Abstract: A method of processing an image having a plurality of picture-elements is disclosed. The method comprises: preprocessing the image to selectively enhance contrast of some picture-elements of the image, and employing a companding procedure for the preprocessed image, thereby providing a processed image. The contrast enhancement optionally and preferably features a mapping function having a plateau region for diminishing image data with intensity levels below an intensity threshold, thereby providing a preprocessed image.
    Type: Grant
    Filed: October 12, 2010
    Date of Patent: July 28, 2015
    Assignees: Ramot at Tel-Aviv University Ltd., Tel HaShomer Medical Research Infrastructure and Services Ltd.
    Inventors: Hedva Spitzer, Yuval Barkan, Lonia Kanelovitch, Itzchak Yacov, Arie Rundstein, Miriam Sklair-Levy
  • Probabilistic error correction in multi-bit-per-cell flash memory
    Patent number: 9094047
    Abstract: Data that are stored in cells of a multi-bit-per cell memory, according to a systematic or non-systematic ECC, are read and corrected (systematic ECC) or recovered (non-systematic ECC) in accordance with estimated probabilities that one or more of the read bits are erroneous. In one method of the present invention, the estimates are a priori. In another method of the present invention, the estimates are based only on aspects of the read bits that include significances or bit pages of the read bits. In a third method of the present invention, the estimates are based only on values of the read bits. Not all the estimates are equal.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: July 28, 2015
    Assignee: Ramot at Tel Aviv University Ltd.
    Inventors: Simon Litsyn, Idan Alrod, Eran Sharon, Mark Murin, Menahem Lasser
  • LINEARIZED OPTICAL DIGITAL-TO-ANALOG MODULATOR
    Publication number: 20150194982
    Abstract: A modulator device for converting digital date into modulation of an optical signal includes an electronic input for receiving an input data word of N bits and an electrically controllable modulator for modulating the intensity of an optical signal, the modulator including M actuating electrodes where M?N. An electrode actuating device, most preferably a digital-to-digital converter, operates actuating electrodes so that at least one electrode is actuated as a function of values of more than one bit of the input data word. According to an alternative, or supplementary, aspect of the invention, the set of electrodes includes at least one electrode having an effective area which is not interrelated to others of the set by factors of two. In one-preferred implementation, a Mach-Zehnder modulator also provides phase modulation to give QAM functionality. Another implementation employs a semiconductor laser.
    Type: Application
    Filed: March 19, 2015
    Publication date: July 9, 2015
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Yossef EHRLICHMAN, Ofer AMRANI, Shlomo RUSCHIN