Patents Assigned to Ramot - Tel-Aviv University
  • Acid addition salt of a nortriptyline-GABA conjugate and a process of preparing same
    Patent number: 8916610
    Abstract: An acid addition salt of a nortriptyline-GABA conjugate, a novel crystalline form of a fumaric acid addition salt of a nortriptyline-GABA conjugate, and processes of preparing the forgoing are disclosed. Uses of the above-indicated forms of a nortriptyline-GABA conjugate in the treatment of CNS disorders, and in the treatment of pain in particular, are also disclosed. Further disclosed in a large-scale process of preparing a nortriptyline-GABA conjugate.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: December 23, 2014
    Assignees: Ramot at Tel-Aviv University Ltd., Bar-Ilan University
    Inventors: Abraham Nudelman, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman, Mazal Shaul, Efrat Halbfinger
  • Efficient processing of compressed communication traffic
    Patent number: 8909813
    Abstract: A method for processing communication traffic includes receiving an incoming stream of compressed data conveyed by a sequence of data packets, each containing a respective portion of the compressed data. The respective portion of the compressed data contained in the first packet is stored in a buffer, having a predefined buffer size. Upon receiving a subsequent packet, at least a part of the compressed data stored in the buffer and the respective portion of the compressed data contained in the subsequent packet are decompressed, thereby providing decompressed data. A most recent part of the decompressed data that is within the buffer size is recompressed and stored in the buffer.
    Type: Grant
    Filed: March 20, 2012
    Date of Patent: December 9, 2014
    Assignees: Ramot at Tel-Aviv University Ltd., Interdisciplinary Center Herzliya
    Inventors: Yehuda Afek, Anat Bremler-Barr, Yaron Koral
  • Salalen ligands and organometallic complexes
    Patent number: 8907032
    Abstract: Use of homogeneous catalytic systems which include as a pre-catalyst a complex of a Group IV metal and a salalen ligand in the polymerization of alpha-olefins, is disclosed. The alpha-olefin polymers obtained are characterized by controlled levels of tacticity. Also disclosed are novel salalen ligands and novel complexes thereof with Group IV metals.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: December 9, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Moshe Kol, Konstantin Press, Ad Cohen
  • Methods of treating autoimmune diseases of the central nervous system (CNS) and neurodegenerative diseases
    Patent number: 8901074
    Abstract: An insulin degrading enzyme (IDE) inhibitor for use in the treatment of a disease selected from the group consisting of an autoimmune disease of the central nervous system and a neurodegenerative disease is disclosed.
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: December 2, 2014
    Assignee: Ramot at Tel-Aviv University
    Inventors: Dan Frenkel, Hilit Levy, Nofit Borenstein, Dorit Farfara, Dorit Trudler
  • Mesenchymal stem cells for the treatment of CNS diseases
    Patent number: 8900574
    Abstract: An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: December 2, 2014
    Assignees: Ramot at Tel-Aviv University Ltd., BrainStorm Cell Therapeutics Ltd.
    Inventors: Avinoam Kadouri, Avihay Bar-Ilan, Eldad Melamed, Daniel Offen, Ofer Sadan, Merav Bahat-Stromza
  • Method and device for processing computerized tomography images
    Patent number: 8897524
    Abstract: A method of processing a computerized tomography image is disclosed. The method comprises preprocessing the image using contrast enhancement weight function, thereby providing a preprocessed image having a first dynamic range; and applying a companding procedure to the preprocessed image, so as to reduce the first dynamic range.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: November 25, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Hedva Spitzer, Hadar Cohen-Duwek, Yuval Barkan
  • METHODS AND DEVICES SUITABLE FOR IMAGING BLOOD-CONTAINING TISSUE
    Publication number: 20140343435
    Abstract: Disclosed are methods and devices useful for imaging blood-containing tissue, for example for angiography, especially retinal angiography, whereby an image is generated by dividing pixels of an image acquired at some wavelength range by corresponding pixels of an image acquired at a different wavelength range. In some embodiments, a first wavelength range includes predominantly light having wavelengths between about 400 nm and about 620 nm and a second wavelength range includes predominantly light having wavelengths between about 620 nm and about 800 nm.
    Type: Application
    Filed: February 8, 2012
    Publication date: November 20, 2014
    Applicants: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD., RAMOT AT TEL AVIV UNIVERSITY LTD.
    Inventors: Genady KOSTENICH, Arie ORENSTEIN, Michael BELKIN
  • Static synchronous generators
    Patent number: 8880236
    Abstract: A method of controlling an inverter, by modelling a synchronous generator is provided.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: November 4, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: George Weiss, Qing-Chang Zhong
  • Oscillatory vorticity generator and applications thereof
    Patent number: 8876064
    Abstract: An oscillatory vorticity generator device for controlling the flow on an aero- or hydrodynamic surface of an element, the oscillatory vorticity generator device comprising: two main walls, positioned opposite to each other, forming a first pair of walls and two other walls, the four walls each having proximal and distal ends, the distal ends connected to an aero- or hydrodynamic surface; a connection connecting the walls at their proximal ends; and an opening in the aero- or hydrodynamic surface, the opening being substantially contiguous with the two main walls and the two other walls.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: November 4, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Avraham Seifert, Oksana Stalnov, Ilan Fono, Isaac Dayan, Victor Troshin, Maor Hai Avnaim, Vitali Palei
  • Method for discovering relationships in data by dynamic quantum clustering
    Patent number: 8874412
    Abstract: Data clustering is provided according to a dynamical framework based on quantum mechanical time evolution of states corresponding to data points. To expedite computations, we can approximate the time-dependent Hamiltonian formalism by a truncated calculation within a set of Gaussian wave-functions (coherent states) centered around the original points. This allows for analytic evaluation of the time evolution of all such states, opening up the possibility of exploration of relationships among data-points through observation of varying dynamical-distances among points and convergence of points into clusters. This formalism may be further supplemented by preprocessing, such as dimensional reduction through singular value decomposition and/or feature filtering.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: October 28, 2014
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Ramot at Tel Aviv University Ltd.
    Inventors: Marvin Weinstein, David Horn
  • System and method for exchanging information over a jacobi MIMO channel
    Patent number: 8873954
    Abstract: A method and system for transmitting data over a Jacobi MIMO channel when using channel state feedback.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: October 28, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Meir Feder, Ronen Dar
  • Bacteriophages for reducing toxicity of bacteria
    Patent number: 8865158
    Abstract: A genetically modified bacteriophage is disclosed which comprises: (i) an exogenous polynucleotide which encodes an agent which reduces the toxicity of a bacterium; and (ii) an exogenous polynucleotide which encodes a selectable marker. Uses thereof and kits comprising same are also disclosed.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: October 21, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Ehud Qimron, Rotem Edgar, Nir Friedman
  • DYNAMIC MAPS FOR EXPLORING AND BROWSING OF IMAGES
    Publication number: 20140304278
    Abstract: A method of mapping a collection of images, or other higher dimensional items including text documents, and three-and-higher dimensional objects, onto a navigable grid for browsing via a user interface comprises obtaining for each of the images a list of nearest neighbor images and similarity scores for each nearest neighbor; placing a first image on a cell within a grid; from a respective list of nearest neighbors of said first image, finding images that maximize a compatibility score with images already placed on the grid and placing resulting images on neighboring cells; and continuing to place further images on the grid until all cells visible to a user are filled with images. As the user pans or zooms the grid, more cells move into the visible area of the screen and are filled with images in the same way.
    Type: Application
    Filed: April 3, 2014
    Publication date: October 9, 2014
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Yanir KLEIMAN, Daniel COHEN-OR
  • Tilting actuator with close-gap electrodes
    Patent number: 8853804
    Abstract: A tunable tilting device is described. The device includes a tilting element and a suspension structure that has one or more flexures coupled to the tilting element. The suspension structure has a variable bending stiffness and configured to bend due to a tilting motion of the tilting element around a pivot axis. The suspension structure is responsive to a tuning force actuating a variation of an extension stress or a compression stress of the suspension structure, and thereby can vary the bending stiffness of the suspension structure.
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: October 7, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Viacheslav Krylov, Tsvi Shmilovich
  • ANTIBODIES TO CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE (CEACAM)
    Publication number: 20140271618
    Abstract: The present invention provides antibodies, as well as molecules having at least the antigen-binding portion of an antibody, recognizing a specific epitope of the protein CEACAM1 and optionally binds also other subtypes of the CEACAM protein family. Disclosed antibodies and antibody fragments are characterized by specific CDR sequences. Methods of production and use in therapy and diagnosis, of such antibodies and antibody fragments are also provided.
    Type: Application
    Filed: October 10, 2012
    Publication date: September 18, 2014
    Applicants: RAMOT AT TEL-AVIV UNIVERSITY LTD., CCAM BIOTHERAPEUTICS LTD.
    Inventors: Gal Markel, Tehila Ben Moshe, Yair Sapir, Ilana Mandel, Jacob Schachter, Rona Ortenberg
  • Diphenylamine salan catalyst
    Publication number: 20140275454
    Abstract: Catalysts comprising Salan ligands with bridged or unbridged diphenyl amine moieties. Also, catalyst systems comprising the catalyst and an activator; methods to prepare the ligands, catalysts and catalyst systems; processes to polymerize olefins using the catalysts and/or catalyst systems; and the olefin polymers prepared according to the processes.
    Type: Application
    Filed: November 11, 2013
    Publication date: September 18, 2014
    Applicants: Ramot at Tel-Aviv University Ltd., ExxonMobil Chemical Patents Inc.
    Inventors: Matthew W. Holtcamp, Meagan E. Evans, David A. Cano, Eric D. Whetmore, Gregory S. Day, Moshe Kol
  • Method and device for radiotherapy
    Patent number: 8834837
    Abstract: A radiotherapy method, comprising positioning a predetermined amount of a radionuclide selected from the group consisting of Radium-223, Radium-224, Radon-219 and Radon-220, in proximity to and/or within a tumor of a subject, for a predetermined time period. The predetermined amount and the predetermined time period are selected sufficient for the radionuclide to administering a predetermined therapeutic dose of decay chain nuclei and alpha particles into the tumor.
    Type: Grant
    Filed: August 26, 2009
    Date of Patent: September 16, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Itzhak Kelson, Lior Arazi
  • METHODS OF MONITORING AND ANALYZING METABOLIC ACTIVITY PROFILES DIAGNOSTIC AND THERAPEUTIC USES OF SAME
    Publication number: 20140255972
    Abstract: A method of measuring a metabolic activity (MA) of a cell is provided. The method comprising independently measuring in an extracellular environment of the cell, time-dependent acidification profiles due to secretion of: (i) non-volatile soluble metabolic products; (ii) non-volatile soluble metabolic products and volatile soluble metabolic products; and (iii) volatile soluble metabolic products; wherein at least one of the time dependent acidification profiles is indicative of the metabolic activity of the cell. Also provided are clinical methods which make use of the assay.
    Type: Application
    Filed: May 18, 2014
    Publication date: September 11, 2014
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Reuven TIROSH, Fernando Patolsky, Hagit Peretz-Soroka
  • Psychotropic agents having glutamate NMDA activity
    Patent number: 8828993
    Abstract: The invention provides novel compounds and pharmaceutical compositions for the treatment of psychological and/or psychiatric diseases or disorders.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: September 9, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Moshe Portnoy, Irit Gil-Ad, Avraham Weizman
  • Method and device for multi phase error-correction
    Patent number: 8832518
    Abstract: Data bits to be encoded are split into a plurality of subgroups. Each subgroup is encoded separately to generate a corresponding codeword. Selected subsets are removed from the corresponding codewords, leaving behind shortened codewords, and are many-to-one transformed to condensed bits. The final codeword is a combination of the shortened codewords and the condensed bits. A representation of the final codeword is decoded by being partitioned to a selected subset and a plurality of remaining subsets. Each remaining subset is decoded separately. A subset whose decoding is terminated is decoded again, at least in part according to the selected subset. If the encoding and decoding are systematic then the selected subsets are of parity bits.
    Type: Grant
    Filed: February 21, 2008
    Date of Patent: September 9, 2014
    Assignee: Ramot at Tel Aviv University Ltd.
    Inventors: Simon Litsyn, Eran Sharon, Idan Alrod, Menahem Lasser