Patents Assigned to Ramot - Tel-Aviv University
  • IL-1 RECEPTOR ANTAGONIST-COATED ELECTRODE AND USES THEREOF
    Publication number: 20140249396
    Abstract: The present invention provides an electrode designed for implantation into the central nervous system (CNS) of a mammal, wherein said electrode is substantially coated with interleukin-1 receptor antagonist (IL-1ra) or a coating composition comprising it, and the IL-1ra actively inhibits scarring on or around the surface of the electrode when implanted into the CNS. The electrode of the invention may be used for brain recording and/or stimulation, and can thus be used for treatment of a brain dysfunction, a brain disease or disorder, or a brain injury, as well as for brain computer interface, brain machine interface, or electrotherapy.
    Type: Application
    Filed: July 23, 2012
    Publication date: September 4, 2014
    Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.
    Inventors: Yosi Shacham-Diamand, Matti Mintz, Aryeh Taub
  • MICRORNA PATTERNS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF MELANOMA
    Publication number: 20140235488
    Abstract: The present invention relates to methods for diagnosing, staging, prognosticating and treating melanoma based on evaluating the expression of specific patterns of oncogenic or suppressive microRNA (miR) molecules in a patient in need thereof.
    Type: Application
    Filed: April 29, 2014
    Publication date: August 21, 2014
    Applicants: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD., RAMOT AT TEL AVIV UNIVERSITY
    Inventors: Gal Markel, Eyal Greenberg, Noam Shomron, Liat Edry, Jacob Schachter
  • Lipidated glycoprotein particles and methods of use
    Patent number: 8808664
    Abstract: Lipidated micro- or macroparticles are prepared by covalently linking a glycoprotein, typically collagen, with at least one lipid. An amino group in the glycoprotein is joined with a primary amine in the lipid. These particles can be used to encapsulate active ingredients, such as drugs.
    Type: Grant
    Filed: July 8, 2005
    Date of Patent: August 19, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Rimona Margalit, Dan Peer
  • THREE-DIMENSIONAL MODELING FROM SINGLE PHOTOGRAPHS
    Publication number: 20140229143
    Abstract: A method of obtaining a three-dimensional digital model of an artificial object, made up of a plurality of geometric primitives, the artificial object being in a single two-dimensional photograph, the method comprising: using edge detection to define a two-dimensional outline of the artificial object within the photograph; interactively allowing a user to define two-dimensional profiles of successive ones of the geometric primitives; interactively allowing a user to sweep respective profiles over an extent of a corresponding one of the geometric primitives within the image; generating successive three-dimensional model parts from existing detected edges of the corresponding geometric primitives and the sweeping of the respective profile; and aligning the plurality of three-dimensional model parts to form the three-dimensional model.
    Type: Application
    Filed: February 11, 2014
    Publication date: August 14, 2014
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Daniel COHEN-OR, Ariel SHAMIR, Tao CHEN
  • Interruption criteria for block decoding
    Patent number: 8806307
    Abstract: While decoding a representation, imported from a channel, of a codeword that encodes K information bits as N>K codeword bits, by updating estimates of the codeword bits in a plurality of iterations, the iterations are interrupted upon satisfaction of an interruption criterion that is either an order-dependent interruption criterion or an interruption criterion that includes an estimate of mutual information of the codeword and a vector that is used in the decoding iterations. Either the iterations are terminated or the iterations are resumed after one or more elements of one or more vectors used in the iterations is/are modified.
    Type: Grant
    Filed: January 2, 2013
    Date of Patent: August 12, 2014
    Assignee: Ramot at Tel Aviv University Ltd.
    Inventors: Idan Alrod, Eran Sharon, Simon Litsyn
  • Vapor deposition of biomolecules
    Patent number: 8802193
    Abstract: A coating method is disclosed. The coating method comprises placing a substrate and a biomolecule in a chamber and applying a vapor deposition process within the chamber so as to form a solid deposition of the biomolecule on at least a portion of a surface of the substrate.
    Type: Grant
    Filed: August 13, 2008
    Date of Patent: August 12, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Ehud Gazit, Lihi Adler-Abramovich, Daniel Aronov, Gil Rosenman
  • Multi-bit-per-cell flash memory device with non-bijective mapping
    Patent number: 8804423
    Abstract: To store a plurality of input bits, the bits are mapped to a corresponding programmed state of one or more memory cells and the cell(s) is/are programmed to that corresponding programmed state. The mapping may be many-to-one or may be an “into” generalized Gray mapping. The cell(s) is/are read to provide a read state value that is transformed into a plurality of output bits, for example by maximum likelihood decoding or by mapping the read state value into a plurality of soft bits and then decoding the soft bits.
    Type: Grant
    Filed: July 3, 2011
    Date of Patent: August 12, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Simon Litsyn, Eran Sharon, Idan Alrod
  • Peptide nanostructures containing end-capping modified peptides and methods of generating and using the same
    Patent number: 8796023
    Abstract: A nanostructure composed of a plurality of peptides, each peptide containing at least one aromatic amino acid, whereby one or more of these peptides is end-capping modified, is disclosed. The nanostructure can take a tubular, fibrillar, planar or spherical shape, and can encapsulate, entrap or be coated by other materials. Methods of preparing the nanostructure, and devices and methods utilizing same are also disclosed.
    Type: Grant
    Filed: July 26, 2010
    Date of Patent: August 5, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Meital Reches, Ehud Gazit
  • Linearized optical digital-to-analog modulator
    Patent number: 8797198
    Abstract: A modulator device for converting digital data into modulation of an optical signal includes an electronic input for receiving an input data word of N bits and an electrically controllable modulator for modulating the intensity of an optical signal, the modulator including M actuating electrodes where M?N. An electrode actuating device, most preferably a digital-to-digital converter, operates actuating electrodes so that at least one electrode is actuated as a function of values of more than one bit of the input data word. According to an alternative, or supplementary, aspect of the invention, the set of electrodes includes at least one electrode having an effective area which is not interrelated to others of the set by factors of two. In one preferred implementation, a Mach-Zehnder modulator also provides phase modulation to give QAM functionality. Another implementation employs a semiconductor laser.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: August 5, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Yossef Ehrlichman, Ofer Amrani, Shlomo Ruschin
  • COMPLIANT STRUCTURES WITH TIME-VARYING MOMENT OF INERTIA
    Publication number: 20140208848
    Abstract: A rotation sensor system is presented. The system comprises a rotating frame configured to be mounted on a gimbal and adapted for controllable rocking motion about a predetermined axis of said frame, and a proof mass assembly mounted on said rotating frame. The proof mass assembly comprises one or more proof mass elements each mounted for controllable movement with respect to the predetermined axis along a certain path, a distance of each proof mass element from said axis corresponding to a direction of the rocking motion of said frame, thereby affecting a moment of inertia of said rotating frame.
    Type: Application
    Filed: April 1, 2012
    Publication date: July 31, 2014
    Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: Viacheslav Krylov, Assaf Ya'Akobovitz
  • CONJUGATE OF A POLYMER, AN ANTI-ANGIOGENESIS AGENT AND A TARGETING MOIETY, AND USES THEREOF IN THE TREATMENT OF BONE RELATED ANGIOGENESIS CONDITIONS
    Publication number: 20140212357
    Abstract: Conjugates of hydroxypropyl methacrylamide (HPMA)-derived copolymers having attached thereto TNP-470 and a high load (e.g., higher than 3 mol %) of alendronate (ALN), and processes of preparing same are disclosed. Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and an oligoaspartate bone targeting agent, and processes of preparing same, are further disclosed. Pharmaceutical compositions containing these conjugates and uses thereof in the treatment and monitoring of bone related disorders are also disclosed.
    Type: Application
    Filed: April 2, 2014
    Publication date: July 31, 2014
    Applicants: University of Utah Research Foundation, Ramot at Tel-Aviv University Ltd.
    Inventors: RONIT SATCHI-FAINARO, EHUD SEGAL, JINDRICH KOPECEK, PAVLA KOPECKOVA, HUAIZHONG PAN
  • NAPHTHOQUINONE DERIVATIVES USEFUL FOR PREVENTION OF AMYLOID DEPOSITS AND TREATMENT OF DISEASES INVOLVING AMYLOIDOGENESIS
    Publication number: 20140213627
    Abstract: The present invention provides pharmaceutical compositions comprising substituted 1,4 naphthoquinones that are effective in preventing oligomerization of beta amyloid and subsequent pathologies associated with amyloid fibrils. These compositions are useful for the treatment of disease involving amyloidogenesis including neurodegenerative diseases such as Alzheimer's Disease or senile dementia. Particularly effective compositions comprise 1,4 naphthoquinones substituted with an amino acid residue selected from a heterocyclic or aromatic amino acid.
    Type: Application
    Filed: January 30, 2014
    Publication date: July 31, 2014
    Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.
    Inventors: Roni SCHERZER, Ehud GAZIT, Daniel SEGAL
  • Method and system for detecting contours in an image
    Patent number: 8792692
    Abstract: A method of processing an image is disclosed. The method comprises: decomposing the image into a plurality of different resolutions; and for each resolution, processing the image at the resolution to extract edge-orientation information; utilizing the edge-orientation information for identifying contours in the image; and transmitting at least the identified contours to a computer-readable medium.
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: July 29, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Eldar Ron, Hedva Spitzer
  • Probabilistic error correction in multi-bit-per-cell flash memory
    Patent number: 8788909
    Abstract: Data that are stored in cells of a multi-bit-per cell memory, according to a systematic or non-systematic ECC, are read and corrected (systematic ECC) or recovered (non-systematic ECC) in accordance with estimated probabilities that one or more of the read bits are erroneous. In one method of the present invention, the estimates are a priori. In another method of the present invention, the estimates are based only on aspects of the read bits that include significances or bit pages of the read bits. In a third method of the present invention, the estimates are based only on values of the read bits. Not all the estimates are equal.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: July 22, 2014
    Assignee: Ramot at Tel Aviv University Ltd.
    Inventors: Simon Litsyn, Idan Alrod, Eran Sharon, Mark Murin, Menahem Lasser
  • Photoelectrical devices for stimulating neurons
    Patent number: 8774936
    Abstract: The present invention provides a novel photoelectrical device for efficient transmission of electrical signals to a neuron. This photoelectrical device comprises one or more charging units for coupling to and stimulating one or more neurons by charge, the charging unit comprising: a nanostructure-based electrode having a surface, which has a predetermined developed surface area for coupling to a neuron and which carries a plurality of photosensitive regions (e.g. quantum dots) interfacing with a biocompatible macromolecule for tuning the relative energy levels between the photosensitive regions and the electrode, as well as for directing the spatial polarity of charge separation the surface being thereby electrically chargeable and dischargeable in response to light excitation of the photosensitive regions, the charges stimulating the neuron when coupled to the surface.
    Type: Grant
    Filed: July 20, 2010
    Date of Patent: July 8, 2014
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd., Ramot at Tel-Aviv University Ltd.
    Inventors: Uri Banin, Shlomo Yitzchaik, Ori Cheshnovsky, Yael Hanein, Evelyne Sernagor
  • MAGNETIC RESONANCE METHOD FOR ANALYZING PORE SIZE DISTRIBUTION
    Publication number: 20140184224
    Abstract: A method of magnetic resonance analysis of a porous structure is disclosed. The method comprises: obtaining a recorded magnetic resonance signal as a function of both a magnetic resonance wavevector and a magnetic resonance angle, in response to a series of magnetic resonance experiments, each featuring a plurality of pairs of bipolar gradient pulse subsequences being characterized by a respective magnetic resonance wavevector and a respective magnetic resonance angle, where the respective magnetic resonance angle is an angle between gradient directions of the bipolar gradient pulse subsequences. The method further comprises performing an at least three-dimensional analysis of the magnetic resonance signal, so as to extract a pore size distribution from the structure; and issuing a report regarding the analysis.
    Type: Application
    Filed: August 9, 2012
    Publication date: July 3, 2014
    Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: Uri Nevo, Dan Benjamini
  • N-phenyl anthranilic acid derivatives and uses thereof
    Patent number: 8765815
    Abstract: Compounds that can be used as openers or blockers of voltage-dependent potassium channels, and which are useful in the treatment of conditions such as central or peripheral nervous system disorders through the modulation of potassium ion flux through voltage-dependent potassium channels and/or depressing or enhancing cortical and/or peripheral neuron activity, compositions containing same and methods utilizing same are disclosed. Also disclosed are modulators of voltage-dependent potassium channels, which exhibit blocking of a TRPV1 channel, and hence are useful in the treatment of TRPV1-related conditions.
    Type: Grant
    Filed: September 18, 2008
    Date of Patent: July 1, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Bernard Attali, Asher Peretz
  • Multi-Bit Magnetic Memory Cell
    Publication number: 20140177328
    Abstract: A device (20) for storing data includes at least first and second ferromagnetic films (F1, F2) and a sensing circuit (28). The ferromagnetic films both have perpendicular magnetic anisotropy that is configured responsively to the stored data, and are connected so that an electrical current traverses the first and second ferromagnetic films and generates respective first and second extraordinary Hall voltages therein. The sensing circuit is configured to read out the stored data by measuring the first and second extraordinary Hall voltages.
    Type: Application
    Filed: July 19, 2012
    Publication date: June 26, 2014
    Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.
    Inventors: Alexander Gerber, Amir Segal
  • SYSTEM AND A METHOD FOR NANO IMPRINTING
    Publication number: 20140175171
    Abstract: A method for creating a highly accurate nanostructure is provided, the method includes: (i) creating a highly accurate nanostructure prototype, wherein the highly accurate nanostructure prototype, when illuminated with a predefined illumination, provides a unique optical pattern; (ii) creating at least one highly accurate nanostructure mold from the highly accurate nanostructure prototype, wherein each highly accurate nanostructure mold enables a creation of a highly accurate nanostructure that is substantially similar to the highly accurate nano structure prototype and which, when illuminated with the predefined illumination, provides the unique optical pattern; and (iii) molding the highly accurate nano structure using the highly accurate nano structure mold, wherein the highly accurate nanostructure, when illuminated with the predefined illumination, provides the unique optical pattern.
    Type: Application
    Filed: February 25, 2014
    Publication date: June 26, 2014
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventor: Jacob Scheuer
  • USE OF INTEGRASE FOR TARGETED GENE EXPRESSION
    Publication number: 20140171494
    Abstract: There are provided methods and compositions for activating the expression of an exogenous gene by an exogenous integrase specifically in cells in which the exogenous integrase is expressed. The invention further relates to uses of the compositions in treatment of various conditions and disorders, as exemplified by selectively activating expression of a toxin only in target cell populations.
    Type: Application
    Filed: August 1, 2012
    Publication date: June 19, 2014
    Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: Mikhail Kolot, Ezra Yagil, Natalia Malchin