Patents Assigned to Ratiopharm GmbH
  • Pharmaceutical composition containing donepezil hydrochloride, tablets produced therefrom and methods for producing the same
    Patent number: 8992976
    Abstract: A pharmaceutical composition is provided according to the invention which is suited for the production of tablets by direct compression and which contains donepezil hydrochloride of polymorphic form I. The polymorphic form I of donepezil hydrochloride in the directly compressed tablet is also stable during long storage.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: March 31, 2015
    Assignee: ratiopharm, GmbH
    Inventors: Julia Schulze Nahrup, Frank Muskulus, Peter Kraass
  • SOLID IVABRADINE-CONTAINING COMPOSITION
    Publication number: 20150038491
    Abstract: The present invention relates to a solid composition containing ivabradine or a pharmaceutically acceptable salt thereof. Further, the invention relates to a method for the preparation of such a composition as well as a pharmaceutical product comprising such a composition.
    Type: Application
    Filed: October 17, 2014
    Publication date: February 5, 2015
    Applicant: ratiopharm GmbH
    Inventors: Dominique MEERGANS, Daniela STUMM, Jens GEIER
  • Salts of rasagiline and pharmaceutical preparations thereof
    Patent number: 8946482
    Abstract: The present invention relates to salts of rasagiline and pharmaceutical preparations thereof. The invention further provides a method of preparing the salts of rasagiline.
    Type: Grant
    Filed: July 7, 2010
    Date of Patent: February 3, 2015
    Assignee: Ratiopharm GmbH
    Inventors: Thomas Thyrann, Christian Janssen, Ramesh Matioram Gidwani
  • Method of treatment using stable liquid formulation of G-CSF
    Patent number: 8946161
    Abstract: Provided are pharmaceutical liquid formulations of G-CSF, which are stable over a long time period and substantially free of excipients, as well as ready-to-use syringes containing such formulations and corresponding kits.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: February 3, 2015
    Assignee: Ratiopharm GmbH
    Inventors: Walter Hinderer, Heinz Lubenau
  • Prasugrel in micronized, crystalline form and pharmaceutical composition thereof
    Patent number: 8940757
    Abstract: The present invention relates to Prasugrel or a pharmaceutically acceptable salt thereof, compositions containing said active ingredient as well as pharmaceutical compositions containing said active ingredient or a composition containing said active ingredient. The present invention further relates to methods for the preparation of the novel compositions.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: January 27, 2015
    Assignee: ratiopharm GmbH
    Inventors: Sandra Brueck, Jana Paetz
  • Melting tablet containing a sildenafil salt
    Patent number: 8933081
    Abstract: The invention relates to an orodispersible tablet comprising the components pharmaceutically acceptable sildenafil salt (a), polymeric adsorbent (b), in particular cation exchanger resin, sweetener (c), and flavoring (d) and, preferably, mucilage (e) and glidant (f). The invention furthermore relates to a process for the preparation of orodispersible tablets comprising a pharmaceutically acceptable sildenafil salt and to the use of a combination of cation exchanger resin and mucilage for masking the flavor of medicaments for treating erectile dysfunction.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: January 13, 2015
    Assignee: ratiopharm GmbH
    Inventors: Sven Winter, Max-Werner Scheiwe
  • SALT OF IVABRADINE WITH ADIPIC ACID
    Publication number: 20140357860
    Abstract: The present invention relates to pharmaceutical compositions with delayed release which contain ivabradine adipate as active substance. The present invention furthermore relates to processes for the preparation of this composition and certain salts of ivabradine.
    Type: Application
    Filed: August 19, 2014
    Publication date: December 4, 2014
    Applicant: ratiopharm GmbH
    Inventors: Ramesh Matioram GIDWANI, Mayur Vilas KOLHATKAR, Dominique MEERGANS, Ralph STEFAN, Jens GEIER
  • Solid ivabradine-containing composition
    Patent number: 8900605
    Abstract: The present invention relates to a solid composition containing ivabradine or a pharmaceutically acceptable salt thereof. Further, the invention relates to a method for the preparation of such a composition as well as a pharmaceutical product comprising such a composition.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: December 2, 2014
    Assignee: ratiopharm GmbH
    Inventors: Dominique Meergans, Daniela Stumm, Jens Geier
  • Pharmaceutical formulation comprising ezetimibe
    Patent number: 8858994
    Abstract: The present invention relates to novel formulations comprising ezetimibe as active ingredient. In particular the invention relates to a pharmaceutical composition comprising 5 to 20 wt-% ezetimibe, 50 to 85 wt-% diluent, 3 to 25 wt-% disintegrant, 1 to 10 wt-% binder, and 0.5 to 1 wt-% lubricant, characterized in that the ezetimibe has a particle size distribution of d(0.9) of 5 ?m to 35 ?m and d(0.5) of 3 ?m to 20 ?m, as well as methods for preparing said formulations.
    Type: Grant
    Filed: December 9, 2008
    Date of Patent: October 14, 2014
    Assignee: Ratiopharm GmbH
    Inventors: Ganesh Gat, Pasupuleti Giridhara Rao, Javed Hussain
  • Pharmaceutical Composition Comprising Dapagliflozin and Cyclodextrin
    Publication number: 20140249098
    Abstract: The present invention relates to pharmaceutical compositions comprising dapagliflozin and cyclodextrin, preferably (2-hydroxy)propyl-b-cyclodextrin or ?-cyclodextrin, preferably as inclusion complex. The invention further relates to a process for producing said pharmaceutical compositions. Finally, the invention relates to the use of cyclodextrin for producing dapagliflozin-containing dosage forms and to methods of purification of dapagliflozin.
    Type: Application
    Filed: June 1, 2012
    Publication date: September 4, 2014
    Applicant: RATIOPHARM GMBH
    Inventors: István Puskas, Lajos Szente
  • Orodispersible tablet containing compacted sildenafil base
    Patent number: 8808739
    Abstract: The invention relates to a process for the preparation of a pharmaceutical intermediate, comprising the steps of (i) mixing (a-i) sildenafil base, (b-i) wicking agent, (c-i) disintegrant, (d-i) optionally glidant; (ii) compacting the mixture; and (iii) milling the compacted material; and to an intermediate obtainable by that process. In addition, the invention relates to a process for the preparation of an orally dispersible tablet (hereinafter also referred to as an “orodispersible tablet”) comprising the intermediate of the invention, and to orodispersible tablets obtainable by that process.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: August 19, 2014
    Assignee: ratiopharm GmbH
    Inventors: Sven Winter, Max-Werner Scheiwe, Dieter Swatschek
  • Process for the preparation of a medicament comprising vardenafil hydrochloride trihydrate
    Patent number: 8772292
    Abstract: The present invention relates to a process for the preparation of a medicament containing vardenafil hydrochloride trihydrate in solid form, in which vardenafil hydrochloride trihydrate is processed with suitable pharmaceutical auxiliaries at a temperature of from approx. 20° C. to approx. 45° C.
    Type: Grant
    Filed: June 12, 2008
    Date of Patent: July 8, 2014
    Assignee: Ratiopharm GmbH
    Inventors: Yogesh S. Deshpande, Sandra Brueck, Julia Schulze Nahrup, Birgit Schnitter, Ganesh Gat, Javed Hussain
  • Process for producing fingolimod salts
    Patent number: 8766005
    Abstract: The invention relates to a process for producing pharmaceutically acceptable salts of fingolimod (I), comprising the step of reacting N-[1,1-bis hydroxymethyl-3-(4-octyl phenyl)-propyl]-acylamide (II) with an acidic compound. Furthermore, the invention provides different pharmaceutically acceptable salts of fingolimod and a polymorphic form of fingolimod hydrochloride.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: July 1, 2014
    Assignee: Ratiopharm GmbH
    Inventors: Ramesh Matioram Gidwani, Channaveerayya Hiremath
  • SOLID PHARMACEUTICAL DOSAGE FORM OF TICAGRELOR
    Publication number: 20140147505
    Abstract: The present invention relates to a solid pharmaceutical dosage form comprising ticagrelor as pharmaceutically active ingredient, to certain particles of ticagrelor and to processes of preparing the same.
    Type: Application
    Filed: January 29, 2014
    Publication date: May 29, 2014
    Applicant: ratiopharm GmbH
    Inventors: Sandra BRUECK, Dominique MEERGANS
  • Oral dosage form of deferasirox
    Patent number: 8703203
    Abstract: The invention relates to an oral dosage form containing deferasirox, binder, disintegrant and optionally wicking agent, wherein the introduction of the dosage form into water leads to a suspension wherein the suspended particles have an average particle size (D50) of 20 ?m to 120 ?m, and also to a method of producing it.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: April 22, 2014
    Assignee: ratiopharm GmbH
    Inventors: Jana Paetz, Katrin Rimkus
  • COMPOSITION AND TABLET COMPRISING RALTEGRAVIR
    Publication number: 20140094478
    Abstract: The present invention relates to a composition and tablet comprising raltegravir and to a process for the preparation of such tablet.
    Type: Application
    Filed: May 29, 2012
    Publication date: April 3, 2014
    Applicant: ratiopharm GmbH
    Inventors: Daniela Stumm, Dominique Meergans
  • OPHTHALMIC PREPARATION COMPRISING A PGF2ALPHA ANALOGUE
    Publication number: 20140088107
    Abstract: The present invention relates to an aqueous ophthalmic preparation comprising a PGF2? analogue and at least one polyvinyl alcohol and the use thereof for the treatment of glaucoma and ocular hypertension.
    Type: Application
    Filed: November 25, 2013
    Publication date: March 27, 2014
    Applicant: RATIOPHARM GMBH
    Inventors: Dieter Swatscheck, Max-Werner Scheiwe, Michael Florenski
  • METHOD FOR THE PRODUCTION OF ADSORBATES OF A RASAGILINE SALT HAVING A WATER-SOLUBLE ADJUVANT
    Publication number: 20140072526
    Abstract: The present invention relates to an adsorbate of a pharmaceutically compatible rasagiline salt comprising at least one pharmaceutically compatible adjuvant, wherein the at least one pharmaceutically compatible adjuvant is a water-soluble, organic solvent and the rasagiline salt is present in the adsorbate as an amorphous substance.
    Type: Application
    Filed: September 3, 2013
    Publication date: March 13, 2014
    Applicant: RATIOPHARM GMBH
    Inventors: Alexander Lehmann, Frank Muskulus, Julia Schulze-Nahrup
  • Solid pharmaceutical dosage form of ticagrelor
    Patent number: 8663661
    Abstract: The present invention relates to a solid pharmaceutical dosage form comprising ticagrelor as pharmaceutically active ingredient, to certain particles of ticagrelor and to processes of preparing the same.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: March 4, 2014
    Assignee: ratiopharm GmbH
    Inventors: Sandra Brueck, Dominique Meergans
  • Oral Dosage Forms for Modified Release Comprising Tasocitinib
    Publication number: 20130344149
    Abstract: The invention essentially relates to oral dosage forms comprising a JAK3 inhibitor, preferably tasocitinib, suitable for modified release, and processes of preparing such oral dosage forms.
    Type: Application
    Filed: January 26, 2012
    Publication date: December 26, 2013
    Applicant: RATIOPHARM GMBH
    Inventors: Ralph Stefan, Frank Sievert