Abstract: The present invention relates to oral pharmaceutical preparations in the form of pellets in which a benzimidazole compound is stabilized by combining it with microcrystalline cellulose.
Type:
Grant
Filed:
July 16, 2003
Date of Patent:
June 8, 2010
Assignee:
Ratiopharm, GmbH
Inventors:
Frank Muskulus, Peter Kraaβ, Andrea Burgenmeister
Abstract: The present invention relates to an adsorbate of a pharmaceutically compatible rasagiline salt comprising at least one pharmaceutically compatible adjuvant, wherein the at least one pharmaceutically compatible adjuvant is a water-soluble, organic solvent and the rasagiline salt is present in the adsorbate as an amorphous substance.
Type:
Application
Filed:
April 30, 2008
Publication date:
June 3, 2010
Applicant:
ratiopharm GmbH
Inventors:
Alexander Lehmann, Frank Muskulus, Julia Schulze-Nahrup
Abstract: The present invention relates to an irbesartan-containing pharmaceutical composition, in particular a tablet thereof, which comprises the active ingredient, a disintegrant with at least one low-substituted hydroxypropyl cellulose.
Type:
Application
Filed:
February 13, 2007
Publication date:
September 3, 2009
Applicant:
Ratiopharm GmbH
Inventors:
Julia Schulze Nahrup, Sandra Brueck, Rainer Alles, Peter Kraass
Abstract: The present invention relates to processes for preparing a compound of the general formula (Ia) wherein X is a halogen atom, or a pharmaceutically acceptable salt thereof, wherein a compound of the formula (II) wherein X is as defined above and Y and Z independently represent a leaving group each, is reacted with an optically active amino alcohol to form a first mixture of diastereomers.
Type:
Application
Filed:
February 10, 2009
Publication date:
June 11, 2009
Applicant:
ratiopharm GmbH
Inventors:
Jiri Stohandl, Jaroslav Frantisek, Winfried Ness
Abstract: The present invention relates to a novel process for preparing losartan, an imidazole derivative with the chemical name 2-n-butyl-4-chloro-5-hydroxymethyl-1-{[2?-(1H-tetrazol-5-yl)biphenyl-4-]methyl}imidazole, and pharmacologically active salts thereof. The invention further relates to novel intermediates which are suitable for preparing losartan and to novel processes for preparing intermediate compounds which are suitable for preparing losartan. One aspect of the invention is a process for preparing a compound of the general formula I which can form as an intermediate in an inventive preparation of losartan.
Type:
Application
Filed:
February 2, 2006
Publication date:
April 30, 2009
Applicant:
RATIOPHARM GMBH
Inventors:
Yaping Wang, Yonggang Li, Yulin Li, Guojun Zheng, Yi Li
Abstract: The present invention relates to processes for preparing a compound of the general formula (Ia) wherein X is a halogen atom, or a pharmaceutically acceptable salt thereof, wherein a compound of the formula (II) wherein X is as defined above and Y and Z independently represent a leaving group each, is reacted with an optically active amino alcohol to form a first mixture of diastereomers.
Type:
Grant
Filed:
December 3, 2004
Date of Patent:
March 24, 2009
Assignee:
ratiopharm GmbH
Inventors:
Jiri Stohandl, Jaroslav Frantisek, Winfried Ness
Abstract: The invention relates to a new process for preparing benzimidazole derivatives having a chiral sulfoxide group in enantiomerically pure form or in a form in which one of the two enantiomers is present in an increased quantity over the other enantiomer. The invention likewise relates to a process for preparing the salts of the individual enantiomers of the benzimidazole derivatives with a chiral sulfoxide group. The invention relates in particular to a process for preparing the S-enantiomer of omeprazole (also known as esomeprazole) and the salts thereof, more particularly the zinc salt of the S-enantiomer of omeprazole. In the new process a prochiral sulfide is oxidized in an organic solvent with an oxidizing agent in the presence of a titanium(IV) complex.
Type:
Application
Filed:
April 19, 2006
Publication date:
December 25, 2008
Applicant:
RATIOPHARM GMBH
Inventors:
Biao Jiang, Xiao-Long Zhao, Jia-Jia Dong, Wan-Jun Wang
Abstract: The invention relates to a novel benzimidazole formulation and to a process for its production. The benzimidazole formulation comprises a layer comprising the benzimidazole compound together with an acidic reacting compound.