Patents Assigned to Ratiopharm GmbH
  • PHARMACEUTICAL COMPOSITIONS COMPRISING RIVAROXABAN
    Publication number: 20120231076
    Abstract: The invention relates to pharmaceutical compositions comprising rivaroxaban, suitable for immediate release, and processes of preparing such compositions, preferably by a melt-granulation process or by a specific direct-compression process.
    Type: Application
    Filed: October 5, 2010
    Publication date: September 13, 2012
    Applicant: Ratiopharm GmbH
    Inventors: Ralph Stefan, Jana Paetz
  • Escitalopram and solid pharmaceutical composition comprising the same
    Patent number: 8252336
    Abstract: The present invention relates to Escitalopram having a small median particle size and a solid pharmaceutical composition comprising the same.
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: August 28, 2012
    Assignee: Ratiopharm GmbH
    Inventors: Parshwakumar V. Kalyankar, Ganesh V. Gat, Jawed Hussain
  • ORALLY DISINTEGRATING PHARMACEUTICAL DOSAGE FORM CONTAINING ARIPIPRAZOLE
    Publication number: 20120214820
    Abstract: The present invention relates to an orally disintegrating dosage form containing aripiprazole. The formulation of the invention shows a fast disintegration.
    Type: Application
    Filed: September 9, 2010
    Publication date: August 23, 2012
    Applicant: ratiopharm GmbH
    Inventors: Parshwakumar V. Kalyankar, Ganesh V. Gat, Javed Hussain
  • PHARMACEUTICAL COMPOSITION HAVING THE ACTIVE SUBSTANCES METFORMIN AND SITAGLIPTIN OR VILDAGLIPTIN
    Publication number: 20120202820
    Abstract: The present invention relates to a pharmaceutical composition that comprises the active substance metformin in combination with one of the active substances sitagliptin or vildagliptin. The present invention further relates to a method of production of said pharmaceutical composition.
    Type: Application
    Filed: September 13, 2010
    Publication date: August 9, 2012
    Applicant: Ratiopharm GMBH
    Inventors: Katrin Rimkus, Ralph Stefan
  • CO-PRECIPITATE COMPRISING A PHOSPHODIESTERASE-5 INHIBITOR (PDE-5-INHIBITOR) AND A PHARMACEUTICALLY COMPATIBLE CARRIER, PRODUCTION AND USE THEREOF
    Publication number: 20120189694
    Abstract: The invention relates to a co-precipitate comprising a phosphodiesterase-5 inhibitor (PDE-5-inhibitor) and a pharmaceutically compatible copolymer carrier comprising 2 or more different acrylic acid derivatives, a method for production thereof and a medication comprising the co-precipitate according to the invention, a method for producing said medication and the use of said medication for treating an illness wherein the inhibiting of phosphodiesterase-5 is of therapeutic benefit.
    Type: Application
    Filed: July 8, 2010
    Publication date: July 26, 2012
    Applicant: ratiopharm GmbH
    Inventors: Katrin Rimkus, Frank Muskulus
  • PROCESS FOR PRODUCING FINGOLIMOD SALTS
    Publication number: 20120184617
    Abstract: The invention relates to a process for producing pharmaceutically acceptable salts of fingolimod (I), comprising the step of reacting N-[1,1-bis hydroxymethyl-3-(4-octyl phenyl)-propyl]-acylamide (II) with an acidic compound. Furthermore, the invention provides different pharmaceutically acceptable salts of fingolimod and a polymorphic form of fingolimod hydrochloride.
    Type: Application
    Filed: July 23, 2010
    Publication date: July 19, 2012
    Applicant: RATIOPHARM GMBH
    Inventors: Ramesh Matioram Gidwani, Channaveerayya Hiremath
  • DESFESOTERODINE IN THE FORM OF A TARTARIC ACID SALT
    Publication number: 20120128773
    Abstract: The invention concerns desfesoterodine in the form of a tartaric acid salt, in particular in the polymorphic “R form”, as well as a process for its production. In a second aspect, the invention concerns the desfesoterodine of the invention in a microencapsulated form.
    Type: Application
    Filed: May 10, 2010
    Publication date: May 24, 2012
    Applicant: RATIOPHARM GMBH
    Inventors: Dirk Fischer, Gettraud Koellner, Katrin Rimkus, Frank Muskulus, Sandra Brueck, Jana Paetz
  • DRY PROCESSING OF RETIGABINE
    Publication number: 20120122973
    Abstract: The invention relates to dry processes for the production of oral dosage forms, especially tablets, containing retigabine and adhesion promoter. In addition, the invention relates to compacted intermediates containing retigabine and an adhesion promoter. Finally, the invention relates to single-dose and multiple-dose containers, preferably sachets and stick-packs, containing the intermediate of the invention.
    Type: Application
    Filed: March 17, 2010
    Publication date: May 17, 2012
    Applicant: ratiopharm GmbH
    Inventors: Jana Paetz, Katrin Rimkus
  • Method for the production of statins
    Patent number: 8148550
    Abstract: The present invention relates to a process for the production of statins, which are known as HMG-CoA reductase inhibitors. A few of the intermediate compounds for use in the process in accordance with the invention are novel compounds and the invention also relates to these novel intermediate compounds.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: April 3, 2012
    Assignee: Ratiopharm GmbH
    Inventors: Vitali Tararov, Armin Boerner, Gerd Koenig, Andrei Korostylev
  • Salts of the active substance rasagiline
    Patent number: 8143315
    Abstract: The invention relates to novel salts of the active substance rasagiline. The salts show excellent processability even after prolonged storage and an excellent storage stability usually superior to known salts after being processed into tablets.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: March 27, 2012
    Assignee: Ratiopharm GmbH
    Inventor: Heinrich P. Stahl
  • MELTING TABLET CONTAINING A SILDENAFIL SALT
    Publication number: 20120071488
    Abstract: The invention relates to an orodispersible tablet comprising the components pharmaceutically acceptable sildenafil salt (a), polymeric adsorbent (b), in particular cation exchanger resin, sweetener (c), and flavoring (d) and, preferably, mucilage (e) and glidant (f).
    Type: Application
    Filed: March 31, 2010
    Publication date: March 22, 2012
    Applicant: ratiopharm GmbH
    Inventors: Sven Winter, Max-Werner Scheiwe
  • RETIGABINE TABLETS, PREFERABLY HAVING MODIFIED RELEASE
    Publication number: 20120058183
    Abstract: The invention relates to tablets, especially tablets with modified release, containing (a) retigabine and a combination of (b) water-soluble excipient and (c) non-water-soluble excipient; and a process for producing them.
    Type: Application
    Filed: March 17, 2010
    Publication date: March 8, 2012
    Applicant: ratiopharm GmbH
    Inventors: Sandra Brueck, Katrin Rimkus
  • SOLID RETIGABINE IN NON-CRYSTALLINE FORM
    Publication number: 20120053238
    Abstract: The invention relates to solid retigabine in non-crystalline form together with a surface stabiliser in the form of a stable intermediate. In the intermediate of the invention, retigabine is preferably present in amorphous form or in the form of a solid solution. The invention further relates to processes for the production of retigabine in a solid, non-crystalline form and to pharmaceutical formulations containing solid, non-crystalline retigabine.
    Type: Application
    Filed: March 17, 2010
    Publication date: March 1, 2012
    Applicant: ratiopharm GmbH
    Inventors: Jana Paetz, Katrin Rimkus
  • AMORPHOUS AMBRISENTAN
    Publication number: 20120022087
    Abstract: The invention relates to amorphous ambrisentan, preferably together with a surface stabiliser in the form of a stable intermediate. The invention further relates to methods of producing stable amorphous ambrisentan and pharmaceutical formulations containing stable amorphous ambrisentan.
    Type: Application
    Filed: August 7, 2009
    Publication date: January 26, 2012
    Applicant: Ratiopharm GmbH
    Inventors: Kathrin Rimkus, Frank Muskulus, Sandra Brueck, Jana Paetz
  • PHARMACEUTICAL COMPOSITION COMPRISING N-[3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY] PHENYL]-6-[5[[[2-(METHYLSULFONYL) ETHYL]AMINO]METHYL]-2-FURYL]-4- QUINAZOLINAMINE
    Publication number: 20120015965
    Abstract: The present invention relates to a pharmaceutical composition comprising N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furyl]-4-quinazolinamine as active pharmaceutical ingredient and a process of preparing such composition.
    Type: Application
    Filed: August 24, 2009
    Publication date: January 19, 2012
    Applicant: Ratiopharm GmbH
    Inventors: Katrin Rimkus, Frank Muskulus, Sandra Brueck, Jana Paetz
  • COMPACTED CINACALCET
    Publication number: 20120009258
    Abstract: The invention relates to an intermediate, obtainable by jointly compacting (i) crystalline cinacalcet or a pharmaceutically acceptable salt thereof, with (ii) a hydrophilising agent, and also tablets containing the intermediates of the invention. The invention further relates to cinacalcet tablets with a bimodal pore size distribution and a method of preparing the tablets of the invention. Finally, the invention relates to the use of a pH adjuster for preparing cinacalcet formulations which can preferably be administered independently of mealtimes.
    Type: Application
    Filed: September 24, 2009
    Publication date: January 12, 2012
    Applicant: RATIOPHARM GMBH
    Inventors: Kathrin Rimkus, Frank Muskulus, Sandra Brueck, Jana Paetz
  • SOLID COMPOSITION CONTAINING THE INGREDIENT RASAGILINE
    Publication number: 20110313050
    Abstract: The present invention relates to a solid composition containing at least one pharmaceutically compatible auxiliary ingredient and rasagiline or a pharmaceutically compatible salt thereof as an active ingredient. The invention further relates to a method for producing said solid composition and to a medicine comprising said solid composition.
    Type: Application
    Filed: December 18, 2009
    Publication date: December 22, 2011
    Applicant: Ratiopharm GMBH
    Inventors: Katrin Rimkus, Sandra Brueck, Frank Muskulus, Jana Paetz
  • PHARMACEUTICAL COMPOSITION COMPRISING N-[3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY]PHENYL]-6-[5[[[2-(METHYLSULFONYL)ETHYL]AMINO]METHYL]-2-FURYL]-4- QUINAZOLINAMINE
    Publication number: 20110305762
    Abstract: The present invention relates to a pharmaceutical composition comprising N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furyl]-4-quinazolinamine as active pharmaceutical ingredient and a process of preparing such composition.
    Type: Application
    Filed: August 24, 2009
    Publication date: December 15, 2011
    Applicant: ratiopharm GmbH
    Inventors: Katrin Rimkus, Frank Muskulus, Sandra Brueck, Jana Paetz
  • PHARMACEUTICAL COMPOSITIONS COMPRISING 5-CHLORO-N-(-METHYL)-2-THIOPHENCARBOXAMID
    Publication number: 20110300214
    Abstract: The invention relates to pharmaceutical compositions comprising 5-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid and processes of preparing such compositions. In a second aspect, the present invention relates to a preferred pellet-layering process for preparing such compositions.
    Type: Application
    Filed: July 7, 2009
    Publication date: December 8, 2011
    Applicant: RATIOPHARM GMBH
    Inventors: Katrin Rimkus, Frank Muskulus, Sandra Brueck, Jana Paetz
  • COMPACTED MOXIFLOXACIN
    Publication number: 20110293717
    Abstract: The invention relates to a process for the preparation of tablets containing moxifloxacin, comprising the steps of (i) providing moxifloxacin, pharmaceutically acceptable salts, solvates or hydrates thereof, optionally mixed with one or more pharmaceutical excipients; (ii) compacting it into a slug; (iii) granulating the slug; and (iv) compressing the resulting granules into tablets; and also tablets, granules and compacted material containing compacted moxifloxacin.
    Type: Application
    Filed: December 4, 2009
    Publication date: December 1, 2011
    Applicant: ratiopharm GmbH
    Inventors: Dieter Swatschek, Max Werner Scheiwe