Abstract: An image reconstruction method includes capturing a reference image of the specimen and capturing a set of original images based on the reference image. The method includes generating a set of analyzed images based on the set of original images by determining an intensity distribution for each pixel of each original image of the set of original images and combining the intensity distribution at each pixel location across the set of original images into an intermediate image. The method includes, identifying an object in the intermediate image. In response to identifying the object in the intermediate image, determining an intensity value of the object in each original image of the set of original images and generating an improved image of the object based on the determined intensity value of the object. The method includes generating a final image including the improved image of the object and displaying the final image.

Abstract: Provided herein are small molecule inhibitors of Polycomb Repressive Complex 1 (PRC1) activity, and methods of use thereof for the treatment of disease, including leukemia and other cancers, as well as other diseases dependent on the activity of PRC1.

Abstract: Aspects of the subject disclosure may include, for example, a method in which a processing system parses a network trace to collect packet information for an encrypted adaptive bite rate (ABR) video stream encoded into a plurality of tracks; detects request packets corresponding to a sequence of requests for video segments to be downloaded at a network client; and determines a traffic volume downloaded at the network client to obtain a sequence of traffic volumes. The processing system identifies, for each of the sequence of traffic volumes, a set of candidate segments each having a size meeting a size-matching criterion; selects a segment from the set of candidate segments to determine a segment sequence meeting an index-matching criterion; and infers characteristics of the sequence of traffic volumes based on the segment sequence. Other embodiments are disclosed.

Abstract: Subject matter disclosed herein may relate to storage and/or processing of signals and/or states representative of neural network parameters in a computing device, and may relate more particularly to compressing signals and/or states representative of neural network nodes in a computing device.

Abstract: A device for wound irrigation and debridement includes a body extending along a longitudinal axis. The body comprises an interior region and an opening such that that the interior region and the first opening are configured to transfer an irrigation fluid. The body comprises a compliant region having a first stiffness and a debridement region having a different second stiffness. The compliant region defines a distal surface. In a first configuration, the compliant region defines a first axial dimension, the distal surface engages a target body region, and the debridement region is axially offset from the distal surface and disengaged from the target body region. In a second configuration, the compliant region is compressed to define a second axial dimension less than the first axial dimension, thereby engaging the debridement region with the target body region, and the distal surface engages the target body region.

Abstract: Provided herein are compositions, systems, and methods for detecting microorganisms. In particular, provided herein are compositions, systems, and methods for rapid, multiplex detection of microorganism in unpurified biological samples.

Abstract: Inhibitors of mTOR, MEK, JAK and PI3K and compositions containing the same are disclosed. Methods of using the inhibitors in the treatment of a variety of diseases and conditions wherein inhibition of one or more of mTOR, MEK, JAK and PI3K provides a benefit also are disclosed. Methods of using chemical attachment moieties and linkers for the purposes of modifying compound solubility and/or lymphatic absorption are also disclosed.

Abstract: Methods for enhancing the bioavailability of N-(2,6-bis(1-methylethyl)phenyl)-N?-((1-(4-(dimethylamino)phenyl)cyclopentyl)-methyl)urea hydrochloride (ATR-101) through administration with food, and compositions and kits related thereto.

Abstract: The present disclosure provides compositions and methods for using one or more polypeptide probes to profile an immune response. The polypeptide probe can be used to detect one or more antibodies from a sample. Furthermore, the present disclosure provides methods and compositions for characterizing a cancer based on the detection of one or more antibodies, such as autoantibodies.

Abstract: A selectively rigidizable membrane for cargo management comprises a vacuum bladder, and a first architectural layer and a second architectural layer, each of the first and second architectural layers including a plurality of tiles interconnected by flexural elements, each of the tiles of the first and second architectural layers including at least one constraining element extending therefrom, wherein, when atmospheric pressure is present within the vacuum bladder, the first and second architectural layers are slidably moveable relative to one another and the membrane is flexible, and further wherein, when negative pressure is applied to the vacuum bladder, the first and second architectural layers are forced into engagement with one another, the constraining elements of the first and second architectural layers providing mechanical interference and preventing sliding movement of the first and second architectural layers relative to one another, causing the membrane to become substantially rigid.

Abstract: A design for a micro-lens (i.e., a lens on the scale of micrometers) incorporates existing nanofabrication techniques and can be incorporated into High Concentrating Photovoltaic (HCPV), solar thermal collectors, and traditional flat PV systems. Using the theory of wave optics, the design is able to achieve a high numerical aperture, i.e., it can receive light over a wider range of angles. The design also reduces the distance the focal point shifts as the light source shifts; this eliminates the need for a tracking system in CPV and PV applications. Reducing the lens size also facilitates smaller, lightweight CPV systems, which makes CPV attractive for additional applications. Finally, these concentrators reduce the exchanging area of a typical flat solar thermal system where heat is received, which improves the overall system's efficiency and allows its use also during rigid winter time.

Abstract: Methods and devices for lyo-processing biological materials are provided. The methods include submerging the biological molecules or cells in a buffer solution comprising trehalose, withdrawing the biological molecules or cells from the buffer solution in an environment that does not include oxygen to generate lyo-stabilized biological molecules or cells, and storing the lyo-stabilized biological molecules or cells. The devices include a motor that lowers a horizontal member having a clamp for receiving a substrate toward a solvent reservoir and raises the horizontal member having the clamp up and away from the solvent reservoir.

Abstract: The present disclosure generally relates to organic photosensitive optoelectronic devices and polaron pair recombination dynamics to impact efficiency and open circuit voltages of organic solar cells. The present disclosure also relates, in part, to methods of making organic photosensitive optoelectronic devices comprising the same.

Abstract: A device includes a nozzle including a discharge end for discharging a fluid, a shutter plate including an aperture, the shutter plate positioned at the discharge end of the nozzle, a plurality of tethers coupled to the shutter plate, and a plurality of electrostatic actuators. Each of the plurality of electrostatic actuators are coupled to one or more of the plurality of tethers. The plurality of electrostatic actuators are configured to move the shutter plate between an open position and a closed position relative the discharge end of the nozzle. In the open position, the aperture is in fluid communication with the discharge end of the nozzle to permit fluid from the discharge end of the nozzle to flow through the aperture. In the closed position, at least a portion of the shutter plate inhibits fluid from the discharge end of the nozzle from flowing through the aperture.

Abstract: A laser whose emission is modulated by ultrasound is presented. The laser is usually micron-sized. In response to ultra-sound modulation, the laser emission increases and decreases. Such a change in emission can be detected by external optical detectors. This type of laser can be used as a new type of imaging modality, in which laser emission in combination with sound waves or ultra-sound waves, is used for imaging Laser emission has a much narrower spectral linewidth and stronger intensity than fluorescence and therefore is able to achieve higher sensitivity, whereas sound waves are used to provide a better spatial resolution of the laser emission from the laser. In ultrasound modulated laser based imaging, multiple lasers can be placed inside cells or tissues.

Abstract: A light source and a method of generating a light using the light source is disclosed. The light source is configured to produce a plurality of distinct colors in generating the light, one of the distinct colors falling within a blue spectral light band. A light controller modulates the spectral light produced by the plurality of distinct colors. The modulation provides melanopsin contrast in order to increase melanopsin responsiveness of a subject exposed to the generated light and maintains the color temperature, color quality, and color constancy experienced by the subject in a lit viewing environment within an acceptable range.

Abstract: A water tower system having a catchment system to collect climatically-produced water and route the water to an output; a water mattress system fluidly coupled below to the catchment system to collect the water from the catchment system; an elevated water tower storage system fluidly coupled to the water mattress system to receive and store water from the water mattress system, the elevated water tower storage system is located at or below the water mattress system; and a water distribution system fluidly coupled to the elevated water tower storage system to receive water from the elevated water tower storage system and distribute the water to a predetermined location.

Abstract: A method is presented for assigning billing codes for medical procedures. For each string in an input record describing a medical procedure in the input text description, comparing the string to entries in a dictionary of common misspelling and, in response to the string matching an entry in the dictionary, replacing the string with proper spelling; for each string in the input record, comparing the string to entries in another dictionary of abbreviations and, in response to the string matching an entry in the dictionary, replacing the string with expanded text for the abbreviation; constructing a feature vector by extracting features from the input record; for each billing code in a listing of possible billing codes, computing a classifier score for the feature vector using machine learning; and assigning a billing code to the input record from the listing of possible billing codes based on the classifier scores.

Abstract: In various aspects, the present disclosure provides photodetector devices that may be provided in arrays. The photodetector includes a first electrode, a second electrode, and a photoactive layer assembly disposed therebetween. The photoactive layer assembly comprises a first charge transport layer, a second charge transport layer, and an amorphous silicon (a-Si) material substantially free of doping and being substantially free of doping disposed between the first charge transport layer and the second charge transport layer. The photodetector device transmits light in a predetermined range of wavelengths and is capable of generating detectable photocurrent when light having a light intensity of less than or equal to about 50 Lux is directed towards the photodetector device.

Abstract: Electromagnetic fields within a waveguide can be expressed in terms of the complex amplitudes of the electromagnetic modes it supports. The electromagnetic fields can be shaped by controlling the complex amplitudes of modes. Here, mode-converting metasurfaces are designed to transform a set of incident modes on one side to a different set of desired modes on the opposite side of the metasurface. A mode-converting metasurface comprises multiple inhomogeneous (spatially-varying) reactive electric sheets that are separated by dielectric spacers. The reactance profile of each electric sheet to perform the needed mode conversion is found through optimization. The optimization routine takes advantage of a multimodal solver that uses two main concepts: modal network theory and a discrete Fourier transform algorithm. With modal network theory, the modes can be translated between the electric sheets using matrix multiplication.