Abstract: A vehicle line-of-sight optical communication system and method for use in ad hoc networks formed with a vehicle during traveling of the vehicle along a roadway. The communication system includes: an electronic control unit (ECU) having an electronic processor that operates under control of a program to process messages sent or received by the communication system; at least one light source that comprises a part of a vehicle external lamp module; a driver circuit electrically connected to the ECU to energize the light source(s) in response to a transmission signal from the ECU so as to send messages via the light source(s); at least one light sensor that comprises a part of the vehicle external lighting system; and a receiver circuit electrically connected to the ECU to provide the ECU with a reception signal indicative of messages received via the light sensor(s).

Abstract: Disclosed herein are small molecule inhibitors of 12(S)-Lipoxygenase (12-LOX), and methods of using the small molecules to inhibit 12-LOX activation and to treat diseases, such as platelet hemostasis and thrombosis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

Abstract: The present invention relates to micelle drug carriers and methods of using the micelles to deliver drugs to target cells. The micelles are useful, for example, for carrying and targeting drugs for the treatment of cancer to cancer cells. As one example, the disclosure provides pegylated octadecyl lithocholate micelles that are labeled with a peptide ligand for colorectal neo-plasia and that carry the small molecule mTOR inhibitor rapamycin to colorectal cancer cells.

Abstract: The present disclosure provides a mechanically-actuated tool for cutting a tissue graft having a hollow core and methods for use thereof. A portion of a biological structure, such as a nerve, is attached to the hollow core to form an implantable neural graft assembly. The tool has a cutter mechanism and a grasper mechanism. The grasper mechanism has one or more component(s) that open and close via an actuation mechanism, like a handle, and rotate via a controller component, like a rotatable wheel. The cutter mechanism may be a cutting tube component that harvests the tissue graft. The tool may also have an ejector mechanism to remove the tissue graft as part of the implantable neural graft assembly. Such devices and methods are particularly suitable for treating neuromas and other neural regeneration procedures.

Abstract: A computer system includes an ensemble moving target defense architecture that protects the computer system against attack using a plurality of composable protection layers that change each churn cycle, thereby requiring an attacker to acquire information needed for an attack (e.g., code and pointers) and successfully deploy the attack, before the layers have changed state. Each layer may deploy a different attack information asset protection providing multiple different attack protections each churn cycle.

Abstract: A rotationally compliant bearing roller assembly having a roller, at least one bearing member operably coupled to a base configured to support rotational movement about a rotational axis; and a rotary compliant joint interconnecting the at least one bearing member to the roller. The rotary compliant joint having a first compliance in a rotational direction about the rotational axis to permit movement of the roller in the rotational direction relative to the at least one bearing member, such that the first compliance being greater than a friction induced compliance of the at least one bearing member in the rotational direction. The compliant joint having a second compliance in a direction orthogonal to the rotational direction, such that the second compliance being less than the first compliance.

Abstract: Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species. Also disclosed is a fluorination method comprising providing, a salt comprising a cation and an aryloxylate, and SO2F2 to a reaction mixture; reacting the SO2F2 and the ammonium salt to provide a fluorinated aryl species. Further disclosed a fluorination method comprising providing a compound having the structure Ar—OH to a reaction mixture; where Ar is an aryl or heteroaryl; providing SO2F2 to the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SO2F2, the fluorinating reagent and the compound having the structure Ar—OH to provide a fluorinated aryl species having the structure Ar—F.

Abstract: A sparse video inference chip is designed to extract spatio-temporal features from videos for action classification and motion tracking. The core is a sparse video inference processor that implements recurrent neural network in three layers of processing. High sparsity is enforced in each layer of processing, reducing the complexity by two orders of magnitude and allowing all multiply-accumulates (MAC) to be replaced by select-accumulates (SA). The design is demonstrated in a 3.98 mm2 40 nm CMOS chip with an Open-RISC processor providing software-defined control and classification.

Abstract: The increased use of graph algorithms in diverse fields has highlighted their inefficiencies in current chip-multiprocessor (CMP) architectures, primarily due to their seemingly random-access patterns to off-chip memory. Here, a novel computer memory architecture is proposed that processes operations on vertex data in on-chip memory and off-chip memory. The hybrid computer memory architecture utilizes a vertex's degree as a proxy to determine whether to process related operations in on-memory or off-chip memory. The proposed computer memory architecture manages to provide up to 4.0× improvement in performance and 3.8× in energy benefits, compared to a baseline CMP, and up to a 2.0× performance boost over state-of-the-art specialized solutions.

Abstract: A natural language interface for databases (NLIDB) component of a database-management system receives a user-submitted natural-language query. The NLIDB parses the query into keywords and maps each keyword onto a corresponding query fragment that identifies a predicate of a non-join condition, or other type of expression, of a structured query. The NLIDB selects an optimal mapping for each keyword with the aid of a Query Fragment Graph (QFG) that counts the number of occurrences of each fragment, and the number of co-occurrences of each pair of fragments, in previously received structured queries. The NLIDB then uses the QFG, optionally augmented by contextual data, to select join paths most likely to be consistent with the semantic intent of the user. The NLIDB generates a structured query that incorporates the mapped query fragments and selected join paths and forwards. The structured the query is then forwarded to downstream DBMS components.

Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to cancer markers as diagnostic markers and clinical targets for lung cancer.

Abstract: An actuated telescoping system for navigation within a vascular lumen and thrombectomy of a thrombus. The system includes a tubular catheter member having an open distal end defining a catheter lumen, a vacuum source, a rotational drive system, a flexible shaft having a channel coupled to the rotational drive system for rotational movement in response thereto, and an optional guidewire selectively inserted at least partially within the flexible shaft. The flexible shaft is at least partially disposed within the tubular catheter member configured for uncoupled rotational and translational motion therein and to optionally define a corkscrew motion in response to rotational driving force by the drive system that results in formation of hydrodynamic vortices within the catheter lumen.

Abstract: Provided herein is technology relating to treating sleep apnea and particularly, but not exclusively, to treating sleep apnea with immunotherapeutics and/or anti-inflammatory drugs such as beta-interferons and glatiramer acetate.

Abstract: The present invention relates to nanoparticles complexed with biomacromolecule agents configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising nanoparticles (e.g., synthetic high density lipoprotein (sHDL)) carrying biomacromolecule agents (e.g., nucleic acid, peptides, glycolipids, etc.), methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).

Abstract: Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.

Abstract: A pneumatic textile system capable of transforming from a two-dimensional structure to a three-dimensional structure under pneumatic pressure is provided. The pneumatic textile system includes a seamless knit fabric having a grid configuration defining a plurality of grid areas—a first of the plurality of grid areas having a tensile strength that is different from a second of the plurality of grid areas. A pneumatic bladder member is disposed along at least a portion of a boundary between adjacent ones of the plurality of grid areas and is inflatable to exert a force on the seamless knit fabric, wherein upon inflation of the pneumatic bladder member the force is exerted on the seamless knit fabric such that the first of the plurality of grid area assumes a shape different than the second of the plurality of grid areas resulting in a three-dimensional structure transformation.

Abstract: Optically transparent, highly conductive conductor materials are provided, which in certain variations may also be flexible. Methods of making transparent conductive conductors, such as electrodes, are also provided. Such a method may include creating a groove pattern on a substrate that defines a two-dimensional array. Then an electrically conductive material may be selectively applied within the groove pattern of the substrate so as to create a transparent conductor (e.g., a transparent conductive electrode (TCE)). The transparent conductor has a sheet resistance of ?about 5 Ohms/Square and a transmissivity of ?about 50% for a predetermined range of target wavelengths of electromagnetic energy. Such methods may form linear micromesh conductive arrays and tortuous micromesh conductive arrays that can be used in a variety of optoelectronic applications, including as optically transparent, flexible and mechanically reconfigurable zeroth-order resonant (ZOR) antennas.

Abstract: A multi-photon optical probe includes a probe housing, a lateral scanning stage coupled to a lateral mirror assembly and a remote axial scanning stage coupled to an axial mirror assembly. The lateral scanning stage is adapted to scan output laser energy over a planar scan area of the sample by moving the lateral mirror assembly. The axial scanning stage is adapted to scan the output laser energy over a vertical depth range of the sample, which, combined with the planar scan area, forms a 3-dimensional volume. A controller operates in conjunction with a number of remote actuating legs coupled to the axial mirror assembly in order to provide level imaging plane which in turn provides for a clear scanned image.

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having an oxadiazole-oxadiazolone structure (e.g., oxadiazole-phenyl-oxadiazolone compounds, oxadiazole-pyridine-oxadiazolone compounds, oxadiazole-indole-oxadiazolone compounds, oxadiazole-quinoline-oxadiazolone compounds, oxadiazole-pyrrole-oxadiazolone compounds, and oxadiazole-vinyl-oxadiazolone compounds), and their use as therapeutics for the treatment of cancer and other diseases.

Abstract: Mobile devices are only as useful as their battery lasts. Unfortunately, the operation and life of a mobile device's battery degrade over time and usage. The state-of-health (SoH) of batteries quantifies their degradation, but mobile devices' support for its estimation is very poor due mainly to the limited hardware and dynamic usage patterns, causing various problems such as shutting off the devices unexpectedly. To remedy this lack of support, a low-cost user-level SoH estimation service is developed for mobile devices based only on their battery voltage, which is already available on all commodity mobile devices. The design of the estimation service is inspired by an empirical observation that the relaxing voltages of a device battery fingerprint its SoH, and is steered by extensive measurements with 13 batteries used for various devices, such as Nexus 6P, Nexus 5X, Xperia Z5, Galaxy S3, iPhone 6 Plus, etc.