Abstract: The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to cancer markers as diagnostic markers and clinical targets for lung cancer.

Abstract: Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.

Abstract: The present invention relates to nanoparticles complexed with biomacromolecule agents configured for treating, preventing or ameliorating various types of disorders, and methods of synthesizing the same. In particular, the present invention is directed to compositions comprising nanoparticles (e.g., synthetic high density lipoprotein (sHDL)) carrying biomacromolecule agents (e.g., nucleic acid, peptides, glycolipids, etc.), methods for synthesizing such nanoparticles, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).

Abstract: A pneumatic textile system capable of transforming from a two-dimensional structure to a three-dimensional structure under pneumatic pressure is provided. The pneumatic textile system includes a seamless knit fabric having a grid configuration defining a plurality of grid areas—a first of the plurality of grid areas having a tensile strength that is different from a second of the plurality of grid areas. A pneumatic bladder member is disposed along at least a portion of a boundary between adjacent ones of the plurality of grid areas and is inflatable to exert a force on the seamless knit fabric, wherein upon inflation of the pneumatic bladder member the force is exerted on the seamless knit fabric such that the first of the plurality of grid area assumes a shape different than the second of the plurality of grid areas resulting in a three-dimensional structure transformation.

Abstract: A multi-photon optical probe includes a probe housing, a lateral scanning stage coupled to a lateral mirror assembly and a remote axial scanning stage coupled to an axial mirror assembly. The lateral scanning stage is adapted to scan output laser energy over a planar scan area of the sample by moving the lateral mirror assembly. The axial scanning stage is adapted to scan the output laser energy over a vertical depth range of the sample, which, combined with the planar scan area, forms a 3-dimensional volume. A controller operates in conjunction with a number of remote actuating legs coupled to the axial mirror assembly in order to provide level imaging plane which in turn provides for a clear scanned image.

Abstract: Mobile devices are only as useful as their battery lasts. Unfortunately, the operation and life of a mobile device's battery degrade over time and usage. The state-of-health (SoH) of batteries quantifies their degradation, but mobile devices' support for its estimation is very poor due mainly to the limited hardware and dynamic usage patterns, causing various problems such as shutting off the devices unexpectedly. To remedy this lack of support, a low-cost user-level SoH estimation service is developed for mobile devices based only on their battery voltage, which is already available on all commodity mobile devices. The design of the estimation service is inspired by an empirical observation that the relaxing voltages of a device battery fingerprint its SoH, and is steered by extensive measurements with 13 batteries used for various devices, such as Nexus 6P, Nexus 5X, Xperia Z5, Galaxy S3, iPhone 6 Plus, etc.

Abstract: Optically transparent, highly conductive conductor materials are provided, which in certain variations may also be flexible. Methods of making transparent conductive conductors, such as electrodes, are also provided. Such a method may include creating a groove pattern on a substrate that defines a two-dimensional array. Then an electrically conductive material may be selectively applied within the groove pattern of the substrate so as to create a transparent conductor (e.g., a transparent conductive electrode (TCE)). The transparent conductor has a sheet resistance of ?about 5 Ohms/Square and a transmissivity of ?about 50% for a predetermined range of target wavelengths of electromagnetic energy. Such methods may form linear micromesh conductive arrays and tortuous micromesh conductive arrays that can be used in a variety of optoelectronic applications, including as optically transparent, flexible and mechanically reconfigurable zeroth-order resonant (ZOR) antennas.

Abstract: The present invention relates to the treatment of cancer and to the prevention of cancer growth and/or metastasis. In particular, the invention relates to cellular and acellular vaccines containing C3d, a proteolytic product of complement (C3), and methods of enhancing a host immune response (e.g., a T cell mediated immune response) against cancers using same. Compositions and methods of the invention find use, alone or in conjunction with other cancer therapies, in treating lymphoma and/or cancers that develop and/or persist by evading host immune surveillance and/or responses (e.g., T-cell mediated immune responses). Compositions and methods of the invention find use in both clinical and research settings, for example, within the fields of biology, immunology, medicine, and oncology.

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having an oxadiazole-oxadiazolone structure (e.g., oxadiazole-phenyl-oxadiazolone compounds, oxadiazole-pyridine-oxadiazolone compounds, oxadiazole-indole-oxadiazolone compounds, oxadiazole-quinoline-oxadiazolone compounds, oxadiazole-pyrrole-oxadiazolone compounds, and oxadiazole-vinyl-oxadiazolone compounds), and their use as therapeutics for the treatment of cancer and other diseases.

Abstract: Provided are prodrugs of various therapeutic agents that provide enhanced bioavailability of the therapeutic agent, and methods of treatment conditions in a subject by administration of the one or prodrugs. As provided herein a prodrug includes a therapeutic agent covalently attached to a cap, the cap having a structure according to formula (I) where: R1 is a branched or linear substituted or unsubstituted C2-C6 alkyl, alkenyl, or alkynl; X is —S(0)2-; R2 is a branched or linear substituted or unsubstituted C4-C20 alkyl, alkenyl, or alkynyl; and R3 is —H, C3-C5 cycloalkyl, C3-C5 cycloheteroalkyl, —C(CH3)3, —CF3, —C(CF3)3, or a substituted or unsubstituted phenyl.

Abstract: Cyber-physical systems depend on sensors to make automated decisions. Resonant acoustic injection attacks are already known to cause malfunctions by disabling MEMS-based gyroscopes. However, an open question remains on how to move beyond denial of service attacks to achieve full adversarial control of sensor outputs. This work investigates how analog acoustic injection attacks can damage the digital integrity of a popular type of sensor: the capacitive MEMS accelerometer. Spoofing such sensors with intentional acoustic interference enables an out-of-spec pathway for attackers to deliver chosen digital values to microprocessors and embedded systems that blindly trust the unvalidated integrity of sensor outputs. Two software-based solutions are presented for mitigating acoustic interference with output of a MEMS accelerometer and other types of motion sensors.

Abstract: There is disclosed ultrathin film material templating layers that force the morphology of subsequently grown electrically active thin films have been found to increase the performance of small molecule organic photovoltaic (OPV) cells. There is disclosed electron-transporting material, such as hexaazatriphenylene-hexacarbonitrile (HAT-CN) can be used as a templating material that forces donor materials, such as copper phthalocyanine (CuPc) to assume a vertical-standing morphology when deposited onto its surface on an electrode, such as an indium tin oxide (ITO) electrode. It has been shown that for a device with HAT-CN as the templating buffer layer, the fill factor and short circuit current of CuPc:C60 OPVs were both improved compared with cells lacking the HAT-CN template. This is explained by the reduction of the series resistance due to the improved crystallinity of CuPc grown onto the ITO surface.

Abstract: Durable superhydrophobic components have a superhydrophobic material disposed (e.g., disposed) thereon that exhibits an apparent advancing dynamic contact angle of ?about 150° and a roll-off angle of about ?15° for water after at least 100 abrasion cycles. The superhydrophobic material may comprise a low surface energy material and a polymeric material. The superhydrophobic material may be self-healing and capable of recovering its wettability after damage. In yet other aspects, a component comprises a surface that is superhydrophobic and reduces drag in turbulent flow conditions. The surface has an apparent advancing dynamic contact angle of ?about 150° and a roll-off angle of ?about 15° for water, and a product of dimensionless roughness (k+) and a higher-pressure contact angle hysteresis of less than or equal to about 5.8. Methods of making such materials are also provided.

Abstract: A new civil infrastructure construction scheme is provided that is capable of meeting various objectives, including reducing climate change, addressing labor shortage issues, and enhancing construction productivity. Methods of forming load-bearing structures include placing a first reusable load-bearing element adjacent to a second reusable load-bearing element. The first reusable load-bearing element is fixed with respect to the second reusable load-bearing element without any adhesive or mortar. The first reusable load-bearing element and the second reusable load-bearing element respectively have a compressive strength of greater than or equal to about 25 MPa. The first and second reusable load-bearing elements optionally may be formed by additive manufacturing with a printable cementitious composition, such as an engineered cementitious composite.

Abstract: Materials and methods are provided for treatment and/or prevention of Staphylococcal diseases and disorders such as infection and dermal inflammation.

Abstract: A blood clot retraction assay device and methods of measuring whole-blood clot retractive forces during coagulation are described. When placed in proximity to a micro-beam, a blood droplet attaches thereto, applying a force to the micro-beam during clot formation. Using Piezoresistive micro-beams or other Piezoresistive components disposed upon such micro-beams, the device measures retractive force of a blood droplet based upon changes in resistance. The sensitivity of such measurements allows use of small quantities of blood for measurement, between 15 microliters and 300 microliters. The device further permits continuous measurement of coagulation, allowing measurement of distinct reaction, contraction development, and fibrinolysis phases for each blood sample.

Abstract: Bulk acoustic wave resonators are presented. Such resonators typically operate based on a dynamic nonuniform effective piezoelectricity in composite multilayer ferroelectrics with large electrostriction coefficients, like barium strontium titanate (BST). Harmonic resonance modes of a multilayer bulk acoustic wave resonator can be selectively excited with an electromechanical coupling coefficient equal to the fundament mode, which is contrary to the trend K2?1/n2 exhibited by conventional piezoelectric bulk acoustic resonators. Such a resonator allows for the design of a new class of band-switching filters.

Abstract: The present disclosure provides compounds represented by Formula I-A: A1-L1-B1 I-A and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein A1, B1, and L1 are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I-A for use to treat a condition or disorder responsive to degradation of MDM2 protein such as cancer.

Abstract: An actuated telescoping system for navigation within a vascular lumen and thrombectomy of a thrombus. The system includes a tubular catheter member having an open distal end defining a catheter lumen, a vacuum source, a rotational drive system, a flexible shaft having a channel coupled to the rotational drive system for rotational movement in response thereto, and an optional guidewire selectively inserted at least partially within the flexible shaft. The flexible shaft is at least partially disposed within the tubular catheter member configured for uncoupled rotational and translational motion therein and to optionally define a corkscrew motion in response to rotational driving force by the drive system that results in formation of hydrodynamic vortices within the catheter lumen.

Abstract: The present disclosure provides a method in a data processing system that includes at least one processor and at least one memory. The at least one memory includes instructions executed by the at least one processor to implement a driving encounter recognition system. The method includes receiving information, from one or more sensors coupled to a first vehicle, determining first trajectory information associated with the first vehicle and second trajectory information associated with a second vehicle, extracting a feature vector, providing the feature vector to a trained classifier, the classifier trained using unsupervised learning based on a plurality of feature vectors, and receiving, from the trained classifier, a classification of the current driving encounter in order to facilitate the first vehicle to perform a maneuver based on the current driving encounter.