Patents Assigned to Rensselaer Polytechnic Institute
  • Patent number: 12386007
    Abstract: One embodiment provides a method of sound source enumeration and direction of arrival (DoA) estimation. The method, the method includes estimating, by an enumeration module, a number of sound sources associated with an acoustic signal. The estimating includes selecting a specific parametric model from a generalized model. The generalized model is related to a microphone array architecture used to capture the acoustic signal. The method further includes estimating, by a DoA module, a direction of arrival of each sound source of the number of sound sources based, at least in part, on the selected model. The estimating the number of sound sources and estimating the DoA of each sound source are performed using a Bayesian framework.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: August 12, 2025
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Ning Xiang, Dane Bush, Christopher Landschoot
  • Patent number: 12389712
    Abstract: A solar cell device having a solid state light absorber region that incorporates a donor-acceptor particle structure. The particle structure includes acceptor particles that generate a flow of electrons in the solid state light absorber region in response to absorbed photons; and donor particles comprising a phosphorescent material, wherein each donor particle is coupled to a group of acceptor particles, and wherein the phosphorescent material absorbs high energy photons and emits lower energy photons that are absorbed by the acceptor particles.
    Type: Grant
    Filed: June 9, 2023
    Date of Patent: August 12, 2025
    Assignee: Rensselaer Polytechnic Institute
    Inventor: Vidhya Chakrapani
  • Patent number: 12380343
    Abstract: Methods and apparatus for complementary evidence identification in natural language inference. A given question is obtained and a set of N passages is obtained from a database. A probability is determined, for each passage of the set of N passages, of a corresponding passage being a supportive passage for the given question and the set of N passages is ranked based on the determined probabilities. M passages that are ranked 1 to M of the set of N passages are selected. A set of L passages is selected based on a plurality of scores, each score assigned to a set of candidate passages of the set of N passages, each score being based on the determined probabilities, the selected M passages, and a weighted regulation parameter. The set of L passages is provided to a computerized machine learning system to answer the question based on the set of L passages.
    Type: Grant
    Filed: August 10, 2020
    Date of Patent: August 5, 2025
    Assignees: International Business Machines Corporation, Rensselaer Polytechnic Institute
    Inventors: Mo Yu, Li Zhang, Hui Su, Shiyu Chang, Ming Tan, Xiangyang Mou
  • Patent number: 12379092
    Abstract: In an embodiment, there is provided an apparatus. The apparatus includes an optic configured for a selected illumination application. The optic includes a first lens structure and a second lens structure. The first lens structure includes a first planar external surface configured to receive incident light, and a first internal nonplanar refractive surface opposing the first planar external surface. The second lens structure includes a second planar external surface configured to emit output light, and a second internal nonplanar refractive surface opposing the second planar external surface. The second planar external surface opposes the first planar external surface. The first internal nonplanar refractive surface and the second internal nonplanar refractive surface define a cavity. The first internal nonplanar refractive surface, the second internal nonplanar refractive surface, and the cavity are positioned between the first planar external surface and the second planar external surface.
    Type: Grant
    Filed: February 1, 2024
    Date of Patent: August 5, 2025
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Nadarajah Narendran, Akila Shan Udage
  • Patent number: 12367597
    Abstract: One embodiment provides an apparatus for registering a two dimensional (2D) ultrasound (US) frame and a three dimensional (3D) magnetic resonance (MR) volume. The apparatus includes a first deep neural network (DNN) and an image fusion management circuitry. The first DNN is configured to determine a 2D US pose vector based, at least in part, on 2D US frame data. The image fusion management circuitry is configured to register the 2D US frame data and a 3D MR volume data. The registering is based, at least in part, on the 2D US pose vector.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: July 22, 2025
    Assignee: Rensselaer Polytechnic Institute
    Inventor: Pingkun Yan
  • Patent number: 12366617
    Abstract: A transition metal dichalcogenides device includes a substrate, at least one layer of boron nitride, a tungsten diselenide monolayer positioned such that the at least one layer of boron nitride at least partially encapsulates the tungsten diselenide monolayer, and a plurality of electrodes. Each of the plurality of electrodes includes gold and few-layer graphene, and the at least one layer of boron nitride includes hexagonal few-layer boron nitride. The tungsten diselenide monolayer is configured to reveal excitons when at least one of a K valley and a K? valley of the tungsten diselenide monolayer is exposed to excitation photon energy and an external magnetic field. The excitons are giant valley-polarized Rydberg excitons in excited states ranging from 2 s to 11 s when the external magnetic field is in the range of about ?17 T to about 17 T.
    Type: Grant
    Filed: February 5, 2024
    Date of Patent: July 22, 2025
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Sufei Shi, Tianmeng Wang
  • Patent number: 12369241
    Abstract: A method of adjusting lighting to reduce sky glow. The method includes the steps of detecting, by a plurality of sensors, an amount of cloud coverage in a region of the troposphere; determining, by a sky glow reduction circuitry, whether the amount of clouds is greater than, less than, or equal to a predetermined cloud coverage threshold; and adjusting, by a light output controller circuitry, a light output of a plurality of light sources to reduce sky glow if the amount of clouds is less than or equal to the predetermined cloud coverage threshold. The adjusting step is at least partially based on a predetermined policy.
    Type: Grant
    Filed: June 1, 2021
    Date of Patent: July 22, 2025
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Mark S. Rea, Andrew Bierman, John D. Bullough
  • Publication number: 20250230206
    Abstract: Inhibitors are provided for targeting ?-secretase to reduce amyloid load as a viable strategy in Alzheimer's disease treatment and drug discovery. ?-secretase has been shown to cleave amyloid precursor protein, causing an increase in the extracellular concentration of amyloid-? peptides. This extracellular concentration increase can lead to a build-up of amyloid plaques in patients and associated health complications for them. The inhibitors bind adjacent the transmembrane domain of amyloid precursor protein through both covalent and non-covalent interactions. These interactions inhibit the ability of ?-secretase to cleave the amyloid precursor protein, halting the build-up of extracellular amyloid plaques. The inhibitors exhibit specificity for amyloid precursor proteins, reducing concerns of potential off-target effects.
    Type: Application
    Filed: April 1, 2025
    Publication date: July 17, 2025
    Applicant: Rensselaer Polytechnic Institute
    Inventor: Chunyu Wang
  • Patent number: 12354274
    Abstract: A method of ultrasound image volume reconstruction includes: providing a convolutional neural network (“CNN”); receiving a first dataset comprising at least one pair of consecutive ultrasound images; inputting the first dataset to the CNN; training the CNN with the first dataset; receiving a second dataset comprising an ultrasound video comprising a plurality of consecutive ultrasound images; inputting the second dataset to the CNN; and processing, by the CNN, the second dataset to produce as output a reconstructed 3D ultrasound image volume.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: July 8, 2025
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Pingkun Yan, Hengtao Guo
  • Patent number: 12352408
    Abstract: In an embodiment, there is provided a three-dimensional (3-D) optic for beam shaping. The 3-D optic includes a first surface, a second surface and a beam forming feature. The first surface is configured to receive incident light. The second surface is positioned relative to the first surface and is configured to emit a light beam having a shape. The emitted beam shape is related to the beam forming feature. The beam forming feature is formed by a 3-D manufacturing process.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: July 8, 2025
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Nadarajah Narendran, Ukwatte Lokuliyanage Indika Upendra Perera
  • Patent number: 12349472
    Abstract: A photodiode structure including a silicon substrate, an oxide layer on the silicon substrate, a silicon on insulator region on the oxide layer, a germanium absorption region, a silicon nitride waveguide, a cathode region, and an anode region is provided. The germanium absorption region is at least partially disposed in a recess of the silicon on insulator region. The germanium absorption region includes a top surface having a first width and a bottom surface having a second width, the first width being greater than the second width. The cathode region is formed at a first side of the germanium absorption region, and the anode region is formed at a second side of the germanium absorption region that is opposite the first side.
    Type: Grant
    Filed: December 3, 2021
    Date of Patent: July 1, 2025
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Asif Jahangir Chowdhury, Mona Mostafa Hella
  • Patent number: 12338333
    Abstract: The electrochemical energy conversion system include an anode, a cathode, and a proton exchange membrane disposed between the anode and the cathode. The proton exchange membrane includes a polymer having a hard block polymer, a soft block polymer, and one or more hydrophilic functional groups attached to the soft block polymer. The glass transition temperature of the hard block polymer is higher than a glass transition temperature of the soft block polymer, such that the hard block polymer is non-elastic and the soft block polymer is elastic at a desired operating temperature. The hydrophilic functional groups are attached to the soft block polymer via a thiol-ene reaction to modify double bonds in the soft block polymer.
    Type: Grant
    Filed: April 22, 2024
    Date of Patent: June 24, 2025
    Assignee: Rensselaer Polytechnic Institute
    Inventor: Chulsung Bae
  • Publication number: 20250189533
    Abstract: A bead-based assay system and methods for screening molecule inhibitors of protein-glycan interactions. The assay system includes at least one donor bead and at least one acceptor bead. A first molecule is coupled to the at least one donor bead. The first molecule comprises a protein. A second molecule is coupled to the at least one acceptor bead. The second molecule comprises a glycan. The bead-based assay system includes a screening molecule to be screened for inhibiting protein-glycan interactions. The screening molecule is enabled to interact at a protein-glycan interface of the first molecule and the second molecule.
    Type: Application
    Filed: December 11, 2024
    Publication date: June 12, 2025
    Applicant: Rensselaer Polytechnic Institute
    Inventors: Shannon Faris, Chunyu Wang
  • Patent number: 12318770
    Abstract: The electrochemical energy conversion system of the present disclosure includes an anode, a cathode, and an ion exchange membrane including a polymer having an aromatic polymer chain and an alkylated substrate including an alkyl chain, and at least one ionic group. The alkylated substrate is bound to at least one aromatic group in the polymer chain via Friedel-Crafts alkylation of the at least one aromatic group. The alkylation reaction utilizes a haloalkylated tertiary alcohol or a haloalkylated alkene as a precursor. In the presence of an acid catalyst, a carbocation is generated in the precursor which reacts with the aromatic rings of the polymer chain. The at least one ionic group is then replaced with a desired cationic or anionic group using a substitution reaction. The membranes exhibit advantageous stability achieved through a simplified and scalable reaction scheme.
    Type: Grant
    Filed: October 17, 2023
    Date of Patent: June 3, 2025
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Chulsung Bae, Eun Joo Park, Sangtaik Noh, Michael Pagels
  • Patent number: 12297244
    Abstract: Inhibitors are provided for targeting ?-secretase to reduce amyloid load as a viable strategy in Alzheimer's disease treatment and drug discovery. ?-secretase has been shown to cleave amyloid precursor protein, causing an increase in extracellular concentration of amyloid-? peptides. This extracellular concentration increase can lead to build-up amyloid plaques in patients and associated health complications for them. The inhibitors bind to a C-terminal lysine cluster adjacent the transmembrane domain of amyloid precursor protein through both covalent and non-covalent interactions. These interactions inhibit the ability of ?-secretase to cleave the amyloid precursor protein, halting the build-up of extracellular amyloid-? peptides. The inhibitors exhibit specificity for amyloid precursor proteins, reducing concerns of potential off-target effects.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: May 13, 2025
    Assignee: Rensselaer Polytechnic Institute
    Inventor: Chunyu Wang
  • Publication number: 20250131520
    Abstract: Systems and methods of predicting the retention rates of students attending an educational institution are provided. The method includes receiving an initial dataset related to a cohort of students attending the educational institution, dividing the initial dataset into a training dataset and a testing dataset, training a predictive algorithm via the training dataset to generate a prediction model, and processing the testing dataset via the prediction model to output a prediction results dataset. The prediction results dataset includes a listing of the cohort of students organized from most likely to leave the educational institution to least likely to leave the educational institution. The method includes filtering a percentage of the prediction results dataset to identify a watchlist of students likely to leave the educational institution.
    Type: Application
    Filed: February 3, 2023
    Publication date: April 24, 2025
    Applicant: Rensselaer Polytechnic Institute
    Inventors: Jasmine Yang, Lu Enzhe, Jiarun Li, Keith Moo-Young, Yihui Yang, Hui Su, Yifan LIU
  • Patent number: 12282694
    Abstract: One embodiment provides a computing device. The computing device is configured to couple to a display. The computing device includes an ambient detection module configured to detect a characteristic of ambient light relative to at least a portion of a display area of the display. The computing device further includes a displayed image optimization module configured to optimize a feature of at least a portion of a displayed image based, at least in part, on the characteristic of the ambient light.
    Type: Grant
    Filed: October 21, 2020
    Date of Patent: April 22, 2025
    Assignee: Rensselaer Polytechnic Institute
    Inventor: Michael Shur
  • Publication number: 20250120999
    Abstract: A composition is orally or topically administered to a patient susceptible to infection by an orthopoxvirus such as monkeypox (mpox). The composition includes inhibitors configured to bind to orthopoxvirus envelope proteins, e.g., MPXV A29 from mpox. The inhibitors can include sulfated polysaccharides or glycans such as heparin, chondroitin sulfate A, chondroitin sulfate B (dermatan sulfate), chondroitin sulfate C, chondroitin sulfate D, chondroitin sulfate E, pentosan polysulfate, mucopolysaccharide polysulfate, or combinations thereof. Binding of the composition to the envelope proteins inhibits the interaction between the virions and heparan sulfate proteoglycans (HSPG) and thus the ability of the virions to enter the host cell.
    Type: Application
    Filed: October 4, 2024
    Publication date: April 17, 2025
    Applicant: Rensselaer Polytechnic Institute
    Inventors: Fuming ZHANG, Robert Linhardt, Jonathan Dordick, Deling Shi
  • Patent number: 12267931
    Abstract: A luminaire includes a frame, an ambient light source positioned within the frame adjacent a first end of the frame, a downlight light source positioned within the frame adjacent a second end of the frame, a diffuser connected to the frame and at least partially surrounding the ambient light source, and a reflector configured to direct light emitted by the downlight light source. A first driver is in electrical communication with the ambient light source and is configured to adjust the illuminance of the ambient light source. A second driver is in electrical communication with the downlight light source and is configured to adjust the illuminance of the downlight light source. A controller is in electrical communication with and send control signals to the drivers to change the light sources between a plurality of illuminance modes, which includes a circadian effective mode and a circadian ineffective mode.
    Type: Grant
    Filed: February 18, 2022
    Date of Patent: April 1, 2025
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Charles Jarboe, Andrew Bierman, Mariana Gross Figueiro, Mark S. Rea
  • Patent number: 12266104
    Abstract: One embodiment provides an apparatus for fluorescence lifetime imaging (FLI). The apparatus includes a deep neural network (DNN). The DNN includes a first convolutional layer, a plurality of intermediate layers and an output layer. The first convolutional layer is configured to receive FLI input data. Each intermediate layer is configured to receive a respective intermediate input corresponding to an output of a respective prior layer. Each intermediate layer is further configured to provide a respective intermediate output related to the received respective intermediate input. The output layer is configured to provide estimated FLI output data corresponding to the received FLI input data. The DNN is trained using synthetic data.
    Type: Grant
    Filed: January 26, 2024
    Date of Patent: April 1, 2025
    Assignee: Rensselaer Polytechnic Institute
    Inventors: Jason Tyler Smith, Ruoyang Yao, Xavier Intes, Pingkun Yan, Marien Ochoa-Mendoza