Abstract: Novel 20-substituted-pregnene derivatives, compositions containing such derivatives and methods for their use and manufacture are disclosed. The 20-substituted-pregnene derivatives inhibit the androgen biosynthesis enzymes 17(alpha)-hydroxylase/C.sub.17,20 -lyase and 5(alpha)-reducatase and are therefore useful for reducing or inhibiting production of androgens where they have an adverse role in a disease or physiological condition in vertebrate species.

Abstract: A digital frequency domain fluorometer utilizing a computer-controlled digital data acquisition system is use for the study of fluorescence and phosphorescence phenomena in the bio-chemical, biological and bio-physics arts. The computer is used for the direct collection of data, as well as for the filtering and calculation of the phase and modulation values of the sample under study. From these values, fluorescence lifetimes and anisotropy decay times can determined. The digital data acquisition system provides for the simultaneous collection and processing of several modulation frequencies. In addition, the digital frequency domain fluorometer can utilize an array detector for detecting the modulated light from the various samples under study. The use of the array detector provides a means for independently collecting data over a large number of pixels. This configuration allows for a time resolved image to be collected at once.

Abstract: The invention relates to a chiral selector useful in separating underivatized enantiomers of nonsterodial anti-inflammatory agents, particularly naproxen and other arylacetic acid compounds, and relates to a process for achieving such separation utilizing the chiral selector, which is also useful in achieving the enantiomeric separation of amines, alcohol derivatives, epoxides and sulfoxides. The invention is also directed to an apparatus which comprises the chiral selectors.

Abstract: Gene therapy involves the transfer and stable insertion of new genetic information into cells. The present invention is directed to safe vectors for gene therapy and thus provides hybrid parvovirus vectors which are capable of site-specific integration into a mammalian chromosome without substantial cytotoxicity, and which direct erythroid cell-specific expression of heterologous genes. The hybrid vector is useful in gene therapy, particularly in the treatment of hemoglobinopathies and other hematopoietic diseases. A method of delivery of constitutive levels of a pharmaceutical product and a method of producing a recombinant protein are also provided.

Abstract: The propagation of mouse population in a given area of actual or potential mice infestation is prevented as inhibited by treating such area with an effective amount of male mouse sesquiterpenic pheromone or a derivative thereof, wherein such pheromone has male mouse aversion signalling properties, and the pheromone is not used in the form of male mouse urine.

Abstract: Spectrophotometric methods, including the use of circular dichroism, spectrophotometric absorption detection fluorescence and derivative spectrophotometric absorption methods for use in clinical chemistry detection methods. More specifically, with the use of such spectrophotometric methods in the measurement of cholesterol levels and direct measurement of cholesterol subfractions in test samples. The invention is also concerned with providing certain absorption detection spectrophotometric apparatus and spectrophotometric reagents useful in the aforesaid methods.

Abstract: New cytotoxic quionones, designated amamitosenes and iminoazamitosenes are found to have significant activity against ovarian tumors, colon cancer, myecloma and the like neoplastic diseases.Pharmaceutical preparations and therapeutic regimens utilizing azamitosenes and iminoazamitosenes and their pharmaceutically active derivatives are disclosed.

Abstract: Apparatus and method for qualitatively and quantitatively analyzing infrared emission from excited molecules in samples of interest is disclosed. Over the wavelength interval from 1 to 5 um, two strong emission bands are observed with a PbSe detector when organic compounds are introduced into an hydrogen/air flame. The band at 4.3 um (2326 cm.sup.-1 is due to the asymmetric stretch of carbon dioxide while the band at 2.7 um is due to both water and carbon dioxide emission. The carbon dioxide emission at 4.3 um is most intense at the tip of the flame, and increases with the amount of organic compound introduced into the flame. For chromatographic application, an optical filter can be used to isolate the 4.3 um emission band. The infrared emission detection system finds application in the determination of total inorganic carbon, chloride and available chlorine in aqueous samples.

Abstract: Spectrophotometric methods, including the use of convention spectroscopic absorption or circular dichroism, for clinical chemistry detection methods. More specifically, with the use of such spectrophotometric methods in the measurement of cholesterol levels and direct measurement of cholesterol subfractions in clinical samples, and in the measurement of lipoprotein levels in a clinical test sample, as well as in the detection of anabolic steroids and other steroid products. The invention is also concerned with providing certain CD and conventional spectrophotometric apparatus useful in each of the aforesaid chemical methods.

Abstract: The present invention is directed to a compound of the formula: ##STR1## or pharmaceutically acceptable salts thereof which are useful in the treatment of glaucoma and in the assessment of corneal function.

Abstract: The present invention relates to contrast enhancing agents, conjugates thereof, pharmaceutical compositions thereof, and methods for diagnostic analysis, particularly NMR image analysis using these agents. The contrast enhancing agents are chelates of paramagnetic, ferromagnetic or diamagnetic metal ion(s) complexed with new lipophilic complexing acids related to polyaminopolycarboxylic acids.

Abstract: The present invention relates to modified .beta.-chains of human hemoglobin having an oxygen binding affinity equal to or less than natural human hemoglobin. The modified the .beta.-chain of human hemoglobin of the invention preferably has at least one chloride binding site not present in .beta.-chain of natural human hemoglobin.

Abstract: The present invention relates to a method of treatment of functional bowel disease in mammals. More specifically, this invention contemplates prophylaxis and treatment of functional bowel disease in mammals by the administration of antagonists of corticotropin releasing factor. The present invention also relates to pharmaceutical compositions of these antagonists useful in the treatment of functional bowel disease in mammals.

Abstract: A lesion localization and marking wire and needle assembly for marking non-palpable lesions within the body. A marking device having a helically wound coil of wire attached to an end of the shaft which is insertable into the body through a needle or cannula for rotatingly anchoring the marking device into a lesion or tumor is provided. The needle or cannula is inserted into the body with the marking device positioned therein so that when the cannula is positioned proximate to a lesion the shaft of the marker is rotated to advance the marker into the lesion to mark it for subsequent surgical procedures. A second helical wire may be provided on the shaft which cooperates with a wire guide device attached to the needle to enable the physician to determine the depth of the marking device as it anchors into the lesion. In particular, the device is provided for marking for biopsy lesions of the breast.

Abstract: Hydrated lime having high surface area and small particle size is prepared by hydrating lime with an aqueous hydration solution of an organic solvent, and preferably washing the resulting hydrate with an aqueous solution of an organic solvent prior to drying. The high surface area hydrates of the invention are excellent sorbents for SO.sub.2 removal from gas streams.

Abstract: This invention relates to compounds of the formula: ##STR1## wherein R is an electron withdrawing group;R.sub.1 is H or COZ;X.sub.1 and X.sub.2 are independently H, lower alkyl, aryl, aryl lower-alkyl or polystyrene or R and X.sub.1 taken together with the carbon atoms to which they are attached form a ring containing from 4 to 15 ring carbon atoms and may contain up to 2 heteroatoms, wherein the heteroatoms are O, S, or N; andZ is an amino acid residue, a peptide residue or a leaving group. The compounds of the present invention are adaptable as blocking or protecting groups for an amine composition useful in peptide synthesis. The present invention is also directed to a method of protecting an amino group of an organic molecule during a reaction which modifies a portion of the molecule other than the protected amino group.

Abstract: The present invention relates to substantially pure stereoisomers of a compound of the formula: ##STR1## wherein n.sub.1 and n.sub.2 are the same or different and are 1 or 2; X is alkyl (C.sub.1 -C.sub.10), aryl (C.sub.6 -C.sub.10) or aralkyl (C.sub.7 -C.sub.12); and wherein R, R.sub.1, R.sub.2 and R.sub.3 are the same or different and are chosen from H, alkyl (C.sub.1 -C.sub.10), aryl (C.sub.6 -C.sub.10), aralkyl (C.sub.7 -C.sub.12), or a heterocyclic group, and addition salts thereof with pharmaceutically acceptable acids. The invention also relates to a method for the inhibition of blood platelet aggregation in a blood supply comprising administering to said blood supply a blood platelet aggregation inhibiting amount of the compounds of the present invention.

Abstract: A water disinfection system is disclosed. The system comprises a permanganate in a concentration of up to about 15 mg/L, copper ions in a concentration of up to about 900 .mu.g/L, and silver ions in a concentration of up to about 90 .mu.g/L. In addition, a method for disinfecting water utilizing this system is described.

Abstract: Arrangements are disclosed for producing images based upon diffusional wave theory and frequency domain analysis. A medium to be imaged is illuminated with amplitude modulated radiation, and diffusional radiation transmitted or reflected by the medium is detected at a plurality of detection locations, as by a television camera. The phase and also the amplitude demodulation of the amplitude modulated diffusional radiation is detected at each detection location. A relative phase image and also a demodulation amplitude image of the medium are then generated from respectively the detected relative phase values and the detected demodulation amplitudes of the diffusional radiation at the plurality of locations. The present invention is particularly suited for medical applications for generating images of internal anatomical details of the body by using a near infrared amplitude modulated source for illumination of the body.