Abstract: The present invention provides soluble and/or stable sources of tyrosine, cysteine and glutamine for use in total parenteral nutrition (TPN), as well as a gradual release source of glutamic acid. In particular, these sources are gamma-glutamyltyrosine (.gamma.-GluTyr) gamma-glutamylcysteine derivatives (.gamma.-GluCys) and gamma-glutamylglutamine (.gamma.-GluGln). This invention provides TPN formulations, and methods of formulating and using such solutions containing .gamma.-GluTyr, .gamma.-GluCys and/or .gamma.-GluGln to provide adequate nutritional levels of tyrosine, cysteine or glutamine during TPN.

Abstract: This invention relates to an assay for fibrin polymers for use in the diagnosis of patients at risk of thrombosis and in monitoring the effects of treatment in such patients. More particularly, the present invention relates to an assay for soluble crosslinked fibrin polymers in patent samples involving the in vitro treatment of the sample with a proteolytic enzyme such as t-PA which generates the D-dimer fragment of soluble fibrin polymers. The amount of D-dimer formed is determined by an immunoassay specific for D-dimer. The measurement of D-dimer is thus a useful reflection of the hypercoagulability state and the test may be useful for assessing pre-thrombotic or thrombotic disorders such as myocardial infarction, pulmonary embolism and deep vein thrombosis, as well as for soluble fibrin formation in neoplastic, immune, inflammatory states, or other pathologic conditions, and for evaluations of therapy such as with anticoagulants that are used to treat these conditions.

Abstract: A method of and system for utilizing circularly polarized microwave radiation in order to provide for the direct overwriting of previously recorded data on a single-layer magneto-optical disk is disclosed in which a microwave source is used to generate a sinusoidal magnetic wave having a fixed magnitude and fixed frequency which is applied to a phase shift switch whose phase is shifted between right circular and left circular polarization states, depending upon each bit of binary data to be recorded. The output from the phase shift switch is fed to a microwave antenna which is utilized to radiate the right circular or left circular polarized microwave signal to a small area of the magnetic film utilized in a magneto-optical disk which is heated by a focused laser beam at the moment during which recording at that location is desired.

Abstract: A lesion localization and marking wire and needle assembly for marking non-palpable lesions within the body. A marking device having a helically wound coil of wire attached to an end of the shaft which is insertable into the body through a needle or cannula for rotatingly anchoring the marking device into a lesion or tumor is provided. The needle or cannula is inserted into the body with the marking device positioned therein so that when the cannula is positioned proximate to a lesion the shaft of the marker is rotated to advance the marker into the lesion to mark it for subsequent surgical procedures. A second helical wire may be provided on the shaft which cooperates with a wire guide device attached to the needle to enable the physician to determine the depth of the marking device as it anchors into the lesion. In particular, the device is provided for marking for biopsy lesions of the breast.

Abstract: The present invention relates to novel sweet compounds derived from the leaves of the subtropical weed Abrus precatorius, and their use as sweeteners. In particular, the present invention contemplates four novel sweet compounds isolated from A. precatorius or A. fruticulosus, and particularly, Abrusosides A, B, C and D and related compounds. The present invention also contemplates the use of these abrusosides and related compounds as sugar substitutes. The present invention contemplates the use of Abrusosides A-D as individual components or in mixtures, in a method for sweetening comestibles, foodstuffs, beverages and medicinal agents.

Abstract: Cyclophosphamides possessing anti-tumor activity and having the formula ##STR1## and salts thereof; wherein R is lower alkyl, aryl, aryl-lower alkyl or a nitrogen, sulfur or oxygen containing heterocyclic or heterocyclic lower alkyl, andR' is hydrogen, hydroxy or OOH with the proviso that when R' is hydrogen, R is other than methyl or phenyl and when R' is hydroxy, R is other than methyl.

Abstract: Fabry disease results from an X-linked deficiency in the enzyme .alpha.-galactosidase A. The present invention is directed to recombinant human .alpha.-galactosidase A and provides baculovirus expression vectors and recombinant virus that provide stable expression of extracellular and intracellular levels of this enzyme in an insect cell culture. The recombinant-derived enzyme can be used in enzyme replacement therapy to treat Fabry patients. Composition useful in therapeutic administration of .alpha.-galactosidase A are also provided.

Abstract: The present invention is directed to replicable expression vectors for producing fusion proteins which are secreted in membraneous particles budded from the cell membrane. In particular these vectors express a hybrid gene product composed of a modified retrovirus gag gene fused to a heterologous gene, or any part thereof, wherein the gag gene modification is sufficient to enable a cell to produce the hybrid gene product in a membraneous particle by budding from the cell membrane into the culture medium or extracellular space, a process known as retrovirus-mediated secretion. The minimum gag sequences needed to obtain particle formation are described. The invention also provides hosts containing the expression vectors, and the fusion proteins produced by the vectors. Further the invention provides the membraneous particles produced by retrovirus-mediated secretion and uses of these particles for protein purification and in therapeutics.

Abstract: Compounds of the formulae: ##STR1## useful as anti-obesity, anti-diabetic, anti-coronary and hypolipidemic agents.

Abstract: A chiral catalyst is disclosed together with methods of using it for enantioselective syntheses. The chiral catalyst includes a nucleus with two metal atoms that has four bridging ligands oriented radially to the axis of the nucleus. Each of these ligands includes two complexing atoms each complexed to one of the metal atoms. At least one of the bridging ligands includes a chiral center which is bonded to one of the complexing atoms. Preferably, all four of the bridging ligands include a chiral center bonded to one of the complexing atoms. The catalyst of the invention has been found to be useful in catalyzing carbenoid transformation reactions such as cyclopropanation.

Abstract: The present invention relates to contrast enhancing agents, conjugates thereof, pharmaceutical compositions thereof, and methods for diagnostic analysis, particularly NMR image analysis using these agents. The contrast enhancing agents are chelates of paramagnetic, ferromagnetic or diamagnetic metal ion(s) complexed with new lipophilic complexing acids related to polyaminopolycarboxylic acids.

Abstract: The invention comprises a factor having the following characteristics:a) It inhibits granulocyte-macrophage colony and cluster formation;b) It has a molecular weight of about 8 kDa as determined by SDS-PAGE;c) It has a weak anionic charge at pH 7.4 as shown by anion exchange chromatography;d) It has a flattened isoelectric titration curve as shown by anion exchange chromatography; ande) It is a protein.The invention also comprises methods of making and using the factor and compositions comprising the factor.

Abstract: An explosive detection screening system used for the detection of explosives and other controlled substances such as drugs or narcotics. The screening system detects the vapor and/or particulate emissions from the aforementioned substances and reports that they are present on an individual or object and the concentration of each substance detected. The screening system comprises a sampling chamber for the collection of the vapor and/or particulate emissions, a concentration and analyzing system for the purification of the collected vapor and/or particulate emissions and subsequent detailed chemical analysis of the emissions, and a control and data processing system for the control of the overall system.

Abstract: The present invention relates to DNA and proteins of human adenovirus Type 41 and their use in detection of said virus. More specifically, the present invention relates to the isolation of a 41.4 kd short fiber protein and a 60.6 kd long fiber protein of adenovirus type 41 (Ad41), as well as proteins derived from the Ad41 E3 region, thereby providing virus-derived antigens and active derivatives and parts thereof, useful in the development of diagnostic assays, DNA probes and vaccines for said virus or other related viruses belonging to the human enteric adenovirus family. In addition, the present invention is directed to recombinant DNA molecules containing the human enteric adenovirus Type 41 Tak long fiber protein gene, the Ad41 short fiber protein gene and the Ad41 E3 gene (encoding the Ad41 proteins RL-1 to RL-6) thereby providing a source of recombinant viral components useful in the development of said diagnostic assays, DNA probes and vaccines for human adenoviruses.

Abstract: This invention relates to compounds of the formula a compound of the formula ##STR1## wherein X is O, CR.sub.7 R.sub.8, S or NR.sub.9 wherein R.sub.7 and R.sub.8 are independently hydrogen, or lower alkyl, and R.sub.9 is lower alkyl;n is 0 or 1;R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, monoorganosilyl, diorganosilyl, triorganosilyl, halogen, aryl, or nitro;R.sub.3 is hydrogen, lower alkyl, monoorganosilyl, diorganosilyl, triorganosilyl, halogen, 9-fluorenylalkyl, cycloalkyl, aryl or aralkyl;R.sub.4 and R.sub.5 are independently hydrogen, lower alkyl, or aryl or one of R.sub.4 and R.sub.5 is 9-fluorenyl;R.sub.6 is H or COZ wherein Z is an amino acid, a peptide residue or a leaving group; andwith the provisos that when n is 0 and R.sub.3 is hydrogen, R.sub.1 and R.sub.2 are not hydrogen, halogen or nitro; that when n is 0 and R.sub.3 is lower alkyl, R.sub.1 and R.sub.2 are not hydrogen; and that when X is O or CR.sub.7 R.sub.8 wherein R.sub.7 and R.sub.8 are H, that R.sub.1, R.sub.2, R.sub.

Abstract: A method and apparatus for providing maximum rate modulation or compression encoding and decoding for use with magnetic and optical recording and optical fiber communications is disclosed in which primarily two algorithms are utilized which satisfy the conditions that encoding and decoding require only a small constant number of elementary operations, without multiplications or divisions and that only a small amount of memory space for a small number of integers is required. Thus, the present invention operates with only linear time complexity and only linear memory complexity. The invention utilizes a direct enumeration algorithm to accomplish a mapping and an inverse enumeration algorithm to accomplish an inverse mapping back to enumeration.

Abstract: A method for releasing trialkylamines into the dye circulation stream of a dye laser and a filter cartridge containing a resin bound anion stabilizing agent for insertion into the dye circulation stream of a dye laser improves the performance thereof, especially with respect to excimer and flashlamp pumped coumarin and carbostyryl dye lasers. The resin bears quaternary ammonium groups, and borohydride, bromide, hudroxide or chloride may be used as the counter ion. A resin bound borohydride stabilizing agent is capable of releasing trialkylamine into the dye circulation stream and reducing the carbonyl functional groups of polyarbonyl material in the stream to less light absorbing alcohol functional groups. A resin bound chloride stabilizing agent is capable of releasing trialkylamine into the dye circulation stream as a quencher and radical scavenger.

Abstract: The invention relates to a process for the high yield, cost efficient means of separating enantiomers. The process utilizes a supported liquid membrane and a chiral carrier which selectively complexes with one of the two enantiomeric optical configurations. The invention is also directed to an apparatus adaptable to the continuous and staged separation of enantiomers. In one embodiment, the apparatus utilizes a semi-permeable barrier and source and receiving locations each of which may be kept at temperatures which facilitate the complexation and dissociation processes.

Abstract: This invention relates to a new and distinct cultivar of Geranium Pelargonium.times.hortorum named Jubilee that possesses a flower color that is a unique combination of red-orange and watermelon shades, and is early flowering, floriferous, self-branching, and compact.