Abstract: This invention is directed to compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof wherein R.sub.6 is hydrogen or lower alkyl;each R.sub.1 is hydrogen, lower alkyl, halogen, nitro, trihaloalkyl, lower alkoxy, formyl, lower alkanoyl, loweralkylamino or diloweralkylamino ##STR2## X is O, S or NR.sub.5 ; R.sub.2 is OR.sub.7 or NR.sub.7 R.sub.8 ;each R.sub.3 and R.sub.4 are independently hydrogen or lower alkyl;R.sub.5 R.sub.7 and R.sub.8 are independently hydrogen or lower alkyl;n is 0-3 andm is 0-6.These compounds are useful for treating glaucoma or assessing corneal function in mammals.

Abstract: This invention relates to compounds of the following formula useful as a carbonic anhydrase inhibitor:A compound of the formula: ##STR1## and pharmaceutically acceptable salts thereof wherein X is NR.sub.12 ;R.sub.1 is ##STR2## R.sub.2 is ##STR3## R.sub.3 is hydrogen or lower alkyl; R is hydrogen or lower alkyl;each R.sub.4 and R.sub.5 are independently hydrogen or lower alkyl;each R.sub.7 and R.sub.8 are independently hydrogen or lower alkyl;R.sub.6 is OR.sub.10 or NR.sub.10 R.sub.11 ;R.sub.9 is OR.sub.13 OR NR.sub.11 R.sub.13 ;R.sub.10, R.sub.11 R.sub.12, and R.sub.13 are independently hydrogen or lower alkyl; andn and m are independently 0-6.

Abstract: The invention concerns novel monoclonal antibodies with high specificity to and affinity for human carcinoembryonic antigen (CEA), derivatives thereof, processes for the preparation of these antibodies and their derivatives, hybridoma cell lines secreting the antibodies, and processes for the preparation of said cell lines. The monoclonal antibodies of the invention and their derivatives are useful in the diagnosis and therapy of cancer and serial monitoring of cancer patients for recurrent disease or response to therapy. Test kits and pharmaceutical compositions containing said monoclonal anti-CEA antibodies are also subject of the invention.

Abstract: The invention relates to a process for the rapid, high yield conversion of select rare earth oxides or hydroxides, to their corresponding carbonates by contact with supercritical carbon dioxide.

Abstract: The present invention contemplates a treatment for ocular inflammation.More particularly, one aspect of the present invention relates to a method of reducing, inhibiting or preventing ocular inflammation in a mammal which comprises administering to said mammal an effective amount of matrine or a derivative thereof.Another aspect of the present invention is directed to a pharmaceutical composition useful in reducing, inhibiting or preventing ocular inflammation in a mammal comprising an effective amount of matrine or a derivative thereof and a pharmaceutically acceptable carrier.Yet another aspect of the present invention contemplates a method of inducing ocular analgesia and a pharmaceutical composition useful for same.

Abstract: Particles comprising a core surrounded by at least one shell wherein at least one of the core or one of the shells is a metal and at least one of the core or one of the shells is a dielectric material which exhibits a third order nonlinear response. The "shell" of a metal particle may be the adjacent region of a medium in which said particle is suspended, said medium having a third order nonlinear response. In a preferred embodiment, the particles are suspended in a dielectric medium that may be linear or may exhibit a third order nonlinear response. Enhancement of the effective .chi..sup.(3) of the particles and suspensions result from the concentration of the electric field in and around the particles at the plasmon resonance frequency of the metal.

Abstract: A lesion localization and marking wire and needle assembly for marking non-palpable lesions within the body. A marking device having a helically wound coil of wire attached to an end of the shaft which is insertable into the body through a needle or cannula for rotatingly anchoring the marking device into a lesion or tumor is provided. The needle or cannula is inserted into the body with the marking device positioned therein so that when the cannula is positioned proximate to a lesion the shaft of the marker is rotated to advance the marker into the lesion to mark it for subsequent surgical procedures. A second helical wire may be provided on the shaft which cooperates with a wire guide device attached to the needle to enable the physician to determine the depth of the marking device as it anchors into the lesion. In particular, the device is provided for marking for biopsy lesions of the breast.

Abstract: The present invention relates to a novel antineoplastic agent, designated IMIC (Inhibitor of Mevalonate Incorporation Into Cholesterol) having the following characteristics:(a) is present in the retentate of dialyzed skim milk;(b) is non-dialyzable;(c) has general properties of pyrimidines;(d) is bound to a protein in the proteose-peptone fration of milk;(e) is soluble in water;(f) is insoluble in organic solvents;(g) is stable in acid;(h) is not bound or retained by a C.sub.18 or C.sub.8 reverse phase HPLC columns;(i) is not retained by a C.sub.18 or silica gel sep. pak;(j) has .lambda. maximum absorbance at 208 nm and 278 nm (UV) in neutral ad acidic solution and in a basic solution at 223 and 290 nm;(k) provides peaks with a retention time of 7.52 minutes upon fractionation by HFLC on a Biorad Aminex resin column (30 cm .times.7.9 nm) with 0.05 NH.sub.2 SO.sub.4 as the mobile phase and with a flow rate of 0.7 ml/minute;(l) provides peaks with a retention time of 9.

Abstract: Propagation modes within a corrugated optical waveguide are used to excite fluorescence from a layer of material which defines a wall of the waveguide. The fluorescence is emitted at discrete angles, which are a function of the wavelength and polarization of the emitted fluorescence. The intensity of fluorescence detected at the discrete angles of detection can approach 2000 times the intensity detected from the same fluorescence material coated on a glass slide. These features enable a number of tests to be performed simultaneously on an unknown sample, as well as providing a finer and more accurate determination of concentration of a substance over prior art systems.

Abstract: An explosive detection screening system used for the detection of explosives and other controlled substances such as drugs or narcotics. The screening system detects the vapor and/or particulate emissions from the aforementioned substances and reports that they are present on an individual or object and the concentration of each substance detected. The screening system comprises a sampling chamber for the collection of the vapor and/or particulate emissions, a concentration and analyzing system for the purification of the collected vapor and/or particulate emissions and subsequent detailed chemical analysis of the emissions, and a control and data processing system for the control of the overall system.

Abstract: Compounds of the formulae: ##STR1## are useful as anti-hypertensives.

Abstract: A continuous blooming, compact, self branching geranium plant having large, showy, predominantly red-purple floret clusters, and excellent tolerance to high heat and low light conditions.

Abstract: This invention relates to a new and distinct cultivar of Geranium (Pelargonium.times.hortorum) named #821-(82-116-13) substantially as described herein, characterized as being particularly well adapted to both commercial greenhouse production and garden performance, and as being early flowering and floriferous, self-branching and compact, heat-tolerant and low-light-tolerant.

Abstract: A prostate antigen distinct from prostatic acid phosphatase has been detected in normal, benign hypertrophic and malignant prostatic tissues, but not in other human tissues. The prostate antigen was purified to homogeneity from prostatic tissues by ammonium sulfate precipitation, DEAE-BioGel A anion exchange chromatography, molecular sievings on Sephadex G-100 and Sephadex G-75,This invention was supported in part by Grants No. CA-15126 and CA-15437 from the National Cancer Institute, U.S. Public Health Service.

Abstract: This invention relates to a new and distinct cultivar of regal Pelargonium (Pelargonium.times.domesticum) named `Majestic` substantially as illustrated and described herein, particularly characterized as being compact and self-branching, early flowering and floriferous, and having medium red flowers with a ruby spot and feathering primarily on the upper petals.

Abstract: This invention relates to a new and distinct cultivar of regal pelargonium (Pelargonium .times.domesticum) named `Fantasy` substantially as illustrated and described herein, particularly characterized as being compact and self-branching, early flowering and floriferous, and having a maroon blotch fading to a blush pink background on the upper petals and lighter blush pink to near white lower petals.

Abstract: This invention relates to a new and distinct cultivar of geranium (Pelargonium.times.Xhortorum) named `Centennial` substantially as described herein, characterized as being particularly well adapted to both commercial greenhouse production and garden performance, and as being early flowering, floriferous, self-branching, compact and producing bright scarlet semidouble flowers.

Abstract: This invention relates to a new and distinct cultivar of regal Pelargonium (Pelargonium.times.domesticum) named Flair substantially as illustrated and described herein, particularly characterized as being compact and self-branching, early flowering and floriferous, and having flowers which are light orange-red in color with red-purple feathering primarily on the upper petals.

Abstract: This invention relates to a new and distinct cultivar of geranium (Pelargonium.times.hortorum) named #(81-344-3) substantially as described herein, characterized as having bright, luminescent scarlet flowers and being particularly well adapted to both commercial greenhouse production and garden performance, and as being early flowering, floriferous, self-branching, and compact.

Abstract: This invention relates to a new and distinct cultivar of regal Pelargonium (Pelargonium.times.domesticum) named `Splendor` substantially as illustrated and described herein, particularly characterized as being compact and self-branching, early flowering and floriferous, and having bright salmon pink flowers with ruby feathering on the upper petals.