Patents Assigned to Research Development
  • Image sensor readout method and apparatus
    Patent number: 9087756
    Abstract: A pixel readout circuit including at least first, second and third memory locations. During an integration period of a pixel, the pixel readout circuit repeatedly samples the pixel output level during the integration period, stores the first sample in the first memory location, and stores each subsequent sample in memory locations other than the first memory location. Each sample is stored with a time corresponding to when that sample was taken, such that at any one time subsequent to the first three samples having been stored, at least the first sample and the two most recent samples are stored. Also disclosed is a corresponding method of reading out of a pixel output over an undefined integration period.
    Type: Grant
    Filed: December 10, 2012
    Date of Patent: July 21, 2015
    Assignee: STMicroelectronics (Research & Development) Limited
    Inventor: Robert Golding
  • Particulate drug carriers as desensitizing agents
    Patent number: 9078812
    Abstract: The present invention provides methods for desensitization for prevention or diminishing hypersensitivity reactions including C activation-related pseudoallergy (CARPA) and other reactions to particulate medicines. The desensitization is performed via pretreatment using a drug-free vehicle or carrier to eliminate or diminish the clinical symptoms of hypersensitivity.
    Type: Grant
    Filed: December 7, 2008
    Date of Patent: July 14, 2015
    Assignees: The Bay Zoltan Foundation for Applied Research, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yechezkel Barenholz, Janos Szebeni, Miklos Toth, Laszlo Rosivall
  • Methods for diagnosing oral or oral-pharyngeal cancer
    Patent number: 9075060
    Abstract: A method of diagnosing oral cancer or oral pharyngeal cancer in a subject in need thereof is provided. The method comprising determining a level or activity of at least one marker in a saliva sample of the subject, wherein a significant alteration in the level or the activity of the marker with respect to an unaffected saliva sample is indicative of the cancer, wherein the saliva marker is selected from the group consisting of Cyclin D1, phospho-Src, 8-oxoguanine DNA glycosylase (OGG1), Maspin, KI67 and translocator protein 18 kDa (TSPO).
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: July 7, 2015
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Rafael M. Nagler, Moshe Gavish
  • Aminoglycosides and uses thereof in the treatment of genetic disorders
    Patent number: 9073958
    Abstract: A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: July 7, 2015
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Timor Baasov, Tamar Ben-Yosef, Igor Nudelman, Annie Rebibo-Sabbah, Dalia Shallom-Shezifi, Mariana Hainrichson
  • 2-(2-phenylethenyl) 1,3-benzodiazepine derivatives useful for the treatment of cancer
    Patent number: 9073880
    Abstract: The present invention provides compounds of formula (1) acting as protein kinase (PK) and receptor kinase (RK) signaling modulators. The invention further provides methods of their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as anti-cancer agents for preventions and treatments of PK- and RK-related disorders, in particular cancer. (I) wherein A is H or CN; Z is S, SO or S02; X1, X2, X3, X4, X5, Y1 and Y2 are each independently selected from H, halogen, alkyl, haloalkyl and OR1; and Y3 and Y4 are each OR1, wherein each R1 is independently H, C1-C4 alkyl, acyl, —(CH2CH20)n wherein n is an integer of 1 to 20, or a functional group that gives rise to hydroxyl upon hydrolysis.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: July 7, 2015
    Assignee: Yissum Research Development Company of the Hebrew University of Jeruselem Ltd.
    Inventors: Hadas Reuveni, Alexander Levitzki
  • Neuroprotective Natural Extract from Passion Fruit
    Publication number: 20150182569
    Abstract: Methods for the treatment and prevention of neural cell and neuro-pathological disorders are provided, comprising contacting the neural cells, or administering to a subject in need thereof, botanical raw material (BRM) or an extract obtainable from passion fruits. Compositions, as well as a nutraceutical composition comprising the same are also provided.
    Type: Application
    Filed: January 15, 2015
    Publication date: July 2, 2015
    Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., The State of Israel, Ministry of Agriculture & Rural Dept, Agricultural Research Org. (ARO
    Inventors: Alon Samach, Oren Tirosh, Edna Pesis, Avital Artan, Livnat Goldenberg, Aron Troen
  • TRAVELLING WAVE ANTENNA FEED STRUCTURES
    Publication number: 20150188237
    Abstract: Techniques for implementing series-fed antenna arrays with a variable dielectric waveguide. In one implementation, coupling elements with optional controlled phase shifters are placed adjacent each radiating element of the array. To avoid frequency sensitivity of the resulting array, one or more waveguides have a variable propagation constant. The variable waveguide may use certain materials exhibiting this phenomenon, or may have configurable gaps between layers. Plated-through holes and pins can control the gaps; and/or a 2-D circular or a rectangular travelling wave array of scattering elements can be used as well.
    Type: Application
    Filed: February 28, 2014
    Publication date: July 2, 2015
    Applicant: AMI Research & Development, LLC
    Inventors: John T. Apostolos, Benjamin McMahon, Brian Molen, Judy Feng, William Mouyos
  • Methods of stimulating liver regeneration
    Patent number: 9066925
    Abstract: Provided herein are methods and compositions, including pharmaceutical compositions, for stimulating liver regeneration after partial hepatectomy, massive liver resection and toxic injury, or following liver transplantation, including small-for-size liver transplantation, by inhibiting activation of complement.
    Type: Grant
    Filed: July 2, 2010
    Date of Patent: June 30, 2015
    Assignee: MUSC Foundation for Research Development
    Inventors: Stephen Tomlinson, Songqing He, Carl Atkinson
  • Detecting key corruption
    Patent number: 9069988
    Abstract: Corruption in a key stored in a memory is detected by reading a key from a key memory and determining if detection bits of the key read from the key memory correspond to an expected value. The expected value is a value of the detection bits of the key when the key is written to the key memory.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: June 30, 2015
    Assignee: STMicroelectronics (Research & Development) Limited
    Inventor: Mark Trimmer
  • Modelization of objects in images
    Patent number: 9070207
    Abstract: A system includes an aligner to align an initial position of a partially kinematically, parameterized model with an object in an image, and a modelizer to adjust parameters of the model to match the model to contours of the object, given the initial alignment. An animation system includes a modelizer to hierarchically match a hierarchically rigid model to an object in an image, and a cutter to cut the object from the image and to associate it with the model. A method for animation includes hierarchically matching a hierarchically rigid model to an object in an image, and cutting the object from the image to associate it with the model.
    Type: Grant
    Filed: September 7, 2008
    Date of Patent: June 30, 2015
    Assignee: Yeda Research & Development Co., Ltd.
    Inventors: Yosef Yomdin, Gregory Dinkin, Niv Sarig, Avital Yomdin
  • METHOD AND APPARATUS FOR COMPENSATING A FREQUENCY GENERATOR SUCH AS AN OSCILLATOR FOR FREQUENCY INACCURACIES
    Publication number: 20150180480
    Abstract: An input receives a generated frequency having a first frequency component and a second frequency component. A filter block includes filter coefficients describing a relationship between the second frequency component and an environmental characteristic. The filter block predicts the first frequency component based on the environmental characteristic, and updates the filter coefficients based on an offset between the predicted first frequency component and a received frequency corresponding to the first frequency component.
    Type: Application
    Filed: December 16, 2014
    Publication date: June 25, 2015
    Applicant: STMicroelectronics (Research & Development) Limited
    Inventors: Peter Bagnall, Philip Mattos
  • Intervertebral Implant
    Publication number: 20150173905
    Abstract: An intervertebral implant, particularly an intervertebral implant comprising local degradable hydroxyl apatite/metal block and based on a support mounting model of porous hydroxyl apatite with metal powders held for sintering and molding, guides osseous tissues to grow in porous metal and is steadily merged in upper and lower bones when the implanted hydroxyl apatite is gradually degraded in a certain period.
    Type: Application
    Filed: December 23, 2013
    Publication date: June 25, 2015
    Applicant: Metal Industries Research & Development Centre
    Inventors: Wei-Ching Wang, Meng-Xiu Wu, Fu-Shan Wang, Tzyy-Ker Sue, Wei-Te Chen, Wei-Jen Shih
  • Liquid-retaining elastomeric compositions
    Patent number: 9062245
    Abstract: Disclosed are compositions-of-matter composed of a continuous elastomeric matrix and a liquid; the matrix entrapping the liquid therein in the form of closed-cell droplets dispersed throughout the matrix. The disclosed compositions-of-matter are characterized by a low tensile/compressive modulus and are capable of retaining the liquid for exceedingly long periods of time. Further disclosed are processes for forming the compositions-of-matter and uses thereof.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: June 23, 2015
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Michael S. Silverstein, Inna Gurevitch
  • Method for processing a surface of a metal implant and the metal implant produced by the method
    Patent number: 9062381
    Abstract: A method for treating a surface of a metal implant includes a polishing step, a grafting step and a surface modifying step. The polishing step includes polishing a surface of a metal implant to remove an uneven, natural oxide layer on the surface of the metal implant and to generate an even oxide layer on the surface of the metal implant. The grafting step includes grafting an anti-adhesion macromolecule on an outer face of the even oxide layer. A covalent bond between the anti-adhesion macromolecule and oxygen atoms on the outer face of the even oxide layer is formed. Thus, a macromolecular anti-adhesion layer on the outer face of the even oxide layer can be created. The surface modifying step includes changing a property of the surface of the metal implant with the macromolecular anti-adhesion layer by high temperature and high pressure, providing the metal implant with high hydrophilicity.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: June 23, 2015
    Assignee: Metal Industries Research & Development Centre
    Inventors: Wei-Ching Wang, Wei-The Chen, Wei-Jen Shih
  • Method and device for tactile presentation
    Patent number: 9064426
    Abstract: A method for a tactile presentation of perceivable content. The method comprises receiving a data representing perceivable content, selecting a plurality of electric currents according to the data, each the electric current is associated with at least one of a plurality of regions of a solution having a plurality of macromolecules, and changing a level of acidity (pH) of at least one of the plurality of regions by applying a respective the electric current thereto. A proton concentration in the plurality of regions tactilely presents the perceivable content.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: June 23, 2015
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Uri Sivan, Elad Brod
  • Tip propelled device for motion through a passage
    Patent number: 9061118
    Abstract: A self-propelled device for locomotion through a lumen, comprising a set of serially arranged inflatable chambers, the end ones of which expand at least radially when inflated. Connecting passages provide fluid communication between each pair of adjacent chambers. A fluid source is attached to one of the end chambers. The connecting passages are such that the fluid inflates the chambers in a sequence, beginning with the chamber closest to the source, and ending with the chamber furthest from the source. The same sequence occurs when the chambers deflate, beginning with the chamber closest to the source, and ending with the chamber furthest from the source. The fluid source can either be a fluid supply tube, extending to a supply outside the lumen, or it can be built-in and carried by the device. The device can crawl either along the lumen wall or on an inserted guide wire.
    Type: Grant
    Filed: August 10, 2006
    Date of Patent: June 23, 2015
    Assignee: Technion Research & Development Foundation Ltd.
    Inventors: Moshe Shoham, Noam Hassidov, Daniel Glozman
  • SYSTEM AND METHOD FOR OPTICAL COHERENCE TOMOGRAPHY
    Publication number: 20150168126
    Abstract: A system for optical coherence tomography (OCT) is disclosed. The system comprises an optical interferometer apparatus configured to split an optical beam into a reference beam directed to a reference reflector and a sample beam directed to a sample, and to combine a reflected beam from the reference reflector with a returning beam from the sample to form a combined optical signal. The system further comprises a two photon detector configured to detect the combined optical signal by two photon absorption and to provide a corresponding electrical signal, a frequency separation system configured to separate a low frequency component from the electrical signal, and a data processor configured for providing a topographic reconstruction of the sample based, at least in part, on the low frequency component.
    Type: Application
    Filed: May 6, 2013
    Publication date: June 18, 2015
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Amir Nevet, Tomer Michael, Meir Orenstein
  • COMPOSITIONS COMPRISING PEDF AND USES OF SAME IN THE TREATMENT AND PREVENTION OF OVARY-RELATED SYNDROMES
    Publication number: 20150164989
    Abstract: A method of treating or preventing an ovary-related syndrome associated with infertility in a subject in need thereof is provided. The method comprising administering to the subject a pharmaceutical composition comprising an active ingredient consisting of pigment epithelium-derived factor (PEDF) and a pharmaceutically acceptable carrier, thereby treating or preventing the ovary-related syndrome associated with infertility in the subject.
    Type: Application
    Filed: February 23, 2015
    Publication date: June 18, 2015
    Applicants: Ramot at Tel-Aviv University Ltd., The Fund for Medical Research, Development of Infrastructure and Health Services - Assaf HaRofeh
    Inventors: Ruth SHALGI, Dana Chuderland, Ido Ben-Ami, Raphael Ronel
  • SHAPE-MEMORY STRUCTURES
    Publication number: 20150166753
    Abstract: Polymeric foams and elastomer/hydrogel bicontinuous composite structures derived from high internal phase emulsions and possessing shape-memory characteristics are disclosed, as well as processes for forming the same and uses thereof in, for example, manufacturing of various articles.
    Type: Application
    Filed: December 22, 2014
    Publication date: June 18, 2015
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Michael S. SILVERSTEIN, Inna Gurevitch, Christine Warwar
  • Spiral surface electromagnetic wave dispersive delay line
    Patent number: 9059488
    Abstract: Dispersive properties of a linear dispersive delay line are retained in a spiral configuration by constraining the radius of curvature depending on a desired propagation mode. The compact form factor spiral can be either a continuous spiral or a piecewise linear approximation. The spiral comprises a highly dielectric waveguide such as titanium dioxide or barium tetratitanate. Preferably, a spacer with a low dielectric constant and a microstrip are disposed on the top surface. The microstrip prevents attenuation of low frequencies, thereby increasing the operating frequency range. A second dielectric spacer and a second microstrip can be deposited on the bottom surface of the waveguide. Alternatively, the bottom surface of the waveguide can face a ground plane. The waveguide can be fed by horns or half-horns.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: June 16, 2015
    Assignee: AMI Research & Development, LLC
    Inventors: John T. Apostolos, William Mouyos, Benjamin McMahon