Patents Assigned to Research Development
  • SKELETAL BONE FIXATION MECHANISM
    Publication number: 20150342647
    Abstract: A skeletal fixation apparatus may include two or more bodies that are attached to two or more screws that have been inserted into vertebral bodies associated with a patient. The apparatus may also include two or more cylindrical members that are attached to the bodies to control the movement or alignment of the bodies when the skeletal fixation apparatus is being installed in the patient. The apparatus may further include a rod that includes a first curvature and a second curvature. The first curvature may be different than the second curvature and may be based on a medical diagnosis associated with stabilizing the vertebral bodies. The second curvature may enable the bodies to be immovably fastened to the rod in a manner that precludes the cylindrical members from contacting each other or causing a false torque condition to exist when the skeletal fixation apparatus is installed in the patient.
    Type: Application
    Filed: August 10, 2015
    Publication date: December 3, 2015
    Applicant: MUSC Foundation For Research Development
    Inventors: Bruce M. FRANKEL, Mark Evald SEMLER
  • System and method for electron spin resonance
    Patent number: 9194922
    Abstract: A resonator system for electron spin resonance (ESR) is disclosed. The resonator system comprises: a generally planar resonator layer defining an open-loop gapped by a non-conductive gap in the layer, and a microwave feed, positioned configured for transmitting microwave to the resonator layer such as to concentrate, with a quality factor of at least 100, a magnetic field within an effective volume of less than 1 nL above the layer.
    Type: Grant
    Filed: October 18, 2011
    Date of Patent: November 24, 2015
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Aharon Blank, Ygal Twig
  • CYTOTOXIC TITANIUM AND VANADIUM COMPLEXES
    Publication number: 20150329578
    Abstract: The present application provides a family of highly resistant and water-stable Titanium and Vanadium complexes, which may be administered directly without a further hydrolysis step and which solubility and cell-penetration characteristics may be modifiable by reducing their particle size to the nanoscale.
    Type: Application
    Filed: August 15, 2013
    Publication date: November 19, 2015
    Applicant: Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.
    Inventors: Edit TSHUVA, Jacob HOCHMAN
  • Cyclic peptide inhibitors of lysine-specific demethylase 1
    Patent number: 9186391
    Abstract: Provided herein are cyclic peptide inhibitors of lysine-specific demethylase 1. These cyclic peptides have the potential to treat cancer, diabetes, cardiovascular disease, and neurological disorders.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: November 17, 2015
    Assignee: MUSC Foundation for Research Development
    Inventors: Patrick M. Woster, Isuru R. Kumarasinghe
  • Method of diagnosing and treating cancer
    Patent number: 9187787
    Abstract: A method of diagnosing and treating a glioma or a breast cancer is disclosed. The method of diagnosing comprises analyzing an amount or activity of heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) in a brain or breast cell sample of the subject, wherein an up-regulation in an amount or activity of hnRNP A2/B1 beyond a predetermined threshold with respect to a control cell sample is indicative of the breast cancer or glioma. The method may also be used for staging the cancer and for predicting patient's prognosis of survival. The method of treating glioblastoma and metastatic breast cancer includes inhibiting the expression and/or activity of hnRNP A2/B1.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: November 17, 2015
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventor: Karni Rotem
  • Systems and methods for controlling electric field pulse parameters using transcranial magnetic stimulation
    Patent number: 9180305
    Abstract: A system and methods for controlling pulse parameters during transcranial magnetic stimulation are provided. Multiple coils are placed on external body parts, and are controlled using an external control unit coupled to a stimulator having fast switches. The timing of the switches, as well as other parameters within the stimulator, determine the pulse parameters, such as pulse shape. The variety of pulse shapes obtainable using such a system and methods provides controlled physiologic effects within an internal body organ.
    Type: Grant
    Filed: December 11, 2008
    Date of Patent: November 10, 2015
    Assignee: Yeda Research & Development Co. Ltd. at the Weizmann Institute of Science
    Inventors: Yiftach Roth, Abraham Zangen, Vadim Chudnovsky, Noach Safra, David Hazani
  • Aminoglycosides and uses thereof in treating genetic disorders
    Patent number: 9175029
    Abstract: A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5? position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: November 3, 2015
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Timor Baasov, Dana Atia-Glikin, Jeyakumar Kandasamy, Valery Belakhov
  • Diphtheria toxin first open reading frame operably linked to an H19 promoter and a diphtheria toxin second open reading frame operably linked to an IGF-II promoter as nucleic acid construct
    Patent number: 9173964
    Abstract: The present invention relates to the field of cancer treatment, particularly to a novel constructs useful for treating tumors expressing H19 and/or IGF-II. More specifically, the invention provides compositions and methods utilizing a nucleic acid construct enabling expression of a cytotoxic gene product directed by more than one tumor specific promoter.
    Type: Grant
    Filed: October 23, 2008
    Date of Patent: November 3, 2015
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Avraham Hochberg, Doron Amit
  • Single photon avalanche diode for CMOS circuits
    Patent number: 9178100
    Abstract: A single photon avalanche diode for use in a CMOS integrated circuit includes a deep n-well region formed above a p-type substrate and an n-well region formed above and in contact with the deep n-well region. A cathode contact is connected to the n-well region via a heavily doped n-type implant. A lightly doped region forms a guard ring around the n-well and deep n-well regions. A p-well region is adjacent to the lightly doped region. An anode contact is connected to the p-well region via a heavily doped p-type implant. The junction between the bottom of the deep n-well region and the substrate forms a multiplication region when an appropriate bias voltage is applied between the anode and cathode and the guard ring breakdown voltage is controlled with appropriate control of the lateral doping concentration gradient such that the breakdown voltage is higher than that of the multiplication region.
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: November 3, 2015
    Assignees: STMicroelectronics (Research & Development) Limited, The University Court of the University of Edinburgh
    Inventors: Eric Alexander Garner Webster, Robert Kerr Henderson
  • Pixel circuit with controlled capacitor discharge time of flight measurement
    Patent number: 9171985
    Abstract: A pixel circuit includes a single photon avalanche diode (SPAD) and a measurement circuit including a capacitance. The SPAD detects an incident photon and the measurement circuit discharges the capacitance at a known rate during a discharge time period. The length of the discharge time period is determined by the time of detection of the photon, such that the final amount of charge on the capacitance corresponds to the time of flight of the photon. The pixel circuit may be included in a time resolved imaging apparatus. A method of measuring the time of flight of a photon includes responding to an incident photon detection by discharging a capacitance at a known rate and correlating final capacitance charge to time of flight.
    Type: Grant
    Filed: October 30, 2013
    Date of Patent: October 27, 2015
    Assignee: STMicroelectronics (Research & Development) Limited
    Inventors: Neale Dutton, Robert K. Henderson
  • Method for selective preparation of fatty acid mono- and di-esters of erythritol
    Patent number: 9169191
    Abstract: The invention provides a method of preparing ?-erythritol fatty acid monoester, including: subjecting a fatty acid and erythritol to esterification reaction in the presence of an acid catalyst, a water carrier and an optional phase transfer catalyst, wherein the molar ratio of the fatty acid to erythritol is 1:2 to 1:3, and the temperature of the esterification reaction is 80-100° C. In addition, the invention further provides a method of preparing 2,3-erythritol fatty acid diester, including: subjecting a fatty acid and erythritol to esterification reaction in the presence of an acid catalyst and a water carrier, wherein the molar ratio of the fatty acid to erythritol is 2:1 to 3:1, and the temperature of the esterification reaction is 120-160° C.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: October 27, 2015
    Assignee: Wilmar (Shanghai) Biotechnology Research & Development Center Co., LTD
    Inventors: Zonghui Ma, Yan Zheng, Tiankui Yang, Xuebing Xu
  • Short asynchronous glitch
    Patent number: 9171596
    Abstract: A circuit receives a parameter signal at a set or reset input, a clock signal at a clock input and a constant digital value at a data input. A synchronous signal is output from the circuit: wherein when the parameter signal is in a first state, then the output synchronous signal has the digital value; wherein when the parameter signal transitions to a second state, then the output synchronous signal transitions to an inverse of the digital value at substantially the same time; and wherein when the parameter signal transitions back to the first state, then the output synchronous signal transitions to the digital value on a next clock edge.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: October 27, 2015
    Assignee: STMicroelectronics (Research & Development) Limited
    Inventor: Andrew James Fishleigh
  • Nuclear quadrupole resonance system
    Patent number: 9170311
    Abstract: A Nuclear Quadrupole Resonance detection system with features that include: a) slab radiating structure for the transmit path; b) reduced impedance transmit radiator; c) portal-embedded stripline couplers for receive path; d) wideband chirps each encompassing multiple simultaneous resonances; e) chirp sequencing enabling three channel architecture; f) magnetic amplification effect of ferrite-based directional couplers; g) determining position of substance within portal.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: October 27, 2015
    Assignee: AMI Research & Development, LLC
    Inventors: John T. Apostolos, William Mouyos, Brian Molen, Kurt Colon, Judy Feng, Walter Chase
  • METHODS AND COMPOSITIONS FOR MODULATION OF OLFML3 MEDIATED ANGIOGENESIS
    Publication number: 20150299306
    Abstract: The present invention relates to antibodies against specific domains of Olfml3 and the use of such in angiogenesis. In particular aspects, angiogenesis-related conditions, such as cancer, can be treated by the composition comprising the Olfml3 antagonists.
    Type: Application
    Filed: July 7, 2015
    Publication date: October 22, 2015
    Applicant: Research Development Foundation
    Inventors: Beat A. IMHOF, Marijana MILJKOVIC-LICINA, Philippe HAMMEL
  • Pseudozyma aphidis as a biocontrol agent against various plant pathogens
    Patent number: 9161545
    Abstract: Biocontrol agents are provided, which protect plant and plant material from pests and pathogens, and promote the growth of plants. Also provided are compositions comprising the same, methods for protecting plant and plant material and promoting growth in plants, and uses of said biocontrol agent in the preparation of a pesticidal composition and a growth-promoting composition.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: October 20, 2015
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Marganit Levy, Aviva Gafni
  • Travelling wave antenna feed structures
    Patent number: 9166301
    Abstract: Techniques for implementing series-fed antenna arrays with a variable dielectric waveguide. In one implementation, coupling elements with optional controlled phase shifters are placed adjacent each radiating element of the array. To avoid frequency sensitivity of the resulting array, one or more waveguides have a variable propagation constant. The variable waveguide may use certain materials exhibiting this phenomenon, or may have configurable gaps between layers. Plated-through holes and pins can control the gaps; and/or a 2-D circular or a rectangular travelling wave array of scattering elements can be used as well.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: October 20, 2015
    Assignee: AMI Research & Development, LLC
    Inventors: John T. Apostolos, Benjamin McMahon, Brian Molen, Judy Feng, William Mouyos
  • Titanium oxide-containing aluminum oxide particles based on corundum melted in an electric arc furnace from calcined alumina, and a method for the production thereof
    Patent number: 9163128
    Abstract: Titanium oxide-containing aluminum oxide particles are based on corundum melted in an electric arc furnace from calcined alumina. The particles may have an aluminum oxide content of less than 97.0% by weight, a titanium oxide content ranging from 1.3% by weight to 1.8% by weight, and a zirconium oxide content of ranging from 0.02% by weight to 0.1% by weight. The aluminum oxide particles may have an arithmetic mean compactness of less than 0.8.
    Type: Grant
    Filed: November 23, 2012
    Date of Patent: October 20, 2015
    Assignee: Center For Abrasives and Refractories Research & Development C.A.R.R.D. GmbH
    Inventors: Sebastian Sachse, Andreas Boerger, Alexander Kral
  • HIV-1 integrase derived stimulatory peptides interfering with integrase—Rev protein binding
    Patent number: 9163067
    Abstract: Isolated peptides comprising sequences derived from the protein integrase of HIV-1, as well as their analogs, mixtures, conjugates with permeability enhancing moieties, and pharmaceutical compositions are disclosed. The peptides and compositions are capable of selectively killing HIV-1 infected cells and are used in treatment of HIV infection and AIDS.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: October 20, 2015
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd
    Inventors: Aviad Levin, Zvi Hayouka, Assaf Friedler, Abraham Loyter
  • Reconstruction with partially known attenuation information in time of flight positron emission tomography
    Patent number: 9155514
    Abstract: Reconstruction in positron emission tomography is performed with partially known attenuation. A PET-CT scanner is used to generate a PET image with time of flight emission information. To limit x-ray dose while providing increased sensitivity at the ends of the CT volume in the PET image, attenuation coefficients for oblique LORs passing outside the CT volume are determined from the time of flight emission information. The attenuation coefficients for LORs within the CT volume are derived from the CT data. An objective function may be maximized for the emission distribution without reconstructing the attenuation distribution.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: October 13, 2015
    Assignees: Siemens Medical Solutions USA, Inc., Katholieke Universiteit Leuven, Leuven Research & Development, Vrije Universiteit Brussel
    Inventors: Vladimir Y Panin, Michel Defrise, Johan Nuyts
  • Methods and systems for generating a dynamic multimodal and multidimensional presentation
    Patent number: 9159168
    Abstract: A computerized method of creating a presentation of multidimensional objects in a multidimensional presentation space. The method comprises providing a core element which applies any of functions on a multidimensional object in a multidimensional presentation space, providing a plurality of adaptation components each contains instructions for converting any media object of another of different media types each to a multidimensional object in the multidimensional presentation space, receiving a media object, identifying a matching adaptation component from the adaptation components according to a respective media type of the media object, converting the media objects into a multidimensional object in the multidimensional presentation space using the matching adaptation component, and applying any of the functions on the multidimensional object, using the core element, according to a user selection.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: October 13, 2015
    Assignee: Technion Research & Development Foundation Limited
    Inventor: Gershon Elber