Patents Assigned to Research Development
  • Apparatus and method for incremental physical data clustering
    Patent number: 9058373
    Abstract: In a data storage and retrieval system wherein data arranged in nodes is stored and retrieved in pages, each page comprising a cluster of nodes, a method comprising: monitoring ongoing data retrieval to find retrieval patterns of nodes which are retrieved together and to identify changes in said retrieval patterns over time; and periodically reclustering the data nodes among said pages dynamically during usage of the data to reflect said changes, so that nodes more often retrieved together are migrated to cluster together and nodes more often required separately are migrated to cluster separately, thereby to keep small an overall number of page accesses of said data storage and retrieval system during data retrieval despite dynamic changes in patterns of data retrieval. The low number of page accesses allows the reclustering to be carried out concurrently with data access.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: June 16, 2015
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Oded Shmueli, Lila Shnaiderman
  • SYSTEMS AND METHODS FOR ANALYZING AND MANIPULATING BIOLOGICAL SAMPLES
    Publication number: 20150159191
    Abstract: A system for qualifying cells of a cell sample labeled with a magnetic or magnetizable moiety is provided. The system includes a cell sample holder for holding a cell of the cells and a first cell analyzer which includes a magnetic field source for applying a magnetic field to the cell and a sensor for qualifying and/or quantifying an effect of the magnetic field on the cell.
    Type: Application
    Filed: January 6, 2015
    Publication date: June 11, 2015
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Dan GAZIT, Boris RUBINSKY, Gadi PELLED, Zulma GAZIT
  • Combinational nuclear quadrupole resonance (NQR) and nuclear magnetic resonance (NMR) apparatus with linear frequency chirp detected signals
    Patent number: 9052371
    Abstract: A structure or method for detecting a substance using conductive surfaces. Segments of conductive wire are disposed adjacent each of the surfaces and multi-turn coils are also disposed between the two surfaces, typically such that the windings of the coils are disposed between the respective conductive wires and the surfaces. A linear chirp signal, is applied to the wire segments. With the coils deactivated, emissions from the wire induce the Nuclear Quadrupole Resonance (NQR). With the coils activated to generate a static magnetic field, emissions from the wire induce Nuclear Magnetic Resonance (NMR). As a result, the characteristics of a substance located between the conductive surfaces may be determined using either or both resonant modalties.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: June 9, 2015
    Assignee: AMI Research & Development, LLC
    Inventors: John T. Apostolos, Judy Feng, William Mouyos
  • Detection processing for NQR system
    Patent number: 9052370
    Abstract: A system that uses the nuclear quadrupole resonant effect to detect the presence of materials of interest, such as may be excited by radio frequency fields generated within a portal. Transmitted chirp signals may be processed using matching filtering and other signal processing to accurately detect the presence of such materials.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: June 9, 2015
    Assignee: AMI Research & Development, LLC
    Inventors: John T. Apostolos, Judy Feng, William Mouyos
  • Sp1 polypeptides, modified Sp1 polypeptides and uses thereof
    Patent number: 9051379
    Abstract: SP1 and modified SP1 variant polypeptides capable of forming reversible molecular associations with substances, compositions-of-matter comprising same, and uses thereof are provided.
    Type: Grant
    Filed: July 9, 2006
    Date of Patent: June 9, 2015
    Assignees: Fulcrum SP Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Amnon Wolf, Yehonathan Pouny, Ira Marton, Or Dgany, Arie Altman, Oded Shoseyov
  • Injectable combination of adrenergic receptor agonists with fillers, for decreasing skin reactions due to injection
    Patent number: 9050246
    Abstract: The present invention concerns an injectable composition comprising a filler or a botulinum toxin and an adrenergic receptor agonist, and its use for diminishing, decreasing or avoiding skin reactions due to injection, specially redness, ecchymosis, bruising, bleeding, erythema, oedema, necrosis, ulceration, swelling and/or inflammation.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: June 9, 2015
    Assignee: Galderma Research & Development
    Inventors: Isabelle Bertholon, Florence Brunel, Benjamin Herbage, Sylviane Villard
  • DEBUG CIRCUITRY
    Publication number: 20150154093
    Abstract: A debug circuitry includes a first interface configured to receive at least one operational transaction. The debug circuitry further includes a second interface configured to provide an output. Transaction manipulation circuitry operates to manipulate the at least one operational transaction to provide a manipulated operational transaction output passed to the second interface as the output.
    Type: Application
    Filed: November 24, 2014
    Publication date: June 4, 2015
    Applicant: STMicroelectronics (Research & Development) Limited
    Inventor: Gavin Probyn
  • CIRCUITRY FOR CONFIGURING ENTITIES
    Publication number: 20150154034
    Abstract: A configuration arrangement includes a first interface configured to receive configuration information from a master configuration function and a second interface configured to provide at least one output to one or more entities to be configured. Configuration circuitry operates responsive to the configuration information to provide the at least one output, wherein that output controls the configuration of the one or more entities.
    Type: Application
    Filed: November 25, 2014
    Publication date: June 4, 2015
    Applicant: STMicroelectronics (Research & Development) Limited
    Inventor: Gavin Probyn
  • Systems and methods for spectrally encoded imaging
    Patent number: 9046419
    Abstract: A method of forming an image of a target that comprises illuminating a target with light, maneuvering an optical unit having at least one diffractive element in front of the target through a plurality of positions, capturing, during the maneuvering, a plurality of spectrally encoded frames each from a portion of the light that is scattered from a different of a plurality of overlapping segments along a track traversing an image plane of the target, and combining the plurality of spectrally encoded frames to form a composite multispectral image of at least a portion of said target.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: June 2, 2015
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Dvir Yelin, Avraham Abramov
  • Methods of expanding embryonic stem cells in a suspension culture
    Patent number: 9040297
    Abstract: A method of expanding and maintaining human embryonic stem cells (ESCs) in an undifferentiated state by culturing the ESCs in a suspension culture under culturing conditions devoid of substrate adherence is provided. Also provided are a method of deriving ESC lines in the suspension culture and methods of generating lineage-specific cells from ESCs which were expanded in the suspension culture of the present invention.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: May 26, 2015
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Michal Amit, Joseph Itskovitz-Eldor
  • Shaped or unshaped refractory or kiln furniture composition
    Patent number: 9040442
    Abstract: The present description relates to a refractory composition including 70 weight percent to 98 weight percent particulate refractory material and 2 weight percent to 30 weight percent of a binder phase including reactive filler and a binder, the binder phase substantially includes solely reactive andalusite as reactive filler.
    Type: Grant
    Filed: March 20, 2012
    Date of Patent: May 26, 2015
    Assignee: Center For Abrasives and Refractories Research & Development C.A.R.R.D. GmbH
    Inventors: Xiaoyong Xiong, Michael Weissenbacher
  • Histone deacetylase inhibitor of benzamides and use thereof
    Patent number: 9040727
    Abstract: Disclosed in the present invention is a novel histone deacetylase inhibitor of benzamides and use thereof. The inhibitor has good efficacy in treating diseases caused by abnormal gene expression, such as tumors, endocrine disorders, immune system diseases, genetic diseases and nerve system diseases. The histone deacetylase inhibitor of benzamides is a compound of the following general chemical structural formula (I) or a salt thereof.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: May 26, 2015
    Assignees: Shanghai Institute of Pharmaceutical Industry, Sinopharm A-Think Pharmaceutical Co., Ltd., Sinopharm A-Think Medical and Pharmaceutical Research & Development (Beijing) Co., Ltd.
    Inventors: Jianqi Li, Qingwei Zhang, Zhidan Jia, Jiajing Wang
  • Image reconstruction in computed tomography
    Patent number: 9036885
    Abstract: A method of projection domain processing based on a local transform and shrinkage for use in reconstructing digital images from a set of projections, the method including providing a target image of a target object, providing projection data of the target object, producing filtered projection data by applying a sparsifying transform and a shrinkage function to the projection data, followed by an inverse of the sparsifying transform, producing a restored image by applying a reconstruction transform to the filtered projection data, comparing the restored image to the target image, and producing an optimized projection domain shrinkage function by adapting the shrinkage function to minimize differences between the restored image and the target image. Related apparatus and methods are also described.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: May 19, 2015
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Michael Elad, Joseph Shtok, Michael Zibulevsky
  • Bacteriostatic and anti-collagenolytic dental materials through the incorporation of polyacrylic acid modified CuI nanoparticles
    Patent number: 9034354
    Abstract: Provided are antibacterial and antimicrobial surface coatings and dental materials by utilizing the antimicrobial properties of copper chalcogenide and/or copper halide (CuQ, where Q=chalcogens including oxygen, or halogens, or nothing). An antimicrobial barrier is created by incorporation of CuQ nanoparticles of an appropriate size and at a concentration necessary and sufficient to create a unique bioelectrical environment. The unique bioelectrical environment results in biocidal effectiveness through a multi-factorial mechanism comprising a combination of the intrinsic quantum flux of copper (Cu0, Cu1+, Cu2+) ions and the high surface-to-volume electron sink facilitated by the nanoparticle. The result is the constant quantum flux of copper which manifests and establishes the antimicrobial environment preventing or inhibiting the growth of bacteria.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: May 19, 2015
    Assignees: MUSC Foundation for Research Development, Clemson University
    Inventors: Walter George Renne, Anthony Samuel Mennito, Michael Gerard Schmidt, Jompobe Vuthiganon, George Chumanov
  • Proton concentration topographies, methods and devices for producing the same
    Patent number: 9028664
    Abstract: A device for isoelectric focusing. The device comprises a focusing container configured to contain an electrolyte solution and having a longitudinal axis and at least one electrolysis unit mounted in a close proximity to the longitudinal axis. Each electrolysis unit injects an ion flow into the focusing container so as to create a pH gradient having a plurality of steps in the electrolyte solution, along the longitudinal axis. Each step has a substantially uniform pH level and the pH gradient is defined by at least one pH ramp between every two sequential steps of the plurality of steps.
    Type: Grant
    Filed: August 18, 2010
    Date of Patent: May 12, 2015
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Uri Sivan, Elad Brod
  • NQR detection from continuous Rabi transitions
    Patent number: 9030202
    Abstract: Nuclear quadrupole resonance measurement using two or more wire loop(s) within a space to define a portal, and driving the wire loop(s) with a baseband digital transmitter generating a chirped or stepped signal, to create a corresponding varying electromagnetic field within the portal. Coherent emissions reflected thereby are detected through a directional coupler feeding the transceiver. The detected coherent emissions are processed with a matched filter to determine presence of a target object within the portal.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: May 12, 2015
    Assignee: AMI Research & Development, LLC
    Inventors: John T. Apostolos, Judy Feng, William Mouyos, Benjamin McMahon
  • Methods and compositions relating to improved lentiviral vectors and their applications
    Patent number: 9023646
    Abstract: The present invention provides HIV-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy, especially, in human hematopoietic progenitor cells as well as in all other blood cell derivatives. The lentiviral vectors comprise a self-inactivating configuration for biosafety and promoters such as the EF1 ? promoter as one example. Additional promoters are also described. The vectors can also comprise additional transcription enhancing elements such as the wood chuck hepatitis virus post-transcriptional regulatory element. These vectors therefore provide useful tools for genetic treatments such as inherited and acquired lympho-hematological disorders, gene-therapies for cancers especially the hematological cancers, as well as for the study of hematopoiesis via lentivector-mediated modification of human HSCs.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: May 5, 2015
    Assignee: Research Development Foundation
    Inventors: Didier Trono, Patrick Salmon
  • Processing packet streams
    Patent number: 9026790
    Abstract: A system for processing packet streams includes a first packet queuing circuitry connected between a first processor and a second processor and operable to queue packets for transfer from the first processor to the second processor. The system includes a second packet queuing circuitry connected between the first processor and the second processor and operable to queue packets for transfer from the second processor to the first processor. The first processor is programmed to transfer secure packets to the second processor via the first queuing circuitry for security processing and the second processor is programmed to return the security-processed packets to the first processor via the second queuing circuitry.
    Type: Grant
    Filed: December 30, 2009
    Date of Patent: May 5, 2015
    Assignee: STMicroelectronics (Research & Development) Limited
    Inventors: Martin Bolton, Paul Pearson, Diarmuid Emslie
  • Compositions and methods for blocking ethylene response in plants using 3-cyclopropyl-1-enyl-propanoic acid salt
    Patent number: 9023761
    Abstract: The present invention discloses a method of inhibiting an ethylene response in a plant, comprising step of applying to at least one portion of the plant an effective ethylene response-inhibiting amount of a H1-cyclopropene-1-propanoic acid salt (CPAS). A method of prolonging the life of a cut flower, comprising applying to the cut flower an effective life-prolonging amount of CPAS and a method for the production a CPAS, comprising steps of (i) preparing 4-bromo-4-pentenoic acid or derivatives thereof; (ii) producing 1-cyclopropene-1-propanoic acid; and (iii), converting this acid into its water soluble salt, especially its sodium salt are presented. Additionally, a new family of water soluble CPAS inhibitors for ethylene response in a plant is disclosed.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: May 5, 2015
    Assignees: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., North Carolina State University
    Inventors: Raffi Goren, Akiva Apelbaum, Eliezer Goldschmidt, Moshe Huberman, Joseph Riov, Edward C. Sisler
  • Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
    Patent number: 9023348
    Abstract: A composition-of-matter comprising an antibody or antibody fragment including an antigen-binding region capable of specifically binding an antigen-presenting portion of a complex composed of a human antigen-presenting molecule and an antigen derived from a pathogen is disclosed.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: May 5, 2015
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Yoram Reiter, Cyril Cohen