Patents Assigned to Research Development
  • Fiber laser pumping configuration and method
    Patent number: 8953648
    Abstract: The invention is an apparatus and method for free space pumping of active double-clad fiber based lasers and amplifiers. The apparatus comprises a laser emitting a signal laser beam; an active double-clad fiber having a core defining an optical axis of the apparatus and a pump cladding defining a cone of numerical aperture; an optical arrangement directing the signal laser beam along the optical axis through the core of the active double-clad fiber; at least one pump source emitting a pump beam; at least one delivery means coupling the pump beam to the pump cladding of the active double-clad fiber; and an optical arrangement coupling the amplified signal laser beam exiting the active double-clad fiber out of the apparatus.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: February 10, 2015
    Assignee: Ben-Gurion University of the Negev Research & Development Authority
    Inventors: Amiel Ishaaya, Boris Shulga
  • Pharmaceutical/cosmetic, E.G., anti-acne compositions comprising at least one naphthoic acid compound, benzoyl peroxide and at least one film-forming agent
    Patent number: 8952066
    Abstract: Stable pharmaceutical/cosmetic compositions for topical application, notably for the treatment of acne vulgaris include, formulated into a physiologically acceptable medium, at least one naphthoic acid compound, benzoyl peroxide and at least one film-forming agent, the at least one naphthoic acid compound and the benzoyl peroxide advantageously being in a dispersed form therein.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: February 10, 2015
    Assignee: Galderma Research & Development
    Inventor: Claire Mallard
  • High Filler Loaded Polymer Composition
    Publication number: 20150038637
    Abstract: This disclosure relates to a polymer composition comprising (A) a first polymer; (B) one or more fillers; and optionally (C) a cross-linking pack including cross-linking agents and coagents. The first polymer comprises at least one of (i) a propylene-based copolymer and (ii) an ethylene/C3-C10 alpha-olefin copolymer. The one or more fillers comprise at least one of carbon black, ferrite magnet powder, calcium carbonate, alumina trihydrate, magnesium hydroxide, talc, titanium dioxide, fibers, marble dust, cement dust, clay, feldspar, silica or glass, fumed silica, alumina, magnesium oxide, antimony oxide, zinc oxide, barium sulfate, calcium sulfate, aluminum silicate, calcium silicate, titanium dioxide, titanates, clay, nanoclay, organo-modified clay or nanoclay, glass microspheres, chalk, or any combination thereof.
    Type: Application
    Filed: November 24, 2010
    Publication date: February 5, 2015
    Applicant: ExxonMobil Asia Pacific Research & Development Co., Ltd
    Inventors: Jun Tong, Xiao Bo Peng, Liang Li, Qi Ying
  • Apparatus and use of a neurochemisrty regulator device insertable in the cranium for the treatment of cerebral cortical disorders
    Publication number: 20150038948
    Abstract: A subarachnoid pharmacodialysis apparatus insertable under the scalp, in and under the cranium, with a relatively short and simple neurosurgical procedure, to be kept there safely implanted for a year or longer for the purpose of regulating the neurochemistry of one or more diseased cerebral cortical areas and thus to achieve therapeutic effects via both localized delivery of medication and drainage of local neurotoxic molecules across the subdural meninges and compartments in a feedback-controlled fashion, with or without the additional capability of performing localized neurochemistry regulation in subcortical areas. This apparatus is also used for neurochemical profiling of the diseased brain area or areas by analyzing the removed endogenous molecules and adjusting the composition of the delivered medication based on the patient's specific, abnormal neurochemistry within the treated area or areas.
    Type: Application
    Filed: July 31, 2013
    Publication date: February 5, 2015
    Applicant: G-Tech Electronic Research & Development, LLC
    Inventors: Nandor Ludvig, Geza Medveczky, John G. Kral, Sandor Toth
  • SKELETAL BONE FIXATION MECHANISM
    Publication number: 20150039034
    Abstract: A skeletal fixation apparatus may include two or more bodies that are attached to two or more screws that have been inserted into vertebral bodies associated with a patient. The apparatus may also include two or more cylindrical members that are attached to the bodies to control the movement or alignment of the bodies when the skeletal fixation apparatus is being installed in the patient. The apparatus may further include a rod that includes a first curvature and a second curvature. The first curvature may be different than the second curvature and may be based on a medical diagnosis associated with stabilizing the vertebral bodies. The second curvature may enable the bodies to be immovably fastened to the rod in a manner that precludes the cylindrical members from contacting each other or causing a false torque condition to exist when the skeletal fixation apparatus is installed in the patient.
    Type: Application
    Filed: August 1, 2013
    Publication date: February 5, 2015
    Applicant: MUSC Foundation for Research Development
    Inventors: Bruce M. FRANKEL, Mark Evald SEMLER
  • NOVEL ARYLATED CAMPHENES, PROCESSES FOR THEIR PREPARATION AND USES THEREOF
    Publication number: 20150038728
    Abstract: The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulation of CB2 receptors.
    Type: Application
    Filed: March 31, 2014
    Publication date: February 5, 2015
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Raphael MECHOULAM, Lital MAGID, Esther SHOHAMI, Itai BAB
  • Diagnosing, prognosing and monitoring multiple sclerosis
    Patent number: 8945935
    Abstract: The present invention provides a system and method for diagnosing, monitoring or prognosing Multiple Sclerosis at different stages as well as affording the prediction of disease activity and response to a treatment regimen, using at least one sensor comprising carbon nanotubes or metal nanoparticles, each coated with various organic coatings in conjunction with a pattern recognition algorithm.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: February 3, 2015
    Assignees: Technion Research & Development Foundation Ltd., Mor Research Applications Ltd., Rappaport Family Institute for Research in the Medical Sciences
    Inventors: Hossam Haick, Ariel Miller
  • Methods and systems for producing a video synopsis using clustering
    Patent number: 8949235
    Abstract: Computer-implemented method, system, and techniques for summarization, searching, and indexing of video are provided, wherein data related to objects detected in the video in a selected time interval is received and the objects are clustered into clusters such that each cluster includes objects that are similar in respect to a selected feature or a combination of features. A video summary is generated based on the computed clusters.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: February 3, 2015
    Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
    Inventors: Shmuel Peleg, Yael Pritch, Sarit Ratovitch, Avishai Hendel
  • Medium comprising transforming growth factor ?and basic fibroblast growth factor
    Patent number: 8945925
    Abstract: The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: February 3, 2015
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Michal Amit, Joseph Itskovitz-Eldor
  • Method and system of managing and/or monitoring distributed computing based on geometric constraints
    Patent number: 8949409
    Abstract: A method for managing distributed computing. The method comprises estimating, for each of a plurality of local computing nodes, a distribution of multidimensional values in a space. Each multidimensional value is calculated according to a plurality of locally monitored parameters. The method further includes calculating safe zones in the space where each safe zone is defined according to a respective estimated distribution under a global geometric constraint in the space and setting local geometric constraints for the local computing nodes according to the respective safe zones. Each local geometric constraint is defined such that a detection of at least one monitored multidimensional value violating it by a respective local computing node induces a communication event between the respective local computing node and one or more central computing nodes.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: February 3, 2015
    Assignees: Technion Research & Development Foundation Limited, Carmel-Haifa University Economic Corporation Ltd.
    Inventors: Assaf Schuster, Daniel Keren, Guy Sagy, Izchak Sherfman
  • Electrochemical detection of capsaicinoid compounds in a sample
    Patent number: 8945370
    Abstract: An electrochemical method for capsaicinoid and/or related compound detection in a sample by way of a screen printed electrode having a working electrode, a reference electrode, and a counter electrode. The working electrode can be screen-printed using conductive carbon ink; the reference electrode can be screen printed using conductive carbon ink; and the counter electrode can be screen printed using silver/silver chloride. The method includes contacting the electrode with the sample in the presence of electrolyte solution, and determining whether a change in redox potential occurs by way of differential pulse voltammetry, wherein a modulation amplitude is between approximately 0.1 volt/min and approximately 2.0 volt/min, a step potential is between approximately 0.0005 volt and approximately 0.01 volt, a modulation time is 0.05 seconds, and a corresponding interval time is approximately 0.5 second.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: February 3, 2015
    Assignee: Agricultural Research Development Agency
    Inventors: Werasak Surareungchai, Chatuporn Phanthong
  • Method for engineering proteases and protein kinases
    Patent number: 8945855
    Abstract: Provided are methods for protein engineering, such as engineering proteases or kinases. The methods may utilize yeast display and/or ER sequestration of proteins or substrates. In some aspects, TEV proteases with altered substrate specificity, potency, and/or efficiency are provided.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: February 3, 2015
    Assignee: Research Development Foundation
    Inventors: Brent L. Iverson, George Georgiou, Joseph M. Taft, Li Yi
  • Methods and kits for ascertaining biosafety of an agent
    Patent number: 8945847
    Abstract: A method of ascertaining the bio-safety of an agent is disclosed.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: February 3, 2015
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Nissim Benvenisty, Yoav Mayshar, Ofra Yanuka
  • Image sensors for establishing an image sharpness value
    Patent number: 8941744
    Abstract: A method of compensating for camera shake includes reading a sequential series of images from an image sensing array, establishing a sharpness value for each of the sequential series of images, and performing an image selection based upon each sharpness value. The sharpness value is calculated for each image of the sequential series thereof during the reading.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: January 27, 2015
    Assignee: STMicroelectronics (Research & Development) Limited
    Inventors: Stuart McLeod, Ed Duncan
  • Dermatological compositions comprising at least one naphthoic acid compound and at least one film-forming agent and treatment of keratinization disorders therewith
    Patent number: 8937098
    Abstract: Topically applicable, reduced-irritant dermatological/cosmetic compositions useful for the treatment of a variety of keratinization disorders, for example acne vulgaris, contain at least one naphthoic acid compound essentially uniformly distributed therethrough and an amount of at least one hydrophilic film-forming agent, formulated into a topically applicable, physiologically acceptable medium.
    Type: Grant
    Filed: November 24, 2008
    Date of Patent: January 20, 2015
    Assignee: Galderma Research & Development
    Inventors: Claire Mallard, Eve Ferrara
  • Gel composition for treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt
    Patent number: 8936800
    Abstract: Dermatological/cosmetic compositions suited for preventing or treating cell differentiation and/or proliferation and/or keratinization disorders, including preventing or treating common acne, comprise, in a physiologically acceptable medium, (i) at least one dispersed retinoid, (ii) dispersed benzoyl peroxide, in free or encapsulated form, and (iii) at least one pH-independent gelling agent, selected from the group consisting of (a) polyacrylamide gelling agents, (b) gelling agents which are acrylic polymers coupled to hydrophobic chains, (c) modified starch gelling agents, and mixture thereof, said composition maintaining good chemical stability of (i) and (ii) without their degradation over time at a temperature of between 4° C. and 40° C.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: January 20, 2015
    Assignee: Galderma Research & Development
    Inventors: Sandrine Orsoni, Nathalie Willcox
  • COATING LAYERS OF A NANOCOMPOSITE COMPRISING A NANO-CELLULOSE MATERIAL AND NANOPARTICLES
    Publication number: 20150017432
    Abstract: The invention provides articles and methods for making such articles including a substrate coated on at least one region thereof with a layer of nanocomposites nano-cellulose materials and nanoparticles.
    Type: Application
    Filed: March 6, 2013
    Publication date: January 15, 2015
    Applicant: Yissum Research Development Company of the Herbrew University of Jerasalem Ltd.
    Inventors: Oded Shoseyov, Yossef Paltiel, Shira Yochelis, Sigal Baruch-Sharon, Yuval Nevo
  • Liposomal compositions of glucocorticoid and glucocorticoid derivatives
    Patent number: 8932627
    Abstract: The present invention provides pharmaceutical compositions comprising a glucocorticoid or glucocorticoid derivative stably encapsulated in a liposome. The glucocorticoid or glucocorticoid derivative is selected from an amphipathic weak base glucocorticoid or glucocorticoid derivative having a pKa equal or below 11 and a logD at pH 7 in the range between ?2.5 and 1.5; or an amphipathic weak acid GC or GC derivative having a pKa above 3.5 and a logD at pH 7 in the range between ?2.5 and 1.5. The therapeutic effect of the pharmaceutical composition of the invention was exhibited in vivo with appropriate models of multiple sclerosis and cancer.
    Type: Grant
    Filed: September 11, 2005
    Date of Patent: January 13, 2015
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Yechezkel Barenholz, Alberto A. Gabizon, Yuval Avnir
  • Hydrocolloid carrier beads with inert filler material
    Patent number: 8932634
    Abstract: This invention discloses carrier beads comprising a hydrocolloid polymer comprising at least one inert filler material, wherein the at least one filler material provides improved properties including increased mechanical strength and/or reduced porosity relative to a bead without said at least one filler. The beads are useful per se or for delivery of active agents. Methods for preparation of the beads and the uses thereof are described particularly for controlling the rate of release an active agent from said bead.
    Type: Grant
    Filed: June 17, 2007
    Date of Patent: January 13, 2015
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd
    Inventors: Amos Nussinovich, Avi Gal
  • VESSEL IMAGING SYSTEM AND METHOD
    Publication number: 20150011896
    Abstract: A method for locating a vessel, the method comprising illuminating at least a portion of the vessel with a background light having a substantially high susceptibility to absorption by particles in said portion of the vessel; detecting backscattered light from said illuminated portion of the vessel; reproducing an image from said backscattered light; and identifying dark regions within said reproduced image.
    Type: Application
    Filed: January 17, 2013
    Publication date: January 8, 2015
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Dvir Yelin, Lior Golan