Patents Assigned to Research Development
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Patent number: 5658949Abstract: A novel method of inhibiting production of two important mediators of cellular function, tumor necrosis factor and nitric oxide, and treating a pathophysiological state characterized by an undesirable production or level of tumor necrosis factor or nitric acid. The methods of the present invention employ retinoic acid compounds. The most preferred retinoic acid is all-trans-retinoic acid. Also provided is a method of inhibiting tumor necrosis factor receptors using retinoic acid-like compounds.Type: GrantFiled: November 30, 1994Date of Patent: August 19, 1997Assignee: Research Development FoundationInventor: Bharat B. Aggarwal
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Patent number: 5657631Abstract: An injector for turbine engines which includes a shaped injector core fitted with an eccentric spinner inlet communicating with a cylindrical, annular fuel spinner chamber and a preheater or evaporator for preheating and vaporizing fuel, wherein the vaporized fuel is eccentrically injected into the fuel spinner chamber to effect a spinning fuel sequence around a fuel guidance pin extending through the center of the fuel spinner chamber. Compressed air from the turbine compressors flows through the primary nozzle of an air guidance nozzle surrounding the injector core into a shaped secondary nozzle, where the air mixes with the spinning fuel at a selected air flow angle to facilitate thorough mixing of the fuel and air as the combustible mixture is channeled into the annular turbine combustor.Type: GrantFiled: March 13, 1995Date of Patent: August 19, 1997Assignee: B.B.A. Research & Development, Inc.Inventor: Denis V. Androsov
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Patent number: 5656501Abstract: A flow cell for monitoring blood or any other cell suspension under flow prises a rigid transparent base having a pair of holes with inlets and outlets. One hole transfers the cell suspension from a supply to a flow channel and the other hole transfers the tested suspension back from the flow channel to a receiver. A flow plate is sandwiched between the base and a transparent plate. The flow channel is a wide hole in the middle of the flow channel plate which can be an integral part of either the base or the transparent plate. The transparent plate covers the flow channel plate and a rigid cover covers the transparent plate with a hole enabling a microscope objective to approach the flow channel plate. The transparent plate and the cover are attached to each other firmly by any conventional method or the transparent plate can be an integral part of the cover.Type: GrantFiled: June 6, 1995Date of Patent: August 12, 1997Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Saul Yedgar, Benjamin Gavish, Shuqi Chen
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Patent number: 5653216Abstract: A toy rocket launcher (100) is disclosed for launching a rocket (125) having a fuselage (126) with an elongated tail bore (127) extending from a tail end thereof. The rocket launcher has a launch tube (108) adapted to hold and maintain a selected, elevated pressure level. The launch tube has an opening (109) therein and a valve for controlling the flow of pressurized air flowing from the launch tube through the opening. The launcher also includes a pump (103) for pressurizing the launch tube and a trigger (104) for controlling the launch tube valve.Type: GrantFiled: March 20, 1995Date of Patent: August 5, 1997Assignee: Johnson Research & Development Co, Inc.Inventor: Lonnie G. Johnson
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Patent number: 5653256Abstract: A simplified fluid pressure charge valve assembly for a pressurized mechanical refrigeration system that may be assembled to a housing portion for an automotive air conditioning system including a unitary valve stem adapted to be secured to the housing and having an internal chamber for receiving a cartridge-type valve wherein the cartridge-type valve is secured in place in the valve stem cavity and sealed against internal walls of the valve stem without the necessity for providing internal threads in the valve stem, thereby reducing variable costs in the manufacture of the assembly and simplifying assembly procedure.Type: GrantFiled: September 28, 1995Date of Patent: August 5, 1997Assignee: Nissan Research & Development, Inc.Inventors: John Myers, John Rogers
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Patent number: 5654169Abstract: The invention relates to an expression vector, the nucleic acid sequence of which comprises a promoter that is capable of controlling, when the vector is in a bacterial host and the temperature is lowered to below about 20.degree. C., the production of recombinant peptide or protein encoded by a gene contained within the vector. The invention also relates to host cells containing the vectors and to a method of producing a recombinant protein.Type: GrantFiled: July 21, 1994Date of Patent: August 5, 1997Assignee: Yissum Research & Development Company of the Hebrew UniversityInventors: Amos B. Oppenheim, Hilla Giladi, Daniel Goldenberg, Simi Koby, Idit Azar
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Patent number: 5650316Abstract: The present invention provides novel methods of treating anti-neoplastic and non-neoplastic cell proliferative diseases. The present methods involve administration of triplex forming oligonucleotides to humans to inhibit the biological activity of tumor necrosis factor. Also provided are methods of treating neuro-oncologic states and renal cancer.Type: GrantFiled: June 6, 1994Date of Patent: July 22, 1997Assignee: Research Development FoundationInventors: Bharat B. Aggarwal, Robert F. Rando, Michael E. Hogan
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Patent number: 5650311Abstract: A metod is proposed of obtaining a chemical interaction between at least one reagent trapped in sol-gel glass by doping it with the reagent(s), and diffusible solutes or components in an adjacent liquid or gas phase. The reagents, the solutes or the components can be any organic or inorganic compounds or materials of biological origins including enzymes. The doped sol-gel glass in various forms may be useful as analytical test, chromatographic medium, sensor, catalyst or biocatalyst, electrode or enzyme electrode, or other detection device.Type: GrantFiled: June 28, 1994Date of Patent: July 22, 1997Assignee: Yissum, Research Development Company of the Hebrew University of Jerusalem, IsraelInventors: David Avnir, Michael Ottolenghi, Sergei Braun, Rivka Zusman
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Patent number: 5650175Abstract: The invention relates to an anti-inflammatory factor isolated from milk, methods of purifying the anti-inflammatory factor resulting in substantially or highly purified preparations and to methods for using this factor to remove adhered neutrophils from endothelial cells, to prevent the emigration of cells from the vasculature and to suppress the response of lymphocytes to foreign antigens.Type: GrantFiled: October 3, 1994Date of Patent: July 22, 1997Assignee: Stolle Research & Development CorporationInventors: Lee R. Beck, J. Peter Fuhrer
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Patent number: 5650043Abstract: A silicon substrate is etched by dipping it in a NH.sub.4 F solution while charging it with a potential more negative than an open-circuit potential. The NH.sub.4 F solution preferably has NH.sub.4 F concentration of 10M or less. The potential applied to the silicon substrate is controlled within the range of from the open-circuit potential to a more negative potential by -1.5 V vs. SCE. Since the etched silicon substrate has flatness in atomic order, it is suitable for the precise fabrications to manufacture high-density ir high-functional semiconductor devices.Type: GrantFiled: May 25, 1995Date of Patent: July 22, 1997Assignees: Research Development Corporation of Japan, Kazutoshi Kaji, Toshihiko SakuharaInventors: Kazutoshi Kaji, Shueh Lin Yau, Kingo Itaya, Toshihiko Sakuhara
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Patent number: 5648399Abstract: The invention relates to methods for the treatment of gingivitis, oral plaque and oral or dermatological fungal infections by the administration of a liquid methacrylic acid copolymer composition that contains a release adjusting agent and a pharmacological agent. The composition forms a solid film upon drying, and is capable of accomplishing the sustained release of the pharmacological agent such as to permit its use in the treatment or prevention of dental or dermatological conditions.Type: GrantFiled: April 25, 1995Date of Patent: July 15, 1997Assignees: Perio Products, Ltd., Yissum Research Development Company of the Hebrew University of JerusalemInventors: Michael Friedman, Amnon Sintov
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Patent number: 5648056Abstract: A fullerene composite comprises a matrix formed of ultrafine fullerene such as, for example, C.sub.60 crystallite having diameters in the range of from 5 to 50 nm and a reinforcing member formed of a mixture consisting of carbon nanotubes, carbon nanocapsules, and inevitable indeterminate carbonaceous impurities and incorporated in the matrix. The amount of the reinforcing member incorporated in the matrix is in the range of from 15 to 45% by weight based on the amount of the matrix. Owing to the use of the reinforcing member which contains carbon nanotubes and carbon nanocapsules, the produced fullerene composite is enabled to acquire improved mechanical strength and resistance to deformation, and the wide applicabilities are endowed with fullerene composites.Type: GrantFiled: April 25, 1995Date of Patent: July 15, 1997Assignees: Research Development Corporation of Japan, Shun-ichiro TanakaInventor: Shun-ichiro Tanaka
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Patent number: 5648915Abstract: A system for assessing damage to a simulated human skin includes a mask formed of an opaque material simulating human skin and having an outer surface in a shape simulating a human body part, such as a face, and a form formed of a rigid transparent material and having an outer surface in a shape of the mask for releasably retaining the mask. A light source is positioned behind the form for transmitting light through any laceration in the mask and a camera views the outer surface of the mask and generates an output signal representing an image of at least a portion the outer surface of the mask including any lacerations. A housing encloses the form, the light source and the camera to prevent light exterior to the housing from being viewed by the camera. A computer is responsive to the camera output signal for detecting and measuring a laceration in the mask, and for assigning an injury criteria to the laceration.Type: GrantFiled: November 20, 1995Date of Patent: July 15, 1997Assignee: Triangle research & Development CorporationInventors: Richard A. McKinney, Donald R. Myers, Barbara J. McKinney, David B. Moody, Joseph G. Smrcka, deceased, John J. Smrcka, executor, Joshua Y. Zhu, Daniel P. Weeder
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Patent number: 5648252Abstract: A supported polyionic hydrogel containing biologically active material is epared by impregnating into a porous support material a solution of anionic polysaccharide, a solution of cationic polysaccharide and a biologically active material. The anionic polysaccharide and the cationic polysaccharide react with each other to form a hydrogel containing the biologically active material. The hydrogel may be dried such as by lyophilization. The biologically active material can be in either polysaccharide solution or in another solution impregnated into the porous support material. A paper material or a textile material may be used as the porous support material. Preferably, the anionic polysaccharide is xanthan, dicarboxystarch or dicarboxycellulose and the cationic polysaccharide is chitosan. Especially preferred is a hydrogel formed from xanthan and chitosan.Type: GrantFiled: March 22, 1995Date of Patent: July 15, 1997Assignees: Israel Fiber Institute State of Israel Ministry of Industry and Trade, Yissum Research Development Company of the University of JerusalemInventors: Severian Dumitriu, Itzhak Kahane, Hilda Guttmann
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Patent number: 5646951Abstract: A method of using a distributed saturable absorber added to a laser cavity, which by nonlinear wave-mixing of the counterpropagating beams (or spatial hole-burning) promotes a reduction of the linewidth and a single mode operation.Type: GrantFiled: March 21, 1995Date of Patent: July 8, 1997Assignee: Technion Research & Development Foundation Ltd.Inventors: Baruch Fischer, Ron Daisy, Moshe Horowitz
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Patent number: 5645836Abstract: The present invention provides a novel anti-AIDS immunotoxin. The immunotoxin comprises a toxin chemically conjugated to a monoclonal antibody directed against vital reverse transcriptase. Also provided are various methods of using this novel including methods of treating various diseases.Type: GrantFiled: April 14, 1995Date of Patent: July 8, 1997Assignee: Research Development FoundationInventor: George Barrie Kitto
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Patent number: 5645426Abstract: A prophy angle having a single improved snap-in mounting shaft having an enlarged snap-through outer boss portion that is discontinuous in circumference for retaining the prophy cup rotor in permanent position and isolating the rotor from frictionally engaging other parts other than through the gearing except under stress, a press fit drive shaft retention locking sleeve that frictionally engages the housing when pressed into locking position, a reduction of the surface contact of the drive shaft with the inside of the housing by introducing vanes in contact with the housing wall rather than a continuous cylinder contact, and a closed vent hole with a hub on the drive shaft.Type: GrantFiled: September 27, 1995Date of Patent: July 8, 1997Assignee: Dentsply Research & Development Corp.Inventors: Carlton L. Grim, David B. Schumaker
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Patent number: 5645429Abstract: A method is provided for clinical retention of restorative material by a natural tooth. A first portion of photopolymerizable liquid primer/adhesive dental composition is applied to a tooth surface. After leaving the first portion of the liquid composition on the tooth surface undisturbed for at least 15 seconds on the tooth surface air is conveyed against the first portion of the liquid. The light is impinged on the first portion of the liquid composition whereby at least a portion of the first portion of the liquid composition polymerizes to form a first coating on the tooth. A second portion of the liquid composition is applied to the first coating, and air is substantially immediately conveyed to the second portion of the liquid composition.Type: GrantFiled: May 3, 1996Date of Patent: July 8, 1997Assignee: Dentsply Research & Development Corp.Inventors: Gordon Blackwell, Chin-Teh Huang, Steven Jefferies
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Patent number: 5643447Abstract: The invention provides a planar chromatographic plate comprising a supported homogeneous thin porous film of ceramic material produced by sol-gel technology the film being provided with a porous network enabling elution through the film whereby planar chromatographic separation of chemicals or biochemicals can be carried out therewith.Type: GrantFiled: January 20, 1995Date of Patent: July 1, 1997Assignee: Yissum Research Developement Company of the Hebrew University of JerusalemInventors: Ovadia Lev, Michael Tsionsky
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Patent number: 5643192Abstract: A fibrin glue includes a fibrinogen component and a thrombin component, both prepared from single donor plasma. The plasma is precipitated to produce a precipitate containing fibrinogen and a supernatant containing the thrombin. The precipitate may be resuspended in a small volume of supernatant and used as the fibrinogen component. The supernatant is further treated by clotting to convert residual fibrinogen to fibrin and filtration to remove the fibrin. The resulting serum can be used as the thrombin component.Type: GrantFiled: April 6, 1995Date of Patent: July 1, 1997Assignee: Hamilton Civic Hospitals Research Development, Inc.Inventors: Jack Hirsh, Marilyn Johnston, Kevin Teoh