Patents Assigned to Research Development
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Patent number: 5563815Abstract: A digital tone generator includes a modulo adder, an increment number register, two latches and a master clock. The adder continuously adds one of a plurality of predefined increment numbers with the adder's previously generated sums to create further sums and a carry output corresponding to one of a plurality of predetermined output tone frequencies. The system characteristics and increment numbers are selected to correspond to the predetermined frequencies and generate exact tonal frequency signals. The system characteristics and increment numbers are defined using a formula which accounts for the least common multiple of the rational number representation of the predetermined frequencies. In the preferred embodiment, the digital tone generator is used to select and generate one of a plurality of time code tones.Type: GrantFiled: July 21, 1995Date of Patent: October 8, 1996Assignee: Fostex Research & Development, Inc.Inventor: Cameron W. Jones
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Patent number: 5563173Abstract: The present invention provides a method of inhibiting the proliferation of smooth muscle cells comprising the step of contacting said cells with a pharmacologically effective amount of sodium butyrate.Type: GrantFiled: December 22, 1994Date of Patent: October 8, 1996Assignee: Research Development FoundationInventors: Frank M. Yatsu, Kasturi Ranganna
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Patent number: 5560912Abstract: The invention relates to the use of an organic extract of the plant Cinnamon or a chemical constituent present in said plant, to prepare a pharmaceutical composition useful to inhibit the growth of Helicobacter pylori and the urease activity of Helicobacter pylori. Most preferred chemical constituents are cinnamaldehyde and methoxycinnamaldehyde. The extract may be used either as a drink, with or without additional flavoring ingredients or transformed into a capsule. The invention also relates to in-vitro method for determininig the inhibition of urease activity of Helicobacter pylori using said organic extract of the plant or chemical constituents present in said plant.Type: GrantFiled: June 27, 1994Date of Patent: October 1, 1996Assignee: Technion Research & Development Foundation Ltd.Inventors: Itzhak Neeman, Mina Tabak, Robert Armon
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Patent number: 5558069Abstract: An apparatus and method for cooling or heating fluids, such as fuel in a fuel system of an automotive vehicle. Compressed gas is delivered to a vortex tube or air amplifier 14 so that the gas rapidly expands and cools, thereby cooling a first end 16 of the vortex tube 14 in relation to a warmer second end thereof 18. A first fuel inlet port 20 of a first heat exchanger 16 lies proximate the first end 16 so that fuel flowing into the inlet port 20 is cooled by thermal contact with the first end 16 of the vortex tube 14. A cooled fuel outlet port 22 in the heat exchanger 16 lies proximate the first end 16 so that cooled fuel may leave the heat exchanger 16 for delivery to an engine. A valve with an upstream gate 26 and two downstream gates 28,30 is located so that fuel is selectively delivered to the first fuel inlet port 20 through the upstream gate 26 and one of the two downstream gates 28,30 if cooling of the fuel is desired.Type: GrantFiled: November 9, 1995Date of Patent: September 24, 1996Assignee: Livernois Research & Development CompanyInventor: Kevin E. Stay
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Patent number: 5557959Abstract: A die transfer system for transferring workpieces through successive die stations in a stamping press includes an enlongated finger bar having spaced fingers for engaging workpices at successive die stations, a first drive mechanism for reociprocating the finger bar longitudinally for transferring workpieces between successive die stations, and a second drive mechanism for reciprocating the finger bar laterally into and out of engagment with the workpieces at the die stations. The second drive mechanism has at least two finger bar drive modules coupled to the finger bar and spaced from each other lengthwise of the finger bar. A drive shaft extends between and interconnects the two drive modules. Each of the drive modules has a crank arm coupled to the drive shaft for rotating the crank arm about an axis parallel the finger bar. A cam plate is coupled to the finger bar and mounted for movement lateral to the crank arm axis and the finger bar.Type: GrantFiled: July 25, 1994Date of Patent: September 24, 1996Assignee: Livernois Research & Development CompanyInventors: Bernard J. Wallis, Sabatino A. Bianchi
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Patent number: 5556528Abstract: Devices are useful to capture or dispense target molecules and include an electric field-responsive valve unit. The valve unit includes an active control structure having at least one monomolecular layer and being up to about 10 nm thick. The active control structure is formed by a majority of molecular species with a dipolar moment greater than about 5 Debye, and operable in response to an electric field at a threshold value. A particularly preferred embodiment has the active control structure carried on a microporous membrane with pores in the nanometer range. Applications for inventive embodiments include drug delivery and target molecule capture during electrophoresis separations.Type: GrantFiled: May 10, 1994Date of Patent: September 17, 1996Assignee: Biotechnology Research & Development CorporationInventors: Paul W. Bohn, Wenyuan Lu
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Patent number: 5554665Abstract: A method of forming dental products, such as dentures, denture relines, dental crowns, dental bridges and dental restorative materials, temporary crown, temporary bridge, provisional crown or provisional bridge, from two polymerizable paste compositions each having a complimentary component of a free radical catalyst system and a polymerizable acrylic compound. One of these paste compositions includes an oxidizing agent and a stabilizer and the other includes a reducing agent as components of a redox catalyst system for free radical polymerization. These paste compositions are mixed in a static mixer to form a polymerizing paste composition, which is then shaped into a dental prosthesis. A handheld mixing dispenser useful in carrying out this method, includes a static mixing conduit, and two containers enclosing the polymerizable paste compositions. The static mixing conduit encloses a static mixing member. The containers are adapted to be connected in fluid flow communication with the static mixing conduit.Type: GrantFiled: April 28, 1995Date of Patent: September 10, 1996Assignee: Dentsply Research & Development Corp.Inventors: Louis H. Tateosian, Scott E. Shaffer, Mark A. Latta
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Patent number: 5554028Abstract: A method of preparing an impression of dentition in the oral cavity is provided that overcomes a problem of transfer of inhibitors left by latex gloves that interfere with platinum catalyzed hydrosilation reactions. The method involves applying a surfactant, preferably with peroxide, to the area that is to have its impression taken substantially immediately before applying the impression taking material, rinsing the composition from the area and proceeding with the taking of the dental impression. Preferably the decontaminating composition consists essentially of surfactant, especially polyoxyethylene surfactants, hydrogen peroxide and water.Type: GrantFiled: March 24, 1994Date of Patent: September 10, 1996Assignee: Dentsply Research & Development Corp.Inventors: Robert V. Hare, Paul D. Hammesfahr
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Patent number: 5554514Abstract: Human interferon-beta.sub.2.sbsb.A and interferon-beta.sub.2.sbsb.B are produced in purified form by recombinant DNA techniques. Two separate human genes have been identified which code for the production of IFN-.beta..sub.2.sbsb.A and IFN-.beta..sub.2.sbsb.B, respectively. The sequence of IFN-.beta..sub.2.sbsb.A cDNA is established. These genes and cDNA have been cloned into mammalian cells with an SV40 early promoter sequence and such genomic clones are capable of producing IFN-.beta..sub.2.sbsb.A and IFN-.beta..sub.2.sbsb.B. The antiviral activity of such recombinant IFN-.beta..sub.2.sbsb.A and IFN-.beta..sub.2.sbsb.B is demonstrated as well as other biological activity identifying them as human interferons.Type: GrantFiled: February 19, 1991Date of Patent: September 10, 1996Assignee: Yeda Research & Development Co. Ltd.Inventors: Michel Revel, Asher Zilberstein
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Patent number: 5554513Abstract: Human interferon-beta.sub.2.sbsb.A and interferon-beta.sub.2.sbsb.B are produced in purified form by recombinant DNA techniques. Two separate human genes have been identified which code for the production of IFN-.beta..sub.2.sbsb.A and IFN-.beta..sub.2.sbsb.B, respectively. The sequence of IFN-.beta..sub.2.sbsb.A cDNA is established. These genes and cDNA have been cloned into mammalian cells with an SV40 early promoter sequence and such genomic clones are capable of producing IFN-.beta..sub.2.sbsb.A and IFN-.beta..sub.2.sbsb.B. The anti-viral activity of such recombinant IFN-.beta..sub.2.sbsb.A and IFN-.beta..sub.2.sbsb.B is demonstrated as well as other biological activity identifying them as human interferons.Type: GrantFiled: December 12, 1989Date of Patent: September 10, 1996Assignee: Yeda Research & Development Co. Ltd.Inventors: Michel Revel, Asher Zilberstein
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Patent number: 5552139Abstract: A method for the biological control of pollen in plants, including the thinning of fruits, reducing seeds in citrus plants and reducing the incidence of shotberries in grapes, by applying an effective amount of activated or inactivated RNase or mixtures of these to the flowers of the plants.Type: GrantFiled: November 4, 1993Date of Patent: September 3, 1996Assignee: Yissum Research Development Co. of the Hebrew University of JerusalemInventors: Oded Shoseyov, Levava Roiz, Uzi Ozeri, Ben-Ami Bravdo, Raphael Goren
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Patent number: 5552376Abstract: Powder having a composition in which the contents of Sr, Ca and Cu are increased so that an Sr-Ca-Cu-O phase is precipitated in addition to a 2223 phase of (Bi, Pb)-Sr-Ca-Cu is charged in a metal sheath, and this metal sheath is plastic-worked, then subjected to a primary heat treatment, then plastic-worked and further subjected to a secondary heat treatment. In the as-obtained bismuth oxide superconducting wire, pinning points based on the Sr-Ca-Cu-O phase are introduced into the superconductor, whereby magnetic field characteristic of the critical current density is improved.Type: GrantFiled: November 28, 1994Date of Patent: September 3, 1996Assignees: Sumitomo Electric Industries, Ltd., Director General of National Research Institute for Metals of Science and Technology Agency of Japan, Research Development Corporation of JapanInventors: Takeshi Kato, Kenichi Sato
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Patent number: 5550024Abstract: Disclosed herein are genetic markers for pig litter size, methods for identifying such markers, and methods of screening pigs to determine those more likely to produce larger litters and preferably selecting those pigs for future breeding purposes based on the ESR polymorphisms. The markers are based upon the presence or absence of certain polymorphisms in the pig estrogen receptor gene. Preferably, the polymorphism is a restriction fragment length polymorphism (RFLP).Type: GrantFiled: September 26, 1994Date of Patent: August 27, 1996Assignees: Biotechnology Research & Development Corporation, Iowa State University Research Foundation, Inc.Inventors: Max F. Rothschild, Christopher K. Tuggle, Carol D. Jacobson, David A. Vaske, Alan J. Mileham, Graham S. Plastow
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Patent number: 5550020Abstract: Reliable and cost effective testing for mutations in the RB1 gene can be accomplished by quantitatively amplifying exons of the sample RB1 gene using primers complementary to intron regions flanking each exon; and then determining the lengths and/or quantities of the amplification products for each exon and comparing that length or quantity to the length or quantity of amplification products obtained when a wild-type RB1 gene is amplified using the same primers. Differences in length between an amplified sample exon and the corresponding amplified wild-type exon reflect the occurrence of an insertion or deletion mutation in the sample RB1 gene. Differences in quantity reflect the complete absence of an exon, or heterozygosity for a mutant exon. Next, the nucleic acid sequence of each exon found to contain an insertion or deletion mutation is determined, or of all exons in the event no insertion or deletion mutations are identified.Type: GrantFiled: July 8, 1994Date of Patent: August 27, 1996Assignees: Visible Genetics Inc., HSC Research & DevelopmentInventors: Brenda L. Gallie, James M. Dunn, John K. Stevens
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Patent number: 5549497Abstract: A rocket (100) is disclosed having a body (101) with a bay (102) therein and a hatch (109) which is movable between a bay opened position and a bay closed position by a spring biased hinge (110). The hatch is pivotally coupled to a nose section (104) by a spring biased hinge (11). The hatch is configured to be engaged and disengaged with a catch (118) mounted to the rocket body. With the initial forward movement of the launched rocket the inertia and/or the force of the wind upon the nose section causes the disengagement of the catch whereby the continued movement of the rocket creates a wind upon the nose section which maintains the hatch in its bay closed position.Type: GrantFiled: March 30, 1995Date of Patent: August 27, 1996Assignee: Johnson Research Development Company, Inc.Inventors: Lonnie G. Johnson, John Applewhite
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Patent number: 5549903Abstract: The present invention relates to a microencapsulated chlorpyrifos or endosulfan composition comprising a polyurea shell and one or more photostable ultraviolet and visible light absorbent compound having a log molar extinction coefficient of from about 2 to 5 with respect to radiation having wave lengths in the range of about 310 to 450 nanometers, wherein said photostable ultraviolet and visible light absorbent compound does not react with the monomer used in building the polyurea shell. The result is a microencapsulated composition having unexpected long, extended insecticidal activity with high toxicity to target species and very low toxicity to non-target animals.Type: GrantFiled: July 28, 1994Date of Patent: August 27, 1996Assignee: Ben Gurion University of Negev Research & Development AurthorityInventor: Arie Marcus
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Patent number: 5543166Abstract: A cooking appliance includes a drum for receiving the food articles to be cooked and formed with a plurality of openings smaller than the size of the food articles. The drum is rotatably mounted about a horizontal axis in the cooking compartment of the appliance such that only the lower part of the drum is immersed in the hot liquid therein, e.g., a frying oil. Also described is a method of frying food articles which includes immersing the bottom of a drum, having the food articles therein, in a quantity of hot cooking oil, and rotating the drum such that the food articles tumble into and out of the cooking oil to cause the food articles to become fried to a crisp without absorbing significant quantities of the cooking oil.Type: GrantFiled: May 20, 1994Date of Patent: August 6, 1996Assignee: M V Research & DevelopmentInventors: Ruben Masel, George Valdshtein
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Patent number: 5543399Abstract: A substantially homogeneous protein having cystic fibrosis transmembrane conductance regulator activity is provided. Also provided is a therapeutically effective composition for treating a subject having cystic fibrosis.Type: GrantFiled: October 13, 1994Date of Patent: August 6, 1996Assignee: HSC Research & Development Limited PartnershipInventors: John R. Riordan, Christine E. Bear, Mohabir Ramjeesingh, Canhui Li
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Patent number: 5542373Abstract: A method of manufacturing GaAs single crystals in which gas in the vicinity of the surface of a substrate crystal is irradiated with light so as to an epitaxial growth of GaAs single crystals may be enabled by the halogen transport method under such condition that the temperature of the substrate crystal is lowered less than 700.degree. C.Type: GrantFiled: April 21, 1995Date of Patent: August 6, 1996Assignees: Research Development Corporation of Japan, Junichi Nishizawa, Yoshihiro KokubunInventors: Junichi Nishizawa, Yoshihiro Kokubun
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Patent number: 5542987Abstract: The invention provides a method for cleaning the surfaces of a motor vehicle which is contaminated with wastes containing organic or lipophilic deposits, comprising applying liposomes thereto, which liposomes modify the physical properties of the wastes to increase the polarity and wettability thereof.Type: GrantFiled: December 27, 1994Date of Patent: August 6, 1996Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Shimon Gatt, Yechezkel Barenholz, Herve Bercovier, Zvi Eldar