Abstract: Mammals are brought to a specific state of immunization by administering an amount of an antigenic substance sufficient to elicit an immunization response to said mammal, said antigenic substance being incorporated within a shaped structure of a biocompatible matrix material.

Abstract: Phenyl-3-aminoalkyl-4-methyl-2,6-dioxopiperidines of the Formula I ##STR1## wherein: R.sub.1 represents methoxy, ethoxy or hydroxy,R.sub.2 represents methoxy, ethoxy, hydroxy or hydrogen;each R.sub.3 independently represents methyl or ethyl;R.sub.4 represents hydrogen or methyl;R.sub.5 represents hydrogen or methyl; andn represents 2 or 3,and a pharmacologically acceptable acid addition salt thereof (a) have anxiolytic activity, (b) antagonize the anxiogenic activity of benzodiazepine inverse agonists, (c) reduce chronic abnormally high brain levels of serotonin or its metabolite 5-hydroxy-indoleacetic acid and (d) have antibacterial and antiviral activity. These activities are believed to be related to a reduction in serotonin turnover caused by blocking the depolarization activation of tryptophan hydroxylase. Novel compositions comprise the compounds with a benzodiazepine agonist or benzodiazepine inverse agonist.

Abstract: A pressure-sensitive adhesive tape for masking selected areas of an article such as a printed circuit board during high temperature operations such as wave soldering comprises a polymeric film coated with a layer of pressure-sensitive adhesive, both film and adhesive being resistant to temperatures up to 250.degree. C. for up to 5 seconds and being soluble in a fluorocarbon solvent such as a trichlorotrifluoroethane solvent. More particularly the film and adhesive are resistant to temperatures up to 260.degree. C. for up to 25 seconds.The polymeric film, which is a novel self-supporting film, may suitably comprise a polymethacrylate other than poly(methyl methacrylate) e.g. poly(butyl methacrylate), or ethyl cellulose or polyvinylpyrrolidone.

Abstract: This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said systemic agent an effective amount of a membrane penetration enhancer having the structural formula ##STR1## wherein X may represent sulfur, oxygen or nitrogen; a and b may be 0 or 1, c may be 0, 1 or 2, except that when X is oxygen, a, b and c are 0, when X is nitrogen c is 0 and only one of a or b is 1, and when X is sulfur a and b are 0; A is a branched or a straight chain, divalent aliphatic radical having from 0 to 2 double bonds; R' is selected from the group consisting of H, a lower alkyl group having from 1 to 4 carbon atoms, phenyl, lower alkyl or halogen substituted phenyl, acetamido, halogen, piperidinyl, lower alkyl or halogen substituted piperidinyl, carboalkoxy, carboxamide, and alkanoyl; and R is hydrogen or a lower alkyl group having from 1 to 4

Abstract: A transdermal delivery bandage and system is provided which includes a supply of topically and/or systemically-active drug, an adhesive for releasably securing the bandage to a dermal surface and control means which are separate from the supply of topical and/or systemically-active drug for adjustably controlling surface contact area between the topical and/or systemically-active drug and the dermal surface. The control means are manually operable by a user of the bandage for adjustably controlling the dose of drug to be administered. Alternatively, the maximum available dose from a given bandage may be preselected by a dispensing pharmacist.

Abstract: There is provided a quantum flux parametron-type superconducting circuit in which a path with a Josephson device is connected in parallel with exciting inductors of the quantum flux parametron or inductors of exciting line magnetically coupled with the exciting inductors, thereby constructing a phase regulator.

Abstract: A biological control agent comprising the mycoparasite Trichoderma harzianum T-315 (ATCC No. 20671), which is characterized by fungicidal activity against fungi of the genera Pythium, Rhizoctonia, Sclerotium and Fusarium. This strain is useful for controlling damping-off, root-rot, crown-rot and neck-rot in seedling crops. This strain is also resistant to chemical pesticides and soil-sterilants and useful for integrated biological and chemical control of soil-borne pathogens.

Abstract: Apparatus for measuring the quantity of fibres present in a gaseous fluid is based on the use of a nozzle to align the orientation of fibrous particles as they flow into a chamber. A charge is applied to the particles which are then precipitated on to a carrier. They are sequentially illuminated in directions normal and transverse to the direction of orientation and from measurements of the relative attenuation of the radiation, an indication of the number of precipitated particles is derived.

Abstract: A fingertip pulse wave sensor includes a fingertip supporting base having either a nail supporting surface or a fingertip cushion supporting surface, and a slider having the other of the nail supporting surface and the fingertip cushion supporting surface. The slider is guided on the fingertip supporting base in such a manner as to be slidable in the direction in which it is moved away from or toward the fingertip supporting base. The slider is urged in the direction in which it is moved toward the fingertip supporting base by an elastic body which is capable of applying a substantially fixed amount of pressure with respect to the variations in the slide stroke in the direction in which the slider is moved away from the fingertip supporting base which occur when different fingertips are set.

Abstract: A method for manufacturing ultrafine particles of hardly water-soluble or water-insoluble organic compounds is disclosed herein, and the method includes heating and evaporating the organic compound in a vacuum vessel in which an inert gas is introduced in a desired pressure, then condensing and depositing the vaporized organic compound on a recovering means cooled, the resulting ultrafine particles exhibiting a high negative zeta potential sufficient to form a stable water dispersion thereof.

Abstract: An electronic speckle pattern interferometric for measuring the movement of a vibrating body (2) uses a coherent light source (16) to illuminate the body. A television camera (4) receives radiation scattered by the body and from a reference beam (7) to form a speckle pattern. Successive measurements are stored in a frame store (8, 9) and displayed on a monitor (10).

Abstract: Compounds in which two or more rings, being a 3-hydroxpypyrid-2-one, 3-hydroypyrid-4-one or 1-hydropyrid-2-one, are linked are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body while the iron complexes of such compounds are of value in the treatment of iron deficien

Abstract: A method for isolating a cDNA specific for P-glycoprotein is disclosed. The P-glycoprotein is the determinant in the multidrug resistance phenotype exhibited by living cells. The nucleic acid equivalent of the cDNA may be cloned in a recombinant plasmid or phage. The cDNA may also be used as a probe in determining multidrug resistance in cells. The DNA molecules specific for the P-glycoprotein is in the form of a gene family where various members of the gene family are amplified to varying degrees in multidrug resistant cells from various sources.

Abstract: This invention provides novel compounds represented by the general formula: ##STR1## R.sub.1 and R.sub.2 are each independently selected from the group consisting of hydrocarbyl radicals and heteroatom-substituted hydrocarbyl radicals, wherein said heteroatoms are selected from the group consisting of nitrogen, oxygen, sulfur, phosphorus and halogen atoms; A is a straight or branched chain hydrocarbon moiety containing from 1 to 12 carbon atoms and from 0 to 2 double bonds; R.sub.3 is selected from the group consisting of oxa- or dioxacycloalkanyl radicals which may be substituted with one or more hydroxy, keto, lower alkyl, phenyl or alkylenedioxy radicals; R.sub.4 is an aryl or heteroaryl radical; and R.sub.5 is a lower alkyl radical or A-R.sub.3 ; and pharmaceutically-acceptable salts thereof. These compounds are useful for treating coronary insufficiency, hypertension, angina pectoris, cardiac arrythmia, heart attack, or coronary vasospasm.

Abstract: A method of encrypting a video signal employing a pseudo-random Space Filling Curve having a highly irregular scanning pattern for scanning the pixel addresses of a video picture stored in a frame buffer. The method is used with a video scrambler/descrambler device and is characterized by a much higher cryptographic strength than existing techniques, which is not subject to simple correlation attacks by comparing and matching of line portions. In addition, the method features a reduction in the video signal bandwidth for typical pictures.

Abstract: New C-substituted crown ethers such as ##STR1## are made by reacting a 1,2-diol (chain length m'4) with ClCH.sub.2 --(CH.sub.2 --O--CH.sub.2 --).sub.n+1 CH.sub.2 Cl.These compounds have a stronger affinity for secondary amines than for tertiary amines and therefore may be used to separate mixtures, especially when attached to polysiloxane backbones or substrates via their unsaturated bond.

Abstract: An endoprosthetic bone component is produced from parts respectively having a projection and cavity engaged in a mutual clearance fit, and a third part of plastics material located in the space of such fit, the space and third part being dimensioned to inhibit ejection of the latter and to lock the two parts against mutual articulation during post-operative use. Normally the space and third part will be of generally uniform thickness overall which is small compared to that of the projection. Also the projection and cavity are preferably of uniform cross-sectional shape over at least major portions thereof. Typically the two parts will be of different materials, such as ceramic and metal, suited respectively to articulation and bone fixation roles.

Abstract: In apparatus for detecting or identifying gas or liquid or for measuring their concentration, an array of sensors arranged for simultaneous exposure to a substance is coupled to electrical circuitry arranged to generate electrical signal values which are linearly related to substance concentration. The sensors are selected to respond differently to a known sample substance or substances. By feeding the signal values to a processor programmed to combine the signal value in a series of linear equations, a series of output values are obtained which are characteristic of the sensed substance or substances which, when compared with stored data allow identification of the sensed substance or substances and the measurement of substance concentration.

Abstract: Derivatives of carbonyl-group containing behavior modifying compounds, in which said carbonyl group has been converted to a photolabile group which regenerates the carbonyl group on exposure to radiation, are of value in various methods for the control of animal, and in particular insect, species.

Abstract: A toilet seat cover is provided for preventing contact between the human bottocks and the toilet seat when the sheet is disposed and aligned with the toilet seat. A microbiocidal shield is created by the perspiration from the bottocks contacting a water-soluble oxidizing agent along with a water-soluble ene-diol compound dispersed as separate particles in the sheet. The water-soluble oxidizing agent and water-soluble ene-diol compound may be separately microencapsulated by a protective film. Capillary action of the fibers in the sheet provide for conducting free water released during reaction between the water-soluble oxidizing agent and the ene-diol compound throughout the toilet seat cover. Fibers of the sheet are adhesively bonded together within the adhesive that is soluble and dispersible in water to enable the toilet seat cover to be flushed down the toilet after use.