Abstract: A precision automatic assembly apparatus for inserting an insertable part into a hole formed in a member includes a movable hand incorporating a movable body to which the insertable part is attached, and an electromagnetic wrist mechanism having a plurality of electromagnetic devices including air core coils and magnetic poles for supporting the movable body and controlling the movable body along a plurality of axes. When the part is inserted into the hole formed in the member, an external force which acts upon the part and the position of a point at which the part contacts the member are estimated by a control unit via position sensing means incorporated in the hand. Currents supplied to the excitation coils of the electromagnetic devices are controlled on the basis of the estimate to adjust the state (position and attitude) of the insertable part, whereby the part is fitted into the hole smoothly and automatically.

Abstract: A composition which comprises at least one solid or liquid particle comprising at least one active substance, the or a plurality of such particles being encapsulated by the in situ cationic (co)polymerization there on of at least on cationically polymerizable monomer or prepolymer.

Abstract: This invention provides a method for treating the symptoms of schizophrenia which comprises administering to a schizophrenic an effective amount of a compound selected from the group consisting of optically-active or racemic compounds represented by the general formula: ##STR1## wherein R.sub.1 is selected from the group consisting of organic radicals having fused rings, phenyl, pyridyl ##STR2## X is oxygen or sulfur, Y, if present, is selected from the group consisting of hydroxy, nitro, cyano, azido, amino, acylamino, carboxyamido, trifluoromethyl, sulfate, sulfonamido halogen, hydrocarbyl and hetero atom-substituted hydrocarbyl radicals, wherein said heteroatoms are selected from the group consisting of halogen, nitrogen, oxygen, sulfur and phosphorus and said hydrocarbyl radicals comprise from 1 to 12 carbon atoms, and a is an integer between zero and 3. R.sub.2, R.sub.3 and R.sub.

Abstract: A sustained release device which comprises a source of at least one trace chemical element incorporated in a cement and releasable therefrom on contact with an aqueous medium.The trace chemical element is exemplified by selenium, cobalt and iodine and the cement is exemplified by a phosphate cement.

Abstract: This invention relates to a selective process for preparing bicyclic lactam-lactone compounds wherein the rings are fused, i.e. the rings share at least two carbon atoms, or are isolated. In particular, the present invention provides a process for selectively reacting novel 1-hydrocarbylamino (or heteroatom-substituted hydrocarbylamino); 1,1-dicarboxylic acid, alkylesters; 1-alkanolactonyl or hydrocarbyl (or heteroatom-substituted hydrocarbyl) alkanonylactonyl methane, as the salt of an acid having a pKa of 0 or more, to provide bicyclic lactam-lactone compounds. The selectively of the reaction to either fused or isolated bicyclic compounds is controlled by cyclizing the novel salts, in the absence of a base, a cyclizing said novel salts, in the presence of an amount of base substantially equivalent to said acid, respectively.

Abstract: A photomultiplier with plural photocathodes comprising a rectangular end face plate, plural photocathodes arranged on the end face plates at predetermined intervals in the longitudinal direction of the end face plate, plural focusing electrodes assigned to the photocathodes respectively, plural dynodes provided in common for all of the photocathodes, and plural anode electrodes assigned to the photocathodes respectively, each of the dynodes having plural electron emitting parts for emitting secondary electrons and insulating parts for preventing the secondary electrons emitted from any one of the electron emitting parts from straying into the other electron emitting parts.

Abstract: A method of treatment of the diseases caused by AIDS virus which comprises administering an effective amount of prostaglandin biosynthesis inhibitor to a subject in need of such treatment.

Abstract: A synthetic vascular prosthesis comprises a hollow tubular base member having a multitude of continuous pores and formed of an elastomer material, and a hydrogel layer formed on the inner surface of the base member. The hydrogel layer is partly embedded in the inner portion of the base member at the pores, thereby permitting anchoring adhesion between the hydrogel layer and the base member. A method for manufacturing the synthetic vascular prosthesis is also disclosed, in which the formation of pores in the base member is effected by two separate steps and the hydrogel layer is formed after formation of an inner porous portion of the base member.

Abstract: Particulate material is supported in a fluid medium by means of an ultrasonic standing wave while a reaction is effected or controlled involving the material so supported, for example with the fluid medium or other material contained in the medium. In a preferred arrangement, the standing wave is established by opposed ultrasonic transducers producing convergent beams that compensate for attenuation of the ultrasonic energy in the fluid medium, and operating in the near field. The support provided by the standing wave is able to avoid settling of the particulate material in the medium and also agitates the material; both effects enhance the rate of chemical reaction and help to ensure that the particulate material is more uniformly exposed. The process has particular applications to biological reactions, such as fermentation, and to chromatography, as examples.

Abstract: An electrochemical sensor for hydrogen has, as its reference, a metal having a choice of oxidation states, the metal redox reaction comprising the reference.The sensor preferably comprises(i) a platinum-black electrode 6 which is electronically conductive and in which the hydrogen to be sensed is mobile,(ii) a solid-state conductor 5 for protons, and(iii) a mixture 4 of FeSO.sub.4 and Fe.sub.2 (SO.sub.4).sub.3 powders, with the Fe(II)/Fe(III) redox reaction in this mixture providing the hydrogen reference.

Abstract: There is disclosed a method and apparatus for effecting cardio-valve replacement surgery. A clamp adapted to be fastened to an ether screen has multiple arms. These arms are linked together by a double clamp having two parts which are pivotable with respect to each other and within which the arms are both rotatable and slidable and which arms are simultaneously clamped in whatever position they may have been set. The clamping is effected by a draw bolt passing through both parts of the double clamp. At the free end of the arms is a clamp adapted to hold a replacement cardio-valve holder. The clamps and the arms are adjusted to present a replacement valve in a position such that it can be sutured into the heart of the patient without the surgeon having concern about the possibility of malalignment of the valve or suturing.

Abstract: This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comnprising topically administering with said systemic agent an effective amount of a membrane penetration enhancer having the structural formula ##STR1## wherein X represents sulfur, oxygen or 2 hydrogen radicals; Y represents --CH.sub.2 --, --NH-- or oxygen; n and m are integers of from 1 to 3; p is an integer of from 3 to 17; wherein p.gtoreq.9; q is 2, 4, 6 or 8; and R' is selected from the group consisting of H, a lower alkyl group having from 1 to 4 carbon atoms, phenyl, lower alkyl or halogen substituted phenyl, acetamido, halogen, piperidinyl, lower alkyl or halogen substituted piperidinyl, carbalkoxy, carboxamide, and alkanoyl.

Abstract: An acoustic standing wave is established in a fluid medium with a varying energy density in its nodal planes. Particles in the fluid medium responsive to the acoustic energy accumulate at these nodal planes and by the action of the variations of energy density in conjunction with the fluid viscous forces and/or field forces acting in the direction of the nodal planes, the movement of the particles held at these planes can be controlled. The adverse effects of attenuation of the acoustic beams producing the standing wave are reduced in this system, because any streaming due to imbalance of the acoustic forces forming the standing wave does not act in the direction in which the movement of the particles can be controlled.

Abstract: Phenyl-3-aminoalkyl-4-methyl-2,6-dioxopiperidines of the Formula I ##STR1## wherein: R.sub.1 represents hydrogen or C.sub.1 -C.sub.4 alkyl;n is 1 or 2;R.sub.2 represents hydrogen or methyl, provided that one R.sub.2 is hydrogen when n is 2;R.sub.3 represents hydrogen or C.sub.1 -C.sub.2 alkyl;R.sub.4 represents C.sub.1 -C.sub.2 alkyl;R.sub.5 and R.sub.6 independently represent hydrogen or methyl;m is 0 to 3; and each Y is in a meta or para position and independently represents hydroxy, C.sub.1 -C.sub.2 alkoxy, C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 hydroxyalkyl, halogen, or trifluoromethyl, provided that hydroxy and alkoxy are not in the para position, and pharmacologically acceptable salts thereof have antiposychotic activity without sedative side effects. They are particularly useful in the treatment of schizophrenia.The presently preferred compound is 3-(3'methoxyphenyl)-3-(3"-N,N-dimethylaminopropyl) -4,4-dimethyl-2,6-dioxopiperidine (AGN 2979).

Abstract: The invention relates to novel (3S,4S)-7-hydroxy-.DELTA..sup.6 -tetrahydrocannabinol homologes and derivatives, essentially free of the (3R,4R) form and to pharmaceutical compositions which have a potent analgetic, antiemetic and antiglaucoma effect, which compositions contain an effective dosage of a compound of this type. The novel pharmaceutical compositions are practically devoid of the undesired side effects of the (3R,4R) type compounds, such as cannabimimetic psychotropic effects. The pharmaceutical compositions are of special utility in cases of acute and of chronic pain. The invention also relates to a process for the production of the above defined novel compounds.

Abstract: A process for producing graphite includes heat treating, in an inert gas or in vacuo, at least one polymer selected from the group consisting of a polyphenyleneoxadiazole, polybenzothiazoles, a polybenzobisthiazole, a polybenzoxazole, a polybenzobisoxazole and a polythiazole, at a temperature of at least 1600.degree. C., preferably at least 2000.degree. C., for at least 30 minutes, preferably at least 60 minutes, to convert the polymer to a highly-graphitized graphite. The process produces almost perfect graphite in any shape, such as film-shaped for large-area graphite, fibrous or powdered.

Abstract: A method of detecting dentin is provided. Also provided is a method of repairing a tooth in which dentin is detected using a substance that stains protein, and is thereby clearly delineated from enamel, the enamel is then selectively acid etched, taking care that none of the acid from the etching procedure contacts dentin, and composite filling material is applied to the tooth. The use of a composition for staining dentin is also provided.

Abstract: A compound of formula II: ArCHR.sub.1 CO.sub.2 CHDR.sub.2in which formula:Ar represents a phenyl or naphthyl group optionally substituted by one or more halogen, alkoxy, haloalkoxy, methylenedioxy, C.sub.1 -C.sub.6 alkyl or haloalkyl groups;R.sub.1 represents the group --CH(CF.sub.3)CH.sub.3 or --C(CF.sub.3).dbd.CH.sub.2R.sub.2 represents the residue of an alcohol R.sub.2 CHDOH in which D is hydrogen or cyano and of which the [1R, cis]2,2-dimethyl-3-(2,2-dibromovinyl)cyclopropane carboxylic ester is significantly insecticidal.

Abstract: A driving connection between a first and hollow shaft (1) and a second shaft (3) within it, the axes (19, 20) of the two shafts being parallel at all times. By relative radial displacement of the two axes, the first shaft rotates at a variable and fluctuating speed within each revolution in response to uniform rotation of the second shaft. The ball (36) or part-cylindrical (22) end of a radial arm (2), carried by the second shaft, engages rotatably with a recess (37, 31) in a block (4) movable in a radial slideway (23) formed on the first shaft. Axial compactness is promoted by the arm, block and slideway all lying in a common radial plane (30), and radial compactness by the manner of engagement between the arm end (36, 22) and the corresponding recess (37, 31). The invention finds particular use where the first shaft (1) is the camshaft of an internal combustion engine, and in which the relative movement of the shaft axes (19, 20) may therefore be used to vary the timing of the engine valves (7, 8).

Abstract: Cosmetic and dermatological compositions containing 1.alpha.-hydroxycholeciferol and a suitable carrier useful in topical treatment of skin disorders and methods employing same are disclosed. Compositions containing 1.alpha.,25-dihydroxycholecalciferol and a suitable carrier and methods employing same are also disclosed for dermatological and cosmetic uses. Various formulations of the compositions including creams, lotions, ointments and sprays are disclosed for use in accordance with this invention. The compositions and formulations may contain additional active ingredients.