Abstract: This disclosure relates to methods and compositions useful for detecting and monitoring low-frequency mutations. Methods and compositions described herein can be used to guide clinical decisions, for example, by informing on which antibiotics should be avoided, or conversely, which antibiotics should be actively used in the case of compounds that select against a specific type of resistance.

Abstract: Immunoreactive engineered polypeptides are provided. The engineered polypeptides can be used to diagnose or induce an immune response against E. chaffeensis or E. canis.

Abstract: Exemplary embodiments of the present disclosure include systems and methods for treatment of occlusions, including coronary artery chronic total occlusions.

Abstract: An assembly for driving linear movement and roll movement of an elongate surgical tool, comprising: an elongate shaft comprising a central lumen extending along the shaft long axis; the elongate shaft comprising a plurality of apertures extending across walls of the elongate shaft and into the central lumen; a set of wheels positioned opposing each other and aligned on two sides of the central lumen, the set of wheels at least partially extending through the apertures beyond the walls of the elongate shaft and into the central lumen to contact an elongate surgical tool received therein; the set of wheels being coupled to the elongate shaft and configured to rotate with the elongate shaft as a single unit when the elongate shaft is rotated about the shaft long axis.

Abstract: Disclosed is a method of fabricating a construction element. The method may include assembling a mold on a rotational casting machine; rotating the mold around at least two axes at a predetermined speed; providing a first portion of magnesium silico-phosphate cement (MSPC) mix, having an altered hardening rate, to the mold while rotating the mold until at least a portion of the mold's walls is covered by a first layer of the MSPC mix; and rotating the mold until the MSPC mix is hardened to a predetermined degree.

Abstract: In an embodiment an apparatus includes a scanning photographic sensor configured to acquire an image, according to an integration time of the sensor, of a scene illuminated with periodically emitted light pulses by a source, so that the image has a regular succession of bands with different luminosities when the integration time of the sensor is different from a period of the light pulses, a processor configured to generate a signature vector representative of the regular succession of bands with different luminosities being present in the image acquired by the photographic sensor, wherein the signature vector is independent of a reflectance of an objects of the scene and of a level of light in the scene, determine a frequency of the bands in the image on basis of the generated signature vector and determine the period of the pulses of the source on basis of the determined frequency of the bands in the image, and a controller configured to adjust the integration time of the photographic sensor so that the int

Abstract: A method of preparing a composition comprising mycelium along with a cellulose and/or plurality of nanoparticles is described herein. The method comprises inoculating a liquid medium with fungus, the liquid medium comprising nutrients and the cellulose and/or nanoparticles. Further described herein are compositions comprising mycelium along with a cellulose and/or plurality of nanoparticles, as well as articles-of-manufacture comprising such a composition, wherein at least 10% of the cellulose and/or nanoparticles in the composition is incorporated within the mycelium. A method of enhancing fungal growth is also described, comprising contacting the fungus with a liquid medium comprising a polymer which comprises carboxylic acid groups.

Abstract: Selective radiation of radio frequency (RF) reference beams in a wireless communications system (WCS) based on user equipment (UE) locations is disclosed. The WCS may include a radio node that communicates RF communications signals in a coverage area via RF beamforming. Thus, the radio node is required to periodically radiate a number of RF reference beams in different directions of the coverage area to help UEs to identify a best-possible RF beam(s). However, radiating the RF beams in different directions periodically can increase power consumption of the radio node, particularly when the UEs are concentrated at a handful of locations in the coverage area. In this regard, the radio node can be configured to selectively radiate a subset of the RF reference beams based on a determined location(s) of the UE(s) in the coverage area, thus making it possible to reduce computational complexity and power consumption of the radio node.

Abstract: A hybrid system, including a solid-oxide fuel cell (SOFC), an internal combustion engine (ICE), and a thermochemical recuperation (TCR) unit. The TCR unit is configured to: (i) receive waist heat from the ICE, (ii) receive a primary fuel, (iii) perform a waste heat recovery process to provide reformed fuel. The SOFC is configured to receive a first part of the reformed fuel and convert the first part of the reformed fuel to electrical work. The ICE is configured to receive a second part of the reformed fuel and convert the second part of the reformed fuel to mechanical work.

Abstract: An apparatus for adjusting lying posture in vehicle seats is connected between a lower side of a height adjusting mechanism of the seat and upper sides of upper sliding rails of the seat and comprises an upper fixed bracket, a front end execution mechanism, a front end supporting and driving mechanism and a rear end bracket assembly. The upper fixed bracket is provided with a front end fixed supporting rod, a left end and a right end of which are connected with a left fixed supporting rod and a right fixed supporting rod respectively; inner sides of the left fixed supporting rod and the right fixed supporting rod are connected with a left fixed bracket and a right fixed bracket respectively; and a connecting hole is formed in each of front parts and rear parts of the left fixed supporting rod and the right front end fixed supporting rod.

Abstract: Compositions comprising liposomes composed of whole cell membrane fraction are provided. The liposomes may be attached to, or encapsulate a pharmaceutical agent. Also provided are methods of generating and using these liposomes.

Abstract: The present disclosure relates to a process for manufacturing an oral pharmaceutical dosage form including: mixing an active pharmaceutical ingredient (API) and surfactant into a blend; feeding the blend into a processor that applies heat and shear forces at a temperature within a range of approximately equal to the melting point of the surfactant to 3° C. below the melting point of the surfactant so as to form API granulates; and formulating the API granulates into a dosage form. The disclosed technology provides a surprisingly effective and economical means for producing high dose solid dosage forms containing poorly soluble APIs with minimal excipient burden.

Abstract: A single photon avalanche diode (SPAD) pixel circuit includes a SPAD, a clamping transistor coupled to the anode of the SPAD, and readout circuitry. The clamping transistor limits the anode voltage to a threshold below the readout circuitry's maximum operating voltage. In one embodiment, quenching and enabling transistors are implemented using single-layer gate oxide technology, while the clamping transistor uses extended drain technology. A regulation circuit generates a voltage clamp control signal for an array of pixels. Another embodiment utilizes a stacked chip design with the SPAD and a cathode-side quenching element on one chip, and the clamping transistor and readout circuitry on another. This incorporates a parasitic capacitance from deep trench isolation. Additional biasing transistors may be used for fine-tuning the clamped anode voltage.

Abstract: A method includes dividing a field of view into a plurality of zones and sampling the field of view to generate a photon count for each zone of the plurality of zones, identifying a focal sector of the field of view and analyzing each zone to select a final focal object from a first prospective focal object and a second prospective focal object.

Abstract: Provided herein are heteroaryl compounds, for example, a compound of Formula I or IA, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, ameliorating, or preventing one or more symptoms of a disorder, disease, or condition mediated by a casein kinase 1 (CK1), an interleukin-1 receptor associated kinase (IRAK1), or a cyclin-dependent kinase 9 (CDK9).

Abstract: A method for controlling an internal light source of a vehicle, wherein the internal light source is for darkening of glasses. The method includes acquiring an image recognition result, wherein the image recognition is for determining whether an occupant of the vehicle wears glasses, and controlling the light source responsive to the acquired image recognition result. In some embodiments, controlling the light source includes activating the light source when the image recognition result indicates that the occupant wears glasses. In some embodiments, the image recognition result is indicative of whether glasses darken responsive to activation of the light source and controlling the light source comprises deactivating the light source when the image recognition result indicates that the glasses do not darken responsive to activation of the light source.

Abstract: The invention relates to a vehicle seat arranged to be adjusted between a forward facing/rearward facing setup. The vehicle seat comprises a seat back and a seat cushion arrangement comprising a seat cushion arranged to be attached to a seat structure, a front pivoting notch and a rear pivoting notch. The seat back comprises a first and a second seat back connection arranged on a seat back side arranged to be releasably engaged with a first and second latch respectively. The second seat back connection is arranged to releasably engage with a first latch when the vehicle seat is in the forward facing setup, and the first seat back connection is arranged to releasably engage with a second latch the vehicle seat is in the rearward facing setup.

Abstract: An additive manufacturing device includes a container for containing feed stock material and having an optically transparent bottom wall. The additive manufacturing device further includes a radiation source configured to emit radiation in an optical path incident on the bottom wall and a sensor positioned in the optical path of the radiation above the bottom wall. The sensor is configured to sense a temperature of feedstock material at a reaction interface as the radiation polymerizes at least a portion of the feedstock material. The sensor is constructed to meet a transparency threshold and a flexibility threshold.

Abstract: A transfer assembly for a hoist unit for a patient includes a motor base, a first frame secured to the motor base for rotation about a pitch axis. The first frame includes one or more first suspension wheels rotatably affixed thereto for rotation about a laterally extending axis. The transfer assembly also includes a second frame secured to the first frame for rotation about a yaw axis. The second frame includes one or more second suspension wheels each of which is rotatably affixed thereto for rotation about a laterally extending axis. The transfer assembly also includes a drive wheel assembly rotatably mounted on the motor base for rotation about a laterally extending drive wheel axis. The transfer assembly also includes a motor assembly secured to the motor base and operatively connected to the drive wheel assembly such that operation of the motor rotates the drive wheel assembly.