Patents Assigned to Research Development
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Patent number: 9506161Abstract: A surface treatment of a magnesium alloy includes preparing a substrate of magnesium alloy, micro-arc oxidizing the substrate of magnesium alloy, forming an oxide layer with a hydroxyl group on the substrate of magnesium alloy, silylizing the oxide layer of the substrate of magnesium alloy with the oxide layer, by soaking the substrate of magnesium alloy in a processing solution with a silyl group-containing compound for 1-300 minutes, and placing the substrate of magnesium alloy with the silylized oxide layer at 70-200° C. for 1-300 minutes, allowing a condensation reaction to occur. The manufactured surface-treated magnesium alloy shows a decreased degradation rate in vivo.Type: GrantFiled: December 12, 2014Date of Patent: November 29, 2016Assignee: Metal Industries Research & Development CentreInventors: Li-Wen Weng, Chun-Chieh Tseng, Yue-Jun Wang, Ho-Chung Fu, Tzyy-Ker Sue
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Patent number: 9509056Abstract: Techniques for implementing series-fed antenna arrays with a variable dielectric waveguide. In one implementation, coupling elements with optional controlled phase shifters are placed adjacent each radiating element of the array. To avoid frequency sensitivity of the resulting array, one or more waveguides have a variable propagation constant. The variable waveguide may use certain materials exhibiting this phenomenon, or may have configurable gaps between layers. Plated-through holes and pins can control the gaps; and/or a 2-D circular or a rectangular travelling wave array of scattering elements can be used as well.Type: GrantFiled: June 9, 2015Date of Patent: November 29, 2016Assignee: AMI Research & Development, LLCInventors: John T. Apostolos, Benjamin McMahon, Brian Molen, Judy Feng, William Mouyos
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Patent number: 9506175Abstract: A dimensionally stable floor covering comprises a tufted textile substrate and a reinforcement layer attached to the textile substrate. The reinforcement layer includes an adhesive backing compound and reinforcement fibers surrounded by the adhesive backing. The fibers may form a continuous layer on the back side of the floor covering or may be dispersed within the adhesive backing compound. The adhesive backing compound may be hot water-soluble to facilitate recycling of the floor covering. The floor covering may optionally include additional backing layers (including cushions) and may be used as a broadloom carpet, a carpet tile, or other modular floor covering products. Methods of manufacturing, installing, and recycling the present floor coverings are also provided.Type: GrantFiled: April 14, 2016Date of Patent: November 29, 2016Assignee: Higgins Research & Development, LLCInventor: Kenneth B. Higgins
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Patent number: 9499310Abstract: A combination includes a child-resistant package and a collapsible tube removably positionable therein. A sidewall of a body of the package has an interior surface and an opposing exterior surface. A cavity is defined by the body. An opening is positioned proximate an open first end of the body. A bottom wall is positioned proximate an open second end of the body. A cap is removably mounted onto at least a portion of the first end of the body. The collapsible tube is surrounded by the body, the bottom wall and the cap when the cap is mounted onto at least a portion of the first end of the body. The collapsible tube includes a generally flexible housing defining a cavity for holding a substance to be dispensed from the housing. A closure is removably mounted onto the housing.Type: GrantFiled: December 28, 2012Date of Patent: November 22, 2016Assignee: Galderma Research & DevelopmentInventor: Sebastien Fily
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Patent number: 9498504Abstract: A process for the preparation of a pharmaceutically effective extract from the cyanobacterium Arthrospira sp. having the following steps: extrusion of a powder containing Arthrospira sp. with the addition of water; extraction of the extrudate with an organic solvent; and provision of the extract as a pharmaceutically effective composition.Type: GrantFiled: May 4, 2012Date of Patent: November 22, 2016Assignee: Ocean Research & Development GmbHInventors: Jorg Keimes, Patrick Gunther
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Patent number: 9502458Abstract: A sensor pixel detects a photon and outputs a first voltage proportional to a time of arrival of the detected photon. This voltage is converted to a multi-bit digital signal in the format of a thermometer code. A number of counter circuits, one counter circuit per bit of the multi-bit digital signal, are provided to accumulate the thermometer coded outputs. Each counter is configured to increment in response to an active logic state of the corresponding bit of the multi-bit digital signal. Accumulated count values in the counter circuits provide a timing histogram with respect to photon detection.Type: GrantFiled: March 10, 2015Date of Patent: November 22, 2016Assignee: STMicroelectronics (Research & Development) LimitedInventor: Luca Parmesan
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Patent number: 9499807Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.Type: GrantFiled: July 2, 2014Date of Patent: November 22, 2016Assignee: Research Development FoundationInventors: Michael G. Rosenblum, Khalid Amanali Mohamedali, Lawrence H. Cheung
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Publication number: 20160333070Abstract: Short bioactive sequences derived from the 2nd loop of the 7-transmembranal receptor of endothelial differentiation gene 3 (EDG3) useful in stimulation of angiogenesis, and peptide conjugates comprising a permeability enhancing moiety, are provided. Also provided are pharmaceutical compositions comprising the peptides and methods of use in conditions were insufficient blood-supply occurs, or which are associated with endothelia dysfunction such as peripheral vascular diseases, coronary artery diseases, cerebrovascular diseases, diabetes and delayed wound healing, pulmonary disease, eye diseases and pathological condition related to severe infection.Type: ApplicationFiled: December 17, 2014Publication date: November 17, 2016Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.Inventors: Shmuel BEN-SASSON, Hadas REUVENI
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Publication number: 20160333084Abstract: The present invention relates to antibodies against specific domains of Olfml3 and the use of such in angiogenesis. In particular aspects, angiogenesis-related conditions, such as cancer, can be treated by the composition comprising the Olfml3 antagonists.Type: ApplicationFiled: August 3, 2016Publication date: November 17, 2016Applicant: Research Development FoundationInventors: Beat A. IMHOF, Marijana MILJKOVIC-LICINA, Philippe HAMMEL
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Publication number: 20160331618Abstract: An adaptive lift includes a base portion including a plurality of rollers, a lift portion coupled to the base portion, the lift portion including a mast extending upward from the base portion in a vertical direction and a lift arm coupled to the mast, a lift bar coupled to the lift arm, a lift system coupled to the base portion and the lift arm, where the lift system raises and lowers the lift bar with respect to the base portion, a support arm pivotally coupled to the mast and positioned above the base portion in the vertical direction, and a braking system coupled to the support arm, the braking system including a release handle that selectively repositions the braking system between an engaged position, in which the braking system prevents rotation of the plurality of rollers, and a disengaged position, in which the plurality of rollers may rotate.Type: ApplicationFiled: April 29, 2016Publication date: November 17, 2016Applicant: Liko Research & Development ABInventors: Michael Scott Hood, Timothy Allen Lane, Neal Wiggermann, Timothy D. Wildman, Robert M. Zerhusen
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Patent number: 9486872Abstract: The present invention relates to a manufacturing method for advanced high-strength steel (AHSS) wheel, comprising the following steps. Take an AHSS with at least 590 MPa of tensile strength for rolling to circular ring of a rim. Apply low heat input welding, such as the cold metal transfer (CMT) welding or the gas tungsten arc welding/tungsten inert gas arc welding (GTAW/TIG), at the junction of the rim to form a hollow cylindrical rim. Then perform hole expanding and spinning/roll forming operations to the rim. Take another AHSS with at least 980 MPa of tensile strength for pressing and forming a disk. Apply low heat input welding, such as cold metal transfer (CMT) welding, to the rim and the disk to produce a wheel. According to the present invention, the welding quality of products can be improved significantly; the fatigue lifetime of wheels can be enhanced; and wheels are lightweight.Type: GrantFiled: September 3, 2013Date of Patent: November 8, 2016Assignee: Metal Industries Research & Development CentreInventors: Chi-Wah Keong, Chih-Lun Lin, Chia-Min Wei, Chun-Chieh Wang, Lung-Tien Wu
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Patent number: 9487856Abstract: A composite structure, comprising a cemented carbide substrate (e.g., tungsten carbide substrate cemented with cobalt, such as WC—Co), a thin interlayer disposed over the substrate, and a contiguous diamond film disposed over the interlayer, as well as processes of preparing such a composite structure and uses thereof, are provided. The composite structure is characterized by at least one of a substrate binder concentration of at least 2 percents by weight, interlayer thickness less than 20 microns, a homogenous interlayer made substantially of crystalline chromium nitride, a low to null binder concentration in the interlayer, and a high co-adhesion of the diamond film to the interlayer and the interlayer to the substrate.Type: GrantFiled: July 22, 2013Date of Patent: November 8, 2016Assignee: Technion Research & Development Foundation LimitedInventor: Alon Hoffman
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Publication number: 20160319241Abstract: Well-defined, xeno-free culture media which comprise a TGF-beta isoform or the chimera formed between IL6 and the soluble IL6 receptor (IL6RIL6), which are capable of maintaining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving embryonic stem cells in such well-defined, xeno-free culture media. In addition, the present invention provides methods of differentiating ESCs or EBs formed therefrom for the generation of lineage specific cells.Type: ApplicationFiled: July 14, 2016Publication date: November 3, 2016Applicant: Technion Research & Development Foundation LimitedInventors: Michal AMIT, Joseph ITSKOVITZ-ELDOR
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Patent number: 9482513Abstract: Exemplary embodiments of the present disclosure include a combined catheter-based optical coherence tomography-two-photon luminescence (OCT-TPL) imaging system. Exemplary embodiments further include methods to detect, and further characterize the distribution of cellular components (e.g., macrophage, collagen/elastin fiber, lipid droplet) in thin-cap fibroatheromas with high spatial resolution in vivo.Type: GrantFiled: March 14, 2014Date of Patent: November 1, 2016Assignee: Research Development FoundationInventors: Marc Feldman, Thomas Milner, Tianyi Wang, Jennifer Phipps
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Publication number: 20160312180Abstract: The present invention is of methods of establishing and propagating human embryonic stem cell lines using feeder cells-free, xeno-free culture systems and stem cells which are capable of being maintained in an undifferentiated, pluripotent and proliferative state in culture which is free of xeno contaminants and feeder cells.Type: ApplicationFiled: July 4, 2016Publication date: October 27, 2016Applicant: Technion Research & Development Foundation LimitedInventors: Michal AMIT, Joseph ITSKOVITZ-ELDOR
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Patent number: 9476060Abstract: A method of generating genotypic variation in a genome of a plant is disclosed. The method comprising introducing into a gamete or a gamete producing tissue of the plant at least one viral expression vector encoding at least one chimeric nuclease which comprises a DNA binding domain, a nuclease and a localization signal to a DNA-containing organelle, wherein the DNA binding domain mediates specific targeting of the nuclease to the genome of the plant, wherein the introducing is performed such that the gamete or gamete producing tissue expresses the chimeric nuclease but not all plant tissues express the chimeric nuclease, thereby generating genotypic variation in the genome of the plant.Type: GrantFiled: October 21, 2010Date of Patent: October 25, 2016Assignees: Danziger Innovations Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.Inventors: Alexander Vainstein, Amir Zuker
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Patent number: 9476062Abstract: The present invention provides HIV-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy, especially, in human hematopoietic progenitor cells as well as in all other blood cell derivatives. The lentiviral vectors comprise a self-inactivating configuration for biosafety and promoters such as the EF1? promoter as one example. Additional promoters are also described. The vectors can also comprise additional transcription enhancing elements such as the wood chuck hepatitis virus post-transcriptional regulatory element. These vectors therefore provide useful tools for genetic treatments such as inherited and acquired lympho-hematological disorders, gene-therapies for cancers especially the hematological cancers, as well as for the study of hematopoiesis via lentivector-mediated modification of human HSCs.Type: GrantFiled: April 22, 2015Date of Patent: October 25, 2016Assignee: Research Development FoundationInventors: Didier Trono, Patrick Salmon
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Patent number: 9478026Abstract: One aspect of the present disclosure relates to a system that can determine a kurtosis diffusion orientation distribution function (dODF) that can, for example, be used with diffusional kurtosis imaging fiber tractography (DKI-FT). The system can include a non-transitory memory storing computer-executable instructions and a processor that executes the computer-executable instructions to perform the following operations. Diffusion magnetic resonance imaging (dMRI) data can be received. Based on the dMRI data, a diffusion tensor (DT) and a diffusional kurtosis tensor (DKT) can be determined. A kurtosis dODF can be determined for the dMRI data based on the DT and the DKT. The kurtosis dODF extends a Gaussian approximation of the DT to include non-Gaussian corrections of the DKT.Type: GrantFiled: March 31, 2015Date of Patent: October 25, 2016Assignee: MUSC Foundation for Research DevelopmentInventors: Jens Jensen, Ali Tabesh, Joseph Helpern
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Publication number: 20160307948Abstract: A pixel is formed by two or more photodiodes and at least one transfer gate. The transfer gate is configured to transfer charge from each of the photodiodes to a common sense node, such that charge from the photodiodes is combined at the common sense node.Type: ApplicationFiled: December 17, 2015Publication date: October 20, 2016Applicant: STMicroelectronics (Research & Development) LimitedInventor: Laurence Stark
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Publication number: 20160303246Abstract: A novel class of antimicrobial polymeric agents, which include a plurality of positively charged amino acid residues and at least one omega-amino-fatty acid residue linking therebetween, designed to exert antimicrobial activity while being stable, non-toxic and avoiding development of resistance thereto and a process of preparing same are disclosed. Further disclosed are pharmaceutical compositions containing same and a method of treating medical conditions associated with pathological microorganisms, a medical device, an imaging probe and a food preservative utilizing same. Further disclosed are conjugates of an amino acid residue and a hydrophobic moiety residue and a process of preparing same.Type: ApplicationFiled: June 20, 2016Publication date: October 20, 2016Applicant: Technion Research & Development Foundation LimitedInventors: Amram MOR, Inna RADZISHEVSKY
