Abstract: A polymerizable unit that yields an electrochemically responsive polymer (advantageously pyrrole) is anchored by polymerization within a polycaprolactone matrix to form an electroactive scaffold upon which cells can be cultured and in which the micro- and nano-topological features of the polycaprolactone matrix are preserved. A scaffold manufactured in accordance with the preferred embodiment can support Schwann cells, which produce nerve growth factor when electrically stimulated. Nerve growth factor has been demonstrated to promote the regeneration of nerve tissue. By implanting the scaffold on which Schwann cells have been cultured into damaged nerve tissue and applying a voltage across the scaffold, nerve growth factor is produced, thereby promoting repair of the damaged nerve tissue.

Abstract: The invention relates to pharmaceutical formulations, and more particularly to formulations containing cannabinoids for administration via a pump action spray. In particular, the invention relates to pharmaceutical formulations, for use in administration of lipophilic medicaments via mucosal surfaces, comprising: at least one lipophilic medicament, a solvent and a co-solvent, wherein the total amount of solvent and co-solvent present in the formulation is greater than 55% wt/wt of the formulation and the formulation is absent of a self emulsifying agent and/or a fluorinated propellant.

Abstract: The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.

Abstract: Systems and methods for decoding code-multiplexed Coulter signals are described herein. An example method can include receiving a code-multiplexed signal detected by a network of Coulter sensors, where the code-multiplexed signal includes a plurality of distinct Coulter signals, and inputting the code-multiplexed signal into a deep-learning network. The method can also include determining information indicative of at least one of a size, a speed, or a location of a particle detected by the network of Coulter sensors by using the deep-learning network to process the code-multiplexed signal. The method can further include storing the information indicative of at least one of the size, the speed, or the location of the particle detected by the network of Coulter sensors.

Abstract: Disclosed herein are immunoglobulin constructs comprising at least one immunoglobulin domain or fragment thereof; and a therapeutic polypeptide or derivative or variant thereof attached to or inserted into said immunoglobulin domain. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a knob domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said knob domain of the CDR3H. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a stalk domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said stalk domain of the CDR3H. Also described herein are methods and compositions comprising the immunoglobulin constructs described herein for treatment and prevention of a disease or condition in a subject.

Abstract: The present invention relates to a method for preparing encoded hydrogel particles for high sensitive detection of a target biomolecule with high accuracy, and encoded hydrogel particles prepared thereby and, specifically, to a method for preparing encoded hydrogel particles, comprising a step of synthesizing hydrogel particles, and then binding a probe thereto, and encoded hydrogel particles prepared thereby. According to the present invention, probes can be loaded with remarkably improved high efficiency, loaded probes can be uniformly distributed, and the potential problem of biomolecule detection inhibition caused by an unreacted end can be resolved. In addition, the present invention can be applied to the diagnosis of diseases or screening of drugs through high sensitive multiplex detection of target biomolecules such as nucleic acids and proteins, and therefore, can be widely used in the field of medical diagnosis including molecular diagnosis.

Abstract: A deformable device includes a deformable beam or hinge having an extended state, a flattened state, and a rolled state if a beam, where a stiffness and strength in the extended state is greater than a different stiffness and strength in the flattened state, the deformable beam or the hinge deformable along a long axis. An end face cross section transverse to the long axis includes a first periodic curved member which defines at least two shaped curves. A second periodic curved member defines at least two shaped curves. The second periodic curved member is mechanically coupled to the first periodic curved member at respective ends of the end face cross section. The first arc length of the first periodic curved member and the second arc length of the second periodic curved member are of about a same arc length.

Abstract: A method, a processing device and a display system for information display are provided. The system includes a display being light transmissive, at least one first information extraction device, at least one second information extraction device, and a processing device. The processing device is connected to the display, the first information extraction device and the second information extraction device. The first information extraction device is configured to extract a user's position information and posture information. The second information extraction device is configured to extract a target object's position information and posture information.

Abstract: The present invention includes a method for screening one or more agents that modulate Regulatory T cell (Treg) activity, the method comprising the steps of: incubating a population CD4+ cells isolated from human blood peripheral mononuclear cells the CD4+ cells in contact with MoT cells in the presence of the one or more agents suspected of modulating Treg activity; detecting activation of the CD4+ cells without or with the agent; and comparing the activation of the CD4+ cells without or with the agent, wherein a change in activation following incubation with the agent relative to the activation of the PBMCs following incubation without the agent indicates that the agent is a modulator of Treg activity.

Abstract: Programmer input in a programming language is received. The programmer input includes i) a built-in function corresponding to retrieving electronic objects from network-accessible storage, and ii) a parameter indicating an electronic object. The programmer input is evaluated to determine that the electronic object is to be retrieved from the network-accessible storage, and one of i) the electronic object, or ii) an evaluation of the electronic object, is retrieved.

Abstract: Described herein are systems and methods of flow-through electroporation can comprise a chamber with a first and a second portion, wherein the first portion is configured to receive cells and the second portion is in fluid communication with the first portion and is configured to receive cells from the first portion; an electrode can be present in the first portion, second portion, or both; a porous membrane can separate the first and second portions, the porous membrane can have one or more pores, and the pores can have one or more interior surfaces configured to allow cells from the first portion to pass through to the second portion; an electric generating device in electrical communication with one or more electrodes, the membrane, or the one or more electrodes and the membrane, wherein the electric generating device is configured to deliver constant voltage or one or more electric pulses to the system.

Abstract: Disclosed herein is a composite comprising a metal alloy matrix; where the metal alloy matrix comprises aluminum in an amount greater than 50 atomic percent; a first metal and a second metal; where the first metal is different from the second metal; and where the metal alloy matrix comprises a low temperature melting phase and a high temperature melting phase; where the low temperature melting phase melts at a temperature that is lower than the high temperature melting phase; and a contracting constituent; where the contracting constituent exerts a compressive force on the metal alloy matrix at a temperature between a melting point of the low temperature melting phase and a melting point of the high temperature melting phase or below the melting points of the high and low temperature melting phases.

Abstract: Provided is a transparent solar cell including a first transparent electrode, a second transparent electrode, a light absorbing layer, a first color implementation layer, and a second implementation layer, wherein each of the first color implementation layer and the second implementation layer includes an insulation layer and a conductive layer. By using a double layer, it is possible to provide a colored transparent solar cell securing stability and durability and implementing colors on both sides.

Abstract: In some embodiments, an apparatus includes a volatile memory, a non-volatile memory, a first processor coupled to the non-volatile memory and configured to receive a data set associated with an object and user information associated with a spatial position of a user in a multi-user virtual (IMVR) environment, and a second processor coupled to the volatile memory, the second processor configured to render an instance of the portion of the object in the IMVR environment from a perspective of the user based on the spatial position of the user. The first processor is configured to generate a look-up table (LUT) based on a set of inputs received from a user. The second processor is configured to render, based on the LUT and information related to a manipulation by a user, an updated instance of the portion of the object that manifests an effect of the manipulation in the IMVR environment.

Abstract: This document relates to methods and materials for treating urinary calculi. For example, ureteral orifice devices and methods for using ureteral orifice devices to treat urinary calculi present within a mammal (e.g., a human) are provided.

Abstract: A computing system for generating optimal tracking control (TC) policies for controlling a machine to track a given time-varying reference (GTVR) trajectory. An updated augmented state of the machine is obtained. Stored in memory is the GTVR trajectory, a constraint-admissible invariant set (CAIS) of machine states satisfying machine state constraints and a corresponding TC policy mapping a machine state within the CAIS to a control input satisfying control input rate constraints. A processor jointly controls the computing system to control the operation to drive an augmented state of the machine to zero, and update the CAIS and TC policy. Joint control includes using a sequence of control inputs and a sequence of augmented machine states within CAIS corresponding to the sequence of tracking control inputs. Execute a constrained tracking approximate dynamic programming (TADP) using the received data to update the value function, update the CAIS and the corresponding TC policy.

Abstract: The present invention relates to a fabric material-based flexible electrode and a manufacturing method thereof, and a fabric material-based flexible electrode according to the present invention comprises: a substrate (10) including multiple fibers (11) crossing each other; a bonding layer (20), on the substrate (10), including an amine group (NH2)-containing monomolecular substance adsorbed thereon; a nanoparticle layer (30), on the bonding layer (20), having metallic nanoparticles (31) coated thereon; and a plating layer (40), on the nanoparticle layer (30), having a predetermined metal electroplated thereon.

Abstract: The present description relates to a modular, reconfigurable splice tray system that comprises a splice tray having a base extending longitudinally from a first end to a second end, a pair of side walls extending longitudinally between the first and second ends of the base, a plurality of cable entrances formed at the first and second end of the base and a receiving portion configured to receive a modular component disposed between the cable entrances at the first end and at the second end.

Abstract: A manipulator learning-control apparatus for controlling a manipulating system that includes an interface configured to receive manipulator state signals of the manipulating system and object state signals with respect to an object to be manipulated by the manipulating system in a workspace, wherein the object state signals are detected by at least one object detector, an output interface configured to transmit initial and updated policy programs to the manipulating system, a memory to store computer-executable programs including a data preprocess program, object state history data, manipulator state history data, a Derivative-Free Semi-parametric Gaussian Process (DF-SPGP) kernel learning program, a Derivative-Free Semi-parametric Gaussian Process (DF-SPGP) model learning program, an update-policy program and an initial policy program, and a processor, in connection with the memory, configured to transmit the initial policy program to the manipulating system for initiating a learning process that operates th

Abstract: Low-density thermoplastic expandable microspheres are disclosed. Various low-density structures, in particular, sandwich panels, based on foam prepared from the low-density microspheres, are also disclosed. Process of preparing low-density polymeric microspheres, per se, and the corresponding low-density structures, based on the microsphere foam, are also disclosed.