Abstract: The present invention relates to methods and systems for increasing the affinity of a T cell receptor (TCR) to its ligand by subjecting the TCR gene to somatic hypermutation. The present invention further relates to use of affinity maturated TCRs to create T cells reactive against a selected antigen.

Abstract: Provided herein are compositions and methods for treating Pitt Hopkins Syndrome (PTHS) by restoring PTHS patient's gut microbiota. These methods can be used with PTHS patient with or without ongoing gastrointestinal symptoms. The methods comprise administering a therapeutic composition comprising a fecal microbe or a fecal microbe preparation to the subject.

Abstract: Provided is a method for exploration based on curiosity and prioritization of experience data in multi-agent reinforcement learning, the method including the steps of: calculating a similarity between a policy of a first agent and a policy of a second agent and computing a final reward using the similarity; and performing clustering on a replay buffer using a result of calculating the similarity between the policy of the first agent and the policy of the second agent and performing sampling on data in the cluster.

Abstract: Disclosed are a side-by-side phase winding, a stator and a motor. The side-by-side phase winding comprises two coil ring groups each consisting of Q coil rings, each coil ring being formed by connecting in series P hairpin conductor groups uniformly distributed in the circumferential direction; each hairpin conductor group comprises two hairpin conductors which are arranged in a staggered manner in the circumferential direction of the stator, each hairpin conductor comprises a hairpin main body which is integrally bent into a U-shape, the hairpin main body comprises two leg parts, a head part and support feet, and adjacent leg parts on the two hairpin conductors arranged in a staggered manner are located in two adjacent slots; and the Q coil rings in each coil ring group are arranged in Q circumferentially continuous adjacent slots of the stator.

Abstract: The present disclosure generally relates to a process for manufacturing a processable dried cellulose nanomaterial using a co-solvent of tert-butyl alcohol (TBA), of which unique physical/chemical properties enable facile modification/derivatization. This present disclosure also relates to materials and process of generating of superhydrophobic surface coating using hydrophobic carboxylic acid modified cellulose nanofibers. Both the processes and the products thereof are within the scope of this disclosure.

Abstract: The present invention relates to a medium composition for culturing a strain for mass production of colanic acid and a method of mass producing colanic acid using the same. Ingredients for the culture medium of the present invention and their concentrations may be optimized using a statistical method, and used to greatly increase the production amount of colanic acid.

Abstract: An apparatus for transmitting broadcasting signal using transmitter identification scaled by 4-bit injection level code and method using the same are disclosed. An apparatus for transmitting broadcasting signal according to an embodiment of the present invention includes a waveform generator configured to generate a host broadcasting signal; a transmitter identification signal generator configured to generate a transmitter identification signal for identifying a transmitter, the transmitter identification signal scaled by an injection level code; and a combiner configured to inject the transmitter identification signal into the host broadcasting signal in a time domain so that the transmitter identification signal is transmitted synchronously with the host broadcasting signal.

Abstract: Disclosed are a method, an apparatus and an electronic device for controlling audio playback of multiple loudspeakers, wherein the method comprises: determining the location information of each speaker and voice signals issued by each speaker; determining the area where each speaker is located according to the location information of each speaker; determining voice instruction corresponding to each voice signal; and controlling the multiple loudspeakers to play the audio indicated by the corresponding voice instruction respectively for the area where the speaker of each voice instruction is located. According to the method and apparatus and/or the electronic device in an embodiment of the present disclosure, different audios can be played for different areas in a preset space.

Abstract: The presently disclosed subject matter provides for antigen-recognizing receptors that specifically target CD371 and cells comprising such CD371-targeted antigen-recognizing receptors. The presently disclosed subject matter further provides uses of the CD371-targeted antigen-recognizing receptors for treatment.

Abstract: A method for analyzing an overcutting defect of a machining process comprises steps as following. A machining code is executed to generate a cutting face, wherein the cutting face comprises a plurality of machining paths. A specified machining path is defined from the plurality of machining paths and a specified node is set on the specified machining path. A sectional plane passing through the specified node is calculated. A plurality of intersection points between the sectional plane and the other machining paths which are different from the specified machining path are obtained. A first adjacent intersection point a second adjacent intersection point are specified from the intersection points. A connection line located between the first adjacent intersection point and the second adjacent intersection point is obtained. A distance between the specified node and connection line is calculate and the distance is defined as an overcutting amount of the specified node.

Abstract: Disclosed herein are a video encoding/decoding method and apparatus. The video decoding method according to the present invention includes: obtaining information on whether filtering is performed on a virtual boundary for a current picture from a bitstream; decoding information on the number of virtual boundaries based on the information on whether filtering is performed on a virtual boundary; decoding information on a position of a virtual boundary based on the information on the number of virtual boundaries; and reconstructing the current picture based on the information on the position of the virtual boundary.

Abstract: The invention relates to antibodies specific for 4-1BB and OX40, as well as to methods for using such antibodies and therapeutic uses thereof.

Abstract: An operation method of a terminal in a communication system may comprise: receiving, from a base station, an RRC message including CG configuration information and parameters for a reconfiguration request on a CG resource configured by the CG configuration information; performing a monitoring operation for uplink communication according to the CG configuration information in a period indicated by a first parameter among the parameters; transmitting, to the base station, a MAC CE requesting reconfiguration of the CG resource, when a result of the monitoring operation satisfies a second parameter among the parameters; and receiving, from the base station, configuration information of the CG resource reconfigured according to the MAC CE.

Abstract: A polymer, an electrolyte, and a lithium-ion battery employing the same are provided. The polymer is a product of a composition via a polymerization. The composition includes a first monomer and a second monomer. The first monomer has a structure represented by Formula (I) and the second monomer is fluorine-containing acrylate, fluorine-containing alkene, fluorine-containing epoxide, or a combination thereof. Particularly, n, m, and l are independently 1, 2, 3, 4, 5, or 6; and, R1, R2, R3, R4, R5 and R6 are as defined in the specification.

Abstract: Exemplary embodiments of the present disclosure apparatus and methods that provide for subtractive material processing, including efficient and precise ablation of tissues. Certain embodiments include a first laser configured to direct a first pulse of energy at a first wavelength to a region of tissue; a second laser configured to direct a second pulse of energy at a second wavelength to the region of tissue; and a control system configured to control operation of the first laser and the second laser.

Abstract: A method of assembling and immobilizing proteinaceous complexes is disclosed. In addition, methods of generating functional RNA polymerase and ribosomal subunits are disclosed.

Abstract: Provided is a method of performing automatic interpretation based on speaker separation by a user terminal, the method including: receiving a first speech signal including at least one of a user speech of a user and a user surrounding speech around the user from an automatic interpretation service providing terminal, separating the first speech signal into speaker-specific speech signals, performing interpretation on the speaker-specific speech signals in a language selected by the user on the basis of an interpretation mode, and providing a second speech signal generated as a result of the interpretation to at least one of a counterpart terminal and the automatic interpretation service providing terminal according to the interpretation mode.

Abstract: A wearable device combines its existing functions (e.g., a headphone) with non-invasive autonomic modulation using tragus or other external auditory meatus stimulation. The wearable device can output audio to a user, such as music, podcast, etc., and further provide modulation of the vagus nerve via tragus stimulation or other external auditory meatus stimulation to treat various diseases.

Abstract: The present invention provides oligonucleotides capable of binding to and modulating the splicing of the pre-mRNA of the CFTR gene, including compositions comprising the oligonucleotides, and uses thereof, such as for suppressing the inclusion of a cryptic exon between exon 22 and 23 as a result of the mutation 3849 +10 Kb C-to-T, optionally in combination with additional CF therapeutics.

Abstract: One embodiment of the present disclosure provides a system and method for facilitating a search for a hybrid-manufacturing process plan for manufacturing an object. During operation, the system can obtain a set of partial order constraints constraining the order in which a set of at least two manufacturing actions, corresponding to addition or removal of predefined regions of space, appear in a process plan. The system can constrain, based on the set of partial order constraints, a search space. The search space can correspond to a tree in which the nodes represent the object's state and the edges represent available actions at each node. The system can then determine a set of optimized process plans represented by orderings of the actions, corresponding to paths on the search tree, that produce the desired final state in a cost-effective manner.