Abstract: Disclosed herein are immunogenic and/or vaccine compositions and methods for treating or preventing Severe acute respiratory syndrome (SARS). The compositions and methods include an immunogenic portion of the receptor-binding domain (RBD) of the SARS-CoV-2-2 (COVID-19) spike protein. In at least particular cases, a mutated version of a portion of the RBD is utilized, such as a deglycosylated, or amino acid substituted mutant of the spike protein.

Abstract: A cartridge 100 for nucleic acid detection is provided with: a first member 110 having multiple nucleic acid extraction wells; a second member 120 having a nucleic acid amplification and determination well for amplification of a nucleic acid and detection of the amplified nucleic acid; and multiple reagent containers 130. The multiple reagent containers 130 are fixed between the first member 110 and the second member 120.

Abstract: Tissue-engineered electronic peripheral nerve interface (TEENI) devices, methods of using TEENI devices, and systems using TEENI devices are provided. In particular, TEENI devices include a support member having a length, at least one thread set comprising a plurality thread set arms having a plurality of electronic leads running through the thread set arms and being fully encapsulated within the support member, and a plurality of electrodes fixed to the plurality of thread set arms.

Abstract: An automated, fieldable ion-selective sensor system for frequent detection of nutrients in soils or water is set forth. In one aspect, an integrated small form-factor housing includes a battery, processor, a fluid manipulation unit and reservoirs, and a chemical species detection cell. A flow-through sampling head can be connected to the detection cell and a waste reservoir by flexible tubing sealingly connected at opposite ends of the tube. In one aspect, improved performance of the ion-selective sensor includes adding an ion-to-electron transfer interlayer between an ion-selective membrane and its working electrode. In one aspect, the sensor is solid-state and uses printed polymeric composite of POT-MoS2. The use of a porous tube for a sampling head and fluid connection at opposite ends allows not only fluid to be removed from the head to the detection cell for measurement but also flow in an opposite direction and out to a waste reservoir to clean and reset for a next sample measurement.

Abstract: A thermoelectric watch including a thermoelectric generator; a voltage booster connected to the thermoelectric generator; an energy management circuit connected to the voltage booster and configured to control the charging of at least one energy storage element, the energy management circuit including an output configured to change from a first logic state to a second logic state when the thermoelectric generator starts generating electrical energy, and to change from the second logic state to the first logic state when the thermoelectric generator finishes generating electrical energy.

Abstract: Disclosed are apparatuses and methods for performing atomic layer etching. A method may include supporting and thermally floating a substrate in a processing chamber, modifying one or more surface layers of material on the substrate by chemical adsorption, without using a plasma, while the substrate is maintained at a first temperature, and removing the one or more modified surface layers by desorption, without using a plasma, while the substrate is maintained at a second temperature, the first temperature being different than the second temperature. An apparatus may include a processing chamber and support features configured to support and thermally float a substrate in the chamber, a process gas unit configured to flow a first process gas onto the substrate, a substrate heating unit configured to heat the substrate, and a substrate cooling unit configured to actively cool the substrate.

Abstract: Provided herein are polynucleic acids and expression vectors for the expression and secretion of angiotensin peptide fragments (e.g., angiotensin-(1-7)) in probiotic bacteria. Provided herein are also probiotic compositions that enable efficient, cost-effective and patient friendly oral therapeutics for treating diverse pathological conditions that involve the renin-angiotensin system (RAS), e.g., pulmonary hypertension, diabetes, diabetic complications, cardiovascular diseases, and ocular inflammatory and neurodegenerative diseases.

Abstract: An environmentally-improved motor oil blend and related methods for properly lubricating components of an engine and favorably modifying a plastic response of components of the engine, the blend being free of zinc di-alkyl-di-thiophosphates (ZDDP) and free of zinc di-thiophosphate (ZDTP), comprising: a motor oil selected from the motor oil group consisting of Group I, Group II, Group III, Group IV, and Group V motor oils; a motor oil additive comprising alpha-olefins and hydroisomerized hydro-treated severe hydrocracked base oil; ZDDP omitted from the chemical constituents of the motor oil; and ZDTP omitted from the chemical constituents of the motor oil.

Abstract: Methods, compositions and uses are provided for bispecific antibodies comprising one or more unnatural amino acids. The bispecific antibodies may bind to two or more different receptors, co-receptors, antigens, or cell markers on one or more cells. The bispecific antibodies may be used to treat a disease or condition (e.g., cancer, autoimmune disease, pathogenic infection, inflammatory disease). The bispecific antibodies may be used to modulate (e.g., stimulate or suppress) an immune response.

Abstract: A system produces sensed images. The system includes a sensor array, an image display device, and a processor that generates an image illustrating contents of an expanded field of view. The processor receives sensor element data from the sensor array, performs zero padding and discrete Fourier transform to result in a sensor wavenumber data buffer. The processor determines reference point locations, and generates a reference Fresnel field. The processor obtains an inverse Huygens-Fresnel transfer data buffer based on the reference Fresnel field. The processor multiplies each data element of the sensor wavenumber buffer with each corresponding data element of the inverse Huygens-Fresnel transfer data buffer. The processor generates a rectilinear spectrum data buffer based on the multiplication. The processor performs Stolt mapping and uniformly resampling to achieve image data.

Abstract: The present disclosure relates to a gate system for an overhead lifting rail system, comprising: a first gate comprising: a rail portion for supporting a lifting carriage; and a bridging element pivotally coupled adjacent a proximal end to the rail portion; and a second gate comprising: a rail portion for suspending a lifting carriage; and a bridging element support portion. Upon the first gate engaging with the second gate, a distal end of the bridging element of the first gate engages with the bridging element support portion of the second gate to form a bridge between the first gate and the second gate; and the distal end of the bridging element and the bridging element support portion are configured such that the ends of the bridging element are substantially aligned with the respective ends of the rail portions of the first and second gates.

Abstract: A distance measuring apparatus includes an image sensor and an image sensor driver. The image sensor includes a photodiode, a first capacitor and a second capacitor, and a first transfer gate and a second transfer gate configured to transmit an output of the photodiode to the respective first and second capacitors. The image sensor driver is configured to complementarily drive the first transfer gate and the second transfer gate.

Abstract: A cryogenic distillation tower for separating a feed stream. The tower includes a distillation section. A controlled freeze zone section is situated above the distillation section and forms a solid from the feed stream. The controlled freeze zone section includes a spray assembly in an upper section and a melt tray assembly in a lower section. The melt tray assembly includes at least one vapor stream riser that directs the vapor from the distillation section into liquid retained by the melt tray assembly, and one or more draw-off openings positioned to permit a portion of the liquid to exit the controlled freeze zone section. The portion of the liquid indirectly exchanges heat with a heating fluid. One or more return inlets return the portion of the liquid to the melt tray assembly after it has been heated in the heat exchanger.

Abstract: A data management system includes a data storage device, a buffer memory, and a controller. The buffer memory is configured to temporally store data read during a reading operation of the data storage device. The controller is configured to, after transmitting a data input/output (I/O) instruction to the data storage device upon an indication of a data reading request, allocate the buffer memory, register a buffer cache of the buffer memory, allocate a direct memory access (DMA) address for the buffer memory, and release the DMA address.

Abstract: A semiconductor device may include a memory controller, which may include a request queue storing requests. Requests include a memory request including a read request to a memory device or a write request to the memory device, and a process in memory (PIM) request requesting a processing operation in the memory device. The memory controller may also include a command generator configured to generate a memory command from a memory request output from the request queue and to generate a PIM command from a PIM request output from the request queue, a command queue storing a memory command and a PIM command output from the command generator, and a command scheduler configured to control output order, output timing, or both of a memory command and a PIM command stored in the command queue.

Abstract: A reflectionless frequency filter circuit is provided. The reflectionless frequency filter circuit may include a first partial circuit including a first inductor and a first resistor connected in parallel with the first inductor, a first inverter connected in parallel with the first partial circuit, and a third partial circuit connected in series with the first inverter, and the third partial circuit may include a third inductor and a third resistor formed in a branch line between the first inverter and the third inductor.

Abstract: Disclosed is an optical transmitter module including a directly modulated laser transmitter based on a directly modulated laser (DML) and an arrayed waveguide grating (AWG) chip that is vertically polished. The directly modulated laser transmitter includes a directly modulated laser chip array including one or more directly modulated laser chips, an impedance matching circuit that allows each of the one or more directly modulated laser chips to operate at a critical speed of 100 Gbps per channel or higher, and a radio frequency-flexible printed circuit board (RF-FPCB) that transmits a radio frequency (RF) modulating signal to the directly modulated laser chip array. The arrayed waveguide grating chip includes an optical waveguides that transfer multi-channel optical signals and a wavelength multiplexer that multiplexes the multi-channel optical signals. The directly modulated laser transmitter and the arrayed waveguide grating chip are spaced apart from each other and are optically coupled in chip-to-chip.

Abstract: There is set forth herein a method including depositing a layer formed of barrier material over a conductive material formation of a photonics structure; and removing material of the layer in a light signal transmitting region of the photonics structure. In one embodiment the barrier material can include silicon carbon nitride. In one embodiment the barrier material can include silicon nitride.

Abstract: The invention disclosed herein relates to novel synergistic medicinal compositions for treating dysfunctional D-serine (DSR) signaling. Particularly the invention provides potent synergistic medicinal composition comprising combination of N-acetyl taurinate salt of divalent metal (M2+AT) as serine racemase enzyme (SR) activator/stimulator and benzoic acid ester salt of monovalent or divalent metals (M+/2+Bz) as d-amino acid oxidase enzyme (DAAO) inhibitor, which are present in weight ratio of 1:0.001 to 1:1.5 along with pharmaceutically acceptable excipients. Further the present synergistic medicinal composition is useful for treating certain neuropsychiatric disorders, neurological disorders and metabolic disorders.

Abstract: A new and distinct cultivar of Spiraea plant named ‘MAD-SP2’, characterized by its pure white colored flowers, medium green foliage and moderately vigorous, compact, low mounded growth habit. Also, for the last 5 years of its existence Spiraea ‘MAD-SP2’ has proven to be leaf spot resistant.