Abstract: The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a delivery device that controls delivery of the drug based on the real-time detection of bioavailable drug concentration.

Abstract: An apparatus with one or more force plates senses of center-of-pressure and force-angle in the sagittal plane for a standing individual to provide an indication of balance capability based on the deduced functional relationship between center-of-pressure and force-angle within a limited band of frequencies. In one embodiment this relationship may be expressed as an intersection point of the force vectors with respect to the individual's center-of-mass.

Abstract: Animal cells, notably adult fibroblasts, are advantageously reprogrammed in direct lineage reprogramming methods using defined factors to produce proliferative and multipotent induced cardiac progenitor cells (iCPC). The iCPC thus produced can be differentiated under suitable differentiation conditions to cardiac lineage cells including cardiomyocytes, smooth muscle cells, and endothelial cells, as evidenced by expression of lineage specific markers. Sets of factors effective in combination to reprogram the fibroblasts can include a set that includes some or all of 5 factors (Mesp1, Baf60c, Nkx2.5, Gata4, Tbx5), a set that includes some or all of 11 factors (Mesp1, Mesp2, Gata4, Gata6, Baf60c, SRF, Isl1, Nkx2.5, Irx4, Tbx5, Tbx20), a set that includes some or all of 18 factors (T, Mesp1, Mesp2, Tbx5, Tbx20, Isl1, Gata4, Gata6, Irx4, Nkx2.5, Hand1, Hand2, Tbx20, Tbx18, Tip60, Baf60c, SRF, Hey2), and a set that includes some or all of 22 factors (T, Mesp1, Mesp2, Tbx5, Tbx20, Isl1, Gata4, Gata6, Irx4, Nkx2.

Abstract: This document provides methods and materials for treating HIV infections. For example, methods and materials for using one or more proteosome inhibitors in combination with one or more other agents to treat HIV infections are provided.

Abstract: The present disclosure provides a control information transmission method, a control information detection method, a network device and a UE. The control information transmission method includes: mapping a control resource set for transmitting control information to at least one RB adjacent to an RB occupied by an SS block in accordance with a predetermined mapping mode; and transmitting the predetermined mapping mode to a UE, and transmitting the control information to the UE on the at least one RB occupied by the control resource set.

Abstract: Technologies are provided for generation of programmable pulse signals using inverse chaotic maps, without reliance on a clocking signal. Some embodiments of the technologies include an apparatus that can receive a sequence of bits having a defined number of bits, where the sequence of bits represent a desired continuous pulse signal having a programmable width in time-domain. The apparatus can also can receive a precursor continuous pulse signal having an arbitrary width in time-domain that fits within the dynamic range of the apparatus. The apparatus can generate the desired continuous pulse signal by transforming the precursor continuous pulse signal using the sequence of bits and an inverse chaotic map.

Abstract: A device (100) for detecting settled solids (300) in a conduit (200) for transporting slurry. The device (100) comprises a housing (110) positionable to define at least a segment of a flow path for the slurry. The device (100) comprises a reference temperature sensor (140) associated with the inside of the housing 110 in order to measure an ambient temperature of the slurry within the conduit. The device (100) further comprises a plurality of heaters (150) spaced around part of the inside circumference housing (110) that are maintained at a target temperature that is higher titan the ambient temperature of the slurry.

Abstract: A parity interleaving apparatus and method for variable length signaling information are disclosed. A parity interleaving apparatus according to an embodiment of the present invention includes a processor configured to generate a parity bit string for parity puncturing by segmenting parity bits of an LDPC codeword whose length is 16200 and whose code rate is 3/15, into a plurality of groups, and group-wise interleaving the groups using an order of group-wise interleaving; and memory configured to provide the parity bit string for parity puncturing to a parity puncturing unit.

Abstract: A catalyst for catalytic oxidation of furfural to prepare maleic acid is composed of a carbon nitride doped with a potassium salt. A method for preparing the catalyst includes mixing the potassium salt, a precursor of the carbon nitride and a solvent to obtain a mixture, and drying and calcining the mixture to obtain the catalyst. A use of the catalyst in catalytic oxidation of furfural to prepare maleic acid, wherein the maleic acid is prepared by the step of oxidizing furfural in a solvent in the presence of the catalyst. The invention has the advantages that by using the method provided by the invention to prepare maleic acid, the conversion rate of furfural can be 99% or more and the yield of maleic acid can be up to 70.40%.

Abstract: Systems and methods are provided for enabling lower-bandwidth hardware components to support higher data rates. In particular, aspects of the disclosed systems and methods use Raised Cosine pulse shaping in short-reach links to band limit the signal spectra and thereby enable existing, such lower-bandwidth components to support higher data rates.

Abstract: A display device (1) for displaying a decorative object (2), including a case (4) provided with a support element (5) on which an area of interest (3) is defined, inside which the decorative object (2) is likely to be disposed and/or handled. A processing unit generates a command for controlling the illumination properties of a main illumination device (8a) and/or of a secondary illumination device (8b) as a function of criteria concerning the viewer's visual perception of the object (3) and controls the main illumination device (8a) and/or the secondary illumination device (8b) as a function of the command for controlling the properties of the illumination devices (8a, 8b).

Abstract: Provided herein are analogs of the natural product icariin represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The analogs can be used to modulate (e.g., inhibit, such as by competitive inhibition) PDE5 and thereby treat a wide range of PDE5-mediated diseases, including cardiovascular, gastrointestinal, pulmonary, musculoskeletal, neurological and reproductive diseases. Also provided herein are compositions and methods including compounds of Structural Formula (I).

Abstract: The present invention relates to an additive for hydraulically setting compositions comprising a colloidally disperse preparation comprising at least one salt of a polyvalent metal cation with at least one organic phosphonate and/or phosphate compound as anion and at least one polymeric dispersant comprising anionic and/or anionogenic groups and polyether side chains. The additive is especially suitable as slump retainer and for improving early strength.

Abstract: The present invention provides methods for detecting and/or treating a subject having an aneurysm or at risk for developing an aneurysm. It has been discovered that a key metabolite of the kynurenine (Kyn) pathway, a major route for the metabolism of essential amino acid tryptophan (Trp) into nicotinamide adenine dinucleotide (NAD+), plays a critical role in the formation of aneurysms, for example abdominal aortic aneurysms. In particular, it has been discovered that 3-Hydroxyanthranilic acid (3-HAA), a product of kynureninase (KYNU), plays a causative role in the formation of aneurysms by, for example exerting pro-inflammatory effects on vascular smooth muscle cells. It has further been discovered that elevated levels of 3-HAA are indicative of the presence and/or progression of an aneurysm, and 3-HAA levels correlate with the size (aortic diameter) of the aneurysm.

Abstract: Disclosed herein is an integrated assay system that can be used, for example, to monitor and screen cells in 3D culture. This system involves a 3D cell growth medium made from a yield stress material that allows cells to be deposited, e.g. by 3D printing, samples to be taken, and the extracellular environment manipulated.

Abstract: A pressure sensor includes a substrate, a patterned circuit, and a conductive material layer. The patterned circuit, formed on the substrate, includes a first-path part and a second-path part of which at least a part is formed at a predetermined gap from at least a part of the first-path part. The conductive material layer, resiliently disposed on the patterned circuit, has protrusions. The conductive material layer deforms to determine a contact area between the protrusions and the substrate, and upon deformation of the conductive material layer to contact the first-path part, the gap between the first-path part and the second-path part, and the second-path part, the first-path part electrically connects to the second-path part.

Abstract: According to some embodiments, the present disclosure may relate to a system including a gaseous fuel consuming engine operating at an air to fuel ratio (AFR) and including a throttle valve controlling a speed of engine, and an engine controller coupled to the engine. The engine controller may be configured to obtain the speed of the engine and obtain the AFR of the engine. The engine controller may also be configured to, based on a transient event affecting the engine, coordinate modification of both the throttle valve to change the speed of the engine and trim valve to change the AFR of the engine to maintain at least one of the speed and the AFR of the engine within a threshold deviance.

Abstract: The present invention generally relates to carbon monoxide releasing compounds and compositions, and their use as carbon monoxide prodrugs. The compounds disclosed herein contain a cyclopentadienone moiety, a non-reactive dienophile, and an enzyme-cleavable tethering moiety connecting the cyclopentadienone moiety to the non-reactive dienophile. Cleavage of the enzyme-cleavable tethering moiety results in conversion of the non-reactive dienophile to a reactive dienophile.

Abstract: A motor drive is provided, which includes a control circuit, a first transistor, a first comparison circuit, a second transistor and a load. The control circuit includes a first output terminal and a second output terminal; the first output terminal outputs a first control signal; the second output terminal outputs a second control signal whose phase is inverse to the phase of the first control signal. The gate of the first transistor receives the first control signal. The first comparison circuit compares the gate-source voltage with a reference voltage to generate a first comparison signal. When the first comparison signal shows that the first control signal is reduced to be lower than the reference voltage, the second control signal generated by the second output terminal is transmitted to the gate of the second transistor.

Abstract: The present specification relates generally to a therapeutic protocol for treating a subject having cancer. Taught herein is a method of treating cancer or reducing the risk of recurrence of cancer in a subject following an anti-cancer therapy.