Patents Assigned to Research
  • Conjugates for immunotherapy
    Patent number: 10449227
    Abstract: The current invention pertains to a molecular conjugate comprising an antagonist of a cell surface receptor specific to a target cell and an immune effector, such as a T cell modulator, conjugated to the antagonist. The target cell can be a cell responsible for development of a disease in a subject, for example, a cancer cell. In certain embodiments, the immune effector is an immune effector protein or an immune effector fragment thereof. The current invention also pertains to a method of treating a disease in a subject, the method comprising administering to the subject a pharmaceutically effective amount of the molecular conjugates of the current invention to the subject. The methods of the current invention can be used to treat cancer, such as breast cancer, ovarian cancer, prostate cancer, lung cancer, pancreatic cancer, or melanoma.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: October 22, 2019
    Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc., University of South Florida
    Inventors: Mark McLaughlin, David L. Morse, Shari Pilon-Thomas, Scott Antonia
  • Two-speed transmission having two clutches for electric vehicle
    Patent number: 10451146
    Abstract: A two-speed transmission having two clutches for an electric vehicle includes an electric motor, a middle shaft, a first clutch, a second clutch, a first gear assembly and a second gear assembly. The electric motor includes a spindle. The first and second clutches are furnished on the middle shaft coaxially. The first gear assembly is furnished on the spindle and the first clutch respectively to generate a first gear ratio. The second gear assembly is furnished on the spindle and the first clutch respectively to generate a second gear ratio different from the first gear ratio. When the first clutch is activated to connect with the middle shaft, the second clutch separates from the middle shaft, and the electric motor outputs a first torque corresponding to the first gear ratio to the middle shaft. Similarly, the electric motor outputs a second torque corresponding to the second gear ratio.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: October 22, 2019
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jui-Tang Tseng, Kun-Ju Xie, Chia Tsao, Tsung-Han Wu
  • Method and device for encoding/decoding image
    Patent number: 10455232
    Abstract: A method and a device for encoding/decoding an image are disclosed. The method for decoding an image comprises the steps of: decoding information on a quantization matrix; and restoring the quantization matrix on the basis of the information on the quantization matrix, wherein the information on the quantization matrix includes information indicating a DC value of the quantization matrix and/or information indicating differential values of quantization matrix coefficients.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: October 22, 2019
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Sung Chang Lim, Hui Yong Kim, Jin Ho Lee, Jin Soo Choi, Jin Woong Kim
  • Methods of treating inflammation or neuropathic pain
    Patent number: 10450302
    Abstract: Provided herein are methods of treating inflammation or neuropathic pain using an effective dose of a monoacylglycerol lipase inhibitor or a composition thereof.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: October 22, 2019
    Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    Inventors: Jacqueline Lorayne Blankman, Jason Robert Clapper, R. Alan B. Ezekowitz, Iain Peter Fraser, Cheryl A. Grice, Todd K. Jones, Gary Paul O'Neill, Archie Wayne Thurston, Jr., Channing Rodney Beals
  • Hydrogel composition and method for using the same
    Patent number: 10449272
    Abstract: The present disclosure provides a hydrogel composition including: a hydrogel having a structure represented by Formula (I) or Formula (II) shown as follows: A-B-BOX-B-A, Formula (I); B-A-B-(BOX-BAB)n-BOX-B-A-B, Formula (II), wherein, A is a hydrophilic polyethylene glycol polymer, B is a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2,2?-Bis(2-oxazoline) for coupling di-block of A-B or tri-block of B-A-B, and n is an integer greater than or equal to 0; and an anti-adhesion additive, wherein the anti-adhesion additive comprises a carbohydrate, a nitrogen-containing cyclic compound, a polymer or a combination thereof.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: October 22, 2019
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Yu-Chi Wang, Hsin-Hsin Shen, Chin-Fu Chen, Meng-Yow Hsieh, Sen-Lu Chen, Yu-Bing Liou, Tsai-Yu Lin, Pei-Shan Li, Wei-Lin Yu
  • Capacitive measurement device with integrated electrical and mechanical shielding
    Patent number: 10448875
    Abstract: A substance measurement device includes: a container portion configured to receive a substance; a sensing device configured to measure a property of the substance related to at least one of a flow rate of the substance into the container portion, a level of the substance within the container portion, and a volume of the substance within the container portion; and at least one shield positioned within the container portion and configured to provide at least one of: a mechanical buffer between the substance entering the container portion and the sensing device; and an electrical shield between the substance entering the container portion and the sensing device.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: October 22, 2019
    Assignees: Stream Dx, Inc, University of Utah Research Foundation
    Inventors: Brian D. Holt, Scott B. McClellan, Alvin Y. Le, Kent James Ogden
  • Regret benefit ratio link scheduler for wireless backhaul with directional antennas
    Patent number: 10455604
    Abstract: A wireless system can include a plurality of directional antennas and a scheduler scheduling multiple links between the plurality of directional antennas. The scheduler can schedule the multiple links concurrently in the same time slot based on Regret Benefit Ratio (RBR). The RBR is a single indicator combining contention for one of the directional antennas and Quality of Service (QoS). The scheduler can introduce a contention graph for the directional antennas that capture a global knowledge of interference.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: October 22, 2019
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventors: Dapeng Oliver Wu, Yun Zhu, Jiade Li, Qiuyuan Huang
  • Image encoding/decoding method and device
    Patent number: 10455241
    Abstract: Disclosed are an image encoding/decoding method and device supporting a plurality of layers. The image decoding method supporting the plurality of layers comprises the steps of; receiving a bitstream comprising the plurality of layers; and decoding the bitstream so as to acquire maximum number information about sublayers with respect to each of the plurality of layers.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: October 22, 2019
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Jung Won Kang, Ha Hyun Lee, Jin Ho Lee, Jin Soo Choi, Jin Woong Kim
  • Method for transceiving broadcast signal using combination of multiple antenna schemes with layered division multiplexing and apparatus for the same
    Patent number: 10454536
    Abstract: Disclosed herein are a method for transceiving a broadcast signal using a combination of multiple antenna schemes with layered division multiplexing and an apparatus for the method. A method for receiving a broadcast signal includes generating received signals based on signals that are received through multiple receiving antennas, estimating channels between the receiving antennas and transmitting antennas, restoring a core-layer signal corresponding to the received signals, and restoring an enhanced-layer signal based on a cancellation process, wherein the cancellation process corresponds to the core-layer signal and is separately performed for the individual receiving antennas.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: October 22, 2019
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Sung-Ik Park, Bo-Mi Lim, Sun-Hyoung Kwon, Heung-Mook Kim, Jae-Hyun Seo, Jae-Young Lee, Nam-Ho Hur, Hoi-Yoon Jung, David Gomez-Barquero, Eduardo Garro
  • Selective automated blossom thinning
    Patent number: 10448578
    Abstract: The invention relates to an end-effector device and automated selective thinning system. The system includes vision acquisition hardware, kinematic targeting and heuristic programming, a robotic arm, and a pomologically designed end-effector. The system is utilized to improve efficiency for the fruit-thinning process in a tree orchard, such as peach thinning By automating the mechanical process of fruit thinning, selective fruit-thinners can eliminate manual labor inputs and further enhance favorable blossom removal. Automation used in conjunction with a heuristic approach provides improvements to the system. The system may also be configured as a robotic arm or as a handheld system by including a battery and switching microcontroller with handle or wrist straps. Handheld thinning devices that are mechanical in nature may also be part of the system.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: October 22, 2019
    Assignee: The Penn State Research Foundation
    Inventors: David Lyons, Paul Heinemann
  • Upgrading ethane-containing light paraffins streams
    Patent number: 10450242
    Abstract: A process for upgrading an ethane-containing C5? paraffin stream comprises contacting the paraffin stream with an oxygen containing gas in the presence of a selective oxidation catalyst under conditions to selectively oxidize at least part of the ethane in the paraffin stream and produce a first product stream comprising ethylene. At least part of the first product stream may then be contacted with an isoparaffin-containing feed in the presence of a solid alkylation catalyst and under conditions to alkylate at least part of the isoparaffin with at least part of the ethylene and produce a second product stream comprising C6+ alkylate. Alternatively, at least part of the ethylene in the first product stream may be dimerized before the alkylation step.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: October 22, 2019
    Assignee: EXXONMOBIL RESEARCH AND ENGINEERING COMPANY
    Inventors: Guang Cao, Jihad M. Dakka
  • Renewable ketone waxes with unique carbon chain lengths and polarities
    Patent number: 10450256
    Abstract: The present disclosure provides ketone waxes, methods of forming ketone waxes, and compositions comprising ketone waxes. In at least one embodiment, a ketone wax is provided. The ketone wax includes about 50 wt % or greater C40-C90 ketone content; about 50 wt % or greater of the ketone wax has a boiling point of 961° F. or greater; and a paraffins content of less than about 10 wt %, as determined by 2-dimensional gas chromatography. In at least one embodiment, a method for forming a C40-C90 ketone wax includes exposing a feed stock to a basic catalyst under conditions suitable for coupling unsaturated carbon chains from the feed to form a composition including a ketone wax, oligomerizing the ketone wax to form a ketone wax having C40-C90 ketone wax, and distilling and/or extracting the oligomerized ketone wax to provide a C40-C90 ketone wax of the present disclosure.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: October 22, 2019
    Assignee: ExxonMobil Research and Engineering Company
    Inventors: Virginia M. Reiner, Michel Daage, Kun Wang, Sarvesh K. Agrawal, Frank C. Wang
  • Method and device for encoding/decoding image
    Patent number: 10455233
    Abstract: A method and a device for encoding/decoding an image are disclosed. The method for decoding an image comprises the steps of: decoding information on a quantization matrix; and restoring the quantization matrix on the basis of the information on the quantization matrix, wherein the information on the quantization matrix includes information indicating a DC value of the quantization matrix and/or information indicating differential values of quantization matrix coefficients.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: October 22, 2019
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Sung Chang Lim, Hui Yong Kim, Jin Ho Lee, Jin Soo Choi, Jin Woong Kim
  • Power amplifier system and learning-based autotuning method thereof
    Patent number: 10454427
    Abstract: A Digital Power-Amplifier (DPA) system includes a power amplifier (PA) circuit having control inputs and an output for generating output signals, and an adaptive control circuit that comprises an input interface, an output interface, a memory storing an adaptive control algorithm and a processor performing instructions based on the adaptive control algorithm in connection with the memory, wherein the input interface receives input-state signals and output signals of the DPA circuit, wherein the adaptive control algorithm determines, in response to the input-state signals and the output signals, control parameters of control signals transmitted to the control inputs from the output interface for controlling operations of the DPA circuit.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: October 22, 2019
    Assignee: Mitsubishi Electric Research Laboratories, Inc.
    Inventors: Rui Ma, Mouhacine Benosman, Koushik Manjunatha, Sufeng Niu, Daniel Antonio Da Costa Dinis
  • Methods of making graphene oxide nanofilters
    Patent number: 10449497
    Abstract: Nanofiltration of aqueous solutions or other water-based fluids in various applications, such as desalination, dialysis, seawater purification, for example, may be enhanced through precisely controlling a filtration cutoff within graphene oxide nanofilters. By initially compressing and constraining the stacked thickness of multiple graphene oxide layers deposited between porous substrates, the interlayer gap size, and thus, the filtration cutoff may be adjusted and optimized.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: October 22, 2019
    Assignee: PALO ALTO RESEARCH CENTER INCORPORATED
    Inventor: David K. Biegelsen
  • NO- and HS-releasing compounds
    Patent number: 10450260
    Abstract: This disclosure relates to compounds containing both an NO-releasing moiety and an H2S-releasing moiety and the use of such compounds in treating inflammatory diseases, including cancers.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: October 22, 2019
    Assignee: Research Foundation of The City University of New York
    Inventors: Khosrow Kashfi, Ravinder Kodela
  • Compositions and methods for enhancing immune response
    Patent number: 10449247
    Abstract: The use of oxidatively transformed carotenoid or a component thereof to enhance the immune response in a subject for the treatment of infection or to enhance the immune response to an antigen in a subject being immunized. Also disclosed are pharmaceutical compositions and kits containing the oxidatively transformed carotenoid.
    Type: Grant
    Filed: October 23, 2008
    Date of Patent: October 22, 2019
    Assignees: Avivagen Inc., National Research Council of Canada
    Inventors: James Johnston, Bozena Korczak, Graham Burton
  • High viscosity base stock compositions
    Patent number: 10450513
    Abstract: Methods are provided for producing Group II base stocks having high viscosity and also having one or more properties indicative of a high quality base stock. The resulting Group II base stocks can have a viscosity at 100° C. and/or a viscosity at 40° C. that is greater than the corresponding viscosity for a conventional Group II base stock. Additionally, the resulting Group II base stocks can have one or more properties that are indicative of a high quality base stock.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: October 22, 2019
    Assignee: ExxonMobil Research and Engineering Company
    Inventors: Suzzy C. H. Ho, Charles L. Baker, Jr., Shuji Luo, Halou Oumar-Mahamat
  • Anti-PD-1 antibodies and methods of use thereof
    Patent number: 10450373
    Abstract: The instant disclosure provides antibodies that specifically bind to human PD-1 and antagonize PD-1 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: October 22, 2019
    Assignees: AGENUS INC., LUDWIG INSTITUTE FOR CANCER RESEARCH LTD, MEMORIAL SLOAN KETTERING CANCER CENTER
    Inventors: Marc Van Dijk, Cornelia Anne Mundt, Gerd Ritter, Jedd David Wolchok, Taha Merghoub, Roberta Zappasodi, Rikke Baek Holmgaard, David Schaer, David Adam Savitsky, Nicholas Stuart Wilson
  • Vehicle control systems and methods of controlling vehicles using behavior profiles
    Patent number: 10452073
    Abstract: Vehicle control systems and methods for controlling a vehicle using behavior profiles of neighboring vehicles are disclosed. In one embodiment, a vehicle control system of a vehicle includes one or more processors and one or more non-transitory memory modules communicatively coupled to the one or more processors and storing machine-readable instructions that, when executed, cause the one or more processors to perform at least at the following: detect a neighboring vehicle within an environment, determine an autonomous software version executed by the neighboring vehicle, determine a behavior profile associated with the autonomous software version, and control one or more vehicle systems of the vehicle based at least in part on the behavior profile associated with the autonomous software version.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: October 22, 2019
    Assignee: TOYOTA RESEARCH INSTITUTE, INC.
    Inventors: Katarina R. C. Miller, Julian M. Mason, James J. Kuffner