Abstract: Expandable vertebral body implants, systems, instruments, and methods of assembly and using the implants, systems, and instruments are disclosed. The vertebral body implant includes a body with a first end and a second end, a first rotating member rotatably coupled to the first end, wherein an end includes a plurality of first notches inset into the first rotating member, a second rotating member rotatably coupled to the second end, wherein an end includes a plurality of second notches inset into the second rotating member, a first extension member moveably coupled to the first end, and a second extension member moveably coupled to the second end. The expandable cage system comprises a vertebral body implant and an insertion instrument. Methods for assembling and using the vertebral body implants and instruments are also disclosed.

Abstract: Disclosed is an apparatus and method of generating a stitched image. A method of generating a stitched image according to the present disclosure includes: obtaining a plurality of input images; determining whether or not a parallax problem occurs between overlapping areas of the obtained input images; updating a predetermined look-up table according to the determination; and generating a stitched image by applying the updated look-up table to the input images.

Abstract: Well-defined, xeno-free culture media which comprise a TGF-beta isoform or the chimera formed between IL6 and the soluble IL6 receptor (IL6RIL6), which are capable of maintaining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving embryonic stem cells in such well-defined, xeno-free culture media. In addition, the present invention provides methods of differentiating ESCs or EBs formed therefrom for the generation of lineage specific cells.

Abstract: The invention provides processes for the preparation of HU-910, which are scalable to industrial purposes, using safer reagents and having high yield and pure product and a crystalline structure of HU-910, which is a unique product thereof.

Abstract: Various designs are provided to mitigate or solve limitation on the bendability of an active matrix backplanes: including breaking large rigid silicon chips (ICs) into smaller rigid ICs, changing the orientation of rigid ICs, changing the placement of the ICs on the array, thinning the ICs to the point where the Si is flexible, and replacing the ICs with high quality TFT processing which can be done on flexible substrates.

Abstract: A laser cleaning apparatus and a laser cleaning method are furnished, for switching the wavelengths of laser beams furnished by a single laser module using a wavelength switching module and cleaning a test piece using the laser beams having wavelengths and energy suitable for manufacturing needs. The laser cleaning method includes: creating a laser beam; switching the wavelength output by the laser based on process requirements; propagating the laser beam via an optical path propagating module for laser cleaning the test piece; and removing debris. A transfer platform allows movements of the laser beams with respect to the test piece to achieve cleaning of the entire test piece. A control module controls the wavelength switching unit, the laser beam regulating module, and the transfer platform. Total laser cleaning with improved laser cleaning quality is achieved by using these laser beams with the appropriate wavelengths and energy.

Abstract: A lift unit docking system includes a docking rail, a docking rail adapter, and a locking mechanism. The docking rail is configured to provide ingress and egress of a lift unit to and from an overhead rail, and includes a body defining a channel and an adapter receiving opening within the body. The docking rail adapter is repositionable relative to the adapter receiving opening of the docking rail and is configured to transport the lift unit into and out of the channel of the docking rail. The locking mechanism is repositionable between a locked position and an unlocked position, wherein the locking mechanism extends into the channel to block movement of a mounted lift unit toward the adapter receiving opening of the docking rail when in the locked position.

Abstract: Provided are uses of a therapeutically effective amount of citrulline for the manufacture of a medicament for treatment of a subject having an inflammatory bowel disease (IBD) and/or colon cancer. Also provided are pharmaceutical compositions comprising a therapeutic effective amount of citrulline and a therapeutically effective amount of a flavonoid for the treatment of an inflammatory bowel disease (IBD) and/or colon cancer and kits comprising same.

Abstract: Method of making interconnected layered porous carbon sheets with porosity within the carbon sheets and in-between the carbon sheets for use as an electrode. Method of making a metal-nanoparticle carbon composite, wherein metal particles are surrounded by shells made of amorphous carbon. Electrodes containing an amorphous carbon structure comprising a plurality of interconnected layered porous carbon sheets. Electrodes containing graphitic carbon structure with a surface area in the range of 5-200 m2/g. Electrodes containing a metal-nanoparticle carbon composite comprising metal core-carbon shell like architecture and an amorphous structure, wherein metal particles are surrounded by shells made of amorphous carbon.

Abstract: Provided are a graphene-based compound, a preparation method thereof, a single-phase composition for preparing a graphene-based compound, and a graphene quantum dot. Specifically, provided are a graphene-based compound prepared from a single-phase composition for preparing a graphene-based compound including hydrocarbyl amine, a hydroxyl group-containing carbon source, and an acid, a preparation method thereof, a single-phase composition for preparing a graphene-based compound, and a graphene quantum dot.

Abstract: A method of generating an isolated population of non graft versus host disease (GvHD) inducing cells comprising a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) providing a population of at least 70% memory T cells; (b) contacting the population of memory T cells with an antigen or antigens so as to allow enrichment of antigen reactive cells; and (c) culturing the cells resulting from step (b) in the presence of cytokines so as to allow proliferation of cells comprising the Tcm phenotype. Cells generated by the method, pharmaceutical compositions and methods of treatment are also disclosed.

Abstract: The present disclosure relates to a biomarker capable of detecting the genes T3dh (type III alcohol dehydrogenase, CG3425), fbp (fructose 1,6-bisphosphatase, CG31692) and AGL (amylo-alpha-1,6-glucosidase, 4-alpha-glucanotransferase, CG9485), which are involved in the induction and occurrence of aging, obesity and cancer, and thereby determining the progression of aging, determining obesity and diagnosing cancer rapidly, accurately and simply. The biomarker may be used to analyze or diagnose the progression of aging, cancer and obesity in a human, a non-human mammal or an insect individually or collectively.

Abstract: A breastfeeding simulation system (BSS). The BSS includes a breast prosthesis having a pliable nipple, and a baby mannequin configured to interface with the breast prosthesis, the baby mannequin includes an articulating head, a motorized jaw, the articulating head further includes a mouth normally placed in a closed position by the motorized jaw, where the motorized jaw opens when an object is detected near the mouth and the baby mannequin is positioned according to a predetermined angular position, and a palate sensor, configured to provide a proper placement signal when the pliable nipple is placed at a predetermined position.

Abstract: Compositions and methods are described for a polymer hydrogel created by a cycloaddition reaction between an azide and an alkyne that proceeds rapidly without catalyst to produce the polymer hydrogel in less than ninety seconds. The polymer hydrogel can be used in in vivo applications for the localized delivery of therapeutic agent in aqueous solutions. An example of therapeutic delivery of a protein in a mouse model is demonstrated.

Abstract: Materials and methods for treating cancer, including materials and methods for treating cancer in patients identified as having elevated levels of Bim.

Abstract: Disclosed herein is an antifouling device for large, nonplanar optical surfaces. The device can be used as marine or implantable applications that has nested multiscale features for active and passive anti-biofouling. By combining active and passive anti-biofouling mechanisms, this device will provide long-term protection against biofouling for over 10 years, extending the lifetime of self-clearing marine or implantable sensors.

Abstract: Provided are methods for extraction of various agents, e.g. active agent, from a plant source, specifically with the use of extraction formulations which are based on micellar liquid systems.

Abstract: Polypeptides comprising maltose/maltotriose transporters are provided. Additionally, polynucleotides, DNA constructs, and vectors encoding a maltose/maltotriose transporter, or yeast cells harboring such polynucleotides are provided. The yeast cell may be a Saccharomyces eubayanus cell modified to increase the expression or transport activity of a maltose/maltotriose transporter at the plasma membrane of the cell. Further, methods are provided for making a fermentation product by culturing any one of the yeast cells described herein with a fermentable substrate. Finally, methods are provided to select for and isolate maltotriose-utilizing strains of Saccharomyces eubayanus.

Abstract: The invention relates to a compound of Formula I: Formula I, or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of Formula (I) as selective inhibitors of tryptophan 2,3-dioxygenase. The invention also relates to the use of the compounds of Formula (I) for the treatment or prevention of cancer and central nervous system disease or disorder, either as a single agent or in combination with other therapies.

Abstract: The invention provides peptides that can reactivate p53 mutants efficiently and specifically, as well as methods that allow the identification, selection and isolation of such peptides, in a precise, cost and time effective manner. In particular, there are provided mutant p53 reactivating peptides that can restore the native wild type p53 folding, and hence the tumor suppressor activity, to the mutant p53 protein. Such peptides are useful for treating various conditions and diseases in which p53 is mutated.