Abstract: Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.

Abstract: Disclosed are a method and a system of device-to-device tunnel establishment between small cells, applied to a wireless backhaul management device, a first small cell and a second small cell. The method comprises: matching the first small cell and the second small cell according to a first discovery response and a second discovery response; submitting a match report; replying with a match report response; conducting a D2D connection authentication procedure between the second small cell and the first small cell; wirelessly connecting the second small cell and the first small cell, conducting a connection test and submitting a connection test report; replying with a D2D tunnel establishment decision according to the connection test report; and establishing a D2D tunnel between the second small cell and the first small cell.

Abstract: An inter prediction method according to the present invention comprises the steps of: selecting candidate units from among reconstructed neighbor units; creating a candidate unit set with respect to units to be decoded, using the selected candidate units; determining a reference unit from among the candidate units which constitute the created candidate unit set; and performing inter prediction on the units to be decoded, using the determined reference unit. According to the present invention, image encoding/decoding efficiency can be improved.

Abstract: Systems and methods are provided for pretreatment and upgrading of crude bio oils for further processing and/or use as fuel products. Crude bio oils can be treated by one or more of flash fractionation and thermal cracking to generate fractions suitable for further processing, such as further hydroprocessing. Blending of crude bio oil fractions with mineral feeds can also be used to reduce metals contents to levels suitable for refinery processing.

Abstract: A system and methods for analyzing seismic data are provided herein. The method includes identifying, via a computing device, a representation of a seismic data set (1802) and determining a number of feature descriptors corresponding to each of a number of aggregates within the representation (1804). The method also includes identifying a query relating to the representation and one or more vocabulary definitions relating to the query (1806), analyzing the representation to compute a likelihood that each of the aggregates satisfies the query (1808), and returning a result of the query (1810).

Abstract: A new compound composition that is free of a side effect to a liver and used for alleviating the toxicity of an acetaminophen (APAP) medicament to the liver. The compound composition comprises (a) a pharmaceutically effective amount of acetaminophen and (b) a frequently-used safe and pharmaceutically acceptable excipient that can be combined with one or more than two medicaments that can reduce the toxicity of a drug via liver enzyme CYP2E1 metabolism to the liver.

Abstract: In one of the exemplary embodiments, the disclosure is directed to a post network entry connection method applicable to a user equipment. The method would include not limited to: receiving a time unit which may include a payload region and a downlink header region which may include a first BQMR for a first scan beam and a second BQMR for a second scan beam; obtaining a first reference signal from the first BQMR and a second reference signal from the second BQMR; calculating a first signal quality measurement by using the first reference signal and calculating a second signal quality measurement by using the second reference signal; selecting the first scan beam based on the first signal quality measurement being better than at least the second signal quality measurement; and transmitting the first signal quality measurement which corresponds to the first scan beam via another time unit.

Abstract: A non-orthogonal transmission method of a terminal in a communication system may comprise generating data based on a signature used to identify the terminal among a plurality of terminals belonging to the communication system; generating an uplink signal including the data and a demodulation reference signal (DM-RS); and transmitting the uplink signal to a base station without an uplink grant.

Abstract: Provided is a method of reproducing an audio signal, the method including determining, when a user moves from a position to another position in a virtual space, a relative position between a sound source and the other position of the user using metadata based on a movement of the user and correcting a first audio signal obtained from the sound source at the position of the user to a second audio signal obtained from the sound source at the other position of the user based on the relative position.

Abstract: The invention relates to an oral tiopronin composition for reducing the dosing frequency in treatment of cysteinuria comprising of therapeutically effective amount of tiopronin and one or more pharmaceutically acceptable excipients.

Abstract: The present disclosure provides CAPN5 substrates and CAPN5 inhibitors, nucleic acids encoding CAPN5 substrates or CAPN5 inhibitors, methods to deliver CAPN5 substrate or CAPN5 inhibitor agents to the eye, and methods of identifying inhibitors of CAPN5.

Abstract: Disclosed herein are methods and compositions for identifying and/or treating subjects having or likely to have amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD). Antibodies specific for one or more di-amino acid repeat-containing proteins are also provided herein.

Abstract: An electrode lead may comprise a flexible circuit that includes a planar dielectric substrate including an elongated lead substrate portion having opposing ends, an electrode carrying substrate portion disposed on one end of the lead substrate portion, and a connector substrate portion disposed on the other end of the lead substrate portion, wherein the lead substrate portion is pre-shaped into a three-dimensional structure. The flexible circuit may further include an electrically conductive trace extending from the connector substrate portion to the electrode carrying substrate portion, a first window formed in the connector substrate portion to expose the electrically conductive trace to form a connector pad, and a second window formed in the electrode carrying substrate portion to expose the electrically conductive trace to form an electrode pad. The electrode lead may further comprise a lead connector that incorporates the connector substrate portion.

Abstract: In one aspect, compositions are described herein. In some embodiments, a composition described herein comprises, consists of, or consists essentially of an MRI-active or MRI-sensitive polymer or oligomer formed from (i) a non-alkoxylated and non-alkenoxylated citric acid, citrate, or ester/amide of citric acid, and optionally an alkoxylated or alkenoxylated citric acid, citrate, or ester/amide of citric acid, (ii) a polyol/polyamine such as a diol/diamine, (iii) a monomer comprising an MRI contrast agent, and (iv) an amino acid monomer. The polymer or oligomer may be photoluminescent and MRI-sensitive. In another aspect, imaging methods utilizing the compositions described herein are described. In another aspect, scaffolds, grafts, and films comprising, consisting of, or consisting essentially of the compositions described herein are described.

Abstract: The present invention provides AAV capsid proteins comprising modification of one or a combination of the surface-exposed lysine, serine, threonine and/or tyrosine residues in the VP3 region. Also provided are rAAV virions comprising the AAV capsid proteins of the present invention, as well as nucleic acid molecules and rAAV vectors encoding the AAV capsid proteins of the present invention. Advantageously, the rAAV vectors and virions of the present invention have improved efficiency in transduction of a variety of cells, tissues and organs of interest, when compared to wild-type rAAV vectors and virions.

Abstract: An electro-absorption optical modulator capable of realizing optical coupling with a Si waveguide with high efficiency, improving modulation efficiency, reducing light absorption by an electrode layer and achieving low optical loss includes a substrate; a first silicon layer doped to exhibit a first type of conductivity and a second silicon layer doped to exhibit a second type of conductivity that are disposed parallel to the substrate; and a Ge1?xSix (0<x<1)/Si stack in which a Ge1?xSix layer and a Si layer are stacked on the first and second silicon layers in this order.

Abstract: Described herein is an electronic device that includes a first integrated circuit die having formed therein at least one photodiode and readout circuitry to convert charge generated by the at least one photodiode to a read voltage and to selectively output the read voltage. A second integrated circuit die is in a stacked arrangement with the first integrated circuit die and has formed therein storage circuitry to selectively transfer the read voltage to at least one storage capacitor for storage as a stored voltage and to selectively transfer the stored voltage to an output. The at least one storage capacitor is formed from a capacitive deep trench isolation. There is an interconnect between the first and second integrated circuit dies for coupling the readout circuitry to the storage circuitry.

Abstract: Methods and systems for reducing an amount of data storage and/or processing power necessary for training data for machine learning by replacing three dimensional models with a plurality of two dimensional images are disclosed. The method includes determining an object of interest from a three-dimensional model and cropping the object of interest into a plurality of two-dimensional images. The plurality of two-dimensional images are cropped such that only the object of interest remain. The plurality of two-dimensional images are cropped with respect to particular attributes, such as a road width, a road angle, or an angle with respect to an adjacent vehicle. An image capturing device captures the real time background images. The objects within the background images are categorized using associated attributes. The attributes are synthesized with the plurality of two-dimensional images such that a plurality of replica two-dimensional images of the 3D model with real-time backgrounds are generated.

Abstract: This invention relates to a method to produce gene alterations in the genomes of a eukaryotic and prokaryotic host cell. The method comprises utilizing Argonaute from Natronobacterium gregoryi (NgAgo) or a mutant thereof, and complementary 5? phosphorylated single-stranded DNA that target the enzyme to cleave specific regions of the chromosome. Additionally, N-terminal truncations (deletion of the repA domain; N-del), or its mutants including N-del/E598A, N-del/D601P, and N-del/E602P reduces random cleavage and can be used for targeted gene editing with a guide DNA. An expression system or a host cell and method of creating thereof are also in the scope of this application.