Abstract: The invention discloses a composition comprising surface modified iron oxide nanoparticles with citric acid modified cyclodextrin with a hydrodynamic diameter of less than 10 nm and a hydrophobic molecule. The composition finds use in targeted delivery of a hydrophobic drug and as contrast agent in imaging applications.

Abstract: Cell penetrating peptides (CPPs) are established as a strategy to move cargoes into the interior of eukaryotic cells by engaging import machinery on the cell surface. In most cases the CPP is covalently linked to the cargo; it is common to express cargo proteins with a CPP extension. In some experiments a non-specific interactions (e.g., hydrophobic interactions) have been used to form CPP-cargo complexes, but this has numerous drawbacks. Transport is less efficient and the lack of specificity means that other macromolecules in the medium will also be internalized. This application describes the use of specific CPP labeled adaptor proteins that can be used to move a wide variety of cargoes into the cell interior. The prototype adaptor protein is calmodulin; it is small, stable and easily produced, and binds short (17 amino acid) targets with high affinity in the presence of calcium. A cargo produced with a calmodulin binding tag can be internalized efficiently by CPP tagged calmodulin.

Abstract: A fixture for a thin-walled workpiece includes two clamping devices. Each of the clamping devices has a metal carrier and a damper. The metal carrier has a carrying portion and a supporting portion, where the supporting portion has a stair portion having a plane surface and a standing surface with a slope. The damper has a metal clamping portion and a damping portion. One end of the metal clamping portion is formed as an inclined surface. The damping portion has at least two elastic layers and at least one metal layer, which are laminated in an interlacing arrangement with the same slope of the inclined surface. One of the elastic layers is disposed to connect the inclined surface. The end of the metal clamping portion connecting the elastic layer is located on the stair portion, while the opposite end of the metal clamping portion protrudes out of the supporting portion.

Abstract: Methods, systems, and computer programs are presented for controlling gas flow in a semiconductor manufacturing chamber. The method includes flowing a reactant gas thorough an inner feed and a tuning gas through an outer feed surrounding the inner feed, such that the gases do not mix until both are introduced in the chamber. Further, the flow of the reactant gas is convective, and the flow of the tuning gas is directed at an angle from the direction of the reactant gas, providing a delivery of the tuning gas in closer proximity to the RF power before further mixing with the reactant gas. Radio frequency power is provided to the electrode to ignite a plasma using the reactant and tuning gases. The diffusive flow of the tuning gas enables the tuning gas to be dissociated by the RF power allowing for control of the local residence time variation and preferential spatial dissociation patterns with respect to the local residence time of the reactant gas.

Abstract: An extended subspace method for inverting geophysical data to infer models for two or more subsurface physical properties, using gradients of an objective function as basis vectors for forming model updates. The extended set of basis vectors provides explicit mixing between gradient components corresponding to different medium parameters, for example P-wave velocity and an anisotropy parameter. In a preferred embodiment, off-diagonal elements of the mixing matrix may be scaled to adjust the degree of mixing between gradient components. Coefficients of the basis vector expansion are determined in a way that explicitly accounts for leakage or crosstalk between different physical parameters. The same extended subspace approach may be used to make further improvement to the model updates by incorporating well constraints, where well log data are available.

Abstract: Disclosed are various approaches for determining the maximum oxygen consumption of a person, also known as maximum aerobic capacity or VO2 Max. A person is positioned on a treadmill. Attached to the person is a harness configured to apply a horizontal force to the person. A work rate for the person can be calculated based at least in part on the magnitude of the horizontal force applied by the harness and the velocity of the belt. The maximum oxygen consumption for the person can then be calculated based at least in part on the previously calculated work rate.

Abstract: The embodiments of the present disclosure provide a coating composition, including: polysilsesquioxane polymer modified organic resin represented by Formula (1): Wherein, R1 is C3-12 epoxy group, C3-12 acrylate group, C3-12 alkylacryloxy group, C3-12 aminoalkyl group, C3-12 isocyanate-alkyl group, C3-12 alkylcarboxylic acid group, C3-12 alkyl halide group, C3-12 mercaptoalkyl group, C3-12 alkyl group, or C3-12 alkenyl group; R2 is half oxygen(O1/2), hydroxyl group, C1-8 alkyl group, or C1-8 alkoxy group; R3 is halide group, C1-8 alkyl halide group, C1-8 alkoxy group, C1-12 alkyl group, or C5-20 aromatic ring; R4 is hydrogen or C1-8 alkyl group; R5 is modified or unmodified carbonyl compound moiety; n is a positive integer from 1 to 200; m is a positive integer from 10 to 500, and s is an integer from 0 to 250.

Abstract: Asymmetric membrane structures are provided that are suitable for various types of separations, such as separations by reverse osmosis. Methods for making an asymmetric membrane structure are also provided. The membrane structure can include at least one polymer layer. Pyrolysis can be used to convert the polymer layer to a porous carbon structure with a higher ratio of carbon to hydrogen.

Abstract: A first thin-film transistor (TFT) communicatively couples a word line to a source signal in response to a selection signal applied to a first gate of the first TFT. The word line used to enable and disable a memory element that is coupled to the word line. A second TFT communicatively decouples the word line from a ground in response to the first signal being applied to a second gate of the second TFT.

Abstract: Provided is an electrochromic display device including a display panel including a plurality of pixels configured to display an image on a basis of a unit frame defined as first to third sub-frames, a timing controller configured to output a data signal and an off signal, and a data driving circuit configured to provide, to the pixels, a data voltage generated based on the data signal during the second sub-frame and provide, to the pixels, an off voltage generated based on the off signal during the third sub-frame, wherein each of the pixels includes an electrochromic element, and a power supply voltage is delivered to the electrochromic element in response to the data voltage during the second sub-frame and the power supply voltage provided to the electrochromic element is blocked in response to the off voltage during the third sub-frame.

Abstract: A device for controlling respiration during sleep based on the user physiological characteristic. The device includes an odor disperser for dispersing an odor; at least one detector for detecting a physiological characteristic of a user; and a controller for controlling respiration of the user by instructing the odor dispenser to disperse an odor responsive to detections by the at least one detector.

Abstract: Techniques are described that provide a reading pane for reading one or more content portions of a work and a guide pane that displays a structured overview of additional information from the corpus that is focused by an analysis of information from the currently-visible content portion of the work. The contents of the currently-visible content portion displayed within the reading page are used to derive dynamic representations of the user's immediate interests. At the user's request, a structured persistent context-aware guide is computed and displayed. The persistent context-aware guide provides a framework for accessing other parts of the corpus having the most-related information. The elements in the persistent context-aware guide are other content portions or other organizations such as sections, chapters, or articles in the corpus. The persistent context-aware guide may also incorporate additional closely-related information elements from outside the corpus including advertisements.

Abstract: The present invention relates to filled polymeric materials including a polymer and a filler distributed within the polymer, and to light weight composites which comprise at least a pair of metallic layers and a polymeric layer interposed between the pair of metallic layers, the polymeric layer containing the filled polymeric material. The composite materials of the present invention may be formed using conventional stamping equipment at ambient temperatures. Composite materials of the present invention may also be capable of being welded to other metal materials. The composite materials may be employed in an automotive part. Preferred composite materials include one or any combination of the following features: metallic fibers, ribbon fibers; or a polyolefin.

Abstract: The present invention provides a liquid coloring composition comprising of a coffee solution or coffee extract and an ink vehicle. The coloring composition is suitable for use as an ink in a non-impact printing device, including an ink jet type printer. The composition is composed of edible components. The invention further provides a process for applying a design to a food substrate, comprising of providing a non-impact printing device, wherein the ink cartridge or external container contains the coloring composition of the invention.

Abstract: An expanded waveguide for providing uniform electromagnetic field is disclosed. The expanded waveguide comprises an expanded area expanded in the direction of the E-plane, an input transition area and an output transition area connected to both sides of the expanded area and configured to pass an electromagnetic wave, and entrance parts formed respectively to an end part of the input transition area and an end part of the output transition area, the electromagnetic wave being inputted and outputted through the entrance parts. Here, a plurality of multilateral pillars are arranged in constant space in the transition areas, and a channel is formed along between the multilateral pillars.

Abstract: Benzenesulfonamide derivatives of formula (I), the pharmaceutically acceptable addition salts thereof, the hydrates and/or solvates thereof, and the use of same as inverse agonist of retinoid-related orphan receptor gamma (ROR?t) are described. A pharmaceutical composition including such compounds, as well as the use thereof for the topical and/or oral treatment of ROR?t receptor-medicated inflammatory diseases, in particular acne, psoriasis and/or atopic dermatitis are also described.

Abstract: In an ultrasonic transducer assembly, a conformable ultrasonic transducer has a piezoelectric layer and electrodes able to conform to curved surfaces, and a clamp for pressing the transducer into ultrasonic contact with a curved surface. Conformability is ensured with a thin, porous piezoelectric layer and suitable electrical conductors and insulators. The ultrasonic transducer may operate without further thermal shielding under harsh environments and/or at high temperatures.

Abstract: A dynamic packet relay method of a personal area network (PAN) coordinator in a sensor network includes receiving a Child_Register message that includes information about a device associated with a coordinator and building or updating a network hierarchical structure; monitoring reception of a packet or a beacon from the coordinator and determining whether the coordinator is defective or not; and in response to a determination that the coordinator is defective, changing the current coordinator to one of devices belonging to a PAN as a new coordinator.

Abstract: The present invention relates to an optical module, and more specifically, to an optical module which allows an optical coupling loss of an optical signal to be minimized and a frequency bandwidth thereof to be maximized. The optical module according to an embodiment of the present invention includes: a circuit substrate; an electronic element mounted on one surface of the circuit substrate; an optical element mounted on another surface perpendicular to the one surface of the circuit substrate; a capacitor mounted between the electronic element and the optical element; and an optical waveguide array on which an optical waveguide is disposed.

Abstract: A method for iteratively inverting seismic data to jointly infer a model for at least P-wave velocity and attenuation parameters of the subsurface, the method including: jointly inverting the P-wave velocity and attenuation parameters with an iterative visco-acoustic full wavefield inversion process, wherein the iterative visco-acoustic full wavefield inversion process includes computing a gradient of an objective function, the objective function measuring a misfit between all or part of the seismic data and corresponding model-simulated seismic data; for each of the P-wave velocity and attenuation parameters, computing a search direction in model space from the gradient; determining line search step sizes ? and ? for the search directions for the P-wave velocity and attenuation parameters, respectively, wherein a ratio of the step sizes is a function of the P-wave velocity parameter; and using the step sizes ? and ? and the search directions for each of the P-wave velocity and attenuation parameters, computi