Abstract: The present invention relates to salts of arachidyl amido cholanoic acid (Aramchol), pharmaceutical compositions comprising Aramchol salts, methods for their preparation, and methods of use thereof in medical treatment.

Abstract: A magneto-plasmonic nanostructure is disclosed. The structure includes a substrate, and a magneto-plasmonic stack, comprising a nano-sized plasmonic resonator, a nanomagnet, and a capping layer, wherein the nano-sized plasmonic resonator is configured to receive circularly polarized light at an intensity to thereby increase normal component of plasmon-generated opto-magnetic field, HOM,z, at least at the interface of one of i) the nano-sized plasmonic resonator and the nanomagnet, or ii) the nanomagnet and the capping layer, whereby the HOM,z direction is perpendicular to the rotational direction of the circularly polarized light and the nanomagnets in the magneto-plasmonic stack switches its magnetic moment in response to a change of the HOM,z direction in response to a change of the rotational direction of the circularly polarized light.

Abstract: The present invention provides compounds comprising fused tricyclic backbone structure and processes for their preparation. The invention further provides compounds and compositions useful in the treatment of pain and any type of disorder or symptom associated therewith.

Abstract: The present invention is directed to the field of immunotherapy. Specifically, the invention provides compositions and methods for improved T cell modulation ex vivo and in vivo and for the treatment of cancer and other pathologies. More specifically, embodiments of the invention are directed to the use of soluble NTB-A polypeptides or agonists thereof for the treatment of cancer patients, for preventing and treating cytopenia in susceptible patients, and for the ex vivo preparation of improved cell compositions.

Abstract: The present invention relates to a method for predicting an inter-layer of an image having a plurality of layers including at least one temporal sub-layer. The method according to present invention comprises the steps of: acquiring information on a temporal sub-layer for inter-layer prediction; inducing a reference picture used for predicting an inter-layer of a current picture on the basis of the information on the temporal sub-layer; and predicting the inter-layer of the current picture on the basis of the reference picture.

Abstract: The present invention relates to a method for encoding an image and method for decoding an image. The method for decoding an image includes: predicting global motion information; and performing inter prediction based on the predicted global motion information, wherein the global motion information is represented by any one of a two-dimensional vector, a geometric transform matrix, a rotation angle, and a magnification ratio.

Abstract: The present invention relates to a composition for promoting mitochondrial biogenesis, which includes azelaic acid as an active ingredient. It was confirmed that azelaic acid is a compound mainly contained in cereals and natural products and has the advantage of no or little side effects, and mitochondrial autophagy and mitochondrial DNA synthesis in cells are induced, thereby ultimately having activity of increasing mitochondrial density. Therefore, azelaic acid can be used for the treatment of mitochondrial dysfunction-associated disease by the failure of homeostasis control of the mitochondria, for example, mitochondrial activity or the decrease in the number of mitochondria.

Abstract: This present application disclosed a series of selective adenylyl cyclase 1 (AC1) inhibitors, compounds having a formula or a pharmaceutically acceptable salt thereof, as a pain therapeutic. Those compounds may provide an effective method of treatment for chronic/inflammatory pain. Those compounds may also prevent opioid dependence and/or reduce opioid dependence. Both method and composition matters are within the scope of this invention.

Abstract: A method for improving fuel efficiency testing precision in on-road vehicles. The method comprises: installing one or more dataloggers in one or more vehicles, each datalogger configured to receive fuel consumption data broadcast by an on-road vehicle's engine control unit (ECU); transmitting the fuel consumption data from the one or more dataloggers in the one or more on-road vehicles to a processor; and analyzing, using the processor, the fuel consumption data from the one or more dataloggers in the one or more on-road vehicles to determine fuel efficiency of the one or more on-road vehicles. The fuel consumption data comprises fuel rate data from the ECU which is transmitted through the one or more dataloggers, engine speed and other operating parameters from the ECU that are transmitted through the one or more dataloggers, torque sensor data which is transmitted through the one or more dataloggers, and traditional fuel log data.

Abstract: A semiconductor package structure includes a redistribution structure, a chip, an upper dielectric layer, a plurality of conductive members and an encapsulation layer. The redistribution structure includes a redistribution layer and a first dielectric layer disposed on the redistribution layer. The upper dielectric layer is disposed between the chip and the first dielectric layer of the redistribution structure, wherein the upper dielectric layer and the first dielectric layer are organic materials. A plurality of conductive members is disposed between the redistribution layer and the chip. Each conductive member has a first end adjacent to the chip and a second end adjacent to the redistribution structure, wherein the first end of said each conductive member contacts with the upper dielectric layer and the second end of said each conductive member contacts with the first dielectric layer.

Abstract: Disclosed are a method and apparatus for an access point (AP) to control channel access of a station in a wireless local area network (WLAN) system. An AP according to one embodiment may determine resource allocation information for protecting a resource for a station not referring to traffic indication map (TIM) information. The determined resource allocation information is transmitted to a station referring to the TIM information, and the station referring to the TIM information does not conduct channel access in a time period specified in the resource allocation information.

Abstract: A fixture for a thin-walled workpiece includes two clamping devices. Each of the clamping devices has a metal carrier and a damper. The metal carrier has a carrying portion and a supporting portion, where the supporting portion has a stair portion having a plane surface and a standing surface with a slope. The damper has a metal clamping portion and a damping portion. One end of the metal clamping portion is formed as an inclined surface. The damping portion has at least two elastic layers and at least one metal layer, which are laminated in an interlacing arrangement with the same slope of the inclined surface. One of the elastic layers is disposed to connect the inclined surface. The end of the metal clamping portion connecting the elastic layer is located on the stair portion, while the opposite end of the metal clamping portion protrudes out of the supporting portion.

Abstract: Disclosed are various approaches for determining the maximum oxygen consumption of a person, also known as maximum aerobic capacity or VO2 Max. A person is positioned on a treadmill. Attached to the person is a harness configured to apply a horizontal force to the person. A work rate for the person can be calculated based at least in part on the magnitude of the horizontal force applied by the harness and the velocity of the belt. The maximum oxygen consumption for the person can then be calculated based at least in part on the previously calculated work rate.

Abstract: The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated state.

Abstract: A method for improving ergonomics of a vehicle obtains a first information defining an initial cockpit configuration. Further, information on a cockpit user's shape and information of a seat and steering wheel position which the user typically uses while driving, are obtained. This information is fed into a bio-mechanical simulation which carries out the simulation based upon the information defining the initial cockpit configuration, the user's shape and the user's seat and steering wheel position. In the bio-mechanical simulation, an ergonomic quality criteria is calculated for reaching movements during driving. Based upon the simulation result which is the quality criteria, the cockpit configuration is changed. The bio-mechanical simulation and the changing of the cockpit configuration in the optimization process is then repeated until a predetermined stop condition is fulfilled. The cockpit configuration which is achieved at that point in time is output as final cockpit-configuration.

Abstract: A miniaturized particulate matter detector that includes a filter and a concentration detector is provided. The filter has a plurality of holes, and the concentration detector is correspondingly disposed under the filter. The concentration detector has a detected area used to detect a concentration of at least one miniaturized particulate matter. A manufacturing method of the filter is also provided.

Abstract: Methods, systems, and computer programs are presented for controlling gas flow in a semiconductor manufacturing chamber. The method includes flowing a reactant gas thorough an inner feed and a tuning gas through an outer feed surrounding the inner feed, such that the gases do not mix until both are introduced in the chamber. Further, the flow of the reactant gas is convective, and the flow of the tuning gas is directed at an angle from the direction of the reactant gas, providing a delivery of the tuning gas in closer proximity to the RF power before further mixing with the reactant gas. Radio frequency power is provided to the electrode to ignite a plasma using the reactant and tuning gases. The diffusive flow of the tuning gas enables the tuning gas to be dissociated by the RF power allowing for control of the local residence time variation and preferential spatial dissociation patterns with respect to the local residence time of the reactant gas.

Abstract: A method for cultivating Cordyceps militaris fruiting body capable of improving C. militaris fruiting body morphology is provided, wherein rice absorbed with a tea liquid is used as a solid-state culture medium. In comparison to using rice absorbed with water as a solid-state culture medium, the C. militaris fruiting body cultivated by using the solid-state culture medium of the present invention under the same cultivation condition are significantly more robust.

Abstract: Provided herein are luminescent probes of formula I: and complexes thereof for the detection of cancer cells.

Abstract: The invention discloses a composition comprising surface modified iron oxide nanoparticles with citric acid modified cyclodextrin with a hydrodynamic diameter of less than 10 nm and a hydrophobic molecule. The composition finds use in targeted delivery of a hydrophobic drug and as contrast agent in imaging applications.