Abstract: Provided herein are methods of site-specific integration of a heterologous sequence into a host genome (e.g., by administering a recombinant adeno-associated virus (rAAV) to a host cell in the presence of a Rep protein), and methods for treating diseases and disorders by delivering an rAAV that comprises a nucleic acid vector comprising a Rep protein. Also provided herein are methods and compositions for producing rAAV particles with improved titer and transduction efficiencies.

Abstract: A magnetohydrodynamic seawater propulsion thruster includes: a first electrode body including a seawater inlet, a seawater flow space, and a seawater outlet; a second electrode body arranged in the seawater flow space to be spaced apart from the first electrode body, and allowing current to flow through the seawater with the first electrode body; a flow guide having a helical shape, arranged between the first electrode body and the second electrode body in the seawater flow space to guide flowing of seawater; a magnetic field formation unit arranged to surround at least a portion of an outer circumference of the first electrode body and generate a magnetic field in an extension direction of the first electrode body; a power supply unit that supplies electricity to the first and second electrode bodies. The power supply unit includes a fuel cell module generating electricity through electrochemical reaction of fuel and oxidizer.

Abstract: Provided is an encoding apparatus for integrally encoding and decoding a speech signal and a audio signal, and may include: an input signal analyzer to analyze a characteristic of an input signal; a stereo encoder to down mix the input signal to a mono signal when the input signal is a stereo signal, and to extract stereo sound image information; a frequency band expander to expand a frequency band of the input signal; a sampling rate converter to convert a sampling rate; a speech signal encoder to encode the input signal using a speech encoding module when the input signal is a speech characteristics signal; a audio signal encoder to encode the input signal using a audio encoding module when the input signal is a audio characteristic signal; and a bitstream generator to generate a bitstream.

Abstract: Disclosed are an optima design method for a middle cross beam of an ROPS framework and a cab for engineering machines. The optimal design method comprises: solving a height dimension of a middle cross beam when the maximum bending moment on pillars is minimum by analyzing the influence of the height dimension of the middle cross beam in a portal hyperstatic structural mechanics model on the distribution relation of two bending moments on the pillars, to obtain an optimal height dimension relation of the middle cross beam; and obtaining a profile sectional parameter design relation of the middle cross beam by analyzing a design objective that the middle cross beam and the pillars enter a plastic deformation zone at the same time, and using the relation to guide the selection of an ROPS framework structure and profiles to improve the design quality of an ROPS framework.

Abstract: A coil structure for near-field wireless power transfer, integrating the traditional inductor and external capacitor structure into one single coil and forming a series resonance. The series resonance is achieved by a terminal connection and layering method. The electric field is canceled via a distributed turn-to-turn interleaving structure. With the integrated capacitor, the costs and space of a resonant capacitor can be saved. With the canceled electric field, the interference with neighboring components, such as touch-screen, can be reduced. Other benefits can include low-profile and fabrication convenience based on RGB technology. This coil can be useful for both consumer electronics and electric vehicle wireless charging.

Abstract: The present invention provides a means useful for delivering a large amount of a functional molecule. More specifically, the present invention provides a construct containing an extracellular vesicle (EV) loading signal-containing nucleic acid and a functional molecule linked thereto, wherein the EV loading signal-containing nucleic acid contains an EV loading signal in one or more genes selected from the group consisting of RAB13, LUC7L3, ANP32B, NET1, NEFM, MTURN, Clorf115, C22orf46, PLEKHA4, HMGN5, TRAK2, RASSF3, FBXW4, ARRDC4, ZSWIM9, CA11 and LINC01952 genes, and wherein the functional molecule is a functional molecule other than an EV loading signal-containing nucleic acid.

Abstract: Embodiments disclosed herein may include operations of receiving a plurality of current cardiovascular performance metrics of a patient and a plurality of candidate drugs to be used to reach a plurality of desired cardiovascular performance metrics and determining optimal dosages of the plurality of candidate drugs to reach the plurality of desired cardiovascular performance metrics. The determining may include optimizing a dosage combination of the plurality of candidate drugs to reach a plurality of desired cardiovascular parameters, corresponding to the plurality of desired cardiovascular performance metrics, from a plurality of current cardiovascular parameters corresponding to the plurality of current cardiovascular performance metrics and mapping the plurality of desired cardiovascular performance metrics from the plurality of desired cardiovascular parameters and the plurality' of current cardiovascular performance metrics from the plurality of current cardiovascular parameters.

Abstract: Semiconductor processing tools with wafer back-side processing capabilities are disclosed. Such tools may be configured to only contact wafers being processed through edge contact, as opposed to underside/planar contact. Such tools may also include wafer-centering features that may allow such wafers to be precisely centered with regard to a particular wafer processing station thereof.

Abstract: Disclosed are an optimal design method for top cross beams of an ROPS framework and a cab for engineering machines. The optimal design method comprises: analyzing bending stress of a portal hyperstatic structural mechanics model to obtain the ratio n of an inertia moment I of top cross beams to an inertia moment I of pillars when the maximum bending stress of the top cross beams is equal to the maximum bending stress of the pillars, such that lightweight design of the ROPS framework is realized.

Abstract: A method for 3D object detection is described. The method includes predicting, using a trained monocular depth network, an estimated monocular input depth map of a monocular image of a video stream and an estimated depth uncertainty map associated with the estimated monocular input depth map. The method also includes feeding back a depth uncertainty regression loss associated with the estimated monocular input depth map during training of the trained monocular depth network to update the estimated monocular input depth map. The method further includes detecting 3D objects from a 3D point cloud computed from the estimated monocular input depth map based on seed positions selected from the 3D point cloud and the estimated depth uncertainty map. The method also includes selecting 3D bounding boxes of the 3D objects detected from the 3D point cloud based on the seed positions and an aggregated depth uncertainty.

Abstract: The present invention relates to an apparatus and method for managing data based on hyper ontology. The apparatus for managing data based on hyper ontology includes a data input module for receiving data manually input by a person and data automatically generated by a machine device, and a processor that matches a data entity in a specific technical field or specific domain with a data entity in another technical field or another domain on the basis of hyper ontology associated with a vocabulary and dictionary pre-stored in a storage module.

Abstract: Provided is a method for producing a biosignal measurement electrode including: preparing a conductive polymer including a coil-type chain structure having a coil shape; providing a sugar alcohol and a water-soluble polymer to the conductive polymer to produce an electrode source including an expanded chain structure in which the coil-type chain structure is expanded and linearly arranged; forming a coating layer by providing the electrode source on a substrate; and producing the biosignal measurement electrode by annealing the coating layer.

Abstract: A method for a replay driver skill improvement system is described. The method includes logging vehicle commands requested by a vehicle operator of an ego vehicle to perform a selected driving maneuver. The method also includes identifying one or more of the logged vehicle commands in which operation of the ego vehicle is outside of a predetermined threshold while performing the selected driving maneuver. The method further includes operating the ego vehicle according to the logged vehicle commands until the one or more of the logged vehicle commands in which operation of the ego vehicle is outside of the predetermined threshold are reached. The method also includes performing, through shared control with the vehicle operator, improved vehicle commands to complete the selected driving maneuver while operating the ego vehicle at or within the predetermined threshold.

Abstract: The present disclosure provides an adhesive constructure including: a substrate and a hollow structure disposed to protrude on the substrate, wherein the hollow structure includes a hollow support portion protruding from the substrate and fixed on the substrate and an adhesive portion disposed below the hollow support portion and exposed to the outside, and the adhesive portion has a larger swelling ratio than the hollow support portion and the adhesive portion has a hollow horn shape of which volume expands in a wet state.

Abstract: The present invention relates to a yeast gene ScFIT3 for regulating and controlling cadmium resistance of an organism and an application thereof. The yeast gene ScFIT3 for regulating and controlling the cadmium resistance of the organism has a nucleotide sequence as shown in SEQ ID NO.1. The present invention discloses, for the first time, the application of the yeast gene ScFIT3 in enhancing cadmium resistance of the organism. The yeast gene ScFIT3 is linked to an expression vector and transformed into a budding yeast, thereby completing construction of a cadmium-resistant yeast. The growth of the budding yeast transformed with the yeast gene ScFIT3 is significantly superior to that of a wild-type budding yeast, indicating that the budding yeast transformed with the yeast gene ScFIT3 has good resistance to cadmium stress, significantly enhances a capability of resisting heavy metal cadmium, and reduces accumulation and absorption of cadmium.

Abstract: An AI-based system for the generation, evaluation, and prediction of performance of banner ads for presentation to specific customers or types of customers. A data set of existing banner ads, ad materials, and design and marketing parameters is used to generate a graph-based model. The graph-based model is used to generate original banner ads, which are then evaluated by a machine learning model, which assigns them scores. The highest-scoring banner ads are then presented to customers. The invention can also use a genetic algorithm in combination with iterative evaluation and generation to diversify design and choose the highest ranked banner ads.

Abstract: An operation method of a first device may comprise: receiving, from a second device, first configuration information signaled for CLI-related procedures; receiving, from the second device, second configuration information signaled for operating a multiplexing operation of the first device; in response to recognizing, with respect to a first resource, a collision between first DL-UL configuration information indicated by the first configuration information and second DL-UL configuration information indicated by the second configuration information, comparing priorities of the first DL-UL configuration information and the second DL-UL configuration information; and determining a DL-UL configuration applied to the first resource based on the compared priorities.

Abstract: According to an aspect of the present disclosure, there is provided a method of implementing a radio access network (RAN)-core convergence mobile network based on cloud native, the method comprising: extending a first open RAN base station including an open RAN-central unit-control plane (O-CU-CP) and a cloud-based second open RAN base station having converged functions of a core network into a service-based architecture (SBA) of the core network; authenticating and accepting user equipment (UE) through the extended SBA; and extending the UE to the SBA through radio resource setting and protocol data unit (PDU) session establishment.

Abstract: A tool posture control device includes a plurality of airbags, a gas supply module and a controller. A tool is allowed to be disposed among the airbags. A gas supply module connects the airbags. The controller is electrically connected to the gas supply module and configured to control the gas supply module to provide a plurality of gas to the airbags respectively according to a target bending angle value of the tool.

Abstract: A video encoding/decoding method and an apparatus use selective transmission of subblock partitioning information. The video encoding/decoding method and apparatus selectively encode and decode the splitting direction of a subblock to reduce the overhead of signal transmission for using subblock partitioning while effectively performing intra prediction per subblock basis.