Abstract: The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalizing the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.

Abstract: A class of quinazoline derivatives or pharmaceutically acceptable salts or solvates thereof with novel structures is provided; meanwhile, a pharmaceutical composition comprising a pharmaceutically effective amount of said quinazoline derivatives or pharmaceutically acceptable salts or solvates thereof, and pharmaceutically acceptable excipients or additives is also provided. By modifying and transforming the quinazoline and screening of the transformed compounds on the activity of tyrosine kinase inhibition, most of the compounds have been found to possess inhibitory activity against one or several of EGFR, VEGFR-2, c-erbB-2, c-erbB-4, c-met, tie-2, PDGFR, c-src, lck, Zap70 and fyn kinases. The present invention has the advantages of reasonable design, broad source of and easy access to the raw materials, simple and easy operation of the preparation methods, mild reaction conditions, high yield of the products and being beneficial for industrial-scale production.

Abstract: An improved method and process unit for desalting petroleum crude oils in which a portion of the stable emulsion layer which forms in the desalter vessel is withdrawn from the desalter and diluted with a liquid diluent, typically oil or water or both to destabilize the emulsion which is then separated into separate oil and water phases.

Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.

Abstract: A magneto-electric (ME) magnetic tunnel junction (MTJ) Exclusive-OR (XOR) gate is provided. The ME MTJ XOR gate includes an insulator separating a top ferromagnetic (FM) layer and a bottom FM layer, a top ME layer on the top FM layer, and a bottom ME layer on the bottom FM layer. The ME MTJ XOR gate also includes a top electrode coupled to the top ME layer and a bottom electrode coupled to the bottom ME layer where a voltage between the top electrode and the top FM layer is a first input, a voltage between the bottom electrode and the bottom FM layer is a second input, and a resistance between the top FM layer and the bottom FM layer is indicative of the XOR of the first input and the second input. The ME MTJ XOR has reduced energy consumption, smaller area, faster switching times, and is non-volatile.

Abstract: Provided are an apparatus and method for multicore emulation based on dynamic context switching. The apparatus for multicore emulation based on dynamic context switching includes a multicore emulation managing unit configured to transmit a signal for requesting determination of a core to be emulated among a plurality of cores, and a context switching managing unit configured to receive the signal for requesting determination of a core to be emulated from the multicore emulation managing unit, determine an ID of a core to be emulated according to the received signal, and executing emulation on a core corresponding to the determined core ID.

Abstract: A sample can be collected from an enclosed container by opening a sample collection valve and drawing the sample from the enclosed container. After delivery of the sample out of a fluid flow path, a sanitizing fluid can be directed along the fluid flow path to sanitize the fluid flow path.

Abstract: The present invention relates to processes for extracting lipid from vegetative plant parts such as leaves, stems, roots and tubers, and for producing industrial products such as hydrocarbon products from the lipids. Preferred industrial products include alkyl esters which may be blended with petroleum based fuels.

Abstract: The present invention relates to a pyrrolopyridine derivative represented by the Chemical Formula I, and a racemate or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and relates to an antiviral composition including the same as an active ingredient. The compound of the Chemical Formula I has excellent antiviral activity and selectivity for wild type and resistant HIV-1, and thereby is useful as a therapeutic agent for acquired immune deficiency syndrome (AIDS).

Abstract: A three-way sequential power amplifier includes an input network connected to a main amplifier, a first peak amplifier, a second peak amplifier, which in turn are connected to a three-way output network. An input signal for an input port of the input network is a wideband radio frequency (RF) signal with a time varying amplitude. An output port of the output network can be connected to an antenna, via a bandpass filter, to attenuate out of band frequencies.

Abstract: A portable self medication management system and method comprising at least a plurality of receptacles, a scanner, a display screen, a housing for a compact electronic box, a compact electronic box and a processor to acquire medication information from a medication container, determine whether the medication information exists in a first database, if the medication information does not exist in the first database, associate the medication information with a location information comprising a receptacle and store the medication information and the location information in the first database, indicate the location information, and confirm placement of the medication container in the associated receptacle, notify a user to administer the medication held in the medication container, and request the user to scan the medication container of the notified medication, detect retrieval of an incorrect medication container from the plurality of receptacles, and issue a warning of the detection, and provide instructions fo

Abstract: An apparatus and a method for measuring quality of a holographic image are disclosed. The apparatus for measuring the quality of the holographic image may include an obtaining unit to obtain a hologram, a reconstruction unit to reconstruct a three-dimensional (3D) holographic image by irradiating the hologram with a light source, a measuring unit to measure depth of the reconstructed holographic image, and an analysis unit to analyze depth representation quality of the holographic image base on the measured depth of the holographic image.

Abstract: A packet-forwarding network node can process a programmable packet based on a reputation value for a name prefix to perform a customized operation on a local resource. The programmable packet can include a name prefix, and a header comprising reputation criteria for the packet's name prefix and one or more resource fields. A resource field can include instructions that perform an operation on a corresponding resource of the network node. When the network node receives the programmable packet, the node determines a reputation value for the name prefix at the local node, and compares this reputation value to the packet's reputation criteria. If the reputation value for the name prefix at the local node satisfies the reputation criteria, the node proceeds to execute the one or more instructions of the respective resource field to perform the operation on the corresponding resource.

Abstract: A method and system for remote collaboration and remote instruction utilizing computing devices at trainee site and mentor sites are disclosed. Annotations are superimposed onto a trainee's view of a view field displayed using a simulated transparent display with augmented reality (“AR”). By tracking the position of the trainee's view point, the position of the trainee's computing device, and the geometry of the view field, the annotations remain anchored to the image of the view field when the trainee device moves and/or when the view field deforms or becomes occluded.

Abstract: The disclosure provides a surface-enhanced Raman scattering substrate, including: a surface-enhanced Raman scattering (SERS)-active substrate; a patterned hydrophilic region and a patterned hydrophobic region formed on the SERS-active substrate, wherein a water contact angle difference between the patterned hydrophilic region and the patterned hydrophobic region is in a range from about 29 degrees to about 90 degrees.

Abstract: A microfluidic detection system for micrometer-sized entities, such as biological cells, includes a detector component incorporating a plate with a plurality of opening, the plate separating two chambers, one in communication with a fluid source containing target entities bound to magnetic beads. The openings are sized to always permit passage of the magnetic beads therethrough into a lower one of the chambers and are further sized to always prevent passage of the target entities from the upper one of the chambers. The detector component further includes a magnet positioned to pull unbound magnetic beads through the openings and to capture target entities bound to magnetic beads on the surface of the plate. In a further feature, the microfluidic detection system is configured to pass target molecules through the plate to be bound to a functionalized surface of the lower chamber.

Abstract: A novel method for real-time small-signal stability analysis for power electronic-based components in a power system. The method may be used to monitor a power system in real-time by perturbing the source side of an electronic-based component of the power system of about 0.5 to 1 percent of a nominal current of the power system at the source side, and perturbing the load side of the power electronic-based component by varying the voltage at the load side using a series voltage injection. Time-domain results of the simultaneous perturbations may be transferred to frequency-domain results and the stability of the power system may be monitored by obtaining a Nyquist contour and employing Generalized Nyquist Criterion or unit circle criterion.

Abstract: The present disclosure generally relates to a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. The present disclosure also generally relates to pharmaceutical compositions comprising the crystalline form, as well of methods of using a crystalline form in the treatment of depression and other conditions and methods for obtaining such crystalline form.

Abstract: A variable-period permanent-magnet undulator which is applicable not only to a planar undulator but also to a helical undulator, in which permanent-magnets and ferromagnetic substances are alternately arranged, and the ferromagnetic substance interposed between the permanent-magnets is saturated to thus enable the magnets to be effectively spaced apart from each other by the repulsive force between the permanent-magnets, thereby adjusting the period of the magnetic field in an easy and precise manner.

Abstract: A device for use in an aerosol inhalation system for delivering aerosolized medication includes a housing that is operatively connected to a source of aerosolized medication such that the aerosolized medication is delivered to the housing. The device also includes a patient interface member removably connected to the housing and being separate therefrom. The patient interface member is in the form of a face mask for placement about a face of the patient and in communication with a mouth of the patient for delivering the aerosolized medication. The patient interface member incorporates an integral inhalation valve and safety feature for protecting against displacement of the inhaltation valve.