Abstract: The present invention relates to a prebiotic composition, a composition for improving gut microorganisms, a composition for improving gut health or gut function, a composition for alleviating, preventing, or treating inflammatory bowel disease or leaky gut syndrome, or a composition for alleviating, preventing, or treating obesity or metabolic disease, which each comprise a molokhia extract or a molokhia polymer fraction as an active ingredient to induce the proliferation of beneficial intestinal bacteria and to improve, prevent, or treat gut heath or gut function. In addition, the composition comprising a molokhia extract or a molokhia polymer fraction as an active ingredient can alleviate, prevent, or treat bowel disease or leaky gut syndrome.
Type:
Grant
Filed:
September 19, 2019
Date of Patent:
September 3, 2024
Assignee:
KOREA FOOD RESEARCH INSTITUTE
Inventors:
Ho-Young Park, Yoon-sook Kim, Young-do Nam, Moon Ho Do, Mi-Jin Oh, Sang-hoon Lee, Eun Jung Lee, Hye-Bin Lee, Hyun Jhung Jhun
Abstract: A method for vehicle prediction, planning, and control is described. The method includes separately encoding traffic state information at an intersection into corresponding traffic state latent spaces. The method also includes aggregating the corresponding traffic state latent spaces to form a generalized traffic geometry latent space. The method further includes interpreting the generalized traffic geometry latent space to form a traffic flow map including current and future vehicle trajectories. The method also includes decoding the generalized traffic geometry latent space to predict a vehicle behavior according to the traffic flow map based on the current and future vehicle trajectories.
Type:
Grant
Filed:
April 28, 2022
Date of Patent:
September 3, 2024
Assignees:
TOYOTA RESEARCH INSTITUTE, INC., TOYOTA JIDOSHA KABUSHIKI
KAISHA
Inventors:
Kuan-Hui Lee, Charles Christopher Ochoa, Arjun Bhargava, Chao Fang, Kun-Hsin Chen
Abstract: An apparatus and method of treatment of an animal using the apparatus are disclosed. The apparatus includes a scalpel, a laser included in the scalpel, and a visible light source included in the scalpel. The visible light source provides a visible targeting beam. The method of treatment includes activating a visible targeting beam in a laser scalpel. The visible targeting beam has an illumination intensity. The method further includes illuminating a tumor that includes cancerous cells and non-cancerous cells with the visible targeting beam, activating an invisible mid-infrared laser included in the scalpel to produce a laser spot at the tumor, and ablating the cancerous cells while leaving the non-cancerous cells substantially undamaged.
Abstract: Described herein are methods of filling features with tungsten and related apparatus. The methods described herein involve deposition of a tungsten nucleation layer prior to deposition of a bulk layer. The methods involve multiple atomic layer deposition (ALD) cycles. According to various embodiments, both a boron-containing reducing agent and silicon-reducing agent may be pulses during a single cycle to react with a tungsten-containing precursor and form a tungsten film.
Abstract: In various embodiments, the present invention relates to heat dissipation systems including a hygroscopic working fluid and methods of using the same. In various embodiments, the present invention provides a method for heat dissipation using a hygroscopic working fluid. The method can include transferring thermal energy from a heated process fluid to the hygroscopic working fluid in a process heat exchanger, to form a cooled process fluid. The method can include condensing liquid from a feed gas on a heat transfer surface of a feed gas heat exchanger in contact with the cooled process fluid, to form a cooled feed gas, the heated process fluid, and a condensate. The method can include dissipating thermal energy from the hygroscopic working fluid to a cooling gas composition with a fluid-air contactor. The method can include transferring moisture between the hygroscopic working fluid and the cooling gas composition with the fluid-air contactor.
Type:
Grant
Filed:
September 14, 2020
Date of Patent:
September 3, 2024
Assignee:
Energy and Environmental Research Center Foundation
Abstract: Provided herein are fumaric and maleic acid-containing compounds, compositions comprising the same and methods for using such compounds to enhance production, growth, spread or titer of interferon-sensitive viruses in cells, particularly cancer and tumor cells. Also provided are methods of treating tumors or cancers in a subject by administering the compounds and compositions.
Abstract: The disclosure relates to a 5G or 6G communication system for supporting a higher data transmission rate than a 4G communication system such as LTE. The disclosure relates to a method and an apparatus for enhancement of self-interference channel estimation performance to secure self-interference removal performance in full-duplex (FD) communication and, more specifically, to a method and an apparatus for scheduling a transmission resource for enhanced self-interference channel estimation in the FD communication.
Type:
Grant
Filed:
November 11, 2021
Date of Patent:
September 3, 2024
Assignees:
Samsung Electronics Co., Ltd., Research & Business Foundation Sungkyunkwan University
Inventors:
Kwonjong Lee, Sang-Hyo Kim, Hyojin Lee, Min Young Chung, Dong Hyun Kong, Yong-Sung Kil, Seungil Park, Seunghyun Lee
Abstract: A buried person search device using a detachable module is disclosed. The device includes a ground drone 10 deployed at a site of a collapse disaster, the ground drone 10 having a communication device 80 and a first beacon, a camera device 40 mounted on the ground drone 10 to photograph surroundings of the ground drone 10, a storage 50 installed on the ground drone 10, a plurality of repeater modules 60 connected by a wireless communication network to relay wireless communications between the ground drone 10, a flying drone 32, and a command and control center 100, each of the repeater modules 60 having a second beacon, and a sensing device 70 installed on the ground drone 10 or the repeater modules 60 to collect a sound, wherein the storage 50 accommodates the repeater modules 60, and throws the repeater modules 60 in response to an operation signal.
Type:
Grant
Filed:
June 21, 2023
Date of Patent:
September 3, 2024
Assignee:
Republic of Korea (National Disaster Management Research Institute)
Inventors:
Si Beum Cho, Kyung Su Lee, Jae Jeong Kim, Cheol Kyu Lee, Tae Wook Lee
Abstract: A method for processing accelerated degradation test data based on Wiener process includes obtaining accelerated degradation test data of a to-be-tested product, selecting a target time conversion model from a predefined set of time conversion models based on the accelerated degradation test data, constructing a nonlinear Wiener degradation process based on the target time conversion model, determining a product reliability function of the to-be-tested product, and testing the reliabilities of the to-be-tested product based on the product reliability function to obtain product reliability test results of the to-be-tested products.
Type:
Grant
Filed:
February 6, 2024
Date of Patent:
September 3, 2024
Assignee:
China Electronic Product Reliability and Environmental Testing Research Institute (The Fifth Electronic Research Institute of Ministry of Industry and Information Technology) (CEPREI)
Abstract: The present invention provides a multimode propulsion system, comprising at least one propellant ejector system, a high speed fluid ejection nozzle coupled to a propellant supply provided in the engine, and a propellant-air mixing system comprising at least one fluid intake member having an inlet end and an outlet end, the inlet end being in fluidic communication with the fluid ejection nozzle to receive the propellant ejected from the nozzle.
Type:
Grant
Filed:
May 5, 2021
Date of Patent:
September 3, 2024
Assignee:
Atlantis Research Labs Inc.
Inventors:
Craig Johansen, William Schuyler Hinman, Vladimir Mravcak
Abstract: A tribometer and technique for determining torque at a physical interface of multiple rotating components. The tool and technique include aligning components about a rotational axis for independent rotation of each component. The components are in physical interface during the rotating with a resultant frictional torque. The torque may be measured by one or more torque meters during the rotating. This measured torque may be compared against an estimated torque for tool accuracy. Further, parameters such as load, temperature, component material, rotating rpm differentials and others may be varied to determine effect on measured frictional torque.
Abstract: A timepiece mechanism including a magnetic gear formed of a first wheel and a second wheel, the first wheel being provided with first alternating magnetic poles forming a magnetic toothing and the second wheel being provided with a toothing made of ferromagnetic material which has a magnetic coupling with the magnetic toothing, such that, when one of the first or second wheels is driven in rotation, this wheel rolls, via the magnetic coupling, over a geometric circle centred on the other wheel and linked to this other wheel. The magnetic gear further includes a ferromagnetic element arranged relative to the first wheel so as to offset at least most of a magnetic disturbance torque to which the first wheel is subjected, resulting from the magnetic coupling, this magnetic disturbance torque having a periodic variation in intensity according to the angular position of the first wheel.
Type:
Grant
Filed:
July 13, 2021
Date of Patent:
September 3, 2024
Assignee:
The Swatch Group Research and Development Ltd
Inventors:
Jean-Jacques Born, Jean-Pierre Mignot, Matthias Imboden, Cédric Nicolas
Abstract: One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-textured surface.
Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.
Type:
Grant
Filed:
January 25, 2023
Date of Patent:
September 3, 2024
Assignees:
ASTEX THERAPEUTICS LIMITED, CANCER RESEARCH TECHNOLOGY LIMITED
Inventors:
Steven Howard, Benjamin David Cons, Jeffrey David St. Denis, Rhian Sara Holvey, Guillaume François Parra, Kim Louise Hirst, Isabelle Anne Lemasson, David John Nash, James Daniel Osborne, Jonas Calleja Priede, Nicholas Paul Richards, Aaron Michael Dumas, Brian Christopher Bishop, David Parry-Jones, Meenakshi Sundaram Shanmugham, Darren James Dixon, Matthew James Gaunt
Abstract: An exemplary system, method and computer-accessible medium for harmonizing neuromelanin (NM) data using combat directly on a NM database or using combat generated coefficients to harmonize future data can include, for example, receiving imaging information of a brain of the patient(s), from one MRI scanner, receiving imaging information of a brain of the patient(s), from a second MRI scanner and using combat to harmonize the data between scanners against a reference dataset. The Neuromelanin (NM) concentration of the patient(s) can then be determined based on the harmonized data. The NM concentration can be determined using a voxel-wise analysis procedure. The voxel-wise analysis procedure can be used to determine a topographical pattern(s) within a substantia nigra (SN) of the brain of the patient(s).
Type:
Grant
Filed:
March 11, 2022
Date of Patent:
September 3, 2024
Assignees:
Terran Biosciences Inc., The Trustees of Columbia University in the City of New York, The Research Foundation for Mental Hygiene, Inc.
Inventors:
Samuel Clark, Kenneth Wengler, Guillermo Horga Hernandez
Abstract: Disclosed are compositions and methods for gene transfer in immune effector cells, e.g. to create chimeric antigen receptors (CARs). In particular, polypeptides are disclosed that comprising an antigen-binding region and a heparin binding domain, wherein the antigen-binding region is capable of specifically binding to an immune cell antigen located on an immune effector cell, and wherein the heparin binding domain is capable of binding a viral vector.
Type:
Grant
Filed:
February 22, 2018
Date of Patent:
September 3, 2024
Assignee:
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Abstract: The present invention provides monoclonal antibodies that recognize human Nectin4 with high affinity and specificity and inhibit its binding to T cell immunoreceptor with Ig and ITIM domains (TIGIT). The present invention further provides pharmaceutical compositions comprising the antibodies and methods for their use in cancer immunotherapy and in diagnosis.
Type:
Grant
Filed:
May 6, 2019
Date of Patent:
September 3, 2024
Assignees:
NECTIN THERAPEUTICS LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW
Inventors:
Ofer Mandelboim, Adi Reches, Stipan Jonjic, Pinchas Tsukerman
Abstract: There is described an infrared spectrometer having an optical circuit which comprises one or more hollow waveguides provided by elongate channels formed in a substrate. The optical circuit is arranged such that infrared light in the optical circuit acquires one or more spectral properties for detection by the spectrometer. A laser source couples laser light into an input hollow waveguide portion of the optical circuit, and an optical detector receives the light from an output hollow waveguide portion of the optical circuit, so that an analyser can determine said one or more spectral properties from the detected light.
Abstract: Disclosed herein are chimeric antigen receptor (CAR) polypeptides, which can be used with adoptive cell transfer to target and kill cancers, that comprise a costimulatory signaling region having a mutated form of a cytoplasmic domain of CD28 with altered phosphorylation at Y206 and/or Y218. Also disclosed are immune effector cells, such as T cells or Natural Killer (NK) cells, that are engineered to express these CARs. Therefore, also disclosed are methods of providing an antitumor immunity in a subject with a tumor associated antigen-expressing cancer that involves adoptive transfer of the disclosed immune effector cells engineered to express the disclosed CARs.
Type:
Grant
Filed:
March 15, 2019
Date of Patent:
September 3, 2024
Assignee:
H. Lee Moffitt Cancer Center and Research Institute, Inc.
Abstract: A variable speed drive for an electrostatic motor provides feedback control by conversion of measured current phases provided to the motor into a vector in a rotating rotor framework. This vector is used for evaluating corrective voltages and then reconverted to a non-rotating framework for application to the motor electrodes. Current-source drive circuits provide current stabilized outputs making such sophisticated control tractable.
Type:
Grant
Filed:
June 7, 2018
Date of Patent:
September 3, 2024
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Aditya N. Ghule, Baoyun Ge, Daniel Colin Ludois