Abstract: A pharmaceutical composition comprising an active agent that causes reduction of the level of systemic immunosuppression in an individual for use in treating a disease, disorder, condition or injury of the CNS that does not include the autoimmune neuroinflammatory disease, relapsing-remitting multiple sclerosis (RRMS), is provided. The pharmaceutical composition is for administration by a dosage regimen comprising at least two courses of therapy, each course of therapy comprising in sequence a treatment session followed by an interval session of non-treatment.

Abstract: A multihull module is provided. The multihull module includes multiple power floats, an actuation interface controller, and a vehicle controller. The power floats are disposed on a vehicle. The actuation interface controller is coupled to the power floats, and is configured to control the power floats. The vehicle controller is coupled to the actuation interface controller, and is configured to provide a control signal to the actuation interface controller. The actuation interface controller controls the power floats according to the control signal.

Abstract: Compositions containing fumed silica are disclosed herein, including emulsions and/or suspensions containing fumed silica and/or asphalt. In some embodiments, stable fumed silica suspensions can be prepared by adding a density modifier to the fumed silica and water.

Abstract: A video encoding method according to the present disclosure includes classifying a plurality of view images into basic images and additional images, performing pruning on at least one of the plurality of view images on the basis of the classification result, generating an atlas based on the pruning results, and encoding the atlas and metadata for the atlas.

Abstract: A method of user equipment may comprise: determining whether an error condition for a first beam communicating with a base station is met; when it is determined that the error condition for the first beam is met, determining whether a first physical uplink control channel (PUCCH) allocated to the user equipment is present within a predetermined first period of time; when it is determined that the first PUCCH is not present, transmitting a sounding reference signal (SRS) transmission approval request and an identifier of the user equipment to the base station through a second PUCCH pre-configured to be shared by all pieces of user equipment; and when an SRS transmission approval is received from the base station, transmitting an SRS to the base station.

Abstract: The present invention discloses a conductive substrate, a perovskite substrate using the conductive substrate, and a solar cell using the perovskite substrate. The conductive substrate, the perovskite substrate, and the solar cell of the present invention include a conductive base and a conductive compound stacked on the conductive base. The conductive compound is represented by Formula 1, 2 or 3. The conductive compound is capable of multi-electron redox reactions, possesses p-type organic molecular properties, and has an oxidation potential or highest occupied molecular orbital (HOMO) matching the valence band of perovskite so that holes generated in an absorber layer are selectively separated for the application of the perovskite material, achieving enhanced photoelectric conversion efficiency of the solar cell and a significantly reduced difference between the forward and reverse conversion efficiencies (hysteresis index) of the solar cell.

Abstract: Multi-well plate compatible device or insert for three-dimensional (3D) cell cultures, use and kit thereof are provided. The device includes outer and inner walls. the inner wall defining a volume and is located within the outer wall, forming a cavity therebetween. It also includes a base configured to position a cell culture sample below the volume within the inner wall and one or more partitions connected to the base. connecting the inner wall to the outer wall and segmenting the cavity into a plurality of voids. Openings in surfaces forming the voids allow fluid flow from a first void. below the volume within the inner wall to a second void, the fluid flow configured to interact with the cell culture sample when flowing through a sample region within the inner wall. The sample region has a depth defined by a height of the inner wall greater than a length defined by an inner distance across the volume within the inner wall.

Abstract: A method of forecasting risk-biased trajectories of agents surrounding an ego vehicle is described. The method includes sampling a risk-neutral latent space generated by a trained encoder of a generative network based on past surrounding agent trajectories. The method also includes predicting, based on the sampling of the risk-neutral latent space, risk-neutral future surrounding agent trajectories using a trained decoder of the generative network. The method further includes sampling a risk-biased latent space distribution generated by a trained, risk-aware encoder of the generative network based on past trajectories of the ego vehicle and a risk-sensitivity. The method also includes predicting, based on the sampling of the risk-biased latent space distribution, risk-biased future surrounding agent trajectories using the trained decoder of the generative network.

Abstract: There is provided a method for managing a virtual memory in a heterogeneous system. The method comprises receiving a request for accessing to a page in the heterogeneous system; determining a physical address corresponding to an address of the page in the device memory; generating a frame indentification of a migration destination of the device memory using an inverted page table stored in the device memory, when the determined physical address indicates an address allocated to the system memory; and performing page migration to the system memory using the frame indentification and the physical address.

Abstract: The present invention relates to a program analysis device and method, wherein the program analysis device may comprise: a selection unit for selecting one of top-down processing or bottom-up processing for at least one analysis equation among a plurality of analysis equations; a first learning unit which, when the selection unit selects the top-down processing, performs top-down processing for the at least one analysis equation on the basis of a first learning algorithm in response to the selection, and thereby acquires at least one first learned analysis equation; and a second learning unit which, when the selection unit selects the bottom-up processing, performs bottom-up processing for the at least one analysis equation on the basis of a second learning algorithm in response to the selection, and thereby acquires at least one second learned analysis equation.

Abstract: A laser beam steering system is disclosed which includes a laser source which produces a pulsed laser light beam with a frequency comb spectrum, a first metasurface configured to i) directly receive the pulsed laser and ii) directly generate a diffracted pulsed laser output at different frequencies with a beam at a center frequency normal to the first metasurface; and a second metasurface configured to i) directly receive the diffracted pulsed laser output and ii) to focus onto different foci at a focal plane, light propagating from the focal plane leads to generation of one or more optical beams that are controlled in space and time.

Abstract: The present disclosure generally relates to a composition matter and a method for cancer treatment. In particular, a composition matter as an antitumor immunotherapy comprising a polyethyleneimine derivative as an immunoadjuvant, a chemotherapeutic drug, and optional components such as a microRNA, messenger RNA, plasmid DNA, siRNA, oligonucleotide, or a cyclic dinucleotide. A method for treating a subject with a cancer by administrating a therapeutic effective amount of a composition comprising a polyethyleneimine derivative and an antitumor agent to the subject in need of relief from said cancer is also within the scope of this disclosure.

Abstract: A control method and a controller related to electromagnetic tracking are provided. In the method, a working position is determined, and the working position is the position at which a magnetic field sensor is located relative to a magnetic field emitter; an electrical characteristic of the magnetic field emitter or the magnetic field sensor is adjusted to a target characteristic corresponding to the working position. In this way, the positioning accuracy may be improved.

Abstract: A method includes: selecting, from among a series of images, a candidate image that was captured at an image-capturing time instant corresponding to a point-cloud-generating time instant at which a point cloud was generated; generating a two-dimensional data set from the point cloud; superimposing the two-dimensional data set on the candidate image to result in a superimposed image; obtaining a derived distance inconsistency between the candidate image and the two-dimensional data set in the superimposed image; feeding the derived distance inconsistency into a conversion model to obtain a derived time difference; calculating a target time instant based on the derived time difference and the image-capturing time instant of the candidate image; and selecting, from among the series of images that have been received from the image capturing device, a target image that was captured at a time instant the closest to the target time instant.

Abstract: The present disclosure relates to a reduced graphene oxide for a secondary battery, a method for preparing the same, an electrode using the same, and a secondary battery using the same. Specifically, the reduced graphene oxide is a powdery two-dimensional crystalline reduced graphene oxide satisfying Relational Expressions 1 to 3 shown below. [Relationship 1] 1?TQ?5 [relational expression 2] 100?EQ?1,000 [Relationship 3]1?BETQ?100. In Relational Expression 1, TQ represents the thickness (nm) of the reduced graphene oxide. In Relational Expression 2, EQ represents the electrical conductivity (S/cm) of the reduced graphene oxide. In Relational Expression 3, BETQ represents the specific surface area (m2/g) of the reduced graphene oxide.

Abstract: A method is provided for evaluating excretion of a substance of interest by a human hepatocyte-like cell, the method including: preparing a sac-like-material-containing solution that contains a sac-like material which is produced in vitro and has a membrane of a human hepatocyte-like cell and 0% to 10% by volume of a suspended extracellular matrix; placing the substance of interest in the sac-like-material-containing solution to bring the substance of interest into contact with the sac-like material; and extracting the sac-like material from the sac-like-material-containing solution and measuring a concentration of the substance of interest or a metabolite thereof excreted into an inner cavity of the sac-like material.

Abstract: The invention provides compositions and methods of making and using effector oligonucleotides, including effector oligonucleotides with greater than one mismatch as compared to its target sequence. These effector oligonucleotides are useful for improving the efficiency of genomic editing as well as providing therapeutic benefits to individuals in need thereof.

Abstract: Methods of minimizing dysregulation of Staufen1-associated RNA metabolism can include introducing an amount of a Staufen1-regulating agent to a target cell sufficient to minimize the dysregulation. Therapeutic compositions for treating a neurodegenerative condition associated with Staufen1-induced dysregulation of RNA metabolism can include a therapeutically effective amount of a Staufen1-regulating agent and a pharmaceutically acceptable carrier.

Abstract: SCGB-based preparations and methods to use these preparations to protect the glycocalyx in medical, veterinary, and cosmetic applications are provided. The secretoglobins (SCGBs) are a family of small secreted globular proteins present in all mammals and sharing conserved structure and thought to share similar immunomodulatory functions. Heparan sulfate proteoglycan proteins (HSPGs) are expressed on the outer membranes of cells and have carbohydrate side chains that, together, make up the glycocalyx. The glycocalyx is a protective layer surrounding all cells, acting as a filter regulating the passage of nutrients into the cell and modifying cell signaling by external factors. There are two major families of HSPGs including syndecans and glypicans, plus several other HSPGs in all mammals. SCGBs bind to, and interact with, HSPGs to further modulate cell signaling and cellular responses to external factors.

Abstract: An adjustable antenna positioning system feed is disclosed herein. The adjustable antenna positioning system feed includes a feed base, a splash plate assembly, and a feed insert. The feed base is configured to be coupled to a reflector. The splash plate assembly is configured to be removably coupled to the feed base. The adjustable antenna positioning system feed is in a primary arrangement when directly coupled. The feed insert is positioned between the feed base and the splash plate. The adjustable antenna positioning system feed is in a secondary arrangement when the feed insert is coupled with the feed base and the splash plate.