Abstract: N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. Conformationally restricted analogs exhibit both high affinity and selectivity at this site, and are able to access the brain due to their ability to act as substrates for the blood-brain barrier choline transporter.

Abstract: A sensor device, method of fabricating the same, and a method of sensing a physical quantity. The sensor device comprises a substrate; a flexure member, one end of the flexure member being attached to the substrate, and a free end of the flexure member having an edge surface; a counter surface formed on the substrate such that the counter surface faces the edge surface of the flexure member and such that a separation distance between the counter surface and the edge surface remains substantially constant for movement of the edge surface as a result of flexure of the flexure member, each of the edge surface and the counter surface including one or more conductor layers disposed in a plane substantially perpendicular to a flexure direction of the flexure member; and means for applying an electrical potential difference between the conductors of the edge surface and the conductors of the counter surface for detecting a quantum tunnelling current therebetween.

Abstract: The subject invention provides materials and methods for convective and/or conductive and/or evaporative cooling of individuals, such as athletes and contestants, for safety, comfort, and enhanced performance. The materials and methods of the subject invention can, advantageously, be used to modify body core temperature or rate of change of temperature. Other uses include heating players or player parts (e.g., a kicker's leg, a pitcher's arm) in cold weather conditions.

Abstract: Provided are method of generating a fiber from a globular protein such as albumin. Also provided are albumin fibers and fabrics and methods of using same for bonding a damaged tissue or for ex vivo or in vivo formation of a tissue.

Abstract: The present invention pertains generally to the field of therapeutic compounds for treating proliferative disorders, cancer, etc., and more specifically to certain pyrido[2,3-b]pyrazin-8-substituted compounds, as described herein, which, inter alia, inhibit RAF (e.g., B-RAF) activity. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit RAF (e.g., BRAF) activity, to inhibit receptor tyrosine kinase (RTK) activity, to inhibit cell proliferation, and in the treatment of diseases and disorders that are ameliorated by the inhibition of RAF, RTK, etc., proliferative disorders such as cancer (e.g., colorectal cancer, melanoma), etc.

Abstract: A system for power saving in communication with a plurality of sensor apparatuses that are located in-body or on-body to sense bioinformation, a management apparatus that performs synchronization by transmitting a beacon signal to the plurality of sensors at each predetermined period, and a sensor apparatus that includes a sensor receiving a first beacon signal, grasps how much time remains until the second beacon signal is received when the sensor is activated to sense the bioinformation, and determines the operation state of the sensor based on the grasped time are provided.

Abstract: Disclosed are a method and apparatus of adaptive transmission signal detection based on a signal-to-noise ratio and a Chi-squared distribution for decoding a reception signal in the form of multi-streams into a transmission signal, the method comprising: receiving a reception signal vector; estimating a channel matrix of a channel that the reception signal vector experienced; performing QR decomposition based on the estimated channel matrix; calculating dimensions of divisional spaces adaptively on the basis of a signal-to-noise ratio (SNR) or a signal-to-interference noise ratio (SINR); detecting a maximum likelihood point having a maximum likelihood value among lattice points within each divisional space obtained on the basis of results from performing the QR decomposition and calculating dimension of the divisional spaces; and recovering a transmission signal vector based on the detected maximum likelihood points.

Abstract: A method for fabricating a bi-polar plate of a fuel cell and the bi-polar plate thereof are presented. A graphite film is formed first. Next, a polymeric material added with electrically conductive powder is coated on a surface of a metal substrate. The graphite film is disposed on the polymeric material and the polymeric material is hardened to form an adhesive layer, such that the graphite film is attached on the surface of the metal substrate.

Abstract: The present invention relates to a missile or munition with a hierarchical, modular, closed-loop flow control system, more particularly to aircraft or munition with flow control system for enhanced aerodynamic control, maneuverability and stabilization. The present invention further relates to a method of operating the flow control system. Various embodiments of the flow control system involve elements including flow sensors, active flow control devices or activatable flow effectors, and logic devices with closed loop control architecture. The sensors are used to estimate or determine flow conditions on the surfaces of a missile or munition. The active flow control device or activatable flow effectors create on-demand flow disturbances, preferably micro-disturbances, at different points along the various aerodynamic surfaces of the missile or aircraft to achieve a desired stabilization or maneuverability effect.

Abstract: An antibody that binds to Mucin17 (Muc17) is disclosed. The antibody of the present invention preferably binds to the peptide of SEQ ID NO:3 and does not bind to the peptide of SEQ ID NO:4 or the peptide of SEQ ID NO:5. Also disclosed are an anti-cancer agent, preferably an anti-cancer agent for pancreatic cancer, which comprises the antibody of the present invention, as well as a method of diagnosing cancer using the antibody of the present invention, preferably the antibody of the present invention that does not bind to the secreted-form of Muc17.

Abstract: A miniature microphone, comprising a diaphragm, supported for displacement in response to acoustic waves, from which a plurality of projections extend; a plurality of projections extending from a surface; a body, supporting the surface to maintain the plurality of projections from the diaphragm and the plurality of projections from the surface in close proximity; and an electromagnetic sensor adapted to sense an electromagnetic interaction between the plurality of projections from the diaphragm and the plurality of projections from the surface and produce an electrical signal in response thereto. The interaction may be detected substantially without inducing a force which tends to substantially displace the diaphragm, since the electrostatic force is substantially parallel to the diaphragm surface.

Abstract: A light uniformization structure including a first material layer having a plurality of microstructures in a surface thereof, a second material layer having a plurality of microstructures in a surface thereof, and a spacer layer located between the first material layer and the second material layer. The refractive index of the spacer layer is smaller than a refractive index of the first material layer and a refractive index of the second material layer. A light emitting module including the light uniformization structure is also disclosed.

Abstract: A material of phosphorus-doped lithium titanium oxide with spinel structure includes a plurality of lithium titanium oxide particles, wherein a portion or the entirety of the surface layer of the lithium titanium oxide particle is doped with phosphorus. The surface layer is from 1 to 10 nanometers in thickness. Alternatively, the entire lithium titanium oxide particle can be doped with phosphorus. The material can be in powdered form, including a plurality of micro-scale particles each constituted by a plurality of the lithium titanium oxide particles.

Abstract: Provided is a wavelength-tunable external cavity laser module. The wavelength-tunable external cavity laser module includes: a gain medium generating light; an optical waveguide combined with the gain medium and including a Bragg grating and a thin film heater adjusting a temperature of the Bragg grating; and a high frequency transmission medium delivering a high frequency signal to the gain medium, wherein the high frequency transmission medium controls an operating speed of the light.

Abstract: A power circuit is applicable to a Direct Current (DC) to DC converter. The power circuit includes a gate driver circuit and a High Electron Mobility Transistor (HEMT). The gate driver circuit functions as a Sigmoid (S) function and controls a gate and a source of the HEMT with a cross voltage of the sigmoid (S) type function. Accordingly, an overall characteristic curve of the HEMT and the gate driver circuit is like a characteristic curve of a single rectifier diode, so as to achieve a rectifying, freewheeling, or reversing effect. In addition, since an energy loss is low when the HEMT is conducted, the energy loss of the whole power circuit is much less than that of a conventional diode.

Abstract: Embodiments of present disclosure provide a method and system for remotely auditing a security posture of a client machine at a centralized server. The system receives an integrity-protected report from the client machine, or other devices related to the client machine, the report comprising entries associated with security events or security states or both related to the client machine. The report entries comprise characteristics of the security events or security states to facilitate identification of a probable security attack at the client machine. The system also detects a pattern among one or more reports. Finally, the system classifies the security posture of the client machine based on the detected pattern, which could indicate a probable security attack at the client machine.

Abstract: Package structures for integrating thermoelectric components with stacking chips are presented. The package structures include a chip with a pair of conductive through vias. Conductive elements are disposed one side of the chip contacting the pair of conductive through vias. Thermoelectric components are disposed on the other side of the chip, wherein the thermoelectric component includes a first type conductive thermoelectric element and a second type conductive thermoelectric element respectively corresponding to and electrically connecting to the pair of conductive through vias. A substrate is disposed on the thermoelectric component, wherein the thermoelectric component, the pair of conductive through vias and the conductive element form a thermoelectric current path. Therefore, heat generated from the chip is transferred outward through a thermoelectric path formed from the thermoelectric components, the conductive through vias and the conductive elements.

Abstract: Three dimensional integrated circuits with double sided power, coolant, and data features and methods of constructing same are provided. According to some embodiments, an integrated circuit package can generally comprise one or more semiconductor wafers and opposing end substrates. The semiconductor wafers can each have a top exterior surface and a bottom exterior surface. The plurality of semiconductor wafers can form a multi-dimensional wafer stack of die wafers such that adjacent wafers have facing surfaces. Each of the semiconductor wafers can comprise one or more channels formed through the wafers. A portion of the channels can extend generally between the top and bottom exterior surfaces of the semiconductor wafers. A portion of the channels can carry conductors for coupling the wafers and/or coolant for cooling the wafers. The opposing end substrates can be disposed proximate opposing ends of the multi-dimensional stack.

Abstract: The present invention discloses an encoding apparatus using a Discrete Cosine Transform (DCT) scanning, which includes: a mode selection means for selecting an optimal mode for intra prediction; an intra prediction means for performing intra prediction onto video inputted based on the mode selected in the mode selection means; a DCT and quantization means for performing DCT and quantization onto residual coefficients of a block outputted from the intra prediction means; and an entropy encoding means for performing entropy encoding onto DCT coefficients acquired from the DCT and quantization by using a scanning mode decided based on pixel similarity of the residual coefficients.

Abstract: A composition-of-matter comprising a substance usable in producing packaging material and at least one compound selected from the group consisting of ar-turmerone, a sesquiterpene alcohol and a turmeric oleoresin solid residue.