Abstract: A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of formula I: wherein X is selected from the group consisting of alkyl and haloalkyl; Ar is an aryl radical selected from the group consisting of phenyl, biphenyl, naphthyl, anthryl, phenanthryl, and fluorenyl; and wherein Ar is optionally substituted with one or more radicals selected from the group consisting of halo, C1-C4 alkyl, C1-C4 haloalkyl, azido, C1-C4 azidoalkyl, aryl, alkylaryl, haloaryl, haloalkylaryl, and combinations thereof; and R is selected from the group consisting of nitrile, acetonitrile, ethylnitrile, propylnitrile, carboxamide, amidine, tetrazole, oxime, hydrazone, acetamidine, aminoacetamide, guanidine, and urea. Also provided are methods of using the compounds for the treatment and prevention of cancer in humans.

Abstract: The subject application provides small compounds that are able to suppress autophagy in various cells. These compounds are useful in augmenting the existing treatments of various cancers and microbial/parasitic infections. Thus, the subject application also provides methods of treating various types of cancers and microbial/parasitic infections. Also provided by the subject application are methods of suppressing the expansion of autophagosomes within cells or individuals and inhibiting the lipidation of autophagy-related protein 8 (Atg8).

Abstract: An arrangement for measuring process parameters within a processing chamber is provided. The arrangement includes a probe arrangement disposed in an opening of an upper electrode. Probe arrangement includes a probe head, which includes a head portion and a flange portion. The arrangement also includes an o-ring disposed between the upper electrode and the flange portion. The arrangement further includes a spacer made of an electrically insulative material positioned between the head portion and the opening of the upper electrode to prevent the probe arrangement from touching the upper electrode. The spacer includes a disk portion configured for supporting an underside of the flange portion. The spacer also includes a hollow cylindrical portion configured to encircle the head portion. The spacer forms a right-angled path between the o-ring and an opening to the processing chamber to prevent direct line-of-sight path between the o-ring and the opening to the processing chamber.

Abstract: A reference voltage supply circuit is provided. The reference voltage supply circuit includes a first amplifier for amplifying a first input voltage and a fed back first reference voltage, a second amplifier for amplifying a second input voltage and a fed back second reference voltage, a reference voltage generator for generating the first reference voltage and the second reference voltage according to output signals of the first and second amplifiers and feeding the first and second reference voltages back to the first and second amplifiers, and a glitch remover turned on/off according to an input pulse signal to conduct or cut off current flowing between a power supply terminal and the ground.

Abstract: Provided herein are methods for inactivating a target polynucleotide. The methods use a psiRNA having a 5? region and a 3? region. The 5? region includes, but is not limited to, 5 to 10 nucleotides chosen from a repeat from a CRISPR locus immediately upstream of a spacer. The 3? region is substantially complementary to a portion of the target polynucleotide. The methods may be practiced in a prokaryotic microbe or in vitro. Also provided are polypeptides that have endonuclease activity in the presence of a psiRNA and a target polynucleotide, and methods for using the polypeptides.

Abstract: Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating such diseases are also described.

Abstract: Vascular endothelial growth factor A (VEGFA) is a chemical signal produced by cells that stimulates the growth of new blood vessels, and overexpression of VEGFA can lead to undesirable physiological conditions. Through the identification of new siRNA and modifications that improve the silencing ability of these siRNA in vivo, therapeutic compositions and methods have been invented to address the problems associated with this overexpression.

Abstract: The present invention relates to a process for preparing a bimodal polyethylene product in a single loop reactor, comprising polymerizing ethylene monomer and optionally one or more olefin co-monomers in the presence of a single heterogeneous polymerization catalyst consisting of a metallocene-alumoxane catalyst immobilized on a porous support wherein said metallocene comprises only one transition metal. Said polymerization catalyst consists of two physically different fractions of support particles onto which said metallocene-alumoxane catalyst is immobilized.

Abstract: This invention relates to a middleware bridge system, for bridging a kernel space module and a user space middleware having a user space interface, including: a kernel space bridge manager, for providing a kernel space interface to receive function call request from the kernel space module; an user space bridge manager, for bringing a function call relating to the function call request to the user space middleware through the user space interface, and receiving a return data from the user space middleware; wherein the architecture of the kernel space interface is the same with the architecture of the user space interface. The present invention further includes a middleware bridge method thereof.

Abstract: A number of DNA methylation inhibitors are described. The DNA methylation inhibitors were identified using a two-component enhanced green fluorescent protein reporter system to screen a compound library containing procainamide derivatives. The DNA methylation inhibitors can be used for cancer therapy and prevention.

Abstract: The present invention relates to tunneling an IPv6 packet through an IPIv4 network. In using a tunneling method upon transmitting an IPv6 packet in an IP network, when destination nodes desired to be communicated are located within the same IPv6 prefix network, IPv6 prefix information is added for the management of a tunnel entry. Hence, tunneling information on terminals located within the same IPv6 prefix network can be managed as one tunnel entry. Accordingly, the time consumed when retrieving a tunnel entry can be reduced.

Abstract: A cylinder head sleeve for an engine is provided comprising a sleeve first part and a sleeve second part which form a cavity to contain a fuel injector or an ignitor, and wherein the sleeve first part and the sleeve second part which form a joint for the sleeve first part and the sleeve second part to move relative to each other. A cylinder head assembly is also provided comprising the sleeve and a cylinder head, as well as a method of providing the cylinder head assembly.

Abstract: A radiated power detection apparatus including a reception antenna and a probe in a Fresnel zone determines a measurement parameter of a wireless communication device and coincides central points of an antenna that is included in the wireless communication device, the reception antenna, and the probe. Next, the radiated power detection apparatus measures the magnitude of an electric field corresponding to at least one measurement point while transferring the reception antenna and the probe according to a measurement parameter, calculates the magnitude of a maximum electric field in a far-field using the magnitude of an electric field, and thus detects radiated power of the wireless communication device based on the magnitude of a maximum electric field.

Abstract: A method of aligning electronic components comprising providing a positioning member 110 having at least one formation 120 for receiving an electronic component; said at least one formation having lateral boundaries 35, 36 for constraining movement of an electronic component; placing a first electronic component 10a in said at least one formation; and providing a force for actively aligning said first electronic component with a lateral boundary of said at least one formation. The force may, for example, be provided by tilting the positioning member, by providing suction or by using an actuator. An apparatus for aligning electronic components and a 3D system of stacked electronic components is also disclosed.

Abstract: A transparent substrate with optical compensation ability comprises polyimide having the following chemical formula: wherein A and A? are cyclic aliphatic or aromatic compounds, B and B? are cyclic aliphatic or aromatic compounds. In particular, the refractive index of the transparent polyimide is nx=ny>nz, that is, it has ability of adjusting the negative type c-plate phase difference, wherein nx represents the lateral refractive index, ny represents the longitudinal refractive index, nz represents the vertical refractive index along the thickness direction, and m and n are between 10 and 10,000.

Abstract: A method of manufacturing a transparent transistor including a substrate, source and drain electrodes formed on the substrate, each having a multi-layered structure of a lower transparent layer, a metal layer and an upper transparent layer, a channel formed between the source and drain electrodes, and a gate electrode aligned with the channel. The lower transparent layer or the upper transparent layer is formed of a transparent semiconductor layer, which is the same as the channel.

Abstract: Modified glucagon peptides are disclosed having enhanced potency at the glucagon receptor relative to native glucagon. Further modification of the glucagon peptides by forming intramolecular bridges or the substitution of the terminal carboxylic acid with an amide group produces peptides exhibiting glucagon/GLP-1 receptor co-agonist activity. The solubility and stability of these high potency glucagon analogs can be further improved by modification of the polypeptides by pegylation, acylation, alkylation, substitution of carboxy terminal amino acids, C-terminal truncation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 26 (GPSSGAPPPS), SEQ ID NO: 27 (KRNRNNIA) and SEQ ID NO: 28 (KRNR).

Abstract: Provided is a high performance tilt rotor aircraft in which a nacelle tilt angle and a flaperon angle mechanically interlock with each other. In the tilt rotor aircraft having nacelles in which rotors are mounted in left and right main wings and configured so that the nacelles rotate according to whether the tilt rotor aircraft conducts forward flight or vertical take-off and landing flight, each of the main wings is provided with a flaperon, and the nacelle and the flaperon are connected to each other by a power transfer unit, such that the flaperon also rotates together with the nacelle at the time of rotation of the nacelle, thereby allowing a change in a nacelle tilt angle to lead to a change in a flaperon angle.

Abstract: In a process for producing a metal containing catalyst composition suitable for effecting hydrocarbon hydrogenation and/or dehydrogenation reactions, a catalyst support comprising a porous crystalline material combined with an amorphous binder is treated with an anchoring material capable of bonding to the surface of the support and to a metal component. In addition, a precursor to the metal component is deposited on the surface of the catalyst support and then the treated catalyst support having the precursor deposited thereon is subjected to conditions effective to convert the precursor to the metal component and to cause the anchoring material to bond to the surface of the support and to the metal component.

Abstract: This invention relates generally to norbornene-monomer, poly(norbornene)homopolymer, and poly(norbornene)copolymer compounds containing a functionalized carbazole side chain, having desirable solution processability and host characteristics. It also relates to hole transport and/or electron blocking materials, and to organic host materials for an organic luminescence layer, an OLED device, and compositions of matter which include these compounds.