Abstract: System, methods, and other embodiments described herein relate to communicating alerts about a recommended speed by adapting headlight color. In one embodiment, a method includes computing a recommended speed using an automated driving system (ADS) during an operator controlling a vehicle while the ADS is disengaged. The method also includes, responsive to determining that a vehicle speed satisfies a threshold associated with the recommended speed and an offset value set according to a driving environment, adapting an alert color projected by headlights of the vehicle according to the vehicle speed and the alert color is corrected for operator perception of visible colors associated with the driving environment.
Type:
Grant
Filed:
February 23, 2022
Date of Patent:
January 9, 2024
Assignee:
Toyota Research Institute, Inc.
Inventors:
Hiroshi Yasuda, Manuel Ludwig Kuehner, Guillermo Pita Gil
Abstract: Disclosed herein are novel Pichia pastoris strains for expression of exogenous proteins with substantially homogeneous N-glycans. The strains are genetically engineered to include a mutant OCH1 allele which is transcribed into an mRNA coding for a mutant OCH1 gene product (i.e., ?-1,6-mannosyltransferase, or “OCH1 protein”). The mutant OCH1 protein contains a catalytic domain substantially identical to that of the wild type OCH1 protein, but lacks an N-terminal sequence necessary to target the OCH1 protein to the Golgi apparatus. The strains disclosed herein are robust, stable, and transformable, and the mutant OCH1 allele and the ability to produce substantially homogeneous N-glycans are maintained for generations after rounds of freezing and thawing and after subsequent transformations.
Abstract: This document provides biomarkers of gut microbiota dysbiosis. Bacteria that are increased or decreased in gut microbiota dysbiosis can be used as biomarkers to predict dysbiosis in patients with diarrhea and/or to predict susceptibility to Clostridium difficile infection (CDI). In addition, provided herein are compositions including at least three bacteria that are decreased in gut microbiota dysbiosis which can be used, for example, to restore heathy gut microbiota (e.g., by probiotic or by fecal microbiota transplant) to treat CDI.
Type:
Grant
Filed:
November 9, 2020
Date of Patent:
January 9, 2024
Assignee:
Mayo Foundation for Medical Education and Research
Inventors:
Purna C. Kashyap, Eric J. Battaglioli, Vanessa L. Hale
Abstract: A workgroup-computing-entity-based fail-safe/evolvable hardware core structure is disclosed which includes a 3-hierarchical-level 6-workgroup-Basic-Building-Block (6-wBBB) created to supplant the node-computing-entity-based non-fail-safe/limited evolvable von-Neumann core structure of 3-hierarchical-level 3-node-BBB, (i.e., base-level IO-devices/mid-level main memory/top-level CPU) and all the first-time fail-safe workgroup systems can be subsequently generated in the second period along the workgroup-computing evolutionary timeline. Furthermore, based on the first 6-wBBB evolvable architecture, the workgroup evolutionary processes can go up to 7 generations in creating all the necessary workgroup-computing entity-based hardware core structures, so that all the real-time intelligent workgroup-computing systems can be generated in the third period along the workgroup-computing evolutionary timeline.
Abstract: This document relates to methods and materials involved in treating cancer. For example, methods and materials for using one or more oncolytic viruses (e.g., one or more replicating oncolytic viruses) to treat cancer in a mammal (e.g., a human) identified as having a cancer likely to respond to oncolytic virotherapy are provided.
Type:
Grant
Filed:
June 15, 2017
Date of Patent:
January 9, 2024
Assignee:
Mayo Foundation for Medical Education and Research
Inventors:
Kah-Whye Peng, Stephen James Russell, Mitesh J. Borad, Yumei Zhou, Amber C. Miller
Abstract: Systems, methods, and other embodiments described herein relate to training a multi-task network using real and virtual data. In one embodiment, a method includes acquiring training data that includes real data and virtual data for training a multi-task network that performs at least depth prediction and semantic segmentation. The method includes generating a first output from the multi-task network using the real data and second output from the multi-task network using the virtual data. The method includes generating a mixed loss by analyzing the first output to produce a real loss and the second output to produce a virtual loss. The method includes updating the multi-task network using the mixed loss.
Type:
Grant
Filed:
March 29, 2021
Date of Patent:
January 9, 2024
Assignee:
Toyota Research Institute, Inc.
Inventors:
Vitor Guizilini, Adrien David Gaidon, Jie Li, Rares A. Ambrus
Abstract: An atomic clock employs alkali metal atoms such as cesium normally used for microwave atomic clocks but with optical stimulation. While alkali metals provide light emissions having a spectral width being as much as 107 wider (and hence less precise) than alkali earth materials commonly targeted for optical atomic clocks, the present inventors have determined that this disadvantage is significantly reduced by improved signal-to-noise ratio in the obtained signal making practical an atomic clock with improved size, weight, and power consumption.
Type:
Grant
Filed:
March 15, 2022
Date of Patent:
January 9, 2024
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Mark Saffman, Shimon Kolkowitz, Arjav Sharma
Abstract: A nucleic acid purification device according to the inventive concept includes an activated carbon fiber filter, wherein the activated carbon fiber filter includes an activated carbon fiber and a potassium compound coated on the surface of the activated carbon fiber.
Type:
Grant
Filed:
May 7, 2020
Date of Patent:
January 9, 2024
Assignee:
Electronics and Telecommunications Research Institute Cancer Rop Co., Ltd.
Inventors:
Eun-Soo Jeong, Min Seon Kim, Kwang Hyo Chung
Abstract: An apparatus in which electric power is generated for an electrical load from differentials in electric field strengths within a vicinity of powerlines includes: a plurality of electrodes separated and electrically insulated from one another for enabling differentials in voltage resulting from differentials in electric field strength experienced there at; and electrical components electrically connected therewith and configurable to establish one or more electric circuits whereby voltage differentials cause a current to flow through the established electric circuit for powering the electrical load.
Abstract: A single-chain variable fragment (ScFv) derived from anti-c-Met monoclonal antibody MetMAb that specifically binds to c-Met receptor is provided. Also provided are chimeric antigen receptor (CAR) vectors including the ScFv, human T cells transduced with the disclosed CAR vectors, pharmaceutical compositions including the CAR T cells, ScFv fusion proteins, and methods of treating a c-Met-positive cancer or a cancer characterized by overexpression of c-Met in a subject in need thereof by administering an effective amount of the disclosed CAR T cells.
Type:
Grant
Filed:
November 2, 2020
Date of Patent:
January 9, 2024
Assignee:
EAST TENNESSEE STATE UNIVERSITY RESEARCH FOUNDATION
Abstract: A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5? position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.
Type:
Grant
Filed:
April 8, 2021
Date of Patent:
January 9, 2024
Assignee:
Technion Research & Development Foundation Limited
Inventors:
Timor Baasov, Dana Atia-Glikin, Jeyakumar Kandasamy, Valery Belakhov
Abstract: Disclosed are an electrochromic element, device, and product, and a manufacturing method therefor. The electrochromic device (7) comprises: an electrochromic yarn (6), an ion storage yarn (18), and a power source (8), wherein the electrochromic yarn (6) contains a first flexible conductive yarn (5) and an electrochromic layer (4) coated on a surface layer of the first flexible conductive yarn (5); the ion storage yarn (18) contains a second flexible conductive yarn (1) and an ion storage layer (17) coated on a surface layer of the second flexible conductive yarn (1); and the first flexible conductive yarn (5) is electrically connected to a negative electrode of the power source (8), and the second flexible conductive yarn (1) is electrically connected to a positive electrode of the power source (8). The electrochromic device (7) can achieve a clear color development effect and make an electrochromic material have a good fastness.
Type:
Grant
Filed:
April 10, 2018
Date of Patent:
January 9, 2024
Assignee:
THE HONG KONG RESEARCH INSTITUTE OF TEXTILES AND APPAREL LIMITED
Inventors:
Edwin Yee Man Keh, Lei Yao, Yeung Yu Hui, Xinxin Huang, Yue Kit Hui, Colin Xin Chen, Derek Lai
Abstract: A pattern detector circuit is provided in a security chip, wherein the pattern detector circuit monitors accesses of a plurality of configuration registers, each of the plurality of configuration registers having a corresponding address. In response to receiving from a host a predefined sequence of accesses of the plurality of configuration registers for one or more operations to the plurality of configuration registers, a processor in the pattern detector circuit determines a value indicative of a current version of a netlist for the security chip. The determined value is made available to be obtained by a read operation by the host at a specific configuration register address.
Type:
Grant
Filed:
September 4, 2020
Date of Patent:
January 9, 2024
Assignee:
CRYPTOGRAPHY RESEARCH, INC.
Inventors:
Scott C. Best, Christopher Leigh Rodgers
Abstract: The electronic apparatus includes a memory stored with a multiple light field unit (LFU) structure in which a plurality of light fields is arranged in a lattice structure, and a processor configured to, based on a view position within the lattice structure being determined, generate a 360-degree image based on the view position by using the multiple LFU structure, and the processor is configured to select an LFU to which the view position belongs from among the multiple LFU structure, allocate a rendering field-of-view (FOV) in predetermined degrees based on the view position, generate a plurality of view images based on a plurality of light fields comprising the selected LFU and the allocated FOV, and generate the 360-degree image by incorporating the generated plurality of view images.
Type:
Grant
Filed:
August 12, 2020
Date of Patent:
January 9, 2024
Assignee:
INHA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
Inventors:
Chae Eun Rhee, Hyunmin Jung, Hyuk-Jae Lee
Abstract: Disclosed herein are prosthesis simulator devices comprising a first restraint configured to restrain one or more fingers of a wearer of the simulator, a second restraint configured to restrain a thumb of the wearer, and a plurality of artificial digits configured to move in a manner to simulate one or more prosthetic fingers and a prosthetic thumb of a prosthesis. The first restraint can be attached to a roof plate connected to a base plate and defining a dorsal side of the prosthesis simulator. The second restraint can be attached to a holster connected to the base plate on a palmar side of the prosthesis simulator. Also disclosed herein are methods of using the same.
Type:
Grant
Filed:
September 8, 2021
Date of Patent:
January 9, 2024
Assignee:
Georgia Tech Research Corporation
Inventors:
Bennett Leonard Alterman, William D. Hendrix, John T. Johnson, Perry J. Lee, Lewis A. Wheaton
Abstract: The present invention relates, in general, to polypeptides capable of binding and neutralizing transforming growth factor beta (TGF-?) ligands, and uses of these polypeptides for treating disorders related to TGF-beta expression or activation (e.g. cancer and fibrotic diseases), and methods of making such molecules.
Type:
Grant
Filed:
March 1, 2018
Date of Patent:
January 9, 2024
Assignee:
National Research Council of Canada
Inventors:
Anne E. G. Lenferink, John C. Zwaagstra, Traian Sulea, Maureen D. O'Connor-McCourt
Abstract: Techniques for generating and administering an oculo-cognitive addition test. Some aspects include identifying, by a system, a set of numbers that are to be displayed to a user during a trial of a cognitive test. The set of numbers includes at least two numbers. The system can administer the trial of the cognitive test, including, for each number in the set of numbers: displaying the number at a particular position of a display environment; tracking, by the system and using one or more optical sensors, eye movement of the user seeking the number in the display environment; and receiving, by the system and after having displayed the number for a time, a command that is to advance or end the cognitive test.
Type:
Grant
Filed:
October 30, 2017
Date of Patent:
January 9, 2024
Assignee:
Mayo Foundation for Medical Education and Research
Inventors:
Gaurav N. Pradhan, Michael J. Cevette, Jan Stepanek, Kenneth H. Brookler
Abstract: A tablet-based method for fabricating a suspension including gold (Au) particles and water can include adding to water a solid tablet prepared from a solid alkaline powder, a solid acid powder, and gold particles. Carbon dioxide (CO2) gas can be generated once the tablet is added to the water. The gold (Au) particles can be in microparticle or nanoparticle form. The solid alkaline powder can include sodium bicarbonate (NaHCO3) or sodium carbonate (Na2CO3). The solid acid powder can include monosodium phosphate (NaH2PO4).
Type:
Grant
Filed:
January 31, 2022
Date of Patent:
January 9, 2024
Assignee:
KUWAIT INSTITUTE FOR SCIENTIFIC RESEARCH
Inventors:
Naser Alsayegh, Husain Bahzad, Nawaf F. Aljuwahel
Abstract: A system for deep sediment flow culture simulating in-situ water pressure includes a flow culture apparatus, an inflow pressurizer and an outflow depressurizer, wherein the inflow pressurizer comprises a pressure tank, an air inlet pipe, a pressure regulating valve, a pressure-resistant container and a first support, and the pressure-resistant container containing in-situ overlying water added with isotopes is placed on the first support, a water outlet of the pressure-resistant container being connected with a water inlet pipe of the flow culture apparatus; the outflow depressurizer comprises a porous medium pipe, a second support, a depressurized water outlet pipe and a water catcher, and an outlet of the porous medium pipe is connected with one end of the depressurized water outlet pipe, the other end of the depressurized water outlet pipe extending into the water catcher.