Abstract: The present invention relates to methods for administering therapeutic doses of bispecific T-cell engaging molecules for the treatment of cancer in a patient. The administration methods reduce the incidence and/or severity of adverse events, such as cytokine release syndrome, and entail administering to a patient a priming dose of the bispecific T-cell engaging molecule by continuous intravenous infusion over a period of days followed by administration of a therapeutic dose of the bispecific T-cell engaging molecule by a bolus intravenous infusion at dosing intervals of at least a week.
Type:
Application
Filed:
September 15, 2021
Publication date:
December 14, 2023
Applicants:
AMGEN INC., AMGEN RESEARCH (MUNICH) GmbH
Inventors:
Adam B. MCCULLOUGH, Hosein KOUROS-MEHR, Peter KUFER, Mark SALVATI, Alexander C. MINELLA, Dirk NAGORSEN, Vijay UPRETI, Mukul MINOCHA, Brett HOUK
Abstract: Disclosed is a radio wave device test system, comprising a fixed part configured to fix a radio wave device; a positioner system configured to control a rotation of the radio wave device by controlling the fixed part; an arch structure whose central point is located at a position where the radio wave device is located; a plurality of probes disposed to be spaced apart from one another at fixed intervals in the arch structure, and configured to receive a radio frequency (RF) signal from the raid wave device; and a plurality of receiving modules located at the plurality of probes, respectively, and configured to transform the RF signal into in-phase/quadrature (I/Q) data by carrying out digital transformation for the RF signal and to detect information on amplitude and a phase from the I/Q data.
Type:
Application
Filed:
September 24, 2022
Publication date:
December 14, 2023
Applicant:
National Radio Research Agency
Inventors:
KANG WOOK KIM, SOON SOO OH, YOUNG BAE JUNG, JONG HYUK LIM, JUNG KUY PARK, SAM YOUNG JUNG
Abstract: Embodiments described herein provide a supervisor for fault management at a production system. During operation, the supervisor can obtain a set of sensor readings and a state of the production system. A respective sensor reading is an output of a sensor in the production system. The supervisor can then determine, using an artificial intelligence (AI) model, whether the set of sensor readings accommodates a fault associated with a corresponding sensor. Subsequently, the supervisor can determine an action that mitigates an effect of the fault and modify the set of sensor readings based on the action. Here, the modified set of sensor readings is used by a controller that controls the production system.
Type:
Application
Filed:
August 2, 2022
Publication date:
December 14, 2023
Applicant:
Palo Alto Research Center Incorporated
Inventors:
Christoforos Somarakis, Erfaun Noorani, Raman Goyal, Aleksandar B. Feldman, Shantanu Rane
Abstract: A robotic system is contemplated. The robotic system comprises a robot comprising a camera, a microphone, memory, and a controller that is configured to receive a natural language command for performing an action within a real world environment, parse the natural language command, categorize the action as being associated with guidance for performing the action, receive the guidance for performing the action, the guidance including a motion applied to at least one portion of the robot within the real world environment for performing the action, and store, in the memory, the natural language command in correlation with the motion that is applied to the at least one portion of the robot.
Type:
Application
Filed:
June 14, 2022
Publication date:
December 14, 2023
Applicants:
Toyota Research Institute, Inc., Toyota Jidosha Kabushiki Kaisha
Abstract: A switchable floating image display device, including a light-emitting stack layer, a light-emitting pattern stack layer, a transparent barrier layer, an optical imaging module, and a power supply module, is provided. The light-emitting stack layer is configured to generate a first pattern beam. The light-emitting pattern stack layer is configured to generate a second pattern beam. The transparent barrier layer is disposed between the light-emitting stack layer and the light-emitting pattern stack layer. The optical imaging module is configured to enable the first pattern beam to form a first floating image, and enable the second pattern beam to form a second floating image. The power supply module is electrically connected to the light-emitting stack layer and the light-emitting pattern stack layer, and configured determine whether to generate the first or second floating image by switching between the light-emitting stack layer and the light-emitting pattern stack layer to emit light.
Type:
Grant
Filed:
April 27, 2022
Date of Patent:
December 12, 2023
Assignee:
Industrial Technology Research Institute
Inventors:
Yi-Hsiang Huang, Yu-Hsiang Liu, Chia-Ping Lin
Abstract: A catalyst system for olefin polymerization contains a main catalyst and a cocatalyst. The cocatalyst contains a twelve-membered ring compound represented by formula (M). The catalyst system is suitable for preparing polypropylene products having high stereoregularity and low ash, and can regulate the melt index of the products within a wide range by adjusting the amount of hydrogenation. It is also suitable for copolymerization systems to improve the copolymerization yield.
Type:
Grant
Filed:
July 24, 2020
Date of Patent:
December 12, 2023
Assignees:
CHINA PETROLEUM & CHEMICAL CORPORATION, BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATION
Inventors:
Jie Lin, Xiaofan Zhang, Ting Huang, Junhui Zhang, Junling Zhou, Zhufang Sun, Xianzhi Xia, Hui Zhao, Zifang Guo, Jin Zhao, Haitao Liu, Meiyan Fu, Jigui Zhang, Lin Qi, Lian Yan, Wei Cen, Yu Wang
Abstract: An anomaly detector for detecting anomaly in input data comprises an auto-encoder trained to encode the input data and decode the encoded input data to reconstruct the input data. Further, the anomaly detector comprises a classifier trained to determine a reconstruction loss indicative of a difference between the accepted input data and the reconstructed input data, where the reconstruction loss includes a weighted combination of a plurality of loss functions evaluating reconstruction losses of a plurality of parts of the reconstructed input data, different types of loss functions, or both. The classifier is further configured to detect an anomaly in the reconstructed input data when the reconstruction loss is above a threshold.
Type:
Grant
Filed:
March 16, 2021
Date of Patent:
December 12, 2023
Assignee:
Mitsubishi Electric Research Laboratories, Inc.
Abstract: A method for cleaning surfaces of a substrate processing chamber includes a) supplying a first gas selected from a group consisting of silicon tetrachloride (SiCl4), carbon tetrachloride (CCl4), a hydrocarbon (CxHy where x and y are integers) and molecular chlorine (Cl2), boron trichloride (BCl3), and thionyl chloride (SOCl2); b) striking plasma in the substrate processing chamber to etch the surfaces of the substrate processing chamber; c) extinguishing the plasma and evacuating the substrate processing chamber; d) supplying a second gas including fluorine species; e) striking plasma in the substrate processing chamber to etch the surfaces of the substrate processing chamber; and f) extinguishing the plasma and evacuating the substrate processing chamber.
Abstract: Provided is a preparing method of a quantum dot, including a process of preparing a solution containing a group III precursor and a solvent, a process of reducing a group V precursor by using a compound represented by Chemical Formula 1, and a process of mixing the solution with the reduced group V precursor.
Type:
Grant
Filed:
November 24, 2021
Date of Patent:
December 12, 2023
Assignee:
Research & Business Foundation Sungkyunkwan University
Abstract: An aluminum alloy material includes 1.2 wt % to 3.0 wt % of Si, 0.1 wt % to 0.8 wt % of Mg, 0.2 wt % to 2.0 wt % of Cu, 0.5 wt % to 2.5 wt % of Zn, 0.2 wt % to 2.0 wt % of Ti, and the remainder being Al and inevitable impurities. The powder of the aluminum alloy material can be processed to form an aluminum alloy object. The aluminum alloy object may further include an anodized film on its surface.
Type:
Grant
Filed:
November 28, 2022
Date of Patent:
December 12, 2023
Assignee:
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Abstract: This document provides methods and materials for identifying malignant skin lesions (e.g., malignant pigmented skin lesions). For example, methods and materials for using quantitative PCR results and correction protocols to reduce the impact of basal keratinocyte contamination on the analysis of test sample results to identify malignant skin lesions are provided.
Type:
Grant
Filed:
July 22, 2019
Date of Patent:
December 12, 2023
Assignee:
Mayo Foundation for Medical Education and Research
Abstract: A neural interfacing device is disclosed. The neural interfacing device includes a microneedle electrode. The microneedle electrode includes a body having a void formed therein and a plurality of microneedles. The void surrounds the plurality of microneedles, and the plurality of microneedles are bent outward with respect to the body to form a three-dimensional microneedle electrode. Additionally, each of the plurality of microneedles is sized and shaped to penetrate a nerve epineurium.
Type:
Grant
Filed:
March 29, 2021
Date of Patent:
December 12, 2023
Assignee:
BioCircuit Technologies, Inc. Georgia Tech Research Corporation
Inventors:
Robert J. Butera, Yogi A. Patel, James D. Ross, Swaminathan Rajaraman, Isaac Clements
Abstract: A thermal management system includes a cooling liquid circulation flow path, a refrigerant circulation flow path and a first heat exchanger. The first heat exchanger includes a first heat exchange portion and a second heat exchange portion. The cooling liquid circulation flow path includes a first heat exchange assembly, a second heat exchange assembly and a first branch. The thermal management system has a heating mode. After passing through the first heat exchange assembly, one path of the cooling liquid flows to the first branch, and another path of the cooling liquid flows to the second heat exchange assembly. The cooling liquid after flowing through the first branch and after flowing through the second heat exchange assembly merge and then flow to the first heat exchange portion. As a result, the number of heat exchangers used by the thermal management system to recover waste heat is reduced.
Type:
Grant
Filed:
September 16, 2020
Date of Patent:
December 12, 2023
Assignee:
HANGZHOU SANHUA RESEARCH INSTITUTE CO., LTD.
Abstract: The disclosure provides a forming method of a halogen-free flame-retardant material. The method includes the followings. A twin-screw extruder including a first zone and a second zone is used. A mixture in the first zone is mixed, melted and heated to form a molten mixture. The mixture includes a halogen-free flame retardant, a wear-resistant modifier, a thermoplastic elastomer, and an antioxidant. In addition, a silane-modified nano-silica aqueous suspension is introduced into the second zone to mix the silane-modified nano-silica aqueous suspension with the molten mixture from the first zone. The first zone and the second zone are continuously connected regions.
Type:
Grant
Filed:
November 5, 2021
Date of Patent:
December 12, 2023
Assignee:
Industrial Technology Research Institute
Abstract: An inter prediction method according to the present invention comprises the steps of: selecting candidate units from among reconstructed neighbor units; creating a candidate unit set with respect to units to be decoded, using the selected candidate units; determining a reference unit from among the candidate units which constitute the created candidate unit set; and performing inter prediction on the units to be decoded, using the determined reference unit. According to the present invention, image encoding/decoding efficiency can be improved.
Type:
Grant
Filed:
January 4, 2022
Date of Patent:
December 12, 2023
Assignee:
Electronics and Telecommunications Research Institute
Inventors:
Sung Chang Lim, Hui Yong Kim, Se Yoon Jeong, Suk Hee Cho, Jong Ho Kim, Ha Hyun Lee, Jin Ho Lee, Jin Soo Choi, Jin Woong Kim, Chie Teuk Ahn
Abstract: Provided area device for detecting sub-atomic particles and method of fabrication thereof. The device includes a plurality of scintillators, a detector provided on a first end of the plurality of scintillators and a prismatoid provided on a second end of the plurality of scintillators. The prismatoid redirects light between adjacent scintillators of the plurality of scintillators.
Type:
Grant
Filed:
January 8, 2020
Date of Patent:
December 12, 2023
Assignee:
The Research Foundation for The State University of New York
Inventors:
Amirhossein Goldan, Andrew Labella, Wei Zhao, Anthony Lubinsky
Abstract: A steel-concrete composite bridge deck slab using inverted U-shaped shear connectors and a method for constructing the same. The steel-concrete composite bridge deck slab includes a bottom steel plate and a bridge deck concrete layer, wherein inverted U-shaped perforated steel plate units are arranged on an upper surface of the bottom steel plate, and bar-mat reinforcements are arranged at upper ends of the inverted U-shaped perforated steel plate units.
Type:
Grant
Filed:
June 1, 2023
Date of Patent:
December 12, 2023
Assignees:
Fuzhou University, Fujian Expressway Technology Innovation Research Institute Co., Ltd.
Abstract: The composition includes: (i) an ethylene-based polymer; (ii) an organic peroxide, (iii) a triorganophosphine, and (iv) a protic acid-source compound (“PASC”) selected from a protic acid, a protic acid-generator compound (“PAGC”), and combinations thereof. The triorganophosphine has the Structure (1): wherein R1, R2, and R3 each is independently selected from a C1-C40 hydrocarbyl group, a C1-C40 heterohydrocarbyl group, and combinations thereof; with the proviso that the phosphorus atom is bound to a carbon atom in each of R1, R2, and R3.
Type:
Grant
Filed:
September 19, 2019
Date of Patent:
December 12, 2023
Assignees:
Dow Global Technologies LLC, Georgia Tech Research Corporation
Inventors:
Bharat I. Chaudhary, Jeffrey M. Cogen, Charles Liotta, Pamela Pollet, Sarath Sarngadharan
Abstract: Disclosed is an electronic device, which includes a plurality of driving coils that are sequentially arranged in a first direction in a plan view, a plurality of sensing electrodes that are spaced and insulated from the plurality of driving coils and are sequentially arranged in a second direction orthogonal or pseudo-orthogonal to the first direction in a plan view, and a processor that is electrically connected with the plurality of driving coils and the plurality of sensing electrodes. At least one of the plurality of sensing electrodes is electrically coupled with a stylus excited by a magnetic field generated by the plurality of driving coils. The processor applies a driving signal to the plurality of driving coils, receives a response signal to the driving signal from the plurality of sensing electrodes, and identifies a contact location of the stylus based on the response signal.
Type:
Grant
Filed:
February 5, 2021
Date of Patent:
December 12, 2023
Assignee:
Korea University Research and Business Foundation