Abstract: This document provides methods and materials for treating multiple system atrophy in a mammal. Specifically, the methods comprises intrathecally administering to the mammal a composition comprising autologous mesenchymal stem cells (e.g. adipose deprived mesenchymal stem cells) to treat multiple system atrophy. Further disclosed is the composition comprising from about 5×10(6) to about 5×10(8) autologous mesenchymal stem cells.

Abstract: Disclosed is a silicon photonics-based optical transmission apparatus. The apparatus includes an optical modulator chip of a ground-signal-ground (GSG) electrode array including two phase shifters for differential driving, a sub-substrate including a metal electrode of a periodic pattern to connect two ground metal electrodes to each other at a GSG electrode connected to each of the two phase shifters, and a solder bump having a same periodic pattern as the metal electrode of the sub-substrate to connect the ground metal electrodes of the optical modulator chip and the metal electrode of the periodic pattern of the sub-substrate.

Abstract: A bird's eye view feature map, augmented with semantic information, can be used to detect an object in an environment. A point cloud data set augmented with the semantic information that is associated with identities of classes of objects can be obtained. Features can be extracted from the point cloud data set. Based on the features, an initial bird's eye view feature map can be produced. Because operations performed on the point cloud data set to extract the features or to produce the initial bird's eye view feature map can have an effect of diminishing an ability to distinguish the semantic information in the initial bird's eye view feature map, the initial bird's eye view feature map can be augmented with the semantic information to produce an augmented bird's eye view feature map. Based on the augmented bird's eye view feature map, the object in the environment can be detected.

Abstract: A battery having a thermal protection arrangement is disclosed which includes a housing, a first electrode, a second electrode, a polymer porous separator positioned between the first electrode and the second electrode, an electrolyte interspersed between the first electrode, the second electrode, and the polymer porous separator, at least one sensor holder having an electrode side and a housing side, with at least one cavity provided on the electrode side, the at least one sensor holder in firm contact with the first electrode or the second electrode, and at least one temperature sensor placed in the at least one cavity of the at least one sensor holder, the at least one cavity sized such that the outer surface of the temperature sensor being flush with remaining surface of the at least one sensor holder, and wherein the at least one temperature sensor has no contact with the polymer porous separator.

Abstract: Aspects of the subject disclosure may include, for example, selecting a first video service model according to a server hostname determined according to transport layer security (TLS) transaction data associated with a video session transmitted over a network, calculating a plurality of data delivery statistics from the TLS transaction data according to the first video service model, where the plurality of data delivery statistics includes session-level statistics over the video session, transaction-level statistics over each transaction, and temporal feature statistics over intervals of the video session, determining a quality of experience (QoE) metric for the video session from the plurality of data delivery statistics according to a course-grained data QoE model, and adjusting a first network element of the network responsive to the determining the QoE metric for the video session. Other embodiments are disclosed.

Abstract: Peptidomimetic macrocycles that comprise all-D configuration ?-amino acids and bind mouse double minute 2 (MDM2 aka E3 ubiquitin-protein ligase) and MDMX (aka MDM4) are described. These all-D configuration ?-amino acid peptidomimetic macrocycles are protease resistant, cell permeable without inducing membrane disruption, and intracellularly activate p53 by binding MDM2 and MDMX thereby antagonizing MDM2 and MDMX binding to p53. These peptidomimetic macrocycles may be useful in anticancer therapies, particularly in combination with chemotherapy or radiation therapy.

Abstract: The present invention relates to flavoprotein improved LOV (iLOV) variants that exhibit enhanced fluorescence intensity compared to iLOV. The present invention also relates to a method for screening any of the iLOV variants. The iLOV variants of the present invention are useful in determining whether target proteins are expressed, irrespective of the presence of oxygen, and isolating and purifying the expressed target proteins due to their enhanced fluorescence intensity and quantum yield compared to existing LOV or iLOV proteins.

Abstract: The present disclosure is related to compositions and methods useful in treating heart conditions. The disclosed compositions and methods are based on gene therapies comprising a recombinant AAV vector for delivering two or more transgenes into the heart of a human subject, wherein the transgenes comprise an S100A1 protein and a cardiac Apoptosis Repressor with caspase recruitment Domain (cARC) apoptotic inhibitor. In various embodiments, the compositions and methods disclosed herein comprise vectors comprising S100A1 and/or cARC cDNA sequences that are codon-optimized for expression in humans. In some aspects, targeting multiple sources of one or more heart conditions can provide synergistic benefits during treatment.

Abstract: Disclosed herein is an array of pixels. Each pixel includes a single photon avalanche diode (SPAD) and a transistor circuit. The transistor circuit includes a clamp transistor configured to clamp an anode voltage of the SPAD to be no more than a threshold clamped anode voltage, and a quenching element in series with the clamp transistor and configured to quench the anode voltage of the SPAD when the SPAD is struck by an incoming photon. Readout circuitry is coupled to receive the clamped anode voltage from the transistor circuit and to generate a pixel output therefrom, the threshold clamped anode voltage being below a maximum voltage rating of transistors forming the readout circuitry.

Abstract: The present invention aims to provide a novel liver fibrosis inhibiting agent or brown adipocyte activating agent, and a prophylactic and/or therapeutic agent for nonalcoholic steatohepatitis which contains the inhibiting agent or activating agent as an active ingredient. The present invention relates to a liver fibrosis inhibiting agent and a brown adipocyte activating agent, each containing taxifolin as an active ingredient, and a prophylactic and/or therapeutic agent for nonalcoholic steatohepatitis, containing taxifolin as an active ingredient.

Abstract: A microelectromechanical heating device includes a substrate, a thermal insulator, and a heater. The thermal insulator includes a plurality of supporting structures and at least one thermal insulation layer. The supporting structures are disposed on the substrate. The thermal insulation layer is located above the substrate and connected to the plurality of supporting structures. The thermal insulation layer is spaced apart from the substrate by a distance. The heater is disposed on the at least one thermal insulation layer.

Abstract: The present disclosure relates to a notched steel beam and a floor slab structure of a flange embedded floor slab and a construction method. The notched steel beam comprises a web (1), wherein an upper flange (2) and a lower flange (3) are respectively arranged on the upper end and the lower end of the web (1); the flange embedded floor slab comprises four rectangularly distributed floor slab stand columns (7), a steel beam (8) is arranged between the adjacent floor slab stand columns (7), laminated slab bottom slabs (9) are arranged between the two steel beams (8) which are symmetrically distributed, floor slab reinforcing steel bars (10) are arranged above the laminated slab bottom slabs (9), a concrete layer (11) is arranged on the floor slab reinforcing steel bars (10); and the steel beam (8) is the notched steel beam of the flange embedded floor slab.

Abstract: Defects on a substrate comprising electronic components can be classified with a computational defect analysis system that may be implemented in multiple stages. For example, a first stage classification engine may process metrology data to produce an initial classification of defects. A second stage classification engine may use the initial classification, along with manufacturing information and/or prior defect knowledge to output probabilities that the defects are caused by one or more potential sources.

Abstract: An image encoding/decoding method and apparatus for performing template matching-based intra prediction are provided. An image decoding method may comprise deriving a first intra-prediction mode for a current block, generating a first intra-prediction block corresponding to the first intra-prediction mode, deriving a second intra-prediction mode for the current block, generating a second intra-prediction block corresponding to the second intra-prediction mode, and generating a final intra-prediction block by using a weighted sum of the first intra-prediction block and the second intra-prediction block.

Abstract: Provided is a solid electrolyte membrane including a porous frame including a metal or a polymer material, solid electrolyte particles covering both surfaces of the porous frame, and filling pores of the porous frame, and a binder between the solid electrolyte particles.

Abstract: The disclosure provides methods for inducing Notch signaling in a targeted manner within aggregations of cells. The methods include contacting the aggregation of cells with a bi-specific molecule that facilitates trans-binding of Notch receptor. The bi-specific molecule comprising a cell-targeting domain that specifically binds to a cell-specific antigen expressed in the aggregation of cells, and a Notch-binding domain that specifically binds to Notch receptor. In some aspects, the disclosed methods and reagents provide methods of promoting pro-inflammatory states in tumor micro-environments.

Abstract: The present application relates generally to methods for treating prostate cancer with substituted heterocyclic derivative 4-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-2- methylisoquinolin-1-one as a bromodomain inhibitor, or the pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to a semiconductor element and a method for manufacturing same, wherein the semiconductor element may comprise: a base element, an intermediate layer formed in at least one direction of the base element; and a metal layer formed on the intermediate layer in a direction opposite to the base element, and wherein a conductive filament may be formed inside the intermediate layer according to the application of a voltage to the intermediate layer.

Abstract: A close-end fuel cell and an anode bipolar plate thereof are provided. The anode bipolar plate includes an airtight conductive frame and a conductive porous substrate disposed within the airtight conductive frame. In the airtight conductive frame, an edge of a first side has a fuel inlet, and an edge of a second side has a fuel outlet. The conductive porous substrate has at least one flow channel, where a first end of the flow channel communicates with the fuel inlet, a second end of the flow channel communicates with the fuel outlet. The flow channel is provided with a blocking part near the fuel inlet to divide the flow channel into two areas.

Abstract: Disclosed is an apparatus for monitoring bioaerosols. More particularly, the apparatus for monitoring bioaerosols includes a capturer configured to capture bioaerosol particles in air in a capture solution; a first droplet discharger configured to electro-spray the capture solution, in which the particles are captured, in a form of first droplets; a second droplet discharger configured to electro-spray a reagent, capable of reacting with the particles of the first droplets, in a form of second droplets; a reactor in which the first and second droplets are mixed so that the particles react with the reagent; and a measurer configured to measure the particles reacted with the reagent, wherein a size of the first droplets discharged from the first droplet discharger is controlled such that the particles are individually included in the first droplets. In accordance with such a configuration, individual particles can react with a reagent, which allows accurate bioaerosol monitoring with the naked eye.