Abstract: Cell-targeted cytotoxic agents, including sortase serine protease constructs, are provided. Such compounds can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant sortase serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity.
Type:
Application
Filed:
November 4, 2021
Publication date:
August 25, 2022
Applicant:
Research Development Foundation
Inventors:
Xinjian LIN, Xiying SHANG, Stephen B. HOWELL
Abstract: A system for directional detection of radiation, comprises a plurality of scintillating crystals, responsive to the radiation and being arranged three-dimensionally, with voids between adjacent crystals, such that there are crystals that are inner and crystals that are outer within the arrangement. The system also comprises a plurality of light sensors coupled to the crystals for receiving optical signals from the crystals and responsively generating electrical signals, and a data processor receiving an electrical signal separately from each light sensor and calculating a direction of the radiation based on relative intensities of the signals and mutual occultation among different crystals.
Type:
Application
Filed:
February 24, 2022
Publication date:
August 25, 2022
Applicants:
Technion Research & Development Foundation Limited, Nuclear Research Center - Negev
Inventors:
Ehud BEHAR, Shlomit TAREM, Lee YACOBI, Roi RAHIN, Alon OSOVIZKY, Max GHELMAN
Abstract: Disclosed in the present invention is use of lysozyme in the preparation of a drug for preventing or treating a uric acid-related disease, a drug for reducing uric acid, and a drug for promoting uric acid excretion. Also disclosed in the present invention are a pharmaceutical composition for preventing or treating a uric acid-related disease, a pharmaceutical composition for reducing uric acid, and a pharmaceutical composition for promoting uric acid excretion, and a method for preventing or treating a uric acid-related disease, reducing uric acid and promoting uric acid excretion.
Type:
Application
Filed:
July 17, 2020
Publication date:
August 25, 2022
Applicants:
GUANGZHOU CENTURY CLINICAL RESEARCH CO., LTD, GUANGZHOU XIN-CHUANGYI BIOPHARMACEUTICAL CO., LTD, GUANGZHOU WELMAN NEW DRUG R&D CO., LTD., XIANGBEI WELMAN PHARMACEUTICAL CO., LTD, NANJING KANGFUSHUN PHARMACEUTICAL CO., LTD
Abstract: The present invention relates to methods for detecting analytes in a sample. The methods may also be used to determine the amount of analyte in the sample. The present invention also relates to antibody or antibody-like molecules and labelled antigens for use in these methods.
Type:
Application
Filed:
April 30, 2020
Publication date:
August 25, 2022
Applicant:
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
Inventors:
Judith SCOBLE, Charlotte WILLIAMS, Stewart NUTTALL, Regina SURJADI, Helen DACRES, Stephen TROWELL
Abstract: Disclosed herein are an apparatus and method for detecting violation of control flow integrity. The apparatus includes memory for storing a program and a processor for executing the program, wherein the processor multiple branch identifier registers to which identifiers of branch targets are written, a set branch identifier instruction configured to command an identifier of a branch target to be written to a branch identifier register at a predetermined sequence number, among the multiple branch identifier registers, and a check branch identifier instruction configured to command a signal indicating detection of a control flow hijacking attack to be issued based on whether a value written to the branch identifier register at the predetermined sequence number is identical to a value of an identifier of a branch target at the predetermined sequence number, wherein the program detects whether a control flow is hijacked based on the multiple branch identifier registers.
Type:
Application
Filed:
November 3, 2021
Publication date:
August 25, 2022
Applicant:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Dong-Wook KANG, Dae-Won KIM, Ik-Kyun KIM, Sang-Su LEE, Jin-Yong LEE, Byeong-Cheol CHOI, Yong-Je CHOI
Abstract: A molecular marker combination linked to quantitative traits of tea plant (+)-catechin content, including a SNP site 1, a SNP site 2, a SNP site 3, a SNP site 4, a SNP site 5, a SNP site 6, a SNP site 7 and a SNP site 8, which are located in tea genomes Scaffold4239:309117, Scaffold3614: 66549, Scaffold349: 3413816, Scaffold1989: 2316385, Scaffold451: 940283, Scaffold3727:442660, Scaffold115:803980 and Scaffold920:281727, respectively, and genotypes thereof are extremely significantly correlated with the (+)-catechin content is provided. A detection method for detecting each site, and one or more molecular marker site is used to evaluate the tea plant (+)-catechin content.
Type:
Application
Filed:
October 14, 2019
Publication date:
August 25, 2022
Applicant:
TEA RESEARCH INSTITUTE, GUANGDONG ACADEMY OF AGRICULTURAL SCIENCES
Inventors:
Kaixing FANG, Hualing WU, Xiaohui JIANG, Hongjian LI, Qiushuang WANG, Dandan QIN, Chendong PAN, Bo LI
Abstract: A molecular marker combination linked to quantitative traits of tea plant caffeine content, including a SNP site 1, a SNP site 2, a SNP site 3, a SNP site 4, a SNP site 5 and a SNP site 6, which are located in tea genomes Scaffold4239:309117, Scaffold115:803980, Scaffold720:596655, Scaffold3614:66549, Scaffold349:3413816 and Scaffold920:281727, respectively, and genotypes thereof are extremely significantly correlated with the caffeine content is provided. A detection method for detecting each site, and one or more molecular marker site is used to evaluate the tea plant caffeine content.
Type:
Application
Filed:
October 14, 2019
Publication date:
August 25, 2022
Applicant:
TEA RESEARCH INSTITUTE, GUANGDONG ACADEMY OF AGRICULTURAL SCIENCES
Inventors:
Hualing WU, Kaixing FANG, Hongjian LI, Xiaohui JIANG, Dandan QIN, Qiushuang WANG, Chendong PAN, Bo LI
Abstract: Systems and methods performed by a fault detection apparatus for fault detection and localization in distribution feeders having branches and nodes. The method including receive feeder raw data in a feeder of a power system. Process the feeder raw data with given operational electrical characteristics of the feeder to generate a branch attribute dataset for each branch separated by a pair of nodes for all branches. Generate a node attribute dataset for each node for all the nodes in the feeder. Input the branch and node attribute datasets into a trained neural network to determine whether a branch has a fault and a fault location within the branch, to output a classification of the fault and the fault location. Generate an alert signal based upon determining the classified fault and fault location in response to the alert signal to an outage response system.
Type:
Application
Filed:
February 24, 2021
Publication date:
August 25, 2022
Applicant:
Mitsubishi Electric Research Laboratories, Inc.
Abstract: A display device for displaying the weather on demand. The display device includes a first indicator member mobile and having a representation of the sun. This representation of the sun is totally or partially concealed by a concealing element that is located on a second mobile indicator member when the user requests it and in particular via a control unit.
Type:
Application
Filed:
February 15, 2022
Publication date:
August 25, 2022
Applicant:
The Swatch Group Research and Development Ltd
Abstract: An operation method of a first communication node in a wireless distributed communication system may comprise: providing a group code and a primary secret key to a third communication node via a second communication node; receiving, from the third communication node, a first packet including a first group trust field through wireless distributed communication, the first group trust field being generated using the group code and the primary secret key; and performing a trustworthiness check of the received first packet by using the first group trust field included in the received first packet, the group code, and the primary secret key.
Type:
Application
Filed:
February 24, 2022
Publication date:
August 25, 2022
Applicant:
Electronics and Telecommunications Research Institute
Abstract: The present invention relates to therapeutic and prophylactic methods based on inhibition of CIS in NK cells. In particular, the present invention relates to treating or preventing a NK-responsive condition by administering to a subject a CIS inhibitor, or administering CIS-inhibited NK cells.
Type:
Application
Filed:
April 13, 2022
Publication date:
August 25, 2022
Applicant:
The Walter and Eliza Hall Institute of Medical Research
Inventors:
Nicholas D. Huntington, Sandra E. Nicholson
Abstract: Disclosed are a disaggregated data center resource management method and apparatus. A resource management method in a disaggregated data center includes receiving a resource allocation request from a client; generating allocated resource information about a computing resource and a memory resource which configure a virtual server in one rack of the data center according to the resource allocation request and optical path setting information for optical path connection of the computing resource and the memory resource; updating a resource management table for the computing resource and the memory resource; and transmitting a resource connection setting message including the allocated resource information and the optical path setting information to the computing resource and the memory resource.
Type:
Application
Filed:
November 1, 2021
Publication date:
August 25, 2022
Applicant:
Electronics and Telecommunications Research Institute
Inventors:
Kyeong-Eun HAN, Chansung PARK, Daeub KIM, Jongtae SONG, Ji Wook YOUN
Abstract: An operation method performed by an access point in a communication system may comprise: transmitting, to a first station, a first frame by using a third communication scheme, the first frame including information on an address of the first station, a first transmission time length, a first reception order, and a first communication scheme to be used for transmitting data to the first station, and information on a second transmission time length, a second reception order, and a second communication scheme to be used for transmitting second data to one or more second stations; receiving, from the first station, a first response frame for the first frame from the first station at a first reception time; and receiving, from the second station, a second response frame for the first frame at a second reception time.
Type:
Application
Filed:
February 25, 2022
Publication date:
August 25, 2022
Applicant:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Abstract: The present application relates to a method for preparing a transparent electrode, the method including a step of forming a thin film by coating a solution containing metal nanowires on a substrate, in which the solution containing the metal nanowires contains a mixed solvent in which a first solvent and a second solvent are mixed, and the first solvent and the second solvent have different surface energies.
Type:
Application
Filed:
February 8, 2022
Publication date:
August 25, 2022
Applicants:
RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY, BKChem Co., Ltd.
Abstract: The present disclosure provides an artificial intelligence-infected asymptomatic people movement-tracing apparatus and a method which in an emergency such as an epidemic pandemic, use an artificial intelligence movement-tracing apparatus of infected asymptomatic people of the present disclosure which is personally installed in the residence of the tracing target to automatically check whether to match the traffic line of the tracing target and the traffic line of the confirmed case and automatically report to the disease control authority only when the traffic lines match to protect individual privacy compared to the centralized system and automatically search for infected asymptomatic people classified as blind confirmed cases (hidden positive people) and self-quarantine subjects to quickly establish an infectious disease management system for suspected disease patients and efficiently manage the people from the spread of infectious diseases.
Type:
Application
Filed:
February 16, 2022
Publication date:
August 25, 2022
Applicant:
RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
Abstract: An operation method of a terminal in a communication system may comprise: receiving, from a base station, first configuration information of a unicast BWP; receiving, from the base station, second configuration information of a multicast and broadcast service (MBS) resource region; receiving control information on an MBS PDCCH within the MBS resource region indicated by the second configuration information; receiving MBS data on an MBS PDSCH within the MBS resource region, the MBS PDSCH being indicated by the control information; and receiving unicast data in the unicast BWP indicated by the first configuration information.
Type:
Application
Filed:
February 18, 2022
Publication date:
August 25, 2022
Applicant:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Abstract: The present disclosure provides methods and compositions for treating tissue to preserve and/or rescue tissue from ischemic and/or reperfusion injury and methods for assessing ischemic and/or injuries in cardiac tissue. The disclosed compositions comprise at least a portion of mesenchymal stem cell-conditioned medium.
Type:
Application
Filed:
February 7, 2022
Publication date:
August 25, 2022
Applicant:
Indiana University Research and Technology Corporation
Abstract: A method for manufacturing an optical element is a method for manufacturing an optical element in which laser light is transmitted, reciprocated, or reflected, and the method includes a first step of obtaining a bonded element formed by subjecting a first element part and a second element part, both being transparent to laser light, to surface activated bonding with a non-crystalline layer interposed therebetween; and after the first step, a second step of crystallizing at least a portion of the non-crystalline layer by raising the temperature of the bonded element. In the second step, the temperature of the bonded element is raised to a predetermined temperature that is lower than the melting points of the first element part and the second element part.
Type:
Application
Filed:
June 12, 2020
Publication date:
August 25, 2022
Applicant:
INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION NATIONAL INSTITUTES OF NATURAL SCIENCES
Inventors:
Takunori TAIRA, Arvydas KAUSAS, Lihe ZHENG
Abstract: Disclosed herein are a video decoding method and apparatus and a video encoding method and apparatus. Coding decision information of a representative channel of a target block is shared as coding decision information of a target channel of the target block, and decoding of the target block is performed using the coding decision information of the target channel. Since the coding decision information of the representative channel is shared with an additional channel, repeated signaling of identical coding decision information may be prevented. By means of this prevention, the efficiency of encoding and decoding of the target block or the like may be improved.
Type:
Application
Filed:
March 15, 2022
Publication date:
August 25, 2022
Applicants:
Electronics and Telecommunications Research Institute, RESEARCH AND BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
Inventors:
Dong-San JUN, Jung-Won KANG, Hyunsuk KO, Sung-Chang LIM, Jin-Ho LEE, Ha-Hyun LEE, Byeung-Woo JEON, Hui-Yong KIM, Jee-Yoon PARK
Abstract: Disclosed herein are a method, apparatus, and storage medium for image encoding/decoding using a reference picture. A reference picture list is configured for encoding/decoding of a target block. Upon configuring the reference picture list, a sequence parameter set and a slice header are used. A picture is divided into sub-pictures and/or slices, and reference picture lists are configured for the sub-pictures and/or slices resulting from division. Reference picture lists for slices may be related to each other, and a current reference picture and a future reference picture in one reference picture list may be used in an additional reference picture list.
Type:
Application
Filed:
June 19, 2020
Publication date:
August 25, 2022
Applicant:
Electronics and Telecommunications Research Institute