Abstract: To provide a method for producing induced pluripotent stem cells (iPS cells) that can initialize somatic cells without using feeder cells or a substrate. For production of iPS cells, the following steps are carried out: I. introducing an initialization gene into a somatic cell; and II. performing initialization and amplification culture of the cell into which the gene has been introduced, in a liquid medium comprising at least one of a protein kinase C? (PKC?) inhibitor and a WNT inhibitor under a suspension culture condition.

Abstract: The present invention relates to a clearing technique which uses a solution containing at least one of a compound having a delipidation ability, a compound having a biochrome decoloring ability, a compound having a decalcification ability, a compound having a refractive index adjusting ability, and a compound having a tissue swelling ability. The clearing technique is suitable for use in high-throughput and low-magnification imaging which involves a simple process.

Abstract: Provided is a method for producing a high-purity aqueous lithium salt solution, the method allowing filtering aluminum phosphate in a short time. The method for producing a high-purity aqueous lithium salt solution includes: a step of adjusting the pH of a slurry containing a mixture of lithium phosphate and aluminum hydroxide obtained from a first aqueous lithium salt solution being a raw material to a range of 2 to 3 to obtain a precipitate of aluminum phosphate; a step of filtering off and removing the precipitate of aluminum phosphate to obtain a second aqueous lithium salt solution; and a step of purifying the second aqueous lithium salt solution to obtain a high-purity aqueous lithium salt solution.

Abstract: The object of the invention is to provide a novel olefin-based molded product useful for various applications. An olefin-based molded product comprising a polymer including a structural unit of at least one polar olefin monomer represented by the general formula (I) CH2?CH—R2—Z(R1)n is provided. In the formula, Z is a hetero atom selected from the group consisting of nitrogen, oxygen, phosphorus, sulfur, and selenium; R1 is a substituted or unsubstituted hydrocarbyl group having 1 to 30 carbon atoms; n is an integer of 1 or 2 depending on the atomic species of Z; and R2 is a substituted or unsubstituted hydrocarbylene group having 2 to 20 carbon atoms.

Abstract: The present invention provides a method for producing retinal cells or a retinal tissue, comprising the following steps (1)-(3): (1) a first step of culturing human pluripotent stem cells in the absence of feeder cells and in a medium comprising a factor for maintaining undifferentiated state, (2) a second step of culturing the pluripotent stem cells obtained in the first step in suspension in the presence of a Sonic hedgehog signal transduction pathway activating substance to form a cell aggregate, and (3) a third step of culturing the aggregate obtained in the second step in suspension in the presence of a 1) a BMP signal transduction pathway activating substance to obtain an aggregate containing retinal cells or a retinal tissue.

Abstract: An object of the present invention is to provide a cell population suitable for transplant of retinal tissue and a method of production thereof. The present invention provides a cell population for transplant, comprising retinal cells with a modified bipolar cell-regulating gene and a method of production thereof.

Abstract: An inspection device includes: a light source for outputting pulsed excitation light with a time width of 10 picoseconds to 10 nanoseconds; a nonlinear optical crystal for generating a terahertz wave by optical wavelength conversion of the pulsed excitation light; a polarization part for reflecting at least a part of a reflected wave of the terahertz wave reflected by an inspection target; and a detector for detecting the reflected wave reflected by the polarization part.

Abstract: Provided is a piston ring including: a low-pressure side ring; and a high-pressure side ring, the low-pressure side ring and the high-pressure side ring are arranged stacked in a direction along the axis so that the high-pressure side ring is closer to a fluid to be compressed, a low-pressure side rotation restriction part configured to restrict rotation in the circumferential direction relative to the piston is formed to the low-pressure side ring, a high-pressure side rotation restriction part configured to restrict rotation in the circumferential direction relative to the piston and a low-pressure side protrusion protruding toward the low-pressure side ring and inserted in the low-pressure side abutment are formed to the high-pressure side ring, and the low-pressure side protrusion is inserted in a low-pressure side abutment with clearances being provided in both sides in the circumferential direction between the low-pressure side ring and the low-pressure side protrusion.

Abstract: A molecular dynamics computation device includes a processor that executes a procedure. The procedure includes: executing machine learning of a first force field for predicting energy for an input structure using, as training data, a structure of a coarse-grained model resulting from coarse-graining an all-atom model sampled by molecular dynamics computation based on an all-atom force field and an energy corresponding to the all-atom model structure; and computing molecular dynamics of a coarse-grained model based on a second force field obtained by combining the first force field that has been subjected to machine learning and an energy based on a coarse-grained model structure.

Abstract: To provide a novel class-A GPCR antagonist, a production method therefor, or a novel compound that interacts with a Na+-water cluster binding site of a class-A GPCR. Used is a compound or a salt thereof comprising a structure comprising a class-A GPCR-binding compound linked to a functional group that can bind to a Na+-water cluster binding site of the class-A GPCR. Also used is a method for producing a class-A GPCR antagonist, comprising the step of linking one compound with another compound that can bind to a Na+-water cluster binding site of the class-A GPCR.

Abstract: The purpose of the invention is to develop and provide a novel therapeutic agent for hepatitis B that differs from the conventional therapeutic agent for hepatitis B in the mechanism of action, or target of interest. Provided is an inhibitor of hepatitis B virus replication consisting of a spike region in the core protein of a hepatitis B virus, or an expression vector containing a nucleic acid encoding the same.

Abstract: The culture insert container has a lower culture container having a bottom portion equipped with a porous membrane and a sidewall, and having an upper insertion fixture having a cylindrical sidewall that is inserted into said lower culture container. The cylindrical sidewall has a land arranged so as to protrude from a top end of the sidewall of the lower culture container at a location such as will cause a top surface of said porous membrane and a bottom end portion of the cylindrical sidewall which is inserted within the lower culture container to be maintained in a noncontacting state. A land is arranged at an outer surface of the cylindrical sidewall so as to cause a constant distance to be maintained between an inner surface of the sidewall of the lower culture container and the outer surface of the cylindrical sidewall.

Abstract: A nondestructive inspecting device (10) includes a neutron emission device (2) that emits a neutron beam to a local irradiation location on a surface (la) of an inspection target (1), a detection device (3) that detects, at each of inspection positions facing the surface (la), scattered neutrons returned from the inspection target (1) as a result of emission of the neutron beam to the irradiation location, and measures the detected number of the scattered neutrons at each of the detection positions, and a ratio calculation unit (5) that calculates, for each of the detection positions, a ratio of the detected number at the detection position to a reference value for the detection position, and outputs the ratios. The reference value is set as the detected number at each of the detection positions in an assumed case of no defects existing in the inspection target (1).

Abstract: To provide a manganese-iridium composite oxide, a manganese-iridium composite oxide and a manganese-iridium composite oxide electrode material, having high catalytic activity produced at low cost, to be used as an anode catalyst for oxygen evolution in water electrolysis, and their production methods. A manganese-iridium composite oxide, which has an iridium metal content ratio (iridium/(manganese+iridium)) of 0.1 atomic % or more and 30 atomic % or less, and has interplanar spacings of at least 0.243±0.002 nm, 0.214±0.002 nm, 0.165±0.002 nm, 0.140±0.002 nm, and a manganese-iridium composite oxide electrode material comprising an electrically conductive substrate constituted by fibers at least part of which are covered with the above manganese-iridium composite oxide.

Abstract: A beam target for generating a nuclear reaction product by irradiation with a beam obtained from a beam generation source includes a cone body which has a tapered inner surface which is reduced in diameter toward a tip, and supply means for supplying liquid metal to the inner surface of the cone body to form a liquid film of the liquid metal on the inner surface. It is possible to form the liquid film of the liquid metal on a cone body surface to increase an irradiation area of the beam, and also dispose a target substance such as LLFP around the cone body, and hence it is possible to efficiently use the nuclear reaction product (e.g., a neutron) generated by beam irradiation of the liquid metal.

Abstract: Disclosed is a compound represented by formula (1) or a salt thereof: (wherein “Base” represents an aromatic heterocyclic group which may have a substituent, or an aromatic hydrocarbon ring group which may have a substituent; X1 represents a hydrogen atom, an alkyl group which may have a substituent, an alkenyl group which may have a substituent, an alkynyl group which may have a substituent, a cycloalkyl group which may have a substituent, or an aryl group which may have a substituent; X2 represents a hydrogen atom or —OR7; R1 to R7 and Z1 and Z2 each represent an atom or a group disclosed in the specification).

Abstract: A tri-axial magnetic field correction coil includes a first coil group and a second coil group with respect to an X-axis direction that passes through a clock transition space in which atoms are disposed. The first coil group is a Helmholtz-type coil composed in a point-symmetrical shape around the clock transition space. The second coil group is composed in a point-symmetrical shape around the clock transition space with respect to the X-axis direction, and is a non-Helmholtz-type coil that differs from the first coil group in terms of coil size, coil shape, or distance between coils.

Abstract: An observation device includes a neutron emission device, a detection device, and a data processing device. The neutron emission device emits neutrons to an inspection object. The detection device detects exit neutrons from the inspection object at one set of detection positions in a peripheral direction around the inspection object, outside the inspection object, and measures the number of the detected exit neutrons for each of the detection positions. The data processing device generates reconstructed cross-sectional data by performing reconstruction processing based on the number of the detected exit neutrons at each of the one set of detection positions. The reconstructed cross-sectional data represent a two-dimensional distribution of a neutron reaction rate in an imaginary cross-section of the inspection object.

Abstract: The present disclosure provides a method for manufacturing a cell aggregate comprising retinal tissue having a layer structure.

Abstract: A method for producing a capsule, including cooling a suspension so as to gel a thermoresponsive polymer including a core 8 formed from a gel of an ionically-bonded polymer and form a shell (17) of a hydrogel, the suspension being obtained by suspending, in oil (10), a sol (9) of the thermoresponsive polymer, and then using a chelating agent to solate the core so as to hollow out the inside.