Abstract: Provided is a cell culture vessel which allows resolution to be high in a Z-axis direction. A cell culture vessel (1) for accommodating a cell or cell tissue therein includes: a frame part (11) which is provided so as to be located at positions that correspond to respective sides of a polyhedral shape; a window part (12) which is light-transmissive and which is provided so as to be located at positions that correspond to a respective plurality of faces out of faces of the polyhedral shape; and a shaft part (17) which extends, from any of vertices of the polyhedral shape, outward in a direction that is not parallel to any of lines normal to the faces of the polyhedral shape.

Abstract: According to a medical system of an aspect example, an ophthalmic data acquiring unit includes at least one ophthalmic examination apparatus for acquiring ophthalmic data from a patient, and an internal medicine data acquiring unit includes at least one internal medicine examination apparatus for acquiring internal medicine data from the patient. An inference processor is configured to perform inference processing using a trained model constructed by machine learning using training data that includes ophthalmic data, internal medicine data, and diagnostic result data. The inference processor generates inferred diagnostic data by performing the inference processing based at least on the ophthalmic data of the patient acquired by the ophthalmic data acquiring unit and the internal medicine data of the patient acquired by the internal medicine data acquiring unit. An output unit outputs a result of the inference processing performed by the inference processor.

Abstract: An ophthalmic information processing apparatus includes a determiner and a detector. The determiner is configured to determine a presence or absence of a disc hemorrhage for a front image of a fundus of a subject's eye, using a disc hemorrhage determination model obtained by performing machine learning using a plurality of fundus images labeled with labels indicating the presence or absence of a disc hemorrhage as first teaching data. The detector is configured to detect a disc hemorrhage region depicted in the front image that is determined to have the disc hemorrhage, using a disc hemorrhage region detection model obtained by performing machine learning using a plurality of pairs of image groups as second teaching data, each pair having a front image of a fundus and a disc hemorrhage region image representing a disc hemorrhage region depicted in the front image.

Abstract: Provided is a novel fluorescent probe. A compound of the following general formula (I) or a salt thereof.

Abstract: The present disclosure provides a method for screening cells, the method including a step of preparing a plurality of cells which are tagged with a first barcode nucleic acid associated with a test target and treated with the test target, a step of sorting the plurality of cells based on cellular phenotype using an imaging cell sorter, and a step of identifying the test target used to treat each cell using the first barcode nucleic acid as an indicator.

Abstract: A factor parameter for estimating a label of a target from a plurality of parameters that can be acquired for the target. In a suggestion device, a calculator learns, by referring to a plurality of records in which each record represents a plurality of parameter values acquired from the target and a label provided to the target, an estimation model that estimates a label from a parameter related to a combination for a part of calculation candidates among a plurality of candidates representing a combination of parameters; calculates performance of the estimation model; causes calculation candidates to compete based on the calculated performance; and calculates a rating value of the calculation candidate. An estimator learns a rating model by a rating value and a combination of parameters of the calculation candidate, and estimates a rating value of an estimation candidate other than the calculation candidate.

Abstract: Maintainability is to be improved. A radio frequency quadrupole linear accelerator includes a tubular housing part having an outer peripheral surface at which two pairs of openings extending in an axial direction are formed facing each other, and a plurality of first vane electrodes inserted into the respective openings of the tubular housing part from outside toward an axial center, detachably attached to the openings, and disposed facing each other.

Abstract: Image signal processing capable of achieving effective data compression is performed while preventing degradation of data obtained in imaging using radiation. A radiation imaging system (100) includes an image sensor (105) having a sensitive surface on which a plurality of pixels are two-dimensionally arranged and outputs signals electrically converted at the pixels in response to incidence of radiation including image information as pixel values. In the radiation imaging system (100), one or more pixels that output significant electrical conversion signals derived from incident radiation are separated from pixels that output only signals due to noise specific to a sensor device based on a threshold that is statistically determined in advance. Then, pixel values due to noise are removed, and pixel values of significant signals are output as radiation image data.

Abstract: A composition for suppressing trypsin activity is disclosed. The composition contains a bacterium belonging to a genus Paraprevotella as an active ingredient.

Abstract: A non-transitory computer-readable recording medium has stored therein a program that causes a computer to execute a process including acquiring a distribution of latent variables output from an encoder in a process of training an autoencoder, generating a path related to deformation based on the distribution of the latent variables, selecting, from a plurality of latent variables generated by inputting a plurality of particle images to the trained encoder, a plurality of neighboring latent variables of which a distance to the path is less than a threshold, selecting a plurality of neighboring particle images corresponding to the plurality of neighboring latent variables among the plurality of particle images, and estimating a plurality of three-dimensional atom models based on the plurality of neighboring particle images.

Abstract: A non-transitory computer-readable recording medium has stored therein an information processing program that causes a computer to execute a process including acquiring training data in which structural information of a protein is used as input data and a difference between reference energy specified based on energy corresponding to the protein and the energy is used as correct data and training a model for inferring energy of the protein based on the training data.

Abstract: The purposes of the present invention are to provide a method of easily introducing a gene to mitochondria from the outside of a cell, and to provide a method of introducing a relatively large nucleic acid to mitochondria. A carrier peptide for introducing a nucleic acid to mitochondria is provided, which comprises a mitochondrial-targeting sequence and a polycationic sequence, wherein said mitochondrial-targeting sequence consists of an N-terminal region comprising a transmembrane domain in a mitoNEET protein.

Abstract: A method of producing a diffraction grating of borosilicate glass or barium borosilicate glass, the method comprising the steps of forming a grating on a surface of a silicon wafer the grating through the Bosch process; forming an oxide film on a surface of the grating by heating and exposure to water vapor of the silicon wafer; removing the oxide film using hydrofluoric acid; making the surface provided with the grating of the silicon wafer and a surface of a glass plate undergo anodic bonding; heating the silicon wafer and the glass plate bonded to each other; polishing a surface opposite to the boded surface of the silicon wafer and a surface opposite to the boded surface of the glass plate; and removing silicon from the glass plate by selective etching using xenon difluoride.

Abstract: Provided are a production method of retinal pigment epithelial (RPE) cells that improves differentiation induction efficiency of pluripotent stem cells into RPE cells, and can provide highly pure RPE cells by a simple and easy operation in a short period, a culture method of RPE cells that can stably grow and culture a cell, a toxicity/efficacy evaluation method using RPE cells useful for transplantation therapy, and a therapeutic drug for a retinal disease. The invention relates to a production method of RPE cells, comprising adhesion culture of human pluripotent stem cells using a culture substrate coated with a laminin-E8 fragment, a culture method of RPE cells, comprising adhesion culture of RPE cells using a culture substrate coated with a laminin-E8 fragment, a toxicity or efficacy evaluation method using RPE cells obtained by producing or culturing by the method, and a therapeutic drug for a retinal disease, containing the RPE cells.

Abstract: The present invention provides an infection prevention device and an infection prevention method including a light source 11 for radiating light in specific wavelength range, and a beam-firming optical element 12 for forming the light radiated from the light source 11 on a radiant film 20 having a predetermined width, wherein pathogenic microorganism which levitates together with airborne droplets or particles or which levitates alone is inactivated or killed by the radiant film 20 formed in air, or moisture of the airborne droplets or the particles is evaporated. According to this, pathogenic microorganism which levitates in air can be inactivated or killed in air.

Abstract: An ophthalmic information processing apparatus includes an acquisition unit and a disease estimation unit. The acquisition unit is configured to acquire a plurality of images with different cross-sectional orientations from each other of a subject's eye. The disease estimation unit is configured to output estimation information for estimating whether or not the subject's eye is a glaucoma eye from the images, using a plurality of learned models obtained by performing machine learning for each type of the images.

Abstract: The invention provides a method for producing a retinal tissue by (1) subjecting pluripotent stem cells to floating culture in a serum-free medium containing a substance inhibiting the Wnt signal pathway to form an aggregate of pluripotent stem cells, (2) subjecting the aggregate to floating culture in a serum-free medium containing a basement membrane preparation, and then (3) subjecting the aggregate to floating culture in a serumcontaining medium. The invention also provides a method for producing an optic-cup-like structure, a method for producing a retinal pigment epithelium, and a method for producing a retinal layer-specific neural cell.

Abstract: In the present invention, the influence by flora of the skin on dermatitis is examined by analyzing Tmem79-knockout model mice, and a bacterium having a suppressive effect on dermatitis is identified, and the present invention relates to a pharmaceutical composition derived from such a bacterium, containing as active components one or more substances selected from: (a) a bacterial cell of an ampicillin-sensitive bacterium, or a constituent component of the bacterium; (b) a culture supernatant of an ampicillin-sensitive bacterium, or a purified product from the culture supernatant; (c) an extract of an ampicillin-sensitive bacterium; and (d) a metabolite of an ampicillin-sensitive bacterium.

Abstract: A superconducting magnet device includes a low temperature vessel disposed in a cylindrical shape around a central axis so as to surround a sample region including the central axis, the low temperature vessel internally having a low temperature region, a winding frame having a cylindrical shape centered on the central axis and disposed in the low temperature region, a superconducting coil including a superconducting wire wound around an outer periphery of the winding frame, the superconducting coil being excited to generate a magnetic field, a shim coil that is arranged in the sample region and generates a magnetic field by being excited, a sample region magnetic shim disposed in the sample region and cooperating with the shim coil to increase homogeneity of a magnetic field of the sample region, and a low temperature magnetic shim in the low temperature region and enhances homogeneity of a magnetic field.

Abstract: The present disclosure provides a cathode electrode that can stably sustain a catalytic reaction producing an olefinic hydrocarbon such as ethylene and an alcohol such as ethanol by a reduction reaction of carbon dioxide over a long term. A cathode electrode that electrically reduces carbon dioxide, including cuprous oxide, copper, and at least one additional metal element selected from the group consisting of silver, gold, zinc, and cadmium.