Patents Assigned to Riken
  • Publication number: 20190218513
    Abstract: The present invention enables efficient suspension culture of stem cells in a serum-free medium by comprising a step for quickly forming a homogenous aggregate of stem cells, and provides a method of selectively inducing the differentiation of nerves from a stem cell, a method of forming a cerebral cortical nerve network in vitro, and a method of producing a steric structure of a brain tissue in vitro, as well as a method of producing hypothalamic neuron progenitor cells, comprising culturing pluripotent stem cells as a suspended aggregate in a serum-free medium that substantially does not contain a Nodal signal promoter, a Wnt signal promoter, an FGF signal promoter, a BMP signal promoter, retinoic acid and an insulin, and isolating hypothalamic neuron progenitor cells from
    Type: Application
    Filed: February 15, 2019
    Publication date: July 18, 2019
    Applicant: RIKEN
    Inventors: Yoshiki SASAI (deceased), Takafumi WATAYA, Mototsugu EIRAKU
  • Patent number: 10351667
    Abstract: Provided is a method for producing a non-colored polyester with a high molecular weight. The method is to produce a polyester represented by a general formula (2). This method comprises: a first step of heating, under the presence of an antimony catalyst, a compound represented by the general formula (1) at a heating temperature in a range of from a melting point of the compound to a temperature that is 10° C. higher than the melting point; and a second step of heating a solid product or viscous product obtained after the first step at a heating temperature in a range of from the melting point of the compound represented by the general formula (1) to 270° C.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: July 16, 2019
    Assignee: RIKEN
    Inventors: Koichiro Tachibana, Hideki Abe
  • Patent number: 10352445
    Abstract: A piston ring includes an annular body having: an inner circumferential surface and an outer circumferential surface; one side surface and the other side surface substantially orthogonal to the inner circumferential surface; and a pair of joint ends. The outer circumferential surface includes an inclined surface and an abutment surface. In a direction connecting the one side surface and the other side surface, a maximum width W1 of the abutment surface at the joint end is 80% to 150% of a maximum width W2 of the abutment surface in a portion other than the joint end. In the body, a two-axis difference (d2?d1) between a diameter d1 in a first axis direction passing through a central position of the joint and a diameter d2 in a second axis direction orthogonal to the first axis direction is greater than ?0.25 mm and less than +0.36 mm.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: July 16, 2019
    Assignee: KABUSHIKI KAISHA RIKEN
    Inventor: Masaaki Fujita
  • Patent number: 10352446
    Abstract: A combined oil control ring comprising a pair of annular side rails each having a gap, and an axially corrugated spacer expander arranged between the side rails; the corrugated spacer expander having on the inside seating tabs for pushing inner peripheral surfaces of the side rails; the side-rail-pushing surface of each seating tab being provided with a nitrided layer; an entire surface of each spacer expander except for those provided with the nitrided layer being coated with a plating film; and the plating film having Vickers hardness HV0.01 of 300 or less.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: July 16, 2019
    Assignee: KABUSHIKI KAISHA RIKEN
    Inventors: Takayuki Ichikawa, Takuma Sekiya
  • Publication number: 20190214513
    Abstract: A photoelectric conversion device includes a photoelectric conversion element formed of a polar material and including no p-n junction, and first and second electrodes provided on the photoelectric conversion element and arranged at an interval. Space-inversion symmetry of a structure of the photoelectric conversion element is broken. The first and second electrodes are each formed of a metal material that generates no substantial potential barrier preventing majority carriers for the photoelectric conversion element from moving from the electrode to the photoelectric conversion element.
    Type: Application
    Filed: December 27, 2018
    Publication date: July 11, 2019
    Applicant: RIKEN
    Inventors: Masao NAKAMURA, Masashi KAWASAKI, Yoshinori TOKURA, Naoto NAGAOSA, Takahiro MORIMOTO, Yoshio KANEKO
  • Patent number: 10344636
    Abstract: To provide a press-fit, sintered valve seat having high valve coolability and wear resistance for use in a high-efficiency engine, and its production method, Cu powder having an average particle size of 45 ?m or less and purity of 99.5% or more is used to form a network-connected Cu matrix, even though a relatively large amount of hard Co-based alloy particles are added; and Fe—P alloy powder is used for densification by liquid-phase sintering.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: July 9, 2019
    Assignee: KABUSHIKI KAISHA RIKEN
    Inventor: Kimiaki Hashimoto
  • Patent number: 10342475
    Abstract: In a threshold estimation apparatus, a setting unit sets an initial intensity value for each electrode. A selection unit randomly selects an electrode. A stimulation unit, via the selected electrode, stimulates a living subject at an intensity set for the electrode. A detection unit detects the presence or absence of a response evoked by the stimulation. An update unit reduces or increases the intensity associated with the selected electrode, based on the presence or absence of the response evoked by the stimulation. An estimation unit, if the thus updated intensity associated with each electrode satisfies a convergence condition, estimates a convergence value as a threshold associated with the electrode. The threshold estimation apparatus repeats these processes until thresholds associated with all electrodes are estimated. If the same electrode was consecutively selected, the time interval between a stimulation and a subsequent stimulation is adjusted.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: July 9, 2019
    Assignee: RIKEN
    Inventors: Atsushi Iriki, Junichi Ushiba, Mitsuaki Takemi
  • Patent number: 10345224
    Abstract: An optical response measuring device is provided with a light source, first and second wavelength conversion elements and a light intensity sensor array. The light source generates a pair of light beams including light beams of first and second wavelengths, and the first wavelength conversion element generates measurement light. The measurement light is irradiated on an object for measurement and a detection light having first phase and second phase is obtained in response to this irradiation. A reference light that carries the phase of the pair of the pair light beams and the detection light both pass through a second wavelength conversion element to obtain a modulated reference light have first and second intensities. The first and second local intensities are then measured by the light intensity sensor array.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: July 9, 2019
    Assignee: RIKEN
    Inventors: Kouji Nawata, Hiroaki Minamide, Shuzhen Fan, Feng Qi, Hiromasa Ito
  • Publication number: 20190201579
    Abstract: The object of the present invention is to provide an artificial skin having hair follicles, sebaceous glands, and hair pores. The present invention provides a method for manufacturing artificial skin having hair follicles, sebaceous glands, and hair pores, characterized in that it comprises each of the following steps: (A): a step of preparing an artificial skin having dermal and epidermal layers or an artificial skin having only a dermal layer; and (B): a step of transplanting isolated hair follicles to the artificial skin prepared in step (A); wherein said isolated hair follicle comprises a sebaceous gland, and said isolated hair follicle is transplanted to said artificial skin so that the surface of said dermal Layer of said artificial skin is in alignment with the position of the hair pore portion of said isolated hair follicle.
    Type: Application
    Filed: June 19, 2017
    Publication date: July 4, 2019
    Applicants: Organ Technologies, Inc., Riken
    Inventors: Takashi TSUJI, Koh-ei TOYOSHIMA, Miho OGAWA
  • Patent number: 10340416
    Abstract: To fabricate a practically useful non-polar AlN buffer layer on a sapphire crystal plate and manufacture a UV light-emitting device on a non-polar crystal substrate by adopting the crystal substrate as an example, an embodiment of the present invention provides a crystal substrate 1D comprising an r-plane sapphire crystal plate 10 and an AlN buffer layer 20D of non-polar orientation. The AlN buffer layer comprises a surface protection layer 22 and a smoothing layer 26. The surface protection layer suppresses roughness increase on a surface of the AlN buffer layer, and the smoothing layer makes the surface of the AlN buffer layer a smoothed surface. Also provided is a crystal substrate 11 comprising an AlN buffer layer 20T to which a dislocation blocking layer 24 for reducing crystallographic defects is added between the surface protection layer 22 and the smoothing layer 26. In another embodiment a deep UV light-emitting device is provided.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: July 2, 2019
    Assignee: RIKEN
    Inventors: Masafumi Jo, Hideki Hirayama
  • Publication number: 20190195363
    Abstract: A piston ring has an annular body including an inner circumferential surface, an outer circumferential surface and first and second side surfaces connecting the inner circumferential surface and the outer circumferential surface, and a joint section. The joint section includes a first protrusion portion, a first reception portion, a second protrusion portion, a second reception portion, a first male portion, a first female portion, a second male portion and a second female portion. The first male portion includes a first mating surface and a first contact surface located adjacent the first mating surface and including either an inclined surface or a curved surface. The second male portion includes a second mating surface and a second contact surface located adjacent the second mating surface including either an inclined surface or a curved surface.
    Type: Application
    Filed: July 25, 2017
    Publication date: June 27, 2019
    Applicant: KABUSHIKI KAISHA RIKEN
    Inventors: Hiroshi SHIMIZU, Daisuke NAKAMURA
  • Patent number: 10332648
    Abstract: A charge stripping film for a charge stripping device of ion beam is a carbon film produced by annealing a polymer film, and has a film thickness of 10 ?m to 150 ?m, an area of at least 4 cm2, and an atomic concentration of carbon of at least 97%. A charge stripping film for a charge stripping device of ion beam is a carbon film having a thermal conductivity in a film surface direction at 25° C. of at least 300 W/mK, and has a film thickness of 10 ?m to 150 ?m, an area of at least 4 cm2, and an atomic concentration of carbon of at least 97%.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: June 25, 2019
    Assignees: KANEKA CORPORATION, RIKEN
    Inventors: Mutsuaki Murakami, Masamitsu Tachibana, Atsushi Tatami, Hiroo Hasebe
  • Publication number: 20190186050
    Abstract: Provided are a composite molding composition such as a composite film and a composite fiber that have properties such as an improved tensile strength, strain and toughness as a result of blending a peptide or polyamino acid having a ?-sheet structure with a natural or artificially modified fibroin-derived protein; a method for producing such composite molding composition; and a method for improving the physical properties of a composite molding composition containing a fibroin-derived protein.
    Type: Application
    Filed: July 24, 2017
    Publication date: June 20, 2019
    Applicants: RIKEN, SPIBER INC.
    Inventors: Keiji NUMATA, Kousuke TSUCHIYA, Junichi SUGAHARA, Takaoki ISHII, Hongfang CHI
  • Publication number: 20190185799
    Abstract: The invention provides a cell and biotissue transporting container for transporting cells or biotissues while maintaining their cultured state. A cell/biotissue transporting container A10 includes a base member 1 with an opening 110 at an upper end and a first tubular portion 11 extending vertically, a lid body 2 including a top plate portion 21 to close the opening 110 and a second tubular portion 22 extending from a peripheral edge of the top plate portion 21 in the thickness direction to fit onto the first tubular portion 11, and a container body 3, formed separately from the base member 1 using a flexible material, where the container body includes a bottom wall portion 31, a tubular side wall portion 32 rising from a peripheral edge of the bottom wall portion 31 and inserted into the opening 110, and a flange 33 extending outward from an upper edge of the side wall portion 32.
    Type: Application
    Filed: June 1, 2017
    Publication date: June 20, 2019
    Applicants: SANPLATEC CORPORATION LTD., RIKEN
    Inventors: Satoshi KATOU, Junichi KUWABARA, Masayo TAKAHASHI, Naoshi KOIDE
  • Publication number: 20190183855
    Abstract: An evaluation system for replication activity of HBV capable of visualizing and quantifying replication of HBV DNA in a short period of time inexpensively, safely, and rapidly and a method for evaluation using the system are developed and provided. Moreover, a novel composition for inhibiting HBV replication with a mode of action different from that of conventional anti-HBV drugs is developed and provided. A therapeutic agent for hepatitis B comprising as an active ingredient an HBV-Pol activity inhibitor consisting of a phosphorylation inhibitor that inhibits phosphorylation of a TxY motif present in Terminal protein region of HBV-Pol is provided.
    Type: Application
    Filed: August 10, 2017
    Publication date: June 20, 2019
    Applicant: RIKEN
    Inventor: Kenji OGAWA
  • Publication number: 20190185824
    Abstract: Identification of a protein having an activity of oxidizing oleanane-type triterpene, and a gene encoding the protein, the protein and the gene, and use thereof are provided. For example, a protein having an activity of oxidizing oleanane-type triterpene obtained from a plant in the family Fabaceae, a gene encoding the protein and use thereof are provided. The protein is shown in, for example, SEQ ID NO: 4, 14 or 18, and the gene encoding the protein is shown in, for example, SEQ ID NO: 3, 13 or 17. A transformant into which the gene is introduced can be produced, and thereby a triterpene oxidase can be obtained.
    Type: Application
    Filed: February 28, 2019
    Publication date: June 20, 2019
    Applicant: RIKEN
    Inventors: Toshiya MURANAKA, Hikaru Seki, Kiyoshi Ohyama, Hiroshi Sudo, Satoru Sawai, Kazuki Saito
  • Patent number: 10323254
    Abstract: According to the present invention, a transgenic plant, wherein expression of the BSS1 gene having activity to bind to a BIL1 protein to inhibit the transfer of the BIL1 protein into the nucleus so as to down-regulate brassinosteroid signaling is suppressed or promoted, and a method for regulating plant growth, wherein expression of the BSS1 gene in a plant body is suppressed or promoted, are provided.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: June 18, 2019
    Assignee: RIKEN
    Inventors: Takeshi Nakano, Tadao Asami, Ayumi Yamagami, Hiroyuki Osada
  • Publication number: 20190178771
    Abstract: A new method capable of evaluating wettability of a surface of a material is provided. The method includes the following: applying a gas jet to a surface of a material that is covered with a liquid so as to squeeze the liquid; imaging a surface of a liquid film formed on the surface of the material after squeezing the liquid; and evaluating wettability of the material based on the presence or absence of interference fringes on the surface of the liquid film.
    Type: Application
    Filed: August 18, 2017
    Publication date: June 13, 2019
    Applicants: Riken, Kitagawa Iron Works Co., Ltd.
    Inventors: Nobuyuki Tanaka, Yuki Nakanishi, Junko Takahara, Akane Awazu, Yo Tanaka, Yoshihide Haruzono, Hiromitsu Nasu
  • Patent number: 10316332
    Abstract: A cell for immunotherapy of the present invention includes a nucleic acid encoding a Wilms tumor 1 gene product or a fragment of the Wilms tumor 1 gene product, wherein the nucleic acid including (i) a region encoding a fragment of the Wilms tumor 1 gene product, the fragment being indicated by positions 194 to 493 of amino acid sequence of SEQ ID NO:1 or by positions corresponding to the positions 194 to 493 of amino acid sequence corresponding to SEQ ID NO:1 and (ii) only one AUG as a functional start codon, connected to a 5? terminal side of the region via 3m (m is 124-192) bases intervening between the AUG as the functional start codon and the 5? terminal side of the region, and a nucleic acid encoding CD1d, wherein the cell has been loaded with a glycolipid recognized by antigen receptor of NKT cell.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: June 11, 2019
    Assignee: RIKEN
    Inventor: Shin-ichiro Fujii
  • Patent number: 10321552
    Abstract: In an undulator magnet array, an upper magnet array is formed by coupling an upper shift magnet array and an upper reference magnet array, and a lower magnet array is formed by coupling a lower reference magnet array and lower shift magnet array arranged so as to face the magnet arrays. With reference to a state where the amplitudes of periodic magnetic fields that can be formed by the upper magnet array and the lower magnet array are maximized, the upper shift magnet array is shifted ¼ of a period to the left as seen from the lower reference magnet array and the lower shift magnet array is shifted ¼ of a period to the left as seen from the upper reference magnet array.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: June 11, 2019
    Assignee: RIKEN
    Inventors: Ryota Kinjo, Takashi Tanaka