Abstract: In one aspect, a novel method that allows for evaluation of an RTK activity is provided.

Abstract: The present invention provides a cell activating the immune system and a pharmaceutical composition containing the cell. According to the present invention, there is provided a mammalian cell having at least one protein selected from the group consisting of E6 protein and E7 protein for early genes of human papillomavirus and a fusion protein of E6 protein and E7 protein, and CD1d protein, wherein the mammalian cell is pulsed with a CD1d ligand. According to the present invention, there are also provided a fusion protein having E7 protein, E6 protein and E7 protein in this order, a nucleic acid encoding the protein and a gene expression vector therefor.

Abstract: A physical package is provided with: a MOT device; an optical chamber which constitutes an optical lattice formation portion; and a vacuum chamber which surrounds these components and has a substantially cylindrical shape. The MOT device is arranged along the beam axis of an atomic beam and traps an atom cluster. The optical lattice formation portion uses optical lattice light that enters therein to form an optical lattice in a cavity, confines the atom cluster trapped by the MOT device in the optical lattice, and transfers, along the X-axis which is a movement axis perpendicular to the beam axis, the atom cluster to a clock transition space which facilitates clock transition. The central axis of the cylinder of the main body of the vacuum chamber passes through the clock transition space, and is set to be substantially parallel with the beam axis.

Abstract: A propulsion strengthening member attached to a surface of an object existing in outer space, the propulsion strengthening member includes: a transparent member that transmits an emitted laser; and an opaque member that is provided between the transparent member and the object and absorbs the laser such that at least a part thereof is evaporated by energy of the laser.

Abstract: The present invention provides a vaccine against a coronavirus. According to the present invention, there is provided a peptide consisting of the amino acid sequence set forth in SEQ ID NO: 1 or a partial peptide of a coronavirus spike protein consisting of the amino acid sequence corresponding to the amino acid sequence of SEQ ID NO: 1 and a multiple antigen peptide containing a plurality of any of these peptides.

Abstract: A light-receiving device includes: a semiconductor substrate including a light-receiving region with light-receiving elements arranged two-dimensionally in matrix, and a peripheral region provided therearound; a first first electrically-conductive region provided at a first surface of the semiconductor substrate for each element and coupled to a first electrode, in the light-receiving region; a second first electrically-conductive region provided at the first surface and around the first first region provided for each element and coupled to a second electrode; a third first electrically-conductive region provided at the first surface and around the second first region provided for each element and having electrically floating state; a fourth first electrically-conductive region provided at the first surface and around the light-receiving region and having electrically floating state, in the peripheral region; and a first second electrically-conductive region embeddedly formed in the semiconductor substrate an

Abstract: The present invention relates to a compound represented by the following formula (I): and an antimalarial drug comprising the compound.

Abstract: A pluripotent stem cell that has higher efficiency of differentiation and is still inhibited from spontaneously differentiating into all three germ layers is produced. A pluripotent stem cell is suspension-cultured in a liquid medium containing a PKC? inhibitor and a WNT inhibitor, and then suspension-cultured in a liquid medium not substantially containing a PKC? inhibitor and/or a WNT inhibitor.

Abstract: Provided are a production method of retinal pigment epithelial (RPE) cells that improves differentiation induction efficiency of pluripotent stem cells into RPE cells, and can provide highly pure RPE cells by a simple and easy operation in a short period, a culture method of RPE cells that can stably grow and culture a cell, a toxicity/efficacy evaluation method using RPE cells useful for transplantation therapy, and a therapeutic drug for a retinal disease. The invention relates to a production method of RPE cells, comprising adhesion culture of human pluripotent stem cells using a culture substrate coated with a laminin-E8 fragment, a culture method of RPE cells, comprising adhesion culture of RPE cells using a culture substrate coated with a laminin-E8 fragment, a toxicity or efficacy evaluation method using RPE cells obtained by producing or culturing by the method, and a therapeutic drug for a retinal disease, containing the RPE cells.

Abstract: An object of the present invention is to provide a new method for evaluating and/or screening an excellent healthcare material or pharmaceutical product based on a new concept. The present invention to solve the above object is a method for evaluating and/or screening a control agent for tissue morphology and/or tissue function, the method including: applying a test substance to a tissue or cell capable of expressing a mechanical stress signaling molecule; and evaluating expression, activity, or intracellular localization of the mechanical stress signaling molecule in the tissue or cell.

Abstract: Provided is a classification device to classify an image by identifying, on a photograph on which a target belonging to one of a plurality of groups is captured, a portion that characterizes a single group.

Abstract: Provided is a cell culture vessel which allows resolution to be high in a Z-axis direction. A cell culture vessel (1) for accommodating a cell or cell tissue therein includes: a frame part (11) which is provided so as to be located at positions that correspond to respective sides of a polyhedral shape; a window part (12) which is light-transmissive and which is provided so as to be located at positions that correspond to a respective plurality of faces out of faces of the polyhedral shape; and a shaft part (17) which extends, from any of vertices of the polyhedral shape, outward in a direction that is not parallel to any of lines normal to the faces of the polyhedral shape.

Abstract: According to a medical system of an aspect example, an ophthalmic data acquiring unit includes at least one ophthalmic examination apparatus for acquiring ophthalmic data from a patient, and an internal medicine data acquiring unit includes at least one internal medicine examination apparatus for acquiring internal medicine data from the patient. An inference processor is configured to perform inference processing using a trained model constructed by machine learning using training data that includes ophthalmic data, internal medicine data, and diagnostic result data. The inference processor generates inferred diagnostic data by performing the inference processing based at least on the ophthalmic data of the patient acquired by the ophthalmic data acquiring unit and the internal medicine data of the patient acquired by the internal medicine data acquiring unit. An output unit outputs a result of the inference processing performed by the inference processor.

Abstract: An ophthalmic information processing apparatus includes a determiner and a detector. The determiner is configured to determine a presence or absence of a disc hemorrhage for a front image of a fundus of a subject's eye, using a disc hemorrhage determination model obtained by performing machine learning using a plurality of fundus images labeled with labels indicating the presence or absence of a disc hemorrhage as first teaching data. The detector is configured to detect a disc hemorrhage region depicted in the front image that is determined to have the disc hemorrhage, using a disc hemorrhage region detection model obtained by performing machine learning using a plurality of pairs of image groups as second teaching data, each pair having a front image of a fundus and a disc hemorrhage region image representing a disc hemorrhage region depicted in the front image.

Abstract: Provided is a novel fluorescent probe. A compound of the following general formula (I) or a salt thereof.

Abstract: The present disclosure provides a method for screening cells, the method including a step of preparing a plurality of cells which are tagged with a first barcode nucleic acid associated with a test target and treated with the test target, a step of sorting the plurality of cells based on cellular phenotype using an imaging cell sorter, and a step of identifying the test target used to treat each cell using the first barcode nucleic acid as an indicator.

Abstract: A factor parameter for estimating a label of a target from a plurality of parameters that can be acquired for the target. In a suggestion device, a calculator learns, by referring to a plurality of records in which each record represents a plurality of parameter values acquired from the target and a label provided to the target, an estimation model that estimates a label from a parameter related to a combination for a part of calculation candidates among a plurality of candidates representing a combination of parameters; calculates performance of the estimation model; causes calculation candidates to compete based on the calculated performance; and calculates a rating value of the calculation candidate. An estimator learns a rating model by a rating value and a combination of parameters of the calculation candidate, and estimates a rating value of an estimation candidate other than the calculation candidate.

Abstract: Maintainability is to be improved. A radio frequency quadrupole linear accelerator includes a tubular housing part having an outer peripheral surface at which two pairs of openings extending in an axial direction are formed facing each other, and a plurality of first vane electrodes inserted into the respective openings of the tubular housing part from outside toward an axial center, detachably attached to the openings, and disposed facing each other.

Abstract: Image signal processing capable of achieving effective data compression is performed while preventing degradation of data obtained in imaging using radiation. A radiation imaging system (100) includes an image sensor (105) having a sensitive surface on which a plurality of pixels are two-dimensionally arranged and outputs signals electrically converted at the pixels in response to incidence of radiation including image information as pixel values. In the radiation imaging system (100), one or more pixels that output significant electrical conversion signals derived from incident radiation are separated from pixels that output only signals due to noise specific to a sensor device based on a threshold that is statistically determined in advance. Then, pixel values due to noise are removed, and pixel values of significant signals are output as radiation image data.

Abstract: A composition for suppressing trypsin activity is disclosed. The composition contains a bacterium belonging to a genus Paraprevotella as an active ingredient.