Patents Assigned to Riken
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Patent number: 12781213Abstract: Wild-type ferulic acid decarboxylase obtained from Saccharomyces has high catalytic activity for the production of unsaturated hydrocarbon compounds. Further, in the ferulic acid decarboxylase, substitution of the amino acid at position 398 of SEQ ID NO: 2 with glutamine, methionine, asparagine, phenylalanine, histidine, or threonine improves the catalytic activity, making it possible to provide a method capable of producing an unsaturated hydrocarbon compound like butadiene with high productivity, and an enzyme used in the method.Type: GrantFiled: September 18, 2020Date of Patent: November 3, 2026Assignees: RIKEN, ZEON CORPORATION, THE YOKOHAMA RUBBER CO., LTD.Inventors: Tomokazu Shirai, Yutaro Mori, Kazuhiro Takahashi, Yayoi Akahori
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Patent number: 12782298Abstract: An observation device includes a neutron emission device, a detection device, and a data processing device. The neutron emission device emits neutrons to an inspection object. The detection device detects exit neutrons from the inspection object at one set of detection positions in a peripheral direction around the inspection object, outside the inspection object, and measures the number of the detected exit neutrons for each of the detection positions. The data processing device generates reconstructed cross-sectional data by performing reconstruction processing based on the number of the detected exit neutrons at each of the one set of detection positions. The reconstructed cross-sectional data represent a two-dimensional distribution of a neutron reaction rate in an imaginary cross-section of the inspection object.Type: GrantFiled: October 25, 2022Date of Patent: November 3, 2026Assignee: RIKENInventors: Kunihiro Fujita, Takaoki Takanashi, Chihiro Iwamoto, Yoshie Otake
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Patent number: 12785236Abstract: A quantum device includes a filter having a plurality of notches in a first frequency band lower than a second frequency band, a first qubit that resonates in the first frequency band, and a second qubit that resonates in the second frequency band. The first qubit is input with a signal having a frequency at which the first qubit resonates via the filter to control a state of the first qubit when executing a one-qubit gating, and is input with a signal having a frequency at which the second qubit resonates via the filter to control a state of the second qubit according to a quantum state of the first qubit when executing a two-qubit gating.Type: GrantFiled: September 6, 2024Date of Patent: November 3, 2026Assignees: Fujitsu Limited, RIKENInventors: Mitsuya Kawashita, Shuhei Tamate
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Patent number: 12765559Abstract: A spider mite repellent comprises at least one oil selected from the group consisting of olive oils, olive pomace oils, and partially hydrogenated high-oleic rapeseed oils as an active ingredient.Type: GrantFiled: January 24, 2022Date of Patent: October 20, 2026Assignee: RIKENInventor: Yutaka Arimoto
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Patent number: 12767666Abstract: A complex in accordance with an embodiment of the present invention contains: an acrolein-reactive site having a chemical structure represented by Formula (1); and a leaving site having another chemical structure. The leaving site is binding to the acrolein-reactive site via a linker that is cleavable by a reaction between the acrolein-reactive site and acrolein.Type: GrantFiled: October 13, 2021Date of Patent: October 20, 2026Assignee: RIKENInventors: Katsunori Tanaka, Ambara Rachmat Pradipta
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Patent number: 12761220Abstract: Provided is an easy to determine immunochromatography detection device that detects a target substance that may be contained in a sample fluid. The detection device includes a flow path for the sample fluid and detection parts 1 to which capture selected substances. In one embodiment, an Metal-Insulator-Metal (MIM) structure is formed when the target substance is included in the sample fluid at the detection parts, and a color is produced at the detection parts by resonance absorption. The MIM structure comprises a metal thin film (M layer) that is formed on a support that acts as either a capture substance/target substance/reference substance composite layer or a capture substance/reference substance composite layer (I layer), and metal fine particles (M layer) with which a reference substance is labeled.Type: GrantFiled: December 16, 2021Date of Patent: October 13, 2026Assignee: RIKENInventor: Takuo Tanaka
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Patent number: 12753213Abstract: A novel fluorescent protein and uses thereof are provided. A polypeptide of the present invention has a fluorescence property, the polypeptide being indicated in any one of (1) to (3) below: (1) a polypeptide having an amino acid sequence set forth in SEQ ID NO: 1; (2) a polypeptide having an amino acid sequence set forth in SEQ ID NO: 1, the amino acid sequence having replaced, deleted, inserted, and/or added therein not less than 1 and not more than 32 amino acids; and (3) a polypeptide having not less than 85% sequence identity with respect to an amino acid sequence set forth in SEQ ID NO: 1.Type: GrantFiled: March 23, 2022Date of Patent: October 6, 2026Assignees: RIKEN, TOHOKU UNIVERSITYInventors: Atsushi Miyawaki, Ryoko Ando, Masahiko Hirano, Noriyo Takeda
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Publication number: 20260297535Abstract: Provided are OCT3/4 protein variants that are capable of inducing reprogramming of somatic cells at a higher efficiency than an OCT3/4 protein consisting of a natural amino acid sequence. Also provided is a method for efficiently producing iPS cells using the OCT3/4 protein variants. The present invention provides OCT3/4 protein variants comprising an amino acid substitution, or a peptide fragment thereof comprising the amino acid substitution.Type: ApplicationFiled: July 7, 2023Publication date: October 1, 2026Applicant: RIKENInventors: Yohei HAYASHI, Shinsaku AMANO
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Patent number: 12750943Abstract: Maintainability is to be improved. A radio frequency quadrupole linear accelerator includes a tubular housing part having an outer peripheral surface at which two pairs of openings extending in an axial direction are formed facing each other, and a plurality of first vane electrodes inserted into the respective openings of the tubular housing part from outside toward an axial center, detachably attached to the openings, and disposed facing each other.Type: GrantFiled: September 6, 2022Date of Patent: September 29, 2026Assignee: RIKENInventors: Shota Ikeda, Yasuo Wakabayashi, Kunihiro Fujita
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Patent number: 12735693Abstract: A method for producing a chain-shaped unsaturated carboxylic acid compound or a geometric isomer thereof, having at least two carbon-carbon double bonds, including the steps of: removing, from a chain-shaped unsaturated carboxylic acid compound or a geometric isomer thereof having an amino group and a carbon-carbon double bond at a terminus, that amino group, in the presence of phenylalanine ammonia lyase, and further forming a carbon-carbon double bond.Type: GrantFiled: December 7, 2021Date of Patent: September 15, 2026Assignees: RIKEN, ZEON CORPORATION, THE YOKOHAMA RUBBER CO., LTD.Inventors: Tomokazu Shirai, Yutaro Mori, Yoshihide Yachi, Misao Hiza, Yayoi Akahori
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Publication number: 20260258404Abstract: A method for preparing a DNA library from a sample containing RNA includes ligating a first DNA linker to the 3? end of at least one RNA molecule in a sample containing RNA to obtain an RNA molecule having the first DNA linker, hybridizing a first oligonucleotide with the RNA molecule having the first DNA linker to obtain the RNA molecule having a double-stranded DNA promoter region, obtaining a complementary strand of the RNA molecule having the first DNA linker (complementary RNA) by in vitro transcription using the RNA molecule having the double-stranded DNA promoter region as a template and an RNA polymerase that recognizes the promoter sequence and initiates transcription; and ligating a second DNA linker to the 3? end of the complementary RNA and further obtaining a single-stranded DNA by reverse transcription using the complementary RNA having the second DNA linker as a template.Type: ApplicationFiled: March 12, 2024Publication date: September 3, 2026Applicant: RIKENInventors: Shintaro IWASAKI, Yuichi SHICHINO, Mari MITO, Taisei WAKIGAWA
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Publication number: 20260259151Abstract: An inspection device is a device for inspecting an inner peripheral surface of an inspection target having a cylindrical shape. The device includes: an inspection part for emitting a terahertz wave to the inner peripheral surface and detecting a reflection wave of the terahertz wave; and a distance measurement part for measuring a distance between the inspection part and the inner peripheral surface. The inspection part and the distance measurement part are rotated along a circumferential direction of the inspection target. The axial-directional position of the inspection part relative to the inspection target is adjusted. The position of the inspection part on a plane which intersects with an axial direction of the inspection target is adjustable. The position adjustment mechanism is controlled such that a rotational center of the rotation part is positioned on a center axis of the inspection target on the basis of a measurement result of the distance measurement part.Type: ApplicationFiled: July 9, 2024Publication date: September 3, 2026Applicants: MITSUBISHI HEAVY INDUSTRIES, LTD., RIKENInventors: Keisuke KAJIKAWA, Jun YASUI, Soki AKUTSU, Hiroaki MINAMIDE
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Publication number: 20260258223Abstract: The present invention relates to a gel structure including a gel composition including at least one type of anisotropic nanostructures, at least one type of liquid, and at least one type of polymer having a crosslinked structure, which has at least one surface in a stationary state, and in which longitudinal axes of the at least one type of anisotropic nanostructures are oriented approximately parallel to each other and non-parallel and non-perpendicular to the at least one surface.Type: ApplicationFiled: February 26, 2024Publication date: September 3, 2026Applicant: RIKENInventors: Yasuhiro ISHIDA, Xiang WANG, Zhihao LI
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Publication number: 20260258473Abstract: A novel fluorescent probe that includes a compound of the following general formula (II) or a salt thereof:Type: ApplicationFiled: April 27, 2026Publication date: September 3, 2026Applicants: THE UNIVERSITY OF TOKYO, PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY, RIKENInventors: Yasuteru URANO, Toru KOMATSU, Shingo SAKAMOTO, Hiroyuki NOJI, Hidehiko NAKAGAWA, Mitsuyasu KAWAGUCHI, Rikiya WATANABE
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Publication number: 20260243779Abstract: In one aspect, a novel method that allows for evaluation of an RTK activity is provided.Type: ApplicationFiled: February 29, 2024Publication date: August 20, 2026Applicants: The University of Osaka, RIKENInventors: Masahiro UEDA, Michio HIROSHIMA, Daisuke WATANABE
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Patent number: 12703867Abstract: The present invention provides a cell activating the immune system and a pharmaceutical composition containing the cell. According to the present invention, there is provided a mammalian cell having at least one protein selected from the group consisting of E6 protein and E7 protein for early genes of human papillomavirus and a fusion protein of E6 protein and E7 protein, and CD1d protein, wherein the mammalian cell is pulsed with a CD1d ligand. According to the present invention, there are also provided a fusion protein having E7 protein, E6 protein and E7 protein in this order, a nucleic acid encoding the protein and a gene expression vector therefor.Type: GrantFiled: June 12, 2020Date of Patent: August 11, 2026Assignee: RIKENInventors: Shinichiro Fujii, Kanako Shimizu
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Patent number: 12704816Abstract: A physical package is provided with: a MOT device; an optical chamber which constitutes an optical lattice formation portion; and a vacuum chamber which surrounds these components and has a substantially cylindrical shape. The MOT device is arranged along the beam axis of an atomic beam and traps an atom cluster. The optical lattice formation portion uses optical lattice light that enters therein to form an optical lattice in a cavity, confines the atom cluster trapped by the MOT device in the optical lattice, and transfers, along the X-axis which is a movement axis perpendicular to the beam axis, the atom cluster to a clock transition space which facilitates clock transition. The central axis of the cylinder of the main body of the vacuum chamber passes through the clock transition space, and is set to be substantially parallel with the beam axis.Type: GrantFiled: March 30, 2021Date of Patent: August 11, 2026Assignees: JEOL Ltd., RIKENInventors: Shigenori Tsuji, Masao Takamoto, Hidetoshi Katori
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Patent number: 12697805Abstract: A propulsion strengthening member attached to a surface of an object existing in outer space, the propulsion strengthening member includes: a transparent member that transmits an emitted laser; and an opaque member that is provided between the transparent member and the object and absorbs the laser such that at least a part thereof is evaporated by energy of the laser.Type: GrantFiled: May 15, 2024Date of Patent: August 4, 2026Assignees: SKY Perfect JSAT Corporation, RikenInventors: Tadanori Fukushima, Jun Yamada, Daisuke Hirata, Toshikazu Ebisuzaki, Satoshi Wada
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Patent number: 12697384Abstract: The present invention provides a vaccine against a coronavirus. According to the present invention, there is provided a peptide consisting of the amino acid sequence set forth in SEQ ID NO: 1 or a partial peptide of a coronavirus spike protein consisting of the amino acid sequence corresponding to the amino acid sequence of SEQ ID NO: 1 and a multiple antigen peptide containing a plurality of any of these peptides.Type: GrantFiled: May 21, 2021Date of Patent: August 4, 2026Assignees: RIKEN, ANIMAL ALLERGY CLINICAL LABORATORIES INC.Inventors: Kenichi Masuda, Takashi Saito
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Patent number: 12696570Abstract: A light-receiving device includes: a semiconductor substrate including a light-receiving region with light-receiving elements arranged two-dimensionally in matrix, and a peripheral region provided therearound; a first first electrically-conductive region provided at a first surface of the semiconductor substrate for each element and coupled to a first electrode, in the light-receiving region; a second first electrically-conductive region provided at the first surface and around the first first region provided for each element and coupled to a second electrode; a third first electrically-conductive region provided at the first surface and around the second first region provided for each element and having electrically floating state; a fourth first electrically-conductive region provided at the first surface and around the light-receiving region and having electrically floating state, in the peripheral region; and a first second electrically-conductive region embeddedly formed in the semiconductor substrate anType: GrantFiled: March 25, 2022Date of Patent: July 28, 2026Assignees: Sony Semiconductor Solutions Corporation, RIKENInventors: Hiroaki Ishiwata, Chihiro Arai, Hikaru Iwata, Takaki Hatsui, Takahiro Kawamura, Kazunobu Ota