Patents Assigned to Riken
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Publication number: 20250259499Abstract: In a locker apparatus, an operation unit includes authentication means, and a control device locks a locking device in order to bring a door into a closed state except when luggage is deposited in a box and when the luggage is taken out from the box. The operation unit includes a reopening door button for giving an instruction to reopen the door. When the reopening door button is operated within 15 minutes after the luggage is deposited in the box, the door is closed, and the locking device is locked once, the control device unlocks the locking device, on a condition that authentication by the authentication means is established, in order to permit the door to be reopened, and locks the locking device again when the door is closed thereafter.Type: ApplicationFiled: October 16, 2024Publication date: August 14, 2025Applicant: TOKAI RIKEN CO., LTD.Inventors: Akihiro SATO, Yoshiaki MUTO, Masami UMEMURA, Risa YONENUMA, Yasufumi ICHIHARA
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Publication number: 20250255425Abstract: In a locker apparatus, a control device locks a locking device in order to bring a door into a closed state except when luggage is deposited in a box and when the luggage is taken out from the box. An operation unit includes a take-out button that is operated in order to take out the luggage from the box in which the luggage has been deposited. When the take-out button is operated, the control device unlocks the locking device in order to open the door of the box in which the luggage has been deposited, and when the door is closed thereafter and it is determined that there is the luggage in the box based on a detection result of a luggage sensor, the control device maintains unlocking of the locking device.Type: ApplicationFiled: October 23, 2024Publication date: August 14, 2025Applicant: TOKAI RIKEN CO., LTD.Inventors: Akihiro SATO, Yoshiaki MUTO, Masami UMEMURA, Risa YONENUMA, Yasufumi ICHIHARA
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Patent number: 12385008Abstract: The present invention provides a production method of a retinal cell or retinal tissue, including the following steps: (1) a first step of culturing mammalian pluripotent stem cells in the absence of a feeder cell for a period not exceeding 30 days in a medium comprising 1) a factor for maintaining an undifferentiated state and 2) an MEK inhibitor, (2) a second step of culturing the cells obtained in the first step in suspension to form a cell aggregate, and (3) a third step of culturing the aggregate obtained in the second step in suspension in the presence of a BMP signal transduction pathway activating substance to obtain an aggregate containing retinal cells or a retinal tissue.Type: GrantFiled: September 8, 2016Date of Patent: August 12, 2025Assignees: SUMITOMO PHARMA CO., LTD., RIKENInventors: Satoshi Ando, Takao Kuroda, Yoshiki Sasai
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Patent number: 12378520Abstract: The present invention provides a method for producing a retinal progenitor cell, including (1) a first step of subjecting pluripotent stem cells to floating culture in a serum-free medium to form an aggregate of pluripotent stem cells, and (2) a second step of subjecting the aggregate formed in step (1) to floating culture in a serum-free medium or serum-containing medium each being free of a substance acting on the Sonic hedgehog signal transduction pathway but containing a substance acting on the BMP signal transduction pathway, thereby obtaining an aggregate containing retinal progenitor cells.Type: GrantFiled: July 21, 2022Date of Patent: August 5, 2025Assignees: SUMITOMO CHEMICAL COMPANY, LIMITED, RIKENInventors: Tokushige Nakano, Yoshiki Sasai, Chikafumi Ozone
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Patent number: 12366542Abstract: A non-destructive inspection system includes: a neutron emission unit capable of emitting neutrons having a first neutron dose; a neutron detection unit capable of detecting a second neutron dose of neutrons scattered inside an inspection object A by the emission of the neutrons from the neutron emission unit; a gamma-ray detection unit capable of detecting a gamma dose of gamma rays released from the inspection object A by the emission of the neutrons from the neutron emission unit; and an analysis unit configured to calculate a content of a predetermined substance based on the gamma dose and correct the content of the predetermined substance based on the first neutron dose and the second neutron dose.Type: GrantFiled: March 31, 2022Date of Patent: July 22, 2025Assignees: TOPCON CORPORATION, RIKENInventors: Shigenori Nagano, Satoshi Yanobe, Akira Yajima, Hanako Aikoh, Satoru Ishiguro, Yoshie Otake, Yasuo Wakabayashi, Masato Takamura
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Publication number: 20250231111Abstract: According to an aspect, a fluorescence detection device includes: a light source configured to irradiate a sample with excitation light in a circularly polarized state; a sample holder configured to hold the sample; a cholesteric liquid crystal layer configured to transmit fluorescence emitted by the sample due to the excitation light and reflect the excitation light; and a sensor configured to detect the fluorescence transmitted through the cholesteric liquid crystal layer.Type: ApplicationFiled: April 1, 2025Publication date: July 17, 2025Applicants: Japan Display Inc., RIKENInventors: Yasuhiro TAKAHASHI, Yasushi TOMIOKA, Rikiya WATANABE, Jun ANDO, Hajime SHINODA
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Publication number: 20250228902Abstract: The invention aims to provide a medicament having a superior anti-malignant tumor effect and a method for treating a malignant tumor therewith. In particular, the medicament contains a bacterium and a liposome encapsulating an anti-malignant tumor agent in combination.Type: ApplicationFiled: March 23, 2023Publication date: July 17, 2025Applicant: RIKENInventors: Hidefumi MUKAI, Akari KATO, Shoko NOMURA
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Patent number: 12362085Abstract: In order to obtain an inductor element advantageous for miniaturization, an inductor element 10 according to an embodiment of the present disclosure is provided with a metal medium 2 in which ordered spins are spatially arranged so as to have a non-collinear spin structure when traced in a certain direction. In the inductor element, an electric current I is applied through the metal medium so as to have a projective component of the direction. Preferable examples of the non-collinear spin structure for the metal medium include a spiral structure and a cycloidal structure.Type: GrantFiled: August 1, 2019Date of Patent: July 15, 2025Assignee: RIKENInventors: Naoto Nagaosa, Yoshinori Tokura, Tomoyuki Yokouchi, Masashi Kawasaki, Yoshichika Otani, Maximilian Anton Hirschberger
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Publication number: 20250197895Abstract: A method for producing methacrylic acid, comprising: decarboxylating mesaconic acid or an isomer thereof in the presence of protocatechuate decarboxylase.Type: ApplicationFiled: March 28, 2023Publication date: June 19, 2025Applicant: RIKENInventors: Tomokazu SHIRAI, Yutaro MORI
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Patent number: 12319751Abstract: The present invention provides an antibody specific to IgE antibody-producing B cells or an antibody binding fragment thereof. More specifically, the present invention provides an isolated monoclonal antibody or an antigen binding fragment thereof that binds to a peptide having a sequence consisting of an amino acid sequence set forth in SEQ ID NO: 1 or 18, and (1) binds to IgE antibody on a B cell surface and/or (2) binds to IgE antibody heated at 56° C.Type: GrantFiled: September 20, 2019Date of Patent: June 3, 2025Assignees: RIKEN, ANIMAL ALLERGY CLINICAL LABORATORIES INC.Inventors: Kenichi Masuda, Takashi Saito
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Patent number: 12315151Abstract: There is disclosed a non-transitory computer-readable recording medium having stored therein an information processing program for causing a computer to execute a process.Type: GrantFiled: May 27, 2022Date of Patent: May 27, 2025Assignees: FUJITSU LIMITED, RIKEN, NATIONAL CANCER CENTERInventors: Akira Sakai, Masaaki Komatsu, Kanto Shozu
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Patent number: 12299880Abstract: A non-transitory computer-readable recording medium has stored therein an evaluating program for causing a computer to execute a process including: specifying a wall of an inspection target in two or more moving images being obtained by photographing two types of cross sections of the inspection target, the two types of cross sections being orthogonal to each other; evaluating photographing quality of each of a plurality of first divisional regions obtained by dividing a region corresponding to the wall specified in a first image related to a first cross section among the two or more moving images; and evaluating photographing quality of each of a plurality of second divisional regions obtained by dividing a region corresponding to the wall specified in a second image related to a second cross section among the two or more moving images, the second cross section being different from the first cross section.Type: GrantFiled: May 27, 2022Date of Patent: May 13, 2025Assignees: FUJITSU LIMITED, RIKEN, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY, NATIONAL CANCER CENTERInventors: Akira Sakai, Masaaki Komatsu, Tetsuo Sasano, Hideki Arima, Ryuji Hamamoto
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Publication number: 20250145965Abstract: To provide a method for producing induced pluripotent stem cells (iPS cells) that can initialize somatic cells without using feeder cells or a substrate. For production of iPS cells, the following steps are carried out: I. introducing an initialization gene into a somatic cell; and II. performing initialization and amplification culture of the cell into which the gene has been introduced, in a liquid medium comprising at least one of a protein kinase C? (PKC?) inhibitor and a WNT inhibitor under a suspension culture condition.Type: ApplicationFiled: February 2, 2023Publication date: May 8, 2025Applicants: RIKEN, KANEKA CORPORATIONInventors: Yohei HAYASHI, Mami TAKASAKI, Sho KAMBAYASHI, Yoshikazu KAWAI
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Patent number: 12292363Abstract: The present invention relates to a clearing technique which uses a solution containing at least one of a compound having a delipidation ability, a compound having a biochrome decoloring ability, a compound having a decalcification ability, a compound having a refractive index adjusting ability, and a compound having a tissue swelling ability. The clearing technique is suitable for use in high-throughput and low-magnification imaging which involves a simple process.Type: GrantFiled: July 19, 2022Date of Patent: May 6, 2025Assignee: RIKENInventors: Hiroki Ueda, Kazuki Tainaka, Tatsuya Murakami
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Patent number: 12291720Abstract: The present invention provides a method for producing retinal cells or a retinal tissue, comprising the following steps (1)-(3): (1) a first step of culturing human pluripotent stem cells in the absence of feeder cells and in a medium comprising a factor for maintaining undifferentiated state, (2) a second step of culturing the pluripotent stem cells obtained in the first step in suspension in the presence of a Sonic hedgehog signal transduction pathway activating substance to form a cell aggregate, and (3) a third step of culturing the aggregate obtained in the second step in suspension in the presence of a 1) a BMP signal transduction pathway activating substance to obtain an aggregate containing retinal cells or a retinal tissue.Type: GrantFiled: January 3, 2022Date of Patent: May 6, 2025Assignees: SUMITOMO PHARMA CO., LTD., RIKENInventors: Atsushi Kuwahara, Suguru Yamasaki, Yasushi Hiramine, Yoshiki Sasai, Masayo Takahashi
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Patent number: 12291585Abstract: The object of the invention is to provide a novel olefin-based molded product useful for various applications. An olefin-based molded product comprising a polymer including a structural unit of at least one polar olefin monomer represented by the general formula (I) CH2?CH—R2—Z(R1)n is provided. In the formula, Z is a hetero atom selected from the group consisting of nitrogen, oxygen, phosphorus, sulfur, and selenium; R1 is a substituted or unsubstituted hydrocarbyl group having 1 to 30 carbon atoms; n is an integer of 1 or 2 depending on the atomic species of Z; and R2 is a substituted or unsubstituted hydrocarbylene group having 2 to 20 carbon atoms.Type: GrantFiled: November 17, 2022Date of Patent: May 6, 2025Assignee: RIKENInventors: Haobing Wang, Yang Yang, Masayoshi Nishiura, Zhaomin Hou
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Patent number: 12294053Abstract: Provided is a method for producing a high-purity aqueous lithium salt solution, the method allowing filtering aluminum phosphate in a short time. The method for producing a high-purity aqueous lithium salt solution includes: a step of adjusting the pH of a slurry containing a mixture of lithium phosphate and aluminum hydroxide obtained from a first aqueous lithium salt solution being a raw material to a range of 2 to 3 to obtain a precipitate of aluminum phosphate; a step of filtering off and removing the precipitate of aluminum phosphate to obtain a second aqueous lithium salt solution; and a step of purifying the second aqueous lithium salt solution to obtain a high-purity aqueous lithium salt solution.Type: GrantFiled: September 28, 2021Date of Patent: May 6, 2025Assignee: Asaka Riken Co., Ltd.Inventors: Keita Yamada, Yukio Sakuma, Hiroto Inoue
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Patent number: 12285543Abstract: An object of the present invention is to provide a cell population suitable for transplant of retinal tissue and a method of production thereof. The present invention provides a cell population for transplant, comprising retinal cells with a modified bipolar cell-regulating gene and a method of production thereof.Type: GrantFiled: November 24, 2017Date of Patent: April 29, 2025Assignees: RIKEN, Sumitomo Pharma Co., Ltd.Inventors: Michiko Mandai, Masayo Takahashi, Suguru Yamasaki
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Patent number: 12287286Abstract: An inspection device includes: a light source for outputting pulsed excitation light with a time width of 10 picoseconds to 10 nanoseconds; a nonlinear optical crystal for generating a terahertz wave by optical wavelength conversion of the pulsed excitation light; a polarization part for reflecting at least a part of a reflected wave of the terahertz wave reflected by an inspection target; and a detector for detecting the reflected wave reflected by the polarization part.Type: GrantFiled: February 17, 2023Date of Patent: April 29, 2025Assignees: MITSUBISHI HEAVY INDUSTRIES, LTD., RIKENInventors: Syusaku Yamamoto, Keisuke Kajikawa, Yuichiro Kamino, Hiroaki Minamide, Koji Nawata
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Patent number: 12281709Abstract: Provided is a piston ring including: a low-pressure side ring; and a high-pressure side ring, the low-pressure side ring and the high-pressure side ring are arranged stacked in a direction along the axis so that the high-pressure side ring is closer to a fluid to be compressed, a low-pressure side rotation restriction part configured to restrict rotation in the circumferential direction relative to the piston is formed to the low-pressure side ring, a high-pressure side rotation restriction part configured to restrict rotation in the circumferential direction relative to the piston and a low-pressure side protrusion protruding toward the low-pressure side ring and inserted in the low-pressure side abutment are formed to the high-pressure side ring, and the low-pressure side protrusion is inserted in a low-pressure side abutment with clearances being provided in both sides in the circumferential direction between the low-pressure side ring and the low-pressure side protrusion.Type: GrantFiled: June 15, 2022Date of Patent: April 22, 2025Assignees: MITSUBISHI HEAVY INDUSTRIES, LTD., KABUSHIKI KAISHA RIKENInventors: Motoshi Harada, Kenji Nakamichi, Yuichi Kihara, Kimihiko Mitsuda, Hideaki Asai, Jun Fukada, Daisuke Hirayama