Patents Assigned to Riken
  • Patent number: 11028925
    Abstract: [Object] To provide a seal ring capable of both reducing a friction loss and reducing oil leakage. [Solving Means] A seal ring includes: an inner circumferential surface; an outer circumferential surface orthogonal to the inner circumferential surface; side surfaces orthogonal to the inner circumferential surface and the outer circumferential surface; and a plurality of pockets provided, spaced apart from one another in one of the side surfaces. The plurality of pockets each have a symmetrical shape in a circumferential direction and are opened on a side of the inner circumferential surface and closed on a side of the outer circumferential surface.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: June 8, 2021
    Assignee: KABUSHIKI KAISHA RIKEN
    Inventor: Namsun Park
  • Publication number: 20210168925
    Abstract: A target structure includes a target and a cooling portion. The target generates neutrons by being irradiated with a charged particle beam. The cooling portion includes a front surface and a back surface that face to sides opposite to each other. The target is joined directly or indirectly to the front surface. A flow path for flowing of cooling liquid including hydrogen elements is formed in the cooling portion. When viewed in a thickness direction of the cooling portion from the front surface to the back surface, the flow path is positioned off a center portion of the target.
    Type: Application
    Filed: August 1, 2019
    Publication date: June 3, 2021
    Applicant: RIKEN
    Inventors: Tomohiro KOBAYASHI, Yoshie OTAKE, Hideyuki SUNAGA, Xiaobo LI
  • Publication number: 20210168936
    Abstract: A current introduction terminal includes a board made of resin. The board has a first face and a second face opposite each other. The board hermetically separates environments of different air pressures from each other. A plurality of through via holes corresponding both to a plurality of metal terminals of a first surface-mount connector to be mounted on the first face and to a plurality of metal terminals of a second surface-mount connector to be mounted on the second face are formed to penetrate between the first and second faces, and then hole parts of the through via holes are filled with resin.
    Type: Application
    Filed: October 5, 2018
    Publication date: June 3, 2021
    Applicant: RIKEN
    Inventors: Yuji Matsuda, Takashi Kameshima, Osami Sugata, Toshiaki Tosue
  • Patent number: 11024482
    Abstract: A lensless Fourier transform holography high accuracy reconstruction method using a charged particle beam apparatus which holds a sample on a diffraction surface of a diffraction grating provided on the downstream side of a traveling direction of the charged particle beam and which is formed of a material having permeability. The charged particle beam passed through the diffraction surface is image-formed, and the formed image is detected. An opening region of the diffraction grating is smaller than an irradiation region of the charged particle beam on the diffraction grating. Image data is obtained in a state where the irradiation region of the charged particle beam diffracted with the diffraction grating is within the irradiation region of the charged particle beam transmitted through the diffraction grating. Plural holograms obtained based on the image data are Fourier transformed and an intensity distribution image is displayed and stored.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: June 1, 2021
    Assignee: RIKEN
    Inventors: Ken Harada, Kodai Niitsu, Keiko Shimada
  • Publication number: 20210154370
    Abstract: The present invention aims to provide a method for suppressing differentiation of ganglion cell, amacrine cell, horizontal cell and/or bipolar cell in a neural retina tissue containing photoreceptor precursor and/or photoreceptor, and the like. A method for suppressing differentiation of a ganglion cell, an amacrine cell, a horizontal cell and/or a bipolar cell in a neural retinal tissue containing a photoreceptor precursor and/or a photoreceptor, including a step of culturing a retinal tissue comprising a neural retinal progenitor cell and in any stage between a differentiation stage immediately after emergence of a ganglion cell and a differentiation stage where emergence rate of a cone photoreceptor precursor reaches maximum in a medium containing a thyroid gland hormone signal transduction pathway agonist.
    Type: Application
    Filed: September 14, 2018
    Publication date: May 27, 2021
    Applicants: RIKEN, SUMITOMO DAINIPPON PHARMA CO., LTD., SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Daiki NUKAYA, Mototsugu EIRAKU, Yuiko KINOSE, Akishi ONISHI, Masayo TAKAHASHI, Yoshiki SASAI (deceased)
  • Patent number: 11011344
    Abstract: An interferometric electron microscope with increased irradiating electric current density which causes electron waves to interfere with each other and includes: an electron source; an irradiating lens system a focusing lens system an observational plane an artificial grating disposed between the electron source and the irradiating lens system and diffracting the electron beam emitted from the electron source to produce a first electron wave and a second electron wave; an electron beam biprism deflecting the first electron wave and the second electron wave to pass the first electron wave through the specimen for use as an object wave and to use the second electron wave as a reference wave; and an electron beam biprism in a focusing system deflecting the objective wave and the reference wave to superimpose the objective wave and the reference wave on the observational plane to produce an image.
    Type: Grant
    Filed: February 11, 2020
    Date of Patent: May 18, 2021
    Assignees: HITACHI, LTD., RIKEN
    Inventors: Toshiaki Tanigaki, Tetsuya Akashi, Ken Harada
  • Patent number: 11002728
    Abstract: It is an object to provide a method for evaluating a medicinal substance targeting a G protein-coupled receptor (GPCR). Specifically, the present invention relates to a method for evaluating the activity of a GPCR comprising a step of bringing a target substance into contact with a cell expressing a GPCR on the cell membrane; and a step of determining the diffusive dynamics of the GPCR on the cell membrane.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: May 11, 2021
    Assignee: RIKEN
    Inventors: Masataka Yanagawa, Yasushi Sako, Michio Hiroshima, Masato Yasui, Masahiro Ueda, Yuichi Togashi
  • Publication number: 20210130854
    Abstract: With the aim of providing a method allowing production of an unsaturated hydrocarbon compound such as butadiene with high productivity and an enzyme used in the method, the present inventors introduced mutations involving amino acid replacement into various positions of a ferulic acid decarboxylase, and prepared multiple modified forms of the enzyme. Then, the present inventors evaluated those modified forms in terms of the catalytic activity for the production of butadiene, and found as a result that the catalytic activity was improved in the case where, for example, the amino acid at position 395 was glutamine, histidine, asparagine, leucine, isoleucine, methionine, lysine, serine, arginine, tyrosine, or phenylalanine.
    Type: Application
    Filed: July 24, 2018
    Publication date: May 6, 2021
    Applicant: RIKEN
    Inventors: Tomokazu SHIRAI, Yutaro MORI
  • Publication number: 20210131981
    Abstract: The non-destructive inspection method includes: a water absorbing or drying step of changing a water-content state of a test piece; a transmission image capturing step of irradiating, with a radiation, the test piece absorbed water or dried for a predetermined time in the water absorbing or drying step and capturing a transmission image created by visualizing the radiation transmitted through the test piece; and an evaluation step of evaluating the test piece on the basis of the water-content state of the test piece determined from the transmission image captured in the transmission image capturing step.
    Type: Application
    Filed: September 27, 2018
    Publication date: May 6, 2021
    Applicants: Topcon Corporation, RIKEN
    Inventors: Yuichi YOSHIMURA, Maki MIZUTA, Hideyuki SUNAGA, Yoshie OTAKE
  • Patent number: 10995043
    Abstract: Provided is a method for producing a perfluoroalkylated compound at low cost, safely and with high efficiency. A method for producing a perfluoroalkylated compound, comprising reacting a bis(perfluoroalkanoyl) peroxide with a compound having a carbon-carbon unsaturated bond and/or an aromatic ring having a hydrogen atom bonded thereto in the presence of a copper catalyst.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: May 4, 2021
    Assignee: Riken
    Inventors: Mikiko Sodeoka, Shintaro Kawamura
  • Publication number: 20210123151
    Abstract: A manganese oxide, a manganese oxide/carbon mixture and a manganese oxide composite electrode material, having high catalytic activity produced at low cost, to be used as an anode catalyst for oxygen evolution in water electrolysis, and their production methods, are provided. A manganese oxide for an oxygen evolution electrode catalyst in water electrolysis is provided, which is a manganese oxide having a metallic valence of higher than 3.0 and at most 4.0, having an average primary particle size of at most 80 nm and an average secondary particle size of at most 25 ?m, a manganese oxide/carbon mixture for an oxygen evolution electrode catalyst in water electrolysis, having a proportion of manganese oxide to the total of the manganese oxide and electrically conductive carbon of from 0.5 to 40 wt %, and a manganese oxide composite electrode material which includes an electrically conductive substrate constituted by fibers.
    Type: Application
    Filed: December 12, 2018
    Publication date: April 29, 2021
    Applicants: RIKEN, TOSOH CORPORATION
    Inventors: Ryuhei NAKAMURA, Toru HAYASHI, Nadege BONNET, Kazumasa SUETSUGU, Kazuyuki CHIBA
  • Publication number: 20210122146
    Abstract: Embodiments provide a multilayer film in which: a first acrylic resin layer (?1), an aromatic polycarbonate resin layer (?), and a second acrylic resin layer (?2) are directly laminated in the stated order; the aromatic polycarbonate resin constituting the aromatic polycarbonate resin layer (?) is a product of ester exchange between a polycarbonic acid ester of an aromatic dihydroxy compound and a low-crystalline or amorphous aromatic polyester; and the relationships (T??T?1)?30 and (T??T?2)?30 (where Tal is the glass transition temperature of the acrylic resin constituting the first acrylic resin layer (?1), T?2 is the glass transition temperature of the acrylic resin constituting the second acrylic resin layer (?2), T? is the glass transition temperature of the aromatic polycarbonate resin constituting the aromatic polycarbonate resin layer (?), and all of the temperatures are measured in degrees Celsius) are satisfied.
    Type: Application
    Filed: May 18, 2018
    Publication date: April 29, 2021
    Applicant: RIKEN TECHNOS CORPORATION
    Inventors: Hideaki YAMBE, Kohei NAKASHIMA
  • Patent number: 10988751
    Abstract: A method enables olefin compound production with a high productivity, and an enzyme is used in the method. Mutations involving amino acid substitution are introduced into various sites of diphosphomevalonate decarboxylase (MVD) to prepare multiple MVD variants. Then, these variants are evaluated in terms of catalytic activity for producing an olefin compound such as isoprene, and have found as a result that the catalytic activity is improved when serine at position 153 and threonine at position 209 are each substituted with a different amino acid. In addition, the catalytic activity of the variants is further improved when glycine at position 152 is further substituted with a different amino acid.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: April 27, 2021
    Assignees: RIKEN, ZEON CORPORATION, THE YOKOHAMA RUBBER CO., LTD.
    Inventors: Ryoko Orishimo, Tomokazu Shirai, Kazuhiro Takahashi, Misao Hiza, Yusuke Tanabe
  • Publication number: 20210115399
    Abstract: Provided is a method of inducing the differentiation of a stem cell into nerve progenitor cells, comprising the step (1) of forming homogenous aggregates of stem cells in a serum-free medium (1) and the step (2) of suspension-culturing the homogenous aggregates of stem cells in the presence of a basement membrane reference standard.
    Type: Application
    Filed: October 5, 2020
    Publication date: April 22, 2021
    Applicants: RIKEN, Sumitomo Chemical Company, Limited
    Inventors: Yoshiki SASAI, Mototsugu EIRAKU
  • Publication number: 20210107997
    Abstract: The present invention relates to a monoclonal antibody or antibody fragment thereof as a human IgG antibody including at least one lysine derivative in a constant region of the human IgG antibody; a modified antibody or antibody fragment thereof, wherein the lysine derivative is modified; a nucleic acid including a nucleotide sequence encoding the antibody or antibody fragment thereof; a vector including the nucleic acid; a transformed cell obtained by introducing the vector into a host cell; a method for producing the antibody or antibody fragment thereof; and a composition containing the antibody or antibody fragment thereof.
    Type: Application
    Filed: December 22, 2020
    Publication date: April 15, 2021
    Applicants: RIKEN, KYOWA KIRIN CO., LTD.
    Inventors: Kensaku Sakamoto, Kazumasa Ohtake, Yoshimi Yamaguchi, Shigeyuki Yokoyama, Tatsuo Yanagisawa, Akiko Matsumoto, Akifumi Kato, Yasuhisa Shiraishi, Kaname Kimura, Masakazu Homma
  • Patent number: 10973854
    Abstract: The invention provides a method for producing a retinal tissue by (1) subjecting pluripotent stem cells to floating culture in a serum-free medium containing a substance inhibiting the Wnt signal pathway to form an aggregate of pluripotent stem cells, (2) subjecting the aggregate to floating culture in a serum-free medium containing a basement membrane preparation, and then (3) subjecting the aggregate to floating culture in a serum-containing medium. The invention also provides a method for producing an optic-cup-like structure, a method for producing a retinal pigment epithelium, and a method for producing a retinal layer-specific neural cell.
    Type: Grant
    Filed: November 22, 2012
    Date of Patent: April 13, 2021
    Assignees: Sumitomo Chemical Company, Limited, RIKEN
    Inventors: Tokushige Nakano, Satoshi Ando, Yoshiki Sasai, Mototsugu Eiraku
  • Publication number: 20210099143
    Abstract: A high-frequency power amplifier apparatus includes: a plurality of amplifiers that respectively amplify a plurality of distributed signals obtained by distributing a high-frequency signal of a predetermined frequency, the amplifiers respectively outputting a plurality of amplified signals; and a cavity-type high-frequency power combiner having a cavity surrounded by a conductor wall, the cavity-type high-frequency power combiner combining together power of the plurality of amplified signals in the cavity by operating in a TE011 resonance mode with a resonance frequency equal to the predetermined frequency.
    Type: Application
    Filed: March 28, 2018
    Publication date: April 1, 2021
    Applicant: RIKEN
    Inventor: Yuji Otake
  • Patent number: 10961548
    Abstract: Mutations involving amino acid substitution were introduced into various sites of diphosphomevalonate decarboxylase (MVD), thus preparing a large number of MVD variants. Then, the variants were each evaluated in terms of a catalytic activity for production of olefin compounds such as isoprene. As a result, it was found that substitution of glycine at position with a different amino acid resulted in improvement in the catalytic activity. In addition, it was found that the MVD in which arginine at position and threonine at position in addition to the position were further substituted with different amino acids, respectively, also had the high catalytic activity.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: March 30, 2021
    Assignees: RIKEN, ZEON CORPORATION, THE YOKOHAMA RUBBER CO., LTD.
    Inventors: Ryoko Orishimo, Tomokazu Shirai, Kazuhiro Takahashi, Misao Hiza, Yusuke Tanabe
  • Publication number: 20210088677
    Abstract: An optical element for a radiation imaging apparatus includes an objective lens and receives incident radiation. A scintillator that receives the radiation to emit fluorescence light with a longer wavelength than the radiation is formed unitarily on a radiation incidence side substrate face of a lens-form substrate included in the objective lens.
    Type: Application
    Filed: July 19, 2018
    Publication date: March 25, 2021
    Applicant: RIKEN
    Inventor: Takashi Kameshima
  • Patent number: D920408
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: May 25, 2021
    Assignee: KABUSHIKI KAISHA RIKEN
    Inventor: Hiroshi Shimizu