Patents Assigned to Riken
  • Publication number: 20220198303
    Abstract: Provided is an environmental factor prediction device that includes a predictor and predicting means. The predictor uses, as explanatory variables: water quality data in a plurality of layers in water, the data including a value corresponding to a biochrome level or a bioluminescence level (e.g. chlorophyll concentration), water temperature, salt concentration, dissolved oxygen, turbidity and flow rate; and meteorological data including atmospheric temperature, precipitation and sunshine duration, and outputs an estimated value of each item of the explanatory variables at a unit time later, based on time series data of the explanatory variables. The predicting means predicts the water quality data up to an N unit time later by repeating prediction using the estimated value acquired by the predictor as input of the predictor again.
    Type: Application
    Filed: April 14, 2020
    Publication date: June 23, 2022
    Applicant: RIKEN
    Inventors: Kengo ITO, Jun KIKUCHI, Tomoko MATSUMOTO, Taiga ASAKURA, Atsushi KUROTANI
  • Publication number: 20220186195
    Abstract: Provided are an enzyme involved in a glycyrrhizin biosynthetic system, a gene of the enzyme and use thereof in order to stably and continuously provide a large amount of glycyrrhizin. Glucuronosyltransferase with an activity of further transferring glucuronic acid to the hydroxy group at the 2-position of glucuronic acid in an oleanane-type triterpenoid monoglucuronide is identified to provide the transferase, a gene for the transferase and use thereof.
    Type: Application
    Filed: September 9, 2021
    Publication date: June 16, 2022
    Applicant: RIKEN
    Inventors: Toshiya MURANAKA, Hikaru SEKI, Kazuki SAITO, Kiyoshi OHYAMA
  • Patent number: 11361443
    Abstract: An aspect of the present invention allows for more accurately identifying a possible lesion in a human lung field. The aspect of the present invention includes an image obtaining section configured to obtain a chest cross-sectional image of a subject, a segmentation section configured to classify, into a plurality of segments, unit elements of the chest cross-sectional image, and an image dividing section configured to divide the chest cross-sectional image into a plurality of regions. A data deriving section is configured to derive data associated with the possible lesion, the data being derived on the basis of a segment of unit elements in the each region among the plurality of segments. An identifying section is configured to output an identification result, which is a result of identification of the possible lesion in the lung field of the subject.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: June 14, 2022
    Assignees: RIKEN, NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM
    Inventors: Taiki Furukawa, Hideo Yokota, Shintaro Oyama, Yoshinori Hasegawa, Yoshimune Shiratori
  • Publication number: 20220170098
    Abstract: The method disclosed herein is for evaluating the quality of a transplant neural retina by sampling a part or the whole of a cell aggregate containing a neural retina having an epithelial structure derived from a pluripotent stem cell as a sample for quality evaluation.
    Type: Application
    Filed: March 13, 2020
    Publication date: June 2, 2022
    Applicants: Sumitomo Dainippon Pharma Co., Ltd., Riken, Sumitomo Chemical Company, Limited
    Inventors: Atsushi Kuwahara, Kenji Watari, Keizo Matsushita, Suguru Yamasaki, Michiko Mandai, Masayo Takahashi
  • Patent number: 11345885
    Abstract: This invention relates to an agent for inducing a callus comprising a compound represented by Formula (I) or a hydrolysis product of an amide bond thereof: wherein Ar1 represents phenyl substituted with substituent or substituents selected from alkoxy and methylenedioxy; Ar2 represents phenyl substituted with halogen; R1 and R2 each represent hydrogen, alkyl, cyano, or carboxyl; R1 and R2 may together form oxo; R3 to R10 each represent hydrogen or methyl; and R3 and R4, R5 and R6, R7 and R8, and/or R9 and R10 may together form oxo; a method for inducing a callus and a method for plant transformation using such agent for inducing a callus.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: May 31, 2022
    Assignee: RIKEN
    Inventors: Takeshi Nakano, Tadao Asami, Ayumi Yamagami, Hiroyuki Osada, Misato Ohtani, Taku Demura
  • Publication number: 20220165446
    Abstract: A beam target for generating a nuclear reaction product by irradiation with a beam obtained from a beam generation source includes a cone body which has a tapered inner surface which is reduced in diameter toward a tip, and supply means for supplying liquid metal to the inner surface of the cone body to form a liquid film of the liquid metal on the inner surface. It is possible to form the liquid film of the liquid metal on a cone body surface to increase an irradiation area of the beam, and also dispose a target substance such as LLFP around the cone body, and hence it is possible to efficiently use the nuclear reaction product (e.g., a neutron) generated by beam irradiation of the liquid metal.
    Type: Application
    Filed: February 3, 2020
    Publication date: May 26, 2022
    Applicant: RIKEN
    Inventors: Hiroki OKUNO, Naoya FURUTACHI, Yoshiharu MORI
  • Publication number: 20220161847
    Abstract: A vehicle knuckle (1) includes a main body portion (10) for supporting an axle, a strut connecting portion (11) for connecting a strut, and an arm portion (12) for connecting the main body portion (10) and the strut connecting portion (11) and having a space (18) inside. The arm portion (12) includes a sidewall portion (120) for connecting the main body portion (10) and the strut connecting portion (11), and has a first through hole (17a) communicating with the space (18), at a coupling portion (12a) with the main body portion (10). The sidewall portion (120) is free of a through hole communicating with the space (18).
    Type: Application
    Filed: April 10, 2020
    Publication date: May 26, 2022
    Applicant: KABUSHIKI KAISHA RIKEN
    Inventors: Cakrawala ANANG, Tadaaki KANBAYASHI, Shuichi KUSAMA
  • Patent number: 11339283
    Abstract: There are provided a thermoplastic resin composition capable of bonding a cyclic polyolefin-based polymer and an ethylene-vinyl alcohol copolymer with sufficient strength and to provide a laminate using the same.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: May 24, 2022
    Assignee: RIKEN TECHNOS CORPORATION
    Inventor: Ryota Nakanishi
  • Publication number: 20220154180
    Abstract: Provided is a composition and method for suppressing the reverse transcription of ribosomal RNA. The composition for suppressing the reverse transcription of ribosomal RNA contains at least one nucleic acid polymer selected from the group consisting of inosinic acid polymers, cytidylic acid polymers, guanylic acid polymers, adenylic acid polymers, thymidylic acid polymers, uridylic acid polymers, deoxyinosinic acid polymers, deoxycytidylic acid polymers, deoxyguanylic acid polymers, deoxyadenylic acid polymers, deoxythymidylic acid polymers, and deoxyuridylic acid polymers.
    Type: Application
    Filed: March 10, 2020
    Publication date: May 19, 2022
    Applicants: TOYOBO CO., LTD., RIKEN
    Inventors: Nana YAMAKOSHI, Tetsutaro HAYASHI, Itoshi NIKAIDO
  • Publication number: 20220128489
    Abstract: The neutron emission unit is configured to emit neutrons such that a center axis (Nh) of neutron emission intersects a center axis direction of collimators (23a to 23e). A calculation unit is capable of generating information about an inspection object in the center axis direction of the collimators, based on position information of the neutron detector and/or position information of the neutron emission unit, information about an angle (?1) at which the center axis of the neutron emission intersects the center axis direction of the collimators, and a neutron amount detected by the neutron detector.
    Type: Application
    Filed: February 27, 2020
    Publication date: April 28, 2022
    Applicants: Topcon Corporation, RIKEN
    Inventors: Hisashi TSUKADA, Shigenori NAGANO, Yoshie OTAKE, Hideyuki SUNAGA, Yuichi YOSHIMURA, Koji IKADO
  • Patent number: 11312974
    Abstract: An object of the present invention is to identify a novel gene that effectively increases plant biomass and to provide said gene as well as techniques utilizing the same. This invention provides a nucleic acid encoding a protein, wherein the protein comprises the amino acid sequence of SEQ ID NO:1 and an amino acid sequence having at least 25% identity or at least 75% similarity to the amino acid sequence of SEQ ID NO:7 or 11, and has an activity to increase plant biomass, as well as techniques utilizing the same.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: April 26, 2022
    Assignees: KANEKA CORPORATION, RIKEN
    Inventors: Takeshi Nakano, Tadao Asami, Tomoko Miyaji, Ayumi Yamagami, Noriko Ishikawa
  • Publication number: 20220119764
    Abstract: The present invention provides a method for producing retinal cells or a retinal tissue, comprising the following steps (1)-(3): (1) a first step of culturing human pluripotent stem cells in the absence of feeder cells and in a medium comprising a factor for maintaining undifferentiated state, (2) a second step of culturing the pluripotent stem cells obtained in the first step in suspension in the presence of a Sonic hedgehog signal transduction pathway activating substance to form a cell aggregate, and (3) a third step of culturing the aggregate obtained in the second step in suspension in the presence of a 1) a BMP signal transduction pathway activating substance to obtain an aggregate containing retinal cells or a retinal tissue.
    Type: Application
    Filed: January 3, 2022
    Publication date: April 21, 2022
    Applicants: SUMITOMO DAINIPPON PHARMA CO., LTD., RIKEN, SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Atsushi KUWAHARA, Suguru YAMASAKI, Yasushi HIRAMINE, Yoshiki SASAI (deceased), Masayo TAKAHASHI
  • Patent number: 11307153
    Abstract: In order to increase reproducibility of a reconstructed tomographic image without increasing the computational load, detection is performed by oversampling in (N+n) directions during imaging for detection by N detection elements. A vector having N×(N+n) elements is obtained, and vector decimation step is performed in which a total of n×N elements corresponding to a sequence {k} 30 denoting a decimation order are removed. In a discrete Radon transform step, a corresponding discrete Radon inverse matrix WSQ?140 is operated, and in an image data generation step, de-vectoring is performed, thereby tomographic image data are acquired. When oversampling is used, a discrete Radon inverse matrix WSQ?1 is obtained. Therefore, a tomographic image is obtained by matrix computation without resorting to iterative approximation.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: April 19, 2022
    Assignees: RIKEN, Nissan Chemical Corporation
    Inventors: Takaoki Takanashi, Shigeho Noda, Masaru Tamura, Yoshie Otake
  • Patent number: 11309454
    Abstract: A deep ultraviolet LED with a design wavelength ?, including a reflecting electrode layer (Au), a metal layer (Ni), a p-GaN contact layer, a p-block layer made of a p-AlGaN layer, an i-guide layer made of an AlN layer, a multi-quantum well layer, an n-AlGaN contact layer, a u-AlGaN layer, an AlN template, and a sapphire substrate that are arranged in this order from a side opposite to the sapphire substrate, in which the thickness of the p-block layer is 52 to 56 nm, a two-dimensional reflecting photonic crystal periodic structure having a plurality of voids is provided in a region from the interface between the metal layer and the p-GaN contact layer to a position not beyond the interface between the p-GaN contact layer and the p-block layer in the thickness direction of the p-GaN contact layer, the distance from an end face of each of the voids in the direction of the sapphire substrate to the interface between the multi-quantum well layer and the i-guide layer satisfies ?/2n1Deff (where ? is the design wav
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: April 19, 2022
    Assignees: Marubun Corporation, Shibaura Machine Co., Ltd., RIKEN, ULVAC, Inc., Tokyo Ohka Kogyo Co., Ltd., Nippon Tungsten Co., Ltd., Dai Nippon Printing Co., Ltd., Dowa Holdings Co., Ltd.
    Inventors: Yukio Kashima, Eriko Matsuura, Mitsunori Kokubo, Takaharu Tashiro, Hideki Hirayama, Noritoshi Maeda, Masafumi Jo, Ryuichiro Kamimura, Yamato Osada, Kanji Furuta, Takeshi Iwai, Yohei Aoyama, Yasushi Iwaisako, Tsugumi Nagano, Yasuhiro Watanabe
  • Publication number: 20220112457
    Abstract: The present invention provides a method for producing neural cells or a neural tissue, including the following steps (1)-(3): (1) a first step of culturing pluripotent stem cells in the absence of feeder cells and in a medium containing 1) a TGF? family signal transduction pathway inhibiting substance and/or a Sonic hedgehog signal transduction pathway activating substance, and 2) a factor for maintaining undifferentiated state, (2) a second step of culturing the cells obtained in the first step in suspension to form a cell aggregate, and (3) a third step of culturing the aggregate obtained in the second step in suspension in the presence or absence of a differentiation-inducing factor to obtain an aggregate containing neural cells or a neural tissue.
    Type: Application
    Filed: December 22, 2021
    Publication date: April 14, 2022
    Applicants: SUMITOMO DAINIPPON PHARMA CO., LTD., RIKEN, SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Atsushi KUWAHARA, Suguru YAMASAKI, Yasushi HIRAMINE, Yoshiki SASAI (deceased), Masayo TAKAHASHI
  • Publication number: 20220113080
    Abstract: Embodiments provide a door body for opening and closing a front part of an article body, whereby the door body includes a front panel constituting a front of the door body, a frame supporting at least a part of an outside edge of the front panel, and a back panel constituting a back of the door body. According to at least one embodiment, the frame includes a support plate extending to an inside of the article body in a substantially vertical direction, the front panel is bonded to the support plate with a double-sided pressure-sensitive adhesive film, the double-sided pressure-sensitive adhesive film extends from a leading edge of the support plate to an inside of the door body, and a radius of curvature of a front side corner of the leading edge of the support plate is 0.1 to 10 mm.
    Type: Application
    Filed: December 21, 2021
    Publication date: April 14, 2022
    Applicant: RIKEN TECHNOS CORPORATION
    Inventors: Nozomu WASHIO, Taketo HASHIMOTO, Shoko NAKAJIMA, Hitomi INOMATA
  • Publication number: 20220106493
    Abstract: Embodiments provide an anchor coat agent, including: (P) a polymer comprised of: (p1) a structural unit derived from a (meth)acrylate having one or more of one or more types of backbones selected from the group consisting of a benzotriazole backbone, a triazine backbone, and a benzophenone backbone per molecule in an amount of 1-50 mol %, (p2) a structural unit derived from an alkyl (meth)acrylate in an amount of 30-95 mol %, and (p3) a structural unit derived from a hydroxyl group-containing (meth)acrylate in an amount of 1-50 mol %, provided that the sum of structural units derived from all constituent monomers is 100 mol %.
    Type: Application
    Filed: December 17, 2021
    Publication date: April 7, 2022
    Applicant: RIKEN TECHNOS CORPORATION
    Inventor: Motohiro SHIMIZU
  • Patent number: 11291431
    Abstract: A non-transitory computer-readable recording medium stores therein an examination assisting program that causes a computer to execute a process including: performing a site detecting process that uses an object detection technique on each of a plurality of ultrasound examination images taken of an examined subject by performing a scan on the examined subject; and displaying a site detection map in which a detection result of each of a plurality of sites included in the examined subject is kept in correspondence with the scan, on a basis of detection results from the site detecting process.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: April 5, 2022
    Assignees: FUJITSU LIMITED, RIKEN, SHOWA UNIVERSITY, NATIONAL CANCER CENTER
    Inventors: Masaaki Komatsu, Hiroyuki Yoshida, Akira Sakai, Akihiko Sekizawa, Ryu Matsuoka, Ryuji Hamamoto
  • Publication number: 20220098550
    Abstract: The present invention provides a method of producing more mature telencephalon or a progenitor tissue thereof, in vitro, from mammalian pluripotent stem cells, comprising obtaining a telencephalon marker-positive aggregate by culturing an aggregate of pluripotent stem cells in suspension in the presence of a Wnt signal inhibitor and a TGF? signal inhibitor, and further culturing the telencephalon marker-positive aggregate in suspension under a high oxygen partial pressure condition. In one embodiment, the suspension culture under a high oxygen partial pressure condition is performed in the presence of a Wnt signal enhancer and a bone morphogenetic factor signal transduction pathway activating substance.
    Type: Application
    Filed: December 13, 2021
    Publication date: March 31, 2022
    Applicants: RIKEN, Sumitomo Chemical Company, Limited
    Inventors: Yoshiki SASAI, Taisuke KADOSHIMA, Hideya SAKAGUCHI
  • Publication number: 20220090210
    Abstract: A method for testing for sensitivity of chemotherapy against colorectal cancer, the method using, as an indicator, methylation in at least one site selected from the group consisting of CpG sites comprised in regions (i) to (xvi) in DNA collected from a colorectal cancer patient (the regions (i) to (xvi) are as described herein).
    Type: Application
    Filed: November 30, 2021
    Publication date: March 24, 2022
    Applicants: TOHOKU UNIVERSITY, RIKEN GENESIS CO., LTD.
    Inventors: CHIKASHI ISHIOKA, SHIN TAKAHASHI, KOUTA OUCHI, AKIRA OKITA, TATSURO SAITO, JUNKO NAKAMURA, AKIHIRO TSUYADA