Patents Assigned to Riken
  • Publication number: 20200216796
    Abstract: An object of the present invention is to provide a method for preserving neural tissue for several hours to several weeks without freezing, a preservation solution therefor, a transport method for neural tissue in accordance with the method and using the preservation solution, and a composition for transplantation. The preservation method for neural tissue, comprising preserving neural tissue in a preservation solution having a potassium ion concentration of more than 0 mM and less than 115 mM at a preservation temperature of 8° C. to 30° C. The preservation solution having a potassium ion concentration of more than 0 mM and less than 115 mM, for preserving neural tissue derived from pluripotent stem cells at a preservation temperature of 8° C. to 30° C.
    Type: Application
    Filed: July 20, 2018
    Publication date: July 9, 2020
    Applicants: Riken, Sumitomo Dainippon Pharma Co., Ltd.
    Inventors: Michiko Mandai, Masayo Takahashi, Atsushi Kuwahara, Kenji Watari, Keizo Matsushita
  • Publication number: 20200208103
    Abstract: The present invention provides a method for maintaining a continuous epithelial structure of a retinal tissue including culturing the retinal tissue in a medium comprising a methyl group donor or a substrate of the methyl group donor at a concentration at which cell differentiation of a neural retinal progenitor cell is suppressed, and a neurite extension inhibitor at a concentration at which neurite extension is suppressed.
    Type: Application
    Filed: July 20, 2018
    Publication date: July 2, 2020
    Applicants: RIKEN, SUMITOMO DAINIPPON PHARMA CO., LTD., SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Hideya SAKAGUCHI, Yoshiki SASAI (deceased), Mototsugu EIRAKU, Daiki NUKAYA, Atsushi KUWAHARA
  • Publication number: 20200206387
    Abstract: A sphere-like cell aggregate according to one embodiment of the present invention comprises: a core part containing neural retina; and a covering part continuously or discontinuously covering at least a portion of a surface of the core part.
    Type: Application
    Filed: September 7, 2018
    Publication date: July 2, 2020
    Applicants: Riken, Sumitomo Dainippon Pharma Co., Ltd.
    Inventors: Masayo Takahashi, Michiko Mandai, Suguru Yamasaki
  • Publication number: 20200212605
    Abstract: In a high-temperature superconducting (HTS) wire connection assembly in which HTS wires each including a HTS layer are connected to each other, a first HTS wire and a second HTS wire that face each other are connected to each other at a plurality of joint portions separated from each other along a longitudinal direction of the first HTS wire and the second HTS wire. Each of the plurality of joint portions may preferably have any one of a rectangle shape, a rounded rectangle shape, and an ellipse shape, and it is preferable to satisfy 0.1<L/W<1.5, and is more preferable to satisfy 0.25<L/W<0.75 when a length in the longitudinal direction of the HTS wire is taken as L and a length in a width direction of the HTS wire is taken as W. It is also preferable that W and/or L monotonously increase from upstream side toward downstream side along the longitudinal direction of the wire.
    Type: Application
    Filed: August 27, 2018
    Publication date: July 2, 2020
    Applicant: RIKEN
    Inventors: Shintetsu KANAZAWA, Hideaki MAEDA, Yoshinori YANAGISAWA
  • Publication number: 20200207817
    Abstract: The present invention relates to a modified fibroin including a domain sequence represented by Formula 1: [(A)n motif-REP]m or Formula 2: [(A)n motif-REP]m-(A)n motif, in which the domain sequence has an amino acid sequence with a reduced content of a glutamine residue equivalent to an amino acid in which one or a plurality of glutamine residues in REP are deleted or substituted with other amino acid residues, as compared with a naturally occurring fibroin. [In Formula 1 and Formula 2, (A)n motif represents an amino acid sequence consisting of 4 to 27 amino acid residues, and the number of alanine residues with respect to the total number of amino acid residues in the (A)n motif is 80% or more. REP represents an amino acid sequence consisting of 10 to 200 amino acid residues. m represents an integer of 10 to 300. A plurality of (A)n motifs may be the same amino acid sequence or different amino acid sequences.
    Type: Application
    Filed: July 25, 2018
    Publication date: July 2, 2020
    Applicants: Spiber Inc., Riken
    Inventors: Keisuke Morita, Yunosuke Abe, Takehisa Maekawa, Koichi Kotaka, Junichi Sugahara, Keiji Numata
  • Patent number: 10697920
    Abstract: Disclosed is a gas sensor having high detection sensitivity, capable of detecting a gas at a low concentration and achieving lower power consumption. In the gas sensor including a gas detection element disposed on a thin-film insulator layer, the gas detection element includes: a heater layer provided on the thin-film insulator layer; and a gas detection layer having a thin-film thermistor part and an electrode part in contact with the thin-film, thermistor part, the gas detection layer being provided on the heater layer so as to be electrically insulated from the heater layer. The gas sensor is configured to detect a temperature change due to contact of a gas with the gas detection element on the basis of a change in resistance value in the thin-film thermistor part. The thin-film thermistor part preferably comprises a composite metal oxide containing Fe2O3, TiO2 and MgO.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: June 30, 2020
    Assignee: RIKEN KEIKI CO., LTD.
    Inventors: Yoshikazu Shibasaki, Hirotaka Obata
  • Patent number: 10697089
    Abstract: An epitaxial substrate includes: a single crystal substrate including projections arranged in an array on a plane. Each projection has a conical or pyramidal shape tapered in a normal direction to the plane. The AlN layer includes: a first AlN crystal covering the plane and the projections with tips of the projections being exposed; second AlN crystals protruding from the tips of the projections along the normal direction and each having a shape of a column whose cross-sectional area increases as a distance from a tip of a corresponding projection increases; and a third AlN crystal as a layer interconnecting ends of the second AlN crystals, opposite the single crystal substrate.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: June 30, 2020
    Assignees: PANASONIC CORPORATION, RIKEN
    Inventors: Norimichi Noguchi, Takuya Mino, Takayoshi Takano, Jun Sakai, Hitomichi Takano, Kenji Tsubaki, Hideki Hirayama
  • Patent number: 10697912
    Abstract: Provided are a gas detection method and a gas detector which have a high durability to silicone poisoning and is capable of detecting the type and the concentration of a target gas to be detected with certain accuracy even when the detector is used in an environment where a silicone compound exists. The gas detector employs a contact combustion-type gas sensor which includes two gas detection elements, each intermittently driven, and in which only one gas detection element is supplied with a gas through a silicone removal filter. Acquired in an energization duration of each of the gas detection elements are two or more pieces of output data by the one gas detection element and two or more pieces of output data by the other gas detection element, which constitutes output variation patterns for a test gas.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: June 30, 2020
    Assignee: RIKEN KEIKI CO., LTD.
    Inventors: Yuki Tanaka, Ryuji Asada, Yoshikazu Shibasaki, Shunsuke Takahashi
  • Patent number: 10699830
    Abstract: There is provided a superconducting magnet device that suppresses interference of a part of a tape wire wound around a center axis with another adjacent part. The number of unit wire layer turns of a first coil among the plurality of first coils is smaller than a mean value of the respective numbers of unit wire layer turns of the plurality of first coils, the number of unit wire layer turns of each of the first coils being expressed by a mean value of the respective numbers of turns of the tape wire in the plurality of wire layers, the first coil being disposed at such a position that compressive force acting on the first coil in a direction in which the center axis extends is the largest on the assumption that the respective numbers of unit wire layer turns of the plurality of first coils were the same.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: June 30, 2020
    Assignees: JAPAN SUPERCONDUCTOR TECHNOLOGY INC., RIKEN
    Inventors: Mamoru Hamada, Yoshinori Yanagisawa
  • Patent number: 10696861
    Abstract: Embodiments relate to a hard coat-laminated film for a touch panel display face plate, the hard coat-laminated film including: a transparent resin film, and a hard coat formed on at least one surface of the transparent resin film from a coating material including an active energy ray-curable resin composition. The hard coat-laminated film meets the following requirements (1-i) to (1-v): (1-i) a total light transmittance of 80% or higher, (1-ii) a haze of 3.0% or lower, (1-iii) a yellowness index of 3 or lower, (1-iv) a water contact angle of a touch surface of 100° or larger; and (1-v) a water contact angle of the touch surface of 100° or larger after 20,000-times reciprocal cotton wiping of the touch panel.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: June 30, 2020
    Assignee: RIKEN TECHNOS CORPORATION
    Inventors: Yasuhiro Itagaki, Shigekazu Ito
  • Patent number: 10689530
    Abstract: Embodiments provide a pressure-sensitive adhesive film having (?) a poly(meth)acrylimide-based resin film layer and (?) a pressure-sensitive adhesive agent layer in that order from the surface layer side and having a total light transmittance of 80% or higher. The pressure-sensitive adhesive film may further have (?) a hard coat layer on the surface layer side of the poly(meth)acrylimide-based resin film layer (?). This hard coat layer (?) may comprise an active energy ray-curable resin composition that contains (A) 100 parts by mass of a polyfunctional (meth)acrylate; (B) 0.2-4 parts by mass of a compound having an alkoxysilyl group and a (meth)acryloyl group; (C) 0.05-3 parts by mass of organic titanium; and (D) 5-100 parts by mass of fine particles having an average particle diameter of 1-300 nm. This active energy ray-curable resin composition may further contain (E) 0.01-7 parts by mass of a water-repelling agent.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: June 23, 2020
    Assignee: RIKEN TECHNOS CORPORATION
    Inventors: Jun Fujimoto, Nozomu Washio
  • Publication number: 20200190301
    Abstract: There is provided an elastomer composition which can be molded like a thermoplastic resin by using a conventional plastics processing equipment, and has a very small compression set like a vulcanized rubber. The elastomer composition comprises: 100 parts by mass of an ethylene/?-olefin copolymer (A); 10 to 150 parts by mass of a propylene-based resin (B); and 5 to 150 parts by mass of a non-aromatic softener for rubber (C); 0.03 to 1 parts by mass of an organic peroxide (D); 0.5 to 7 parts by mass of a silane coupling agent (E); 0 to 2 parts by mass of a crosslinking aid (F); and 0 to 100 parts by mass of an inorganic filler (G).
    Type: Application
    Filed: October 12, 2017
    Publication date: June 18, 2020
    Applicant: RIKEN TECHNOS CORPORATION
    Inventors: Kouichi YAMAMOTO, Rikuo SHIMIZU
  • Patent number: 10683341
    Abstract: An object of the present invention is to provide an albumin-sugar chain complex bound with a number of sugar chains sufficient for obtaining a sugar chain clustering effect while also being able to exist comparatively stably in the body. The present invention provides an albumin-sugar chain complex having five or more molecules of an asparagine-linked sugar chain bound per molecule of albumin; a carrier for selectively delivering a functional molecule to a target tissue in the body that contains the aforementioned albumin-sugar chain complex; and a bioimaging probe having the aforementioned albumin-sugar chain complex as an active ingredient thereof that is administered into the body of an animal.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: June 16, 2020
    Assignees: Glytech, Inc., RIKEN
    Inventors: Katsunori Tanaka, Yasuyoshi Watanabe, Akihiro Ogura, Takahiro Yamamoto
  • Publication number: 20200183251
    Abstract: A terahertz-wave generation method of generating a terahertz wave in a direction satisfying a non-collinear phase-matching condition by making pump light incident on a nonlinear optical crystal capable of generating a terahertz wave by optical parametric effect, makes the pump light incident on the nonlinear optical crystal so that a peak excited power density is equal to or greater than a predetermined terahertz-wave lasing threshold and equal to or less than a predetermined laser damage threshold, and an average excited power density is equal to or less than a predetermined photorefractive effect occurrence threshold, the pump light having a pulse width of 10 ps or more, the pulse width of 1 ns or less, and a repetition frequency of 1 kHz or more.
    Type: Application
    Filed: July 30, 2018
    Publication date: June 11, 2020
    Applicants: TOPCON CORPORATION, RIKEN
    Inventors: Yoshikiyo MORIGUCHI, Hiroaki MINAMIDE
  • Patent number: 10676711
    Abstract: This invention relates to an agent for inducing a callus comprising a compound represented by Formula (I) or a hydrolysis product of an amide bond thereof: wherein Ar1 represents phenyl substituted with substituent or substituents selected from alkoxy and methylenedioxy; Ar2 represents phenyl substituted with halogen; R1 and R2 each represent hydrogen, alkyl, cyano, or carboxyl; R1 and R2 may together form oxo; R3 to R10 each represent hydrogen or methyl; and R3 and R4, R5 and R6, R7 and R8, and/or R9 and R10 may together form oxo; a method for inducing a callus and a method for plant transformation using such agent for inducing a callus.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: June 9, 2020
    Assignee: Riken
    Inventors: Takeshi Nakano, Tadao Asami, Ayumi Yamagami, Hiroyuki Osada, Misato Ohtani, Taku Demura
  • Patent number: 10680134
    Abstract: Provided is a deep ultraviolet LED with a design wavelength ?, including a reflecting electrode layer, an ultra-thin metal layer, and a p-type contact layer that are arranged in this order from a side opposite to a substrate; and a hemispherical lens bonded to a rear surface of the substrate on a side of the p-type contact layer, the hemispherical lens being transparent to light with the wavelength ?. The refractive index of the hemispherical lens is greater than or equal to the average value of the refractive index of the substrate and the refractive index of air and is less than or equal to the refractive index of the substrate. The hemispherical lens has a radius that is greater than or equal to the radius of an inscribed circle of the substrate and is about equal to the radius of a circumscribed circle of the substrate.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: June 9, 2020
    Assignees: Marubun Corporation, Toshiba Kikai Kabushiki Kaisha, RIKEN, ULVAC, INC., Tokyo Ohka Kogyo Co., Ltd.
    Inventors: Yukio Kashima, Eriko Matsuura, Mitsunori Kokubo, Takaharu Tashiro, Hideki Hirayama, Ryuichiro Kamimura, Yamato Osada, Toshiro Morita
  • Publication number: 20200172554
    Abstract: Provided are 2-(piperidin-1-yl)pyrimidin-4(3H)-ones or pharmaceutically acceptable salts thereof, each characterized by having a 1,8-diazaspiro[4.5]deca-3-ene, 1-oxa-8-azaspiro[4.5]deca-3-ene, 2,8-diazaspiro[4.5]deca-3-ene, 2-oxa-8-azaspiro[4.5]deca-3-ene, 2,9-diazaspiro[5.5]undeca-3-ene, 1-oxa-9-azaspiro[5.5]undeca-3-ene, 1,9-diazaspiro[5.5]undeca-4-ene, or 3,9-diazaspiro[5.
    Type: Application
    Filed: June 30, 2017
    Publication date: June 4, 2020
    Applicants: RIKEN, JAPANESE FOUNDATION FOR CANCER RESEARCH
    Inventors: Minoru YOSHIDA, Hiroyuki SEIMIYA, Masayuki OKUE, Yoko YASHIRODA, Fumiyuki SHIRAI, Takeshi TSUMURA, Yuko KANO, Kenichi WASHIZUKA, Nobuko YOSHIMOTO, Yasuko KOUDA, Takehiro FUKAMI, Tsubasa CHIKADA, Takashi WATANABE
  • Patent number: 10669167
    Abstract: A water treatment device includes: a dual-pipe structure unit including an outer pipe, an inner pipe provided in the outer pipe, and a prevention member provided between the outer pipe and the inner pipe; and a light source unit radiating ultraviolet light in the axial direction to irradiate water subject to treatment flowing in the inner pipe. The inner pipe includes an opposing end facing the light source unit across a gap and an inflow end positioned opposite to the opposing end. The outer pipe includes an outflow port provided on an outer circumferential surface of the outer pipe. The water subject to treatment flowing out of the inner pipe via the gap flows out from the outflow port.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: June 2, 2020
    Assignees: NIKKISO CO., LTD., METAWATER CO., LTD., SENKO RIKEN CO., LTD.
    Inventors: Tetsumi Ochi, Shinya Watanabe, Junichi Shiga, Tsukasa Kusano, Eiichi Tsuga, Yusuke Kawakami
  • Patent number: 10670147
    Abstract: Provided is a sliding member having a hard carbon coating that makes high wear resistance compatible with a low coefficient of friction and that has excellent peeling resistance. A sliding member (100) includes a base member (10) and a hard carbon coating (12) formed on the base member (10). The indentation hardness of the hard carbon coating (12) decreases gradually from the base member side to the surface side. The hard carbon coating (12) has an indentation hardness distribution at 0?T/Ttotal?0.6 approximated by a first line and an indentation hardness distribution at 0.9?T/Ttotal?1 approximated by a second line, and the intersection between the first line and the second line (T2/Ttotal, H2) satisfies Expression (1), (H3?H1)×T2/Ttotal+H1<H2?0.9×H1, and Expression (2), 0.6?T2/Ttotal?0.9.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: June 2, 2020
    Assignee: KABUSHIKI KAISHA RIKEN
    Inventors: Kazuya Kameda, Hiroshi Maruyama, Yuuichi Ishida, Takuma Sekiya
  • Patent number: 10670146
    Abstract: Provided is a piston ring for an internal combustion engine that enables size reduction of a chamfered edge without leading to the chipping, and sufficient size reduction of a flow passage of a blow-by gas in a piston ring gap, thus effectively restraining the blow-by gas from passing through the piston ring gap. A piston ring 1 with a piston ring gap 2 used for an internal combustion engine includes a chamfered edge 3 continuous to at least one of piston ring end faces at the piston ring gap 2 and an outer peripheral surface 1a of the piston ring 1. The chamfered edge 3 has a curved shape.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: June 2, 2020
    Assignee: KABUSHIKI KAISHA RIKEN
    Inventors: Kazunori Natabe, Naoya Honjou